| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Fernández-López, J Faustino, N Derugin, M Wendland, I Lizasoain, M A Moro, Z S Vexle. Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. Neuroscience. vol 207. 2012-11-27. PMID:22285309. |
cumulatively, our results show that the cannabinoid agonist win protects against neonatal focal stroke in part due to inhibitory effects on microglia. |
2012-11-27 |
2023-08-12 |
rat |
| Kate Lykke Lambertsen, Knut Biber, Bente Finse. Inflammatory cytokines in experimental and human stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 9. 2012-11-19. PMID:22739623. |
the fact that tnf and il-1, and suppossedly also il-6, are produced by microglia within the therapeutic window place these cells centrally in potential future stroke therapy. |
2012-11-19 |
2023-08-12 |
human |
| F J Ortega, J Gimeno-Bayon, J F Espinosa-Parrilla, J L Carrasco, M Batlle, M Pugliese, N Mahy, M J Rodrígue. ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats. Experimental neurology. vol 235. issue 1. 2012-06-29. PMID:22387180. |
these findings provide that evidence for the key role of k(atp) channels in the control of microglial reactivity are consistent with a microglial effect of glibenclamide into the ischemic brain and suggest a neuroprotective role of microglia in the early stages of stroke. |
2012-06-29 |
2023-08-12 |
rat |
| Ya-Dan Wen, Hui-Ling Zhang, Zheng-Hong Qi. Inflammatory mechanism in ischemic neuronal injury. Neuroscience bulletin. vol 22. issue 3. 2012-06-25. PMID:17704846. |
this review summarizes data regarding roles of cell adhesion molecules, astrocytes, microglia and leukocytes in stroke. |
2012-06-25 |
2023-08-12 |
Not clear |
| Jin-Sun Park, Jin A Shin, Ji-Sun Jung, Jin-Won Hyun, Thi Kim Van Le, Dong-Hyun Kim, Eun-Mi Park, Hee-Sun Ki. Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22207656. |
anti-inflammatory mechanism of compound k in activated microglia and its neuroprotective effect on experimental stroke in mice. |
2012-05-04 |
2023-08-12 |
mouse |
| Chao Jiang, Kefei Cui, Jianping Wang, Yuanhong H. Microglia and cyclooxygenase-2: possible therapeutic targets of progesterone for stroke. International immunopharmacology. vol 11. issue 11. 2012-04-27. PMID:21843661. |
microglia and cyclooxygenase-2: possible therapeutic targets of progesterone for stroke. |
2012-04-27 |
2023-08-12 |
rat |
| Chao Jiang, Kefei Cui, Jianping Wang, Yuanhong H. Microglia and cyclooxygenase-2: possible therapeutic targets of progesterone for stroke. International immunopharmacology. vol 11. issue 11. 2012-04-27. PMID:21843661. |
although there have been reports about the neurotoxicity of activated microglia and cyclooxygenase-2 (cox-2) in animal models of ischemic stroke, the influence of prog on the activation of microglia and the expression of cox-2 after stroke has not been examined in detail. |
2012-04-27 |
2023-08-12 |
rat |
| Chao Jiang, Kefei Cui, Jianping Wang, Yuanhong H. Microglia and cyclooxygenase-2: possible therapeutic targets of progesterone for stroke. International immunopharmacology. vol 11. issue 11. 2012-04-27. PMID:21843661. |
these observations raised the possibility that prog can exert its neuroprotective effects by inhibiting the activation of microglia and the over expression of cox-2 after stroke. |
2012-04-27 |
2023-08-12 |
rat |
| Ursula Heldmann, Yutaka Mine, Zaal Kokaia, Christine T Ekdahl, Olle Lindval. Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21419118. |
selective depletion of mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. |
2011-08-05 |
2023-08-12 |
rat |
| Ursula Heldmann, Yutaka Mine, Zaal Kokaia, Christine T Ekdahl, Olle Lindval. Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21419118. |
stroke also leads to accumulation of microglia in the svz but their role for neurogenesis is unclear. |
2011-08-05 |
2023-08-12 |
rat |
| Ursula Heldmann, Yutaka Mine, Zaal Kokaia, Christine T Ekdahl, Olle Lindval. Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21419118. |
these findings indicate that the mac-1-expressing microglia in the svz do not play a major role either for the number of neuroblasts which exit the svz or their migration in the striatum early following stroke. |
2011-08-05 |
2023-08-12 |
rat |
| D Arsene, Florina Vasilescu, C Toader, Adina Bălan, C Popa, Carmen Ardelean. Clinico-pathological correlations in fatal ischemic stroke. An immunohistochemical study of human brain penumbra. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 52. issue 1. 2011-07-21. PMID:21424029. |
microglia appears active in stroke and stimulating methods directed to it could be useful. |
2011-07-21 |
2023-08-12 |
human |
| Alexander Thiel, Wolf-Dieter Heis. Imaging of microglia activation in stroke. Stroke. vol 42. issue 2. 2011-03-02. PMID:21164114. |
imaging of microglia activation in stroke. |
2011-03-02 |
2023-08-12 |
human |
| Vladimer Darsalia, Susan J Allison, Carlo Cusulin, Emanuela Monni, Daniela Kuzdas, Therése Kallur, Olle Lindvall, Zaal Kokai. Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 1. 2011-02-03. PMID:20531461. |
a substantial number of activated microglia was observed at 48 hours after the insult in the injured striatum, but reached maximum levels 1 to 6 weeks after stroke. |
2011-02-03 |
2023-08-12 |
human |
| Midori A Yenari, Tiina M Kauppinen, Raymond A Swanso. Microglial activation in stroke: therapeutic targets. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 7. issue 4. 2011-01-24. PMID:20880502. |
effective agents are now available for blocking both microglial receptor activation and the microglia effector responses that drive the inflammatory response after stroke. |
2011-01-24 |
2023-08-12 |
Not clear |
| V A Dinapoli, S A Benkovic, X Li, K A Kelly, D B Miller, C L Rosen, J D Huber, J P O'Callagha. Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20633608. |
while activation of perilesional astrocytes and microglia following ischemic brain injury is well documented, the influence of age on these cellular responses after stroke is unclear. |
2011-01-20 |
2023-08-12 |
rat |
| D Famer, L-O Wahlund, M Crisb. Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD. Biochemical and biophysical research communications. vol 402. issue 2. 2010-12-28. PMID:20946880. |
rosuvastatin reduces microglia in the brain of wild type and apoe knockout mice on a high cholesterol diet; implications for prevention of stroke and ad. |
2010-12-28 |
2023-08-12 |
mouse |
| Catherine E Downes, Peter J Crac. Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? British journal of pharmacology. vol 160. issue 8. 2010-11-08. PMID:20649586. |
over the past 20 years, researchers examining brain tissue at various time intervals after stroke observed the presence of inflammatory cells, neutrophils and monocytes at the site of injury, as well as the activation of endogenous glia and microglia. |
2010-11-08 |
2023-08-12 |
Not clear |
| Amjad Shehadah, Jieli Chen, Xu Cui, Cynthia Roberts, Mei Lu, Michael Chop. Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. Journal of the neurological sciences. vol 294. issue 1-2. 2010-10-21. PMID:20451219. |
in this study we examined the effect of combination treatment of experimental stroke with niaspan, a prolonged-release formulation of niacin (vitamin b3), and simvastatin, a cholesterol-lowering drug, on functional outcome, axonal damage, axonal density and the of iba-1 immunoreactive microglia expression in the ischemic brain of rats. |
2010-10-21 |
2023-08-12 |
rat |
| Amjad Shehadah, Jieli Chen, Xu Cui, Cynthia Roberts, Mei Lu, Michael Chop. Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. Journal of the neurological sciences. vol 294. issue 1-2. 2010-10-21. PMID:20451219. |
decreased expression of the ngr and reduced activated microglia may contribute to functional recovery after stroke. |
2010-10-21 |
2023-08-12 |
rat |