| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pär Thored, Ursula Heldmann, Walace Gomes-Leal, Ramiro Gisler, Vladimer Darsalia, Jalal Taneera, Jens M Nygren, Sten-Eirik W Jacobsen, Christine T Ekdahl, Zaal Kokaia, Olle Lindval. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia. vol 57. issue 8. 2009-07-09. PMID:19053043. |
long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. |
2009-07-09 |
2023-08-12 |
rat |
| Pär Thored, Ursula Heldmann, Walace Gomes-Leal, Ramiro Gisler, Vladimer Darsalia, Jalal Taneera, Jens M Nygren, Sten-Eirik W Jacobsen, Christine T Ekdahl, Zaal Kokaia, Olle Lindval. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia. vol 57. issue 8. 2009-07-09. PMID:19053043. |
elevated numbers of igf-1-expressing microglia were found in svz at 2, 6, and 16 weeks after stroke. |
2009-07-09 |
2023-08-12 |
rat |
| Pär Thored, Ursula Heldmann, Walace Gomes-Leal, Ramiro Gisler, Vladimer Darsalia, Jalal Taneera, Jens M Nygren, Sten-Eirik W Jacobsen, Christine T Ekdahl, Zaal Kokaia, Olle Lindval. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia. vol 57. issue 8. 2009-07-09. PMID:19053043. |
the long-term accumulation of microglia with proneurogenic phenotype in the svz implies a supportive role of these cells for the continuous neurogenesis after stroke. |
2009-07-09 |
2023-08-12 |
rat |
| Robert E Iosif, Henrik Ahlenius, Christine T Ekdahl, Vladimer Darsalia, Pär Thored, Stefan Jovinge, Zaal Kokaia, Olle Lindval. Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 9. 2008-10-06. PMID:18493257. |
here we show that the increased proliferation 1 week after stroke occurred concomitantly with elevated microglia numbers and tnf-alpha and tnf receptor-1 (tnf-r1) gene expression in the svz of wild-type mice. |
2008-10-06 |
2023-08-12 |
mouse |
| A Popa-Wagner, Irina Badan, Raluca Vintilescu, L Walker, C Kessle. Premature cellular proliferation following cortical infarct in aged rats. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 47. issue 3. 2007-05-18. PMID:17308679. |
since most proliferating cells at the infarct site are microglia or nestin-positive cells derived from the vascular wall, we conclude that the vasculature plays a hitherto unrecognized role as a source of proliferating neuroepithelial cells after stroke. |
2007-05-18 |
2023-08-12 |
human |
| Sheryl P Denker, Shaoquan Ji, Andra Dingman, Sarah Y Lee, Nikita Derugin, Michael F Wendland, Zinaida S Vexle. Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke. Journal of neurochemistry. vol 100. issue 4. 2007-04-10. PMID:17212701. |
macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke. |
2007-04-10 |
2023-08-12 |
rat |
| Mélanie Lalancette-Hébert, Geneviève Gowing, Alain Simard, Yuan Cheng Weng, Jasna Kri. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 10. 2007-04-09. PMID:17344397. |
more importantly, our results revealed a marked neuroprotective potential of proliferating microglia serving as an endogenous pool of neurotrophic molecules such as igf-1, which may open new therapeutic avenues in the treatment of stroke and other neurological disorders. |
2007-04-09 |
2023-08-12 |
mouse |
| Mohamed G Bani-Hani, David Greenstein, Brian E Mann, Colin J Green, Roberto Motterlin. Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. The Journal of pharmacology and experimental therapeutics. vol 318. issue 3. 2006-10-10. PMID:16772536. |
these results suggest that the anti-inflammatory activity of corm-3 could be exploited to mitigate microglia activity in stroke and other neuroinflammatory diseases. |
2006-10-10 |
2023-08-12 |
Not clear |
| Aaron Y Lai, Kathryn G Tod. Microglia in cerebral ischemia: molecular actions and interactions. Canadian journal of physiology and pharmacology. vol 84. issue 1. 2006-08-23. PMID:16845890. |
the precise role of microglia in stroke and cerebral ischemia has been the subject of debate for a number of years. |
2006-08-23 |
2023-08-12 |
human |
| Elena Fonfria, Cesar Mattei, Kerstin Hill, Jon T Brown, Andrew Randall, Christopher D Benham, Stephen D Skaper, Colin A Campbell, Barry Crook, Paul R Murdock, Jennifer M Wilson, Frank P Maurio, Davina E Owen, Paula L Tilling, Shaun McNult. TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. Journal of receptor and signal transduction research. vol 26. issue 3. 2006-07-31. PMID:16777714. |
trpm2 is elevated in the tmcao stroke model, transcriptionally regulated, and functionally expressed in c13 microglia. |
2006-07-31 |
2023-08-12 |
human |
| Shao-Hua Yang, Ran Liu, Evelyn J Perez, Xiaofei Wang, James W Simpkin. Estrogens as protectants of the neurovascular unit against ischemic stroke. Current drug targets. CNS and neurological disorders. vol 4. issue 2. 2005-07-07. PMID:15857302. |
these protective effects of estrogens are seen in neurons, astrocytes, microglia and vascular endothelial cells and result in a profound protection of the brain during stroke. |
2005-07-07 |
2023-08-12 |
Not clear |
| Erica J Carrier, Christopher S Kearn, Andrew J Barkmeier, Nicole M Breese, Wenqi Yang, Kasem Nithipatikom, Sandra L Pfister, William B Campbell, Cecilia J Hillar. Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Molecular pharmacology. vol 65. issue 4. 2004-04-21. PMID:15044630. |
microglia, as phagocytes and antigen-presenting cells in the central nervous system, are activated in such disease processes as stroke and multiple sclerosis. |
2004-04-21 |
2023-08-12 |
rat |
| Susan L Stevens, Tatyana E Shaw, Emily Dykhuizen, Nikola S Lessov, Jennifer K Hill, Wolfgang Wurst, Mary P Stenzel-Poor. Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and atrocytes that express CRH-R1. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 23. issue 10. 2003-11-12. PMID:14526225. |
in addition, the authors examine a potential role for crh in inflammatory injury after stroke by identifying functional crh receptors on astrocytes and microglia, which are cells that are known to be involved in brain inflammation. |
2003-11-12 |
2023-08-12 |
mouse |
| I Badan, B Buchhold, A Hamm, M Gratz, L C Walker, D Platt, Ch Kessler, A Popa-Wagne. Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 23. issue 7. 2003-08-26. PMID:12843788. |
histologically, a gradual activation of both microglia and astrocytes that peaked by days 14 to 28 with the formation of a glial scar was observed in young rats, whereas aged rats showed an accelerated astrocytic and microglial reaction that peaked during the first week after stroke. |
2003-08-26 |
2023-08-12 |
rat |
| Corinna Trebst, Susan M Staugaitis, Pia Kivisäkk, Don Mahad, Martha K Cathcart, Barbara Tucky, Tao Wei, Mysore R Sandhya Rani, Richard Horuk, Kenneth D Aldape, Carlos A Pardo, Claudia F Lucchinetti, Hans Lassmann, Richard M Ransohof. CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages. The American journal of pathology. vol 162. issue 2. 2003-04-11. PMID:12547701. |
ccr8 was consistently expressed on phagocytic macrophages and activated microglia in stroke and progressive multifocal leukoencephalopathy, but not expressed on microglia in pathologies that lacked phagocytic macrophages such as senile change of the alzheimer's type. |
2003-04-11 |
2023-08-12 |
human |
| Gary H Danton, W Dalton Dietric. Inflammatory mechanisms after ischemia and stroke. Journal of neuropathology and experimental neurology. vol 62. issue 2. 2003-03-05. PMID:12578222. |
this review summarizes data regarding the role of the vasculature, leukocytes, blood-brain barrier, macrophages, and microglia after experimental and clinical stroke. |
2003-03-05 |
2023-08-12 |
Not clear |
| Robert L Jakab, John F Bowye. Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468030. |
parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke. |
2003-02-25 |
2023-08-12 |
rat |
| J M Pocock, A C Liddle, C Hooper, D L Taylor, C M Davenport, S C Morga. Activated microglia in Alzheimer's disease and stroke. Ernst Schering Research Foundation workshop. issue 39. 2002-12-06. PMID:12066408. |
activated microglia in alzheimer's disease and stroke. |
2002-12-06 |
2023-08-12 |
Not clear |
| Hyung Soo Han, Yanli Qiao, Murat Karabiyikoglu, Rona G Giffard, Midori A Yenar. Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12019311. |
therapies directed against microglia or their activation may be useful in treating stroke. |
2002-05-29 |
2023-08-12 |
rat |
| S Chabot, D Charlet, T L Wilson, V W Yon. Cytokine production consequent to T cell--microglia interaction: the PMA/IFN gamma-treated U937 cells display similarities to human microglia. Journal of neuroscience methods. vol 105. issue 2. 2001-05-31. PMID:11275268. |
since this interaction can occur in a non-antigen-dependent manner, it is relevant to a variety of cns diseases where activated t cells, regardless of specificities, come into contact with microglia; these disorders include multiple sclerosis, trauma, stroke and alzheimer's disease. |
2001-05-31 |
2023-08-12 |
human |