| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiruo Liu, Qin Qin, Shisi Wang, Xinmei Kang, Yuxin Liu, Lei Wei, Zhengqi Lu, Wei Cai, Mengyan H. STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions. CNS neuroscience & therapeutics. vol 30. issue 12. 2024-12-19. PMID:39698742. |
monocyte-derived macrophages and microglia initially adopt an anti-inflammatory phenotype following stroke but later transition to a pro-inflammatory state. |
2024-12-19 |
2024-12-21 |
Not clear |
| Zhiruo Liu, Qin Qin, Shisi Wang, Xinmei Kang, Yuxin Liu, Lei Wei, Zhengqi Lu, Wei Cai, Mengyan H. STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions. CNS neuroscience & therapeutics. vol 30. issue 12. 2024-12-19. PMID:39698742. |
this study investigates the activation dynamics of molecular signaling pathways in macrophages and microglia after stroke. |
2024-12-19 |
2024-12-21 |
Not clear |
| Alessandra Maria Testa, Livia Vignozzi, Diana Corallo, Sanja Aveic, Antonella Viola, Manuela Allegra, Roberta Angion. Hypoxic Human Microglia Promote Angiogenesis Through Extracellular Vesicle Release. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684220. |
microglia, the brain-resident immune cells, orchestrate neuroinflammatory responses and are crucial in the progression of neurological diseases, including ischemic stroke (is), which accounts for approximately 85% of all strokes worldwide. |
2024-12-17 |
2024-12-21 |
mouse |
| Ruiqi Cheng, Xiaoqin Luo, Xiaohui Wu, Zijie Wang, Ziqun Chen, Shaoru Zhang, Hongmei Xiao, Jiaju Zhong, Rongrong Zhang, Yang Cao, Xinyue Qi. Artificial Microglia Nanoplatform Loaded With Anti-RGMa in Acoustic/Magnetic Feld for Recanalization and Neuroprotection in Acute Ischemic Stroke. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-10-30. PMID:39475454. |
hence, an artificial nanoplatform loaded with anti-repulsive guidance molecule a monoclonal antibody (anti-rgma) and coated with microglia membrane (micm) is reported for stroke treatment, namely micm@plga/anti-rgma/fe |
2024-10-30 |
2024-11-02 |
Not clear |
| Chuan Qin, Ming-Hao Dong, Yue Tang, Yun-Hui Chu, Luo-Qi Zhou, Hang Zhang, Sheng Yang, Lu-Yang Zhang, Xiao-Wei Pang, Li-Fang Zhu, Wei Wang, Dai-Shi Tia. The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke. Nature aging. 2024-10-29. PMID:39468286. |
our findings suggest that exosomal novel-3, which is primarily derived from macrophage-derived foam cells, targets microglia and macrophages in the brain to induce neuroinflammation and could serve as a potential therapeutic target for patients with stroke who have atherosclerosis. |
2024-10-29 |
2024-10-31 |
mouse |
| Ashley McDonough, Jonathan R Weinstei. Glial 'omics in ischemia: Acute stroke and chronic cerebral small vessel disease. Glia. 2024-10-28. PMID:39463002. |
prior work has identified a key role for glial cells, including microglia, in the multifaceted and temporally evolving neuroimmune response to both stroke and csvd. |
2024-10-28 |
2024-10-30 |
Not clear |
| Ashley McDonough, Jonathan R Weinstei. Glial 'omics in ischemia: Acute stroke and chronic cerebral small vessel disease. Glia. 2024-10-28. PMID:39463002. |
a ribosomal tagging strategy focusing on the cellular translatome analyses carried out in the acute phases post stroke has revealed distinct inflammation-regulating roles for microglia and astrocytes in this setting. |
2024-10-28 |
2024-10-30 |
Not clear |
| Miao Wang, Connor Dufort, Zhihong Du, Ruyu Shi, Fei Xu, Zhentai Huang, Ana Rios Sigler, Rehana K Leak, Xiaoming H. IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke. Journal of neuroinflammation. vol 21. issue 1. 2024-10-25. PMID:39449077. |
brain microglia and infiltrating monocyte-derived macrophages are vital in preserving blood vessel integrity after stroke. |
2024-10-25 |
2024-10-28 |
Not clear |
| Ze Wang, Shuwei Bai, Yaying Song, Weiwei Xiang, Hongda Shao, Lu Han, Desheng Zhu, Jianjun Liu, Yangtai Gua. Impact of NBP on acute ischemic stroke: Tracking therapy effect on neuroinflammation. International immunopharmacology. vol 143. issue Pt 1. 2024-10-07. PMID:39374567. |
studies on the spatial and temporal changes in microglia and the underlying mechanisms help to elucidate the inflammatory cascade after stroke. |
2024-10-07 |
2024-10-10 |
Not clear |
| Song Zhang, Yuanteng Fan, Xiaojian Cao, Chunchu Deng, Jia Xu, Qiuzhi Zhou, Yajie Li, Yatao Yin, Hong Che. Treadmill exercise improves cerebral ischemia injury by regulating microglia polarization via downregulation of MMP12. International immunopharmacology. vol 142. issue Pt B. 2024-09-28. PMID:39340990. |
exercise training is the main strategy for stroke rehabilitation, and it has shown that shifting microglia toward m2 phenotype is beneficial for the recovery of neurological function after stroke. |
2024-09-28 |
2024-10-01 |
Not clear |
| Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xian. Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model European journal of histochemistry : EJH. vol 68. issue 3. 2024-09-17. PMID:39287134. |
propofol alleviates m1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model subarachnoid hemorrhage (sah) is a devastating stroke caused by ruptured intracranial aneurysms, leading to blood accumulation around the brain. |
2024-09-17 |
2024-09-20 |
Not clear |
| Wei Wei, Seyed Siyawasch Justus Lattau, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Lin Zhang, Irina Graf, Yaoyun Kuang, Xuan Zheng, Zhongnan Hao, Aurel Popa-Wagner, Stefan T Gerner, Sabine Huber, Manuel Nietert, Christian Klose, Ertugrul Kilic, Dirk M Hermann, Mathias Bähr, Hagen B Huttner, Hua Liu, Dirk Fitzner, Thorsten R Doeppne. Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet Accumulation and Inflammation Under Ischemic Conditions in Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-09-10. PMID:39252446. |
however, the role of ld-rich microglia (ldrm) under stroke conditions is unknown. |
2024-09-10 |
2024-09-13 |
mouse |
| Wei Wei, Seyed Siyawasch Justus Lattau, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Lin Zhang, Irina Graf, Yaoyun Kuang, Xuan Zheng, Zhongnan Hao, Aurel Popa-Wagner, Stefan T Gerner, Sabine Huber, Manuel Nietert, Christian Klose, Ertugrul Kilic, Dirk M Hermann, Mathias Bähr, Hagen B Huttner, Hua Liu, Dirk Fitzner, Thorsten R Doeppne. Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet Accumulation and Inflammation Under Ischemic Conditions in Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-09-10. PMID:39252446. |
hence, microglia display enhanced levels of ld accumulation and elevated perilipin 2 (plin2) expression patterns when exposed to hypoxia or stroke. |
2024-09-10 |
2024-09-13 |
mouse |
| Yan Huang, Shuang Li, Yuhan Yang, Kunyi Li, Lan Wen, Jinglun L. Chemerin 15 peptide reduces neuroinflammation via the ChemR23 receptor after ischemia-reperfusion injury. Neural regeneration research. 2024-09-09. PMID:39248165. |
however, its effects on microglia and stroke remain unclear. |
2024-09-09 |
2024-09-11 |
mouse |
| Yuhua Chen, Wei He, Junlin Qiu, Yangyang Luo, Chenlong Jiang, Feng Zhao, Hong Wei, Jiao Meng, Tianlin Long, Xin Zhang, Lingjian Yang, Quanhua Xu, Juning Wang, Chi Zhan. Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation. Cellular & molecular biology letters. vol 29. issue 1. 2024-08-29. PMID:39198723. |
further elucidation of factors that regulate microglia and nuclear factor (erythroid-derived 2)-like 1 (nrf1) may lead to a promising strategy for treating neuroinflammation after ischaemic stroke. |
2024-08-29 |
2024-09-01 |
Not clear |
| Raffaela Cipriani, Maria Domerq, Abraham Martín, Carlos Matut. Role of Microglia in Stroke. Advances in neurobiology. vol 37. 2024-08-29. PMID:39207705. |
role of microglia in stroke. |
2024-08-29 |
2024-09-04 |
Not clear |
| Raffaela Cipriani, Maria Domerq, Abraham Martín, Carlos Matut. Role of Microglia in Stroke. Advances in neurobiology. vol 37. 2024-08-29. PMID:39207705. |
activated microglia are one of the most important cellular components of poststroke inflammation, appearing from the first few hours and persisting for days and weeks after stroke injury. |
2024-08-29 |
2024-09-04 |
Not clear |
| Santra Brenna, Markus Glatzel, Tim Magnus, Berta Puig, Giovanna Galliciott. Neuroserpin and Extracellular Vesicles in Ischemic Stroke: Partners in Neuroprotection? Aging and disease. vol 15. issue 5. 2024-08-27. PMID:39191396. |
conversely, ns-deficient animals exhibit larger stroke injury, increased bbb permeability and enhanced microglia activation. |
2024-08-27 |
2024-08-30 |
Not clear |
| Eric Yuhsiang Wang, Hank Szuhan Chen, Meng-Chih Wu, Ya Lan Yang, Hwai-Lee Wang, Che-Wei Liu, Ted Weita La. Microglia through MFG-E8 signaling decrease the density of degenerating neurons and protect the brain from the development of cortical infarction after stroke. PloS one. vol 19. issue 8. 2024-08-07. PMID:39110702. |
microglia through mfg-e8 signaling decrease the density of degenerating neurons and protect the brain from the development of cortical infarction after stroke. |
2024-08-07 |
2024-08-10 |
mouse |
| Eric Yuhsiang Wang, Hank Szuhan Chen, Meng-Chih Wu, Ya Lan Yang, Hwai-Lee Wang, Che-Wei Liu, Ted Weita La. Microglia through MFG-E8 signaling decrease the density of degenerating neurons and protect the brain from the development of cortical infarction after stroke. PloS one. vol 19. issue 8. 2024-08-07. PMID:39110702. |
neuronal loss is a hallmark of stroke and other neurodegenerative diseases, and as such, neuronal loss caused by microglia has been thought to be a contributing factor to disease progression. |
2024-08-07 |
2024-08-10 |
mouse |