| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Confidence Dordoe, Wenting Huang, Canol Bwalya, Xue Wang, Bixin Shen, Hao Wang, Jing Wang, Shasha Ye, Peng Wang, Bao Xiaoyan, Xiaokun Li, Li Li. The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors. Cytokine & growth factor reviews. 2023-08-12. PMID:37573252. |
in this review, we outline current evidence of microglia activation in experimental models of stroke focusing on its ability to exacerbate damage or repair tissue. |
2023-08-12 |
2023-08-16 |
Not clear |
| Hui-Xing Wei, Yun-Ni Guan, Ping-Ping Chen, Zhao-Zeng Rao, Jin-Shan Yan. Upregulation of EphA4 deteriorate brain damage by shifting microglia M1-polarization via NF-κB signaling after focal cerebral ischemia in rats. Heliyon. vol 9. issue 7. 2023-07-31. PMID:37519758. |
promoting microglia phenotype shift from deleterious m1 phenotype to neuroprotective m2 phenotype will be promising in stroke treatment. |
2023-07-31 |
2023-08-14 |
human |
| Yao Ya. NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes. PLoS biology. vol 21. issue 7. 2023-07-26. PMID:37490433. |
nr4a1 destabilizes tnf mrna in microglia and modulates stroke outcomes. |
2023-07-26 |
2023-08-14 |
Not clear |
| Yao Ya. NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes. PLoS biology. vol 21. issue 7. 2023-07-26. PMID:37490433. |
microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. |
2023-07-26 |
2023-08-14 |
Not clear |
| Pinyi Liu, Yan Chen, Zhi Zhang, Zengqiang Yuan, Jian-Guang Sun, Shengnan Xia, Xiang Cao, Jian Chen, Cun-Jin Zhang, Yanting Chen, Hui Zhan, Yuexinzi Jin, Xinyu Bao, Yue Gu, Meijuan Zhang, Yun X. Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization. PLoS biology. vol 21. issue 7. 2023-07-25. PMID:37486903. |
thus, our study illustrates a novel mechanism that nr4a1 posttranscriptionally regulates tnf expression in microglia and determines stroke outcomes. |
2023-07-25 |
2023-08-14 |
mouse |
| Jerry Flores, Jiping Tan. Role of N-formyl peptide receptor 2 in germinal matrix hemorrhage: an intrinsic review of a hematoma resolving pathway. Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488889. |
various articles have demonstrated the beneficial effects of stimulating the polarization of microglia cells into the m2 phenotype, as it has been suggested that they play an essential role in the rapid phagocytosis of the blood clot after hemorrhagic models of stroke. |
2023-07-25 |
2023-08-14 |
Not clear |
| Ping-Long Fan, Sha-Sha Wang, Shi-Feng Chu, Nai-Hong Che. Time-dependent dual effect of microglia in ischemic stroke. Neurochemistry international. 2023-07-16. PMID:37454817. |
in this review, we reviewed the mechanisms of microglia in multiple stages of post-ischemic neuroinflammation development, including acute, sub-acute and chronic phases of stroke. |
2023-07-16 |
2023-08-14 |
Not clear |
| Conelius Ngwa, Abdullah Al Mamun, Shaohua Qi, Romana Sharmeen, Maria P Blasco Conesa, Bhanu P Ganesh, Bharti Manwani, Fudong Li. Central IRF4/5 Signaling Are Critical for Microglial Activation and Impact on Stroke Outcomes. Translational stroke research. 2023-07-11. PMID:37432594. |
however, irf4/5 are expressed by both microglia and monocytes, and it is not clear if it is the microglial (central) or monocytic (peripheral) irf4-irf5 regulatory axis that functions in stroke. |
2023-07-11 |
2023-08-14 |
mouse |
| Zongjian Liu, Dirk M Hermann, Egor Dzyubenko, Guodong Cao, Xiang Ca. Editorial: Modulating microglia to enhance neuroplasticity for restoring brain function after stroke. Frontiers in cellular neuroscience. vol 17. 2023-07-10. PMID:37426552. |
editorial: modulating microglia to enhance neuroplasticity for restoring brain function after stroke. |
2023-07-10 |
2023-08-14 |
Not clear |
| Abdulkarim Alshammari, Yohan Han, Timothy W Jones, Bindu Pillai, Duo Zhang, Adviye Ergul, Payaningal R Somanath, Susan C Faga. Stimulation of Angiotensin II Type 2 Receptor Modulates Pro-Inflammatory Response in Microglia and Macrophages: Therapeutic Implications for the Treatment of Stroke. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374057. |
stimulation of angiotensin ii type 2 receptor modulates pro-inflammatory response in microglia and macrophages: therapeutic implications for the treatment of stroke. |
2023-06-28 |
2023-08-14 |
Not clear |
| Chenghao Jin, Yejie Shi, Ligen Shi, Rehana K Leak, Wenting Zhang, Kong Chen, Qing Ye, Sulaiman Hassan, Junxuan Lyu, Xiaoming Hu, R Anne Stetler, Michael V L Bennett, Jun Che. Leveraging single-cell RNA sequencing to unravel the impact of aging on stroke recovery mechanisms in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 25. 2023-06-12. PMID:37307473. |
in the stroke brain, microglia and macrophages (mg/mΦ) may drive angiogenesis and oligodendrogenesis through a paracrine mechanism. |
2023-06-12 |
2023-08-14 |
mouse |
| Mahdi Yonesi, Milagros Ramos, Carmen Ramirez-Castillejo, Rocío Fernández-Serra, Fivos Panetsos, Adrián Belarra, Margarita Chevalier, Francisco J Rojo, José Pérez-Rigueiro, Gustavo V Guinea, Daniel González-Niet. Resistance to Degradation of Silk Fibroin Hydrogels Exposed to Neuroinflammatory Environments. Polymers. vol 15. issue 11. 2023-06-11. PMID:37299290. |
in this study, the stability of silk fibroin hydrogels exposed to different neuroinflammatory contexts has been explored using an in vitro microglial cell culture and two in vivo pathological models of cerebral stroke and alzheimer's disease. |
2023-06-11 |
2023-08-14 |
Not clear |
| Bo-Ran Choi, Kory R Johnson, Dragan Maric, Dorian B McGaver. Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature. Nature immunology. 2023-05-29. PMID:37248420. |
in the penumbrae of human stroke brain lesions, we identified a subpopulation of microglia that express vascular endothelial growth factor a. |
2023-05-29 |
2023-08-14 |
mouse |
| Wei Shen, Xiaoguang Wang, Meiqi Tang, Lan Yao, Chenyu Wan, Jianli Niu, Pappachan E Kolattukudy, Zhuqing Ji. Huoluo Xiaoling Pellet promotes microglia M2 polarization through increasing MCPIP1 expression for ischemia stroke alleviation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 164. 2023-05-26. PMID:37236023. |
huoluo xiaoling pellet promotes microglia m2 polarization through increasing mcpip1 expression for ischemia stroke alleviation. |
2023-05-26 |
2023-08-14 |
rat |
| Ying Li, Yanan Zhang, Qing Wang, Chuang Wu, Guicheng Du, Lichao Yan. Oleoylethanolamide Protects against Acute Ischemic Stroke by Promoting PPARα-Mediated Microglia/Macrophage M2 Polarization. Pharmaceuticals (Basel, Switzerland). vol 16. issue 4. 2023-04-28. PMID:37111378. |
therefore, oea might be a promising therapeutic drug for stroke and targeting pparα-mediated m2 microglia may represent a new strategy to treat ischemic stroke. |
2023-04-28 |
2023-08-14 |
mouse |
| Victoria G Hernandez, Kendra J Lechtenberg, Todd C Peterson, Li Zhu, Tawaun A Lucas, Karen P Bradshaw, Justice O Owah, Alanna I Dorsey, Andrew J Gentles, Marion S Buckwalte. Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke. Glia. 2023-04-17. PMID:37067534. |
translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke. |
2023-04-17 |
2023-08-14 |
Not clear |
| Victoria G Hernandez, Kendra J Lechtenberg, Todd C Peterson, Li Zhu, Tawaun A Lucas, Karen P Bradshaw, Justice O Owah, Alanna I Dorsey, Andrew J Gentles, Marion S Buckwalte. Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke. Glia. 2023-04-17. PMID:37067534. |
microglia initiated a rapid response to stroke at 4 h by adopting an inflammatory profile associated with the recruitment of immune cells. |
2023-04-17 |
2023-08-14 |
Not clear |
| Ruixia Wang, Weili Zhan. Isoliquiritigenin regulates microglial M1/M2 polarisation by mediating the P38/MAPK pathway in cerebral stroke. The Journal of pharmacy and pharmacology. 2023-04-07. PMID:37027320. |
regulation of microglia polarisation may be a new way to treat ischaemic stroke based on its effects on brain injury. |
2023-04-07 |
2023-08-14 |
Not clear |
| Ze Wang, Yaying Song, Shuwei Bai, Weiwei Xiang, Xiajun Zhou, Lu Han, Desheng Zhu, Yangtai Gua. Imaging of microglia in post-stroke inflammation. Nuclear medicine and biology. vol 118-119. 2023-04-07. PMID:37028196. |
our review discusses alternative biological targets that have attracted considerable interest for the imaging of microglia activation in recent years, and the potential value of imaging of microglia in the assessment of stroke therapies. |
2023-04-07 |
2023-08-14 |
Not clear |
| Chenye Qiao, Zongjian Liu, Shuyan Qi. The Implications of Microglial Regulation in Neuroplasticity-Dependent Stroke Recovery. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979506. |
we have previously shown that the development of neuroplasticity is spatiotemporally consistent with microglial activation, suggesting that microglia may have a profound impact on neuroplasticity after stroke and may be a key therapeutic target for post-stroke rehabilitation. |
2023-03-29 |
2023-08-14 |
Not clear |