| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyan Liao, Jiagui Huang, Jie Liu, Huimin Zhu, Yue Chen, Xuemei Li, Jun Wen, Qin Yan. Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway. Molecular biology reports. 2023-02-01. PMID:36725745. |
cerebral ischemic injury leads to over-activation of microglia, which release pro-inflammatory factors that deteriorate neurological function during the acute phase of stroke. |
2023-02-01 |
2023-08-14 |
Not clear |
| Vivianne E Morrison, Gregory J Bi. The meal Maketh the Microglia: Why studying microglial phagocytosis is critical to stroke research. Neurochemistry international. 2023-01-27. PMID:36707032. |
the meal maketh the microglia: why studying microglial phagocytosis is critical to stroke research. |
2023-01-27 |
2023-08-14 |
Not clear |
| Seung Gyu Choi, Juhee Shin, Ka Young Lee, Hyewon Park, Song I Kim, Yoon Young Yi, Dong Woon Kim, Hee-Jung Song, Hyo Jung Shi. PINK1 siRNA-loaded poly(lactic-co-glycolic acid) nanoparticles provide neuroprotection in a mouse model of photothrombosis-induced ischemic stroke. Glia. 2023-01-19. PMID:36655313. |
application of nanoparticles for pink1 inhibition attenuates rb-induced photothrombotic ischemic injury by inhibiting microglia responses, suggesting that a nanomedical approach targeting the pink1 pathway may provide a therapeutic avenue for stroke treatment. |
2023-01-19 |
2023-08-14 |
mouse |
| Sol Beccari, Virginia Sierra-Torre, Jorge Valero, Marta Pereira-Iglesias, Mikel García-Zaballa, Federico N Soria, Laura De Las Heras-Garcia, Alejandro Carretero-Guillen, Estibaliz Capetillo-Zarate, Maria Domercq, Paloma R Huguet, David Ramonet, Ahmed Osman, Wei Han, Cecilia Dominguez, Travis E Faust, Omar Touzani, Olatz Pampliega, Patricia Boya, Dorothy Schafer, Guillermo Mariño, Emmanuelle Canet-Soulas, Klas Blomgren, Ainhoa Plaza-Zabala, Amanda Sierr. Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy. Autophagy. 2023-01-09. PMID:36622892. |
whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse and preclinical monkey models of stroke (macaques and marmosets) by transient occlusion of the medial cerebral artery (tmcao). |
2023-01-09 |
2023-08-14 |
mouse |
| Elias Sideris, Sophia Kioulaphides, Katrina Wilson, Aaron Yu, Jun Chen, S Thomas Carmichael, Tatiana Segur. Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke. Advanced therapeutics. vol 5. issue 8. 2023-01-02. PMID:36589207. |
here, we show that the direct injection of a hyaluronic acid based microporous annealed particle (map) hydrogel into the stroke core in mice reduces the percent of highly reactive astrocytes, increases the percent of alternatively activated microglia, decreases cerebral atrophy and preserves nf200 axonal bundles. |
2023-01-02 |
2023-08-14 |
mouse |
| Elias Sideris, Sophia Kioulaphides, Katrina Wilson, Aaron Yu, Jun Chen, S Thomas Carmichael, Tatiana Segur. Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke. Advanced therapeutics. vol 5. issue 8. 2023-01-02. PMID:36589207. |
this work shows that the injection of a porous scaffold into the stroke core can lead to clinically relevant decrease in cerebral atrophy and modulates astrocytes and microglia towards a pro-repair phenotype. |
2023-01-02 |
2023-08-14 |
mouse |
| Justin N Nguyen, Anjali Chauha. Bystanders or not? Microglia and lymphocytes in aging and stroke. Neural regeneration research. vol 18. issue 7. 2022-12-26. PMID:36571333. |
microglia and lymphocytes in aging and stroke. |
2022-12-26 |
2023-08-14 |
human |
| Justin N Nguyen, Anjali Chauha. Bystanders or not? Microglia and lymphocytes in aging and stroke. Neural regeneration research. vol 18. issue 7. 2022-12-26. PMID:36571333. |
preclinical strategies in stroke target either microglia or the lymphocytes or the communications between them to promote functional recovery in aged subjects. |
2022-12-26 |
2023-08-14 |
human |
| Maria Arbaizar-Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Plana. Aged lipid-laden microglia display impaired responses to stroke. EMBO molecular medicine. 2022-12-21. PMID:36541061. |
aged lipid-laden microglia display impaired responses to stroke. |
2022-12-21 |
2023-08-14 |
mouse |
| Maria Arbaizar-Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Plana. Aged lipid-laden microglia display impaired responses to stroke. EMBO molecular medicine. 2022-12-21. PMID:36541061. |
we tested whether this strategy restored microglia function and ameliorated stroke outcome in old mice. |
2022-12-21 |
2023-08-14 |
mouse |
| Maria Arbaizar-Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Plana. Aged lipid-laden microglia display impaired responses to stroke. EMBO molecular medicine. 2022-12-21. PMID:36541061. |
old microglia accumulated lipids under steady state and displayed exacerbated innate immune responses to stroke. |
2022-12-21 |
2023-08-14 |
mouse |
| Maria Arbaizar-Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Plana. Aged lipid-laden microglia display impaired responses to stroke. EMBO molecular medicine. 2022-12-21. PMID:36541061. |
moreover, old mice with renewed microglia showed improved motor function 2 weeks after stroke. |
2022-12-21 |
2023-08-14 |
mouse |
| Corinne Benakis, Alba Simats, Sophie Tritschler, Steffanie Heindl, Simon Besson-Girard, Gemma Llovera, Kelsey Pinkham, Anna Kolz, Alessio Ricci, Fabian J Theis, Stefan Bittner, Özgün Gökce, Anneli Peters, Arthur Lies. T cells modulate the microglial response to brain ischemia. eLife. vol 11. 2022-12-13. PMID:36512388. |
neuroinflammation after stroke is characterized by the activation of resident microglia and the invasion of circulating leukocytes into the brain. |
2022-12-13 |
2023-08-14 |
mouse |
| Corinne Benakis, Alba Simats, Sophie Tritschler, Steffanie Heindl, Simon Besson-Girard, Gemma Llovera, Kelsey Pinkham, Anna Kolz, Alessio Ricci, Fabian J Theis, Stefan Bittner, Özgün Gökce, Anneli Peters, Arthur Lies. T cells modulate the microglial response to brain ischemia. eLife. vol 11. 2022-12-13. PMID:36512388. |
here, using a mouse model for ischemic stroke, we demonstrated that early activation of microglia in response to stroke is differentially regulated by distinct t cell subpopulations - with t |
2022-12-13 |
2023-08-14 |
mouse |
| Wei Liu, Zitong Qi, Wanmeng Li, Jia Liang, Liang Zhao, Yijie Sh. M1 Microglia Induced Neuronal Injury on Ischemic Stroke via Mitochondrial Crosstalk between Microglia and Neurons. Oxidative medicine and cellular longevity. vol 2022. 2022-12-08. PMID:36478988. |
traditionally, it is recognized that when stroke occurs, microglia are activated into m1 phenotype and release cytotoxic cytokines, reactive oxygen species, proteases, and other factors, thus exacerbating the injury by further destroying or killing nearby neurons. |
2022-12-08 |
2023-08-14 |
rat |
| Yu Chen, Fu Peng, Ziwei Xing, Junren Chen, Cheng Peng, Dan L. Beneficial effects of natural flavonoids on neuroinflammation. Frontiers in immunology. vol 13. 2022-11-10. PMID:36353622. |
neuroinflammation is the fundamental immune response against multiple factors in the central nervous system and is characterized by the production of inflammatory mediators, activated microglia and astrocytes, and the recruitment of innate and adaptive immune cells to inflammatory sites, that contributes to the pathological process of related brain diseases, such as alzheimer's disease, parkinson's disease, depression, and stroke. |
2022-11-10 |
2023-08-14 |
Not clear |
| Jiale Gao, Mingjiang Yao, Wei Zhang, Bin Yang, Guo Yuan, Jian-Xun Liu, Yunling Zhan. Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-10-22. PMID:36271540. |
it is believed that pns has obvious anti-inflammatory effect, however, the roles of pns on microglia after stroke have not been completely explored and the underlying mechanism of microglia-mediated inflammation remains to be clarified. |
2022-10-22 |
2023-08-14 |
mouse |
| Jiale Gao, Mingjiang Yao, Wei Zhang, Bin Yang, Guo Yuan, Jian-Xun Liu, Yunling Zhan. Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-10-22. PMID:36271540. |
here we only explored the effect of pkm2 on activated microglia, and we would further investigate the impact of pkm2 expressed in other cells on stroke outcome in the future. |
2022-10-22 |
2023-08-14 |
mouse |
| Yuan Wang, Rehana K Leak, Guodong Ca. Microglia-mediated neuroinflammation and neuroplasticity after stroke. Frontiers in cellular neuroscience. vol 16. 2022-09-02. PMID:36052339. |
microglia can exist in pro-inflammatory states and promote secondary brain damage, but they can also secrete anti-inflammatory cytokines and neurotrophic factors and facilitate recovery following stroke. |
2022-09-02 |
2023-08-14 |
Not clear |
| Elisabeth Harmon, Andrea Doan, Jesus Bautista-Garrido, Joo Eun Jung, Sean P Marrelli, Gab Seok Ki. Increased Expression of Interferon-Induced Transmembrane 3 (IFITM3) in Stroke and Other Inflammatory Conditions in the Brain. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012150. |
in collaboration with other cell types in brains, microglia can contribute both to worsened outcome following stroke or other neurodegenerative diseases and to the recovery process by changing their phenotype toward reparative microglia. |
2022-08-26 |
2023-08-14 |
Not clear |