| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanyuan Ran, Shuyan Qie, Fuhai Gao, Zitong Ding, Shuiqing Yang, Guiqin Tian, Zongjian Liu, Jianing X. Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway. Brain research. vol 1770. 2021-12-09. PMID:34418356. |
baicalein indirectly ameliorates neuronal injury after stroke by polarizing microglia toward the anti-inflammatory phenotype via inhibition of the tlr4/nf-κb pathway and down-regulation of phosphorylated stat1, suggesting that baicalein might serve a potential therapy for stroke. |
2021-12-09 |
2023-08-13 |
mouse |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. |
2021-12-09 |
2023-08-13 |
rat |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
in addition, mscs treatment can significantly inhibit the over-activation of hippocampal microglia in heat stroke rats and the levels of pro-inflammatory factors and chemokines in the hippocampus. |
2021-12-09 |
2023-08-13 |
rat |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
early treatment of mscs can greatly promote the activation of cerebellar microglia in heat stroke rats. |
2021-12-09 |
2023-08-13 |
rat |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
in conclusion, the application of mscs in the treatment of heat stroke in rats can significantly reduce mortality and neurological deficits and improve hippocampal damage, possibly by inhibiting the excessive activation of hippocampal microglia in heat stroke rats. |
2021-12-09 |
2023-08-13 |
rat |
| Zhijuan Cao, Sean S Harvey, Terrance Chiang, Aulden G Foltz, Alex G Lee, Michelle Y Cheng, Gary K Steinber. Unique Subtype of Microglia in Degenerative Thalamus After Cortical Stroke. Stroke. vol 52. issue 2. 2021-12-07. PMID:33412903. |
unique subtype of microglia in degenerative thalamus after cortical stroke. |
2021-12-07 |
2023-08-13 |
Not clear |
| Matthieu Lecuyer, Praneeti Pathipati, Joel Faustino, Zinaida S Vexle. Neonatal stroke enhances interaction of microglia-derived extracellular vesicles with microglial cells. Neurobiology of disease. vol 157. 2021-12-06. PMID:34153465. |
we asked whether neonatal stroke alters release of microglial evs (mev) and mev communication with activated microglia. |
2021-12-06 |
2023-08-13 |
mouse |
| Matthieu Lecuyer, Praneeti Pathipati, Joel Faustino, Zinaida S Vexle. Neonatal stroke enhances interaction of microglia-derived extracellular vesicles with microglial cells. Neurobiology of disease. vol 157. 2021-12-06. PMID:34153465. |
cumulatively, these data demonstrate that microglial cells release both microvesicles and exosomes in naïve neonatal brain, that the state of microglial activation determines both properties of released evs and their recognition/uptake by microglia in ischemic-reperfused and control regions, suggesting a modulatory role of mev in neonatal stroke, and that sphingosine/n-smase-2 signaling contributes both to evs release and uptake (predominantly p4-mev) after neonatal stroke. |
2021-12-06 |
2023-08-13 |
mouse |
| Praneeti Pathipati, Matthieu Lecuyer, Joel Faustino, Jacqueline Strivelli, Donald G Phinney, Zinaida S Vexle. Mesenchymal Stem Cell (MSC)-Derived Extracellular Vesicles Protect from Neonatal Stroke by Interacting with Microglial Cells. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 3. 2021-12-06. PMID:34235636. |
herein, we examined if msc-sev protect neonatal brain from stroke and if this effect is mediated via communication with microglia. |
2021-12-06 |
2023-08-13 |
mouse |
| Mikko T Huuskonen, Yaoming Wang, Angeliki Maria Nikolakopoulou, Axel Montagne, Zhonghua Dai, Divna Lazic, Abhay P Sagare, Zhen Zhao, Jose A Fernandez, John H Griffin, Berislav V Zlokovi. Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C. The Journal of experimental medicine. vol 219. issue 1. 2021-12-04. PMID:34846535. |
we show that par1 and par3 were also required for 3k3a-apc's suppression of post-wm stroke microglia and astrocyte responses and overall improvement in neuropathologic and functional outcomes. |
2021-12-04 |
2023-08-13 |
mouse |
| Liping Zhang, Yilin Liu, Sanrong Wang, Lu Long, Qianwen Zang, Jingxi Ma, Lehua Yu, Gongwei Ji. Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke. Biochemical and biophysical research communications. vol 577. 2021-11-26. PMID:34507068. |
microglia are polarized toward the proinflammatory m1 phenotype and neuroprotective m2 phenotype after stroke and play an important role in the pathological process of ischemic stroke. |
2021-11-26 |
2023-08-13 |
rat |
| Liping Zhang, Yilin Liu, Sanrong Wang, Lu Long, Qianwen Zang, Jingxi Ma, Lehua Yu, Gongwei Ji. Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke. Biochemical and biophysical research communications. vol 577. 2021-11-26. PMID:34507068. |
our results revealed that vns can promote m2 microglia polarization and inhibit m1 microglia polarization to alleviate brain injury via inhibition of the tlr4/myd88/nf-κb pathway in microglia in the acute stage of stroke. |
2021-11-26 |
2023-08-13 |
rat |
| Ruiqing Kang, Marcin Gamdzyk, Cameron Lenahan, Jiping Tang, Sheng Tan, John H Zhan. The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke. Current neuropharmacology. vol 18. issue 12. 2021-11-25. PMID:32469699. |
the dual role of microglia in blood-brain barrier dysfunction after stroke. |
2021-11-25 |
2023-08-13 |
Not clear |
| Ruiqing Kang, Marcin Gamdzyk, Cameron Lenahan, Jiping Tang, Sheng Tan, John H Zhan. The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke. Current neuropharmacology. vol 18. issue 12. 2021-11-25. PMID:32469699. |
in this review, we are going to discuss the mechanisms responsible for the dual role of microglia in bbb dysfunction after stroke. |
2021-11-25 |
2023-08-13 |
Not clear |
| Ting Li, Jin Zhao, Wenguang Xie, Wanru Yuan, Jing Guo, Shengru Pang, Wen-Biao Gan, Diego Gómez-Nicola, Shengxiang Zhan. Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. Journal of neuroinflammation. vol 18. issue 1. 2021-11-17. PMID:33757565. |
specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. |
2021-11-17 |
2023-08-13 |
Not clear |
| Chen He, Renhuai Liu, Zhongming Fan, Yi Li, Manping Yang, Hou Wugang, Zhihong Lu, Zongping Fang, Binxiao S. Microglia in the Pathophysiology of Hemorrhagic Stroke and the Relationship Between Microglia and Pain After Stroke: A Narrative Review. Pain and therapy. vol 10. issue 2. 2021-11-17. PMID:34278548. |
microglia in the pathophysiology of hemorrhagic stroke and the relationship between microglia and pain after stroke: a narrative review. |
2021-11-17 |
2023-08-13 |
Not clear |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the tgf-β/smad2/3 pathway. |
2021-11-17 |
2023-08-13 |
mouse |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
systemic transplantation of oxygen-glucose deprivation (ogd)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit the underlying mechanisms have not been sufficiently addressed. |
2021-11-17 |
2023-08-13 |
mouse |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
hence, the present findings suggest a new way of action of evs derived from ogd-preconditioned microglia by regulating the tgf-β/smad2/3 pathway in order to promote tissue regeneration and neurological recovery in stroke mice. |
2021-11-17 |
2023-08-13 |
mouse |
| Yuya Ota, Yasue Kubota, Yuji Hotta, Mami Matsumoto, Nayuka Matsuyama, Taiki Kato, Takashi Hamakawa, Tomoya Kataoka, Kazunori Kimura, Kazunobu Sawamoto, Takahiro Yasu. Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis. PloS one. vol 16. issue 11. 2021-11-12. PMID:34752461. |
immunopathological evaluation showed an accumulation of activated microglia, followed by an increase in reactive astrocytes at the peri-infarct zone after photothrombotic stroke. |
2021-11-12 |
2023-08-13 |
rat |