| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
systemic transplantation of oxygen-glucose deprivation (ogd)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit the underlying mechanisms have not been sufficiently addressed. |
2021-11-17 |
2023-08-13 |
mouse |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
hence, the present findings suggest a new way of action of evs derived from ogd-preconditioned microglia by regulating the tgf-β/smad2/3 pathway in order to promote tissue regeneration and neurological recovery in stroke mice. |
2021-11-17 |
2023-08-13 |
mouse |
| Yuya Ota, Yasue Kubota, Yuji Hotta, Mami Matsumoto, Nayuka Matsuyama, Taiki Kato, Takashi Hamakawa, Tomoya Kataoka, Kazunori Kimura, Kazunobu Sawamoto, Takahiro Yasu. Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis. PloS one. vol 16. issue 11. 2021-11-12. PMID:34752461. |
immunopathological evaluation showed an accumulation of activated microglia, followed by an increase in reactive astrocytes at the peri-infarct zone after photothrombotic stroke. |
2021-11-12 |
2023-08-13 |
rat |
| Ludmila Belayev, Sung-Ha Hong, Raul S Freitas, Hemant Menghani, Shawn J Marcell, Larissa Khoutorova, Pranab K Mukherjee, Madigan M Reid, Reinaldo B Oria, Nicolas G Baza. DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke. CNS neuroscience & therapeutics. vol 26. issue 11. 2021-10-25. PMID:32757264. |
the microglia cell surface receptor (triggering receptor expressed on myeloid cells-2; trem2) regulates the production of pro- and antiinflammatory mediators after stroke. |
2021-10-25 |
2023-08-13 |
Not clear |
| Brooke J Wanrooy, Shu Wen Wen, Connie Hy Won. Dynamic roles of neutrophils in post-stroke neuroinflammation. Immunology and cell biology. vol 99. issue 9. 2021-10-25. PMID:33894069. |
currently, there is some uncertainty as to whether neutrophil diversity is beneficial or harmful in stroke as their interactions with the resident cells of the brain, such as microglia and neurons, would potentially elicit heterogeneous outcomes. |
2021-10-25 |
2023-08-13 |
Not clear |
| Hui Li, Pengfei Wang, Lin Tang, Jingjing Sun, Yanling Zhang, Wei Luo, Cong Luo, Zhaolan Hu, Lin Yan. Distinct Polarization Dynamics of Microglia and Infiltrating Macrophages: A Novel Mechanism of Spinal Cord Ischemia/Reperfusion Injury. Journal of inflammation research. vol 14. 2021-10-23. PMID:34675600. |
recent studies indicate that microglia and monocyte-derived macrophages (mdms) have different roles in diseases such as stroke and spinal cord injury, yet their respective polarized phenotypes and roles remain unclear in spinal cord ischemia/reperfusion injury (sciri). |
2021-10-23 |
2023-08-13 |
Not clear |
| Min Cai, Sisi Sun, Jin Wang, Beibei Dong, Qianzi Yang, Li Tian, Hailong Dong, Shiquan Wang, Wugang Ho. Sevoflurane preconditioning protects experimental ischemic stroke by enhancing anti-inflammatory microglia/macrophages phenotype polarization through GSK-3β/Nrf2 pathway. CNS neuroscience & therapeutics. vol 27. issue 11. 2021-10-22. PMID:34370899. |
in this study, we aimed to assess the effect of spc on microglia polarization after stroke and which signaling pathway was involved in this transition. |
2021-10-22 |
2023-08-13 |
Not clear |
| Zinaida S Vexler, Xian Nan Tang, Midori A Yenar. Inflammation in adult and neonatal stroke. Clinical neuroscience research. vol 6. issue 5. 2021-10-20. PMID:20300490. |
it will review the role of specific cell types and interactions among blood cells, endothelium, glia, microglia, the extracellular matrix and neurons - cumulatively called "neurovascular unit" - in stroke induction and evolution. |
2021-10-20 |
2023-08-12 |
Not clear |
| Kristy A Zera, Marion S Buckwalte. T cells direct microglial repair of white matter after stroke. Trends in neurosciences. vol 44. issue 10. 2021-10-20. PMID:34332802. |
this study elucidates the mechanisms by which tregs direct microglia to alter their phenotype to support oligodendrogenesis, thereby improving white matter integrity and functional recovery after stroke in mice. |
2021-10-20 |
2023-08-13 |
mouse |
| Daniel Berchtold, Josef Priller, Christian Meisel, Andreas Meise. Interaction of microglia with infiltrating immune cells in the different phases of stroke. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:33058417. |
interaction of microglia with infiltrating immune cells in the different phases of stroke. |
2021-10-06 |
2023-08-13 |
Not clear |
| Zhonglin Lyu, Jon Park, Kwang-Min Kim, Hye-Jin Jin, Haodi Wu, Jayakumar Rajadas, Deok-Ho Kim, Gary K Steinberg, Wonjae Le. A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke. Nature biomedical engineering. vol 5. issue 8. 2021-09-13. PMID:34385693. |
here, we report the development and applicability of a functional neurovascular unit on a microfluidic chip as a microphysiological model of ischaemic stroke that recapitulates the function of the blood-brain barrier as well as interactions between therapeutic stem cells and host cells (human brain microvascular endothelial cells, pericytes, astrocytes, microglia and neurons). |
2021-09-13 |
2023-08-13 |
human |
| Sumin Kim, Youngsook So. Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and Microglia. International journal of molecular sciences. vol 22. issue 16. 2021-09-13. PMID:34445510. |
in this study, we aimed to elucidate whether astrocytes and microglia could crosstalk to induce microglial polarization and proliferation, which can be further regulated under a microenvironment mimicking that of brain stroke. |
2021-09-13 |
2023-08-13 |
Not clear |
| Kai Zheng, Lingmin Lin, Wei Jiang, Lin Chen, Xiyue Zhang, Qian Zhang, Yi Ren, Junwei Ha. Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021-09-09. PMID:34496660. |
notably, microglia displayed a cell differentiation diversity after stroke among its five distinct subtypes. |
2021-09-09 |
2023-08-13 |
mouse |
| Cuicui Yang, Shili Gong, Xiaoping Chen, Mingyang Wang, Li Zhang, Lan Zhang, Chaoying H. Analgecine regulates microglia polarization in ischemic stroke by inhibiting NF-κB through the TLR4 MyD88 pathway. International immunopharmacology. vol 99. 2021-09-08. PMID:34229178. |
therapeutic strategies used to attenuate inflammation and to increase recovery of neurons after a stroke include microglia anti-inflammatory (m2) polarization and repression of proinflammatory (m1). |
2021-09-08 |
2023-08-13 |
rat |
| Shirley Marino Lee, Jacob Hudobenko, Louise D McCullough, Anjali Chauha. Microglia depletion increase brain injury after acute ischemic stroke in aged mice. Experimental neurology. vol 336. 2021-08-30. PMID:33221396. |
aged microglia acquire a senescent phenotype and produce more inflammatory cytokines after stroke. |
2021-08-30 |
2023-08-13 |
mouse |
| Bhakta Prasad Gair. Microglia as the Critical Regulators of Neuroprotection and Functional Recovery in Cerebral Ischemia. Cellular and molecular neurobiology. 2021-08-30. PMID:34460037. |
furthermore, this review also sheds the light on the therapeutic potential of microglia in stroke patients. |
2021-08-30 |
2023-08-13 |
Not clear |
| Junxuan Lyu, Di Xie, Tarun N Bhatia, Rehana K Leak, Xiaoming Hu, Xiaoyan Jian. Microglial/Macrophage polarization and function in brain injury and repair after stroke. CNS neuroscience & therapeutics. vol 27. issue 5. 2021-08-27. PMID:33650313. |
after stroke injury, microglia and cns-resident macrophages are rapidly activated and regulate neuropathological processes to steer the course of functional recovery. |
2021-08-27 |
2023-08-13 |
Not clear |
| Qingkun Liu, Siamak K Sorooshyar. Quantitative and Correlational Analysis of Brain and Spleen Immune Cellular Responses Following Cerebral Ischemia. Frontiers in immunology. vol 12. 2021-08-23. PMID:34194419. |
furthermore, the correlation among neurological deficit and various immune cells suggests that microglia and splenic adaptive immune cells (t and b cells) are protective while infiltrating peripheral myeloid cells (macrophage and neutrophils) worsen stroke outcome. |
2021-08-23 |
2023-08-13 |
mouse |
| Xin Zhou, Ya-Ni Zhang, Fang-Fang Li, Zhao Zhang, Li-Yuan Cui, Hong-Yuan He, Xu Yan, Wen-Bin He, Hong-Shuo Sun, Zhong-Ping Feng, Shi-Feng Chu, Nai-Hong Che. Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke. Acta pharmacologica Sinica. 2021-08-13. PMID:34385606. |
neuronal chemokine-like-factor 1 (cklf1) up-regulation promotes m1 polarization of microglia in rat brain after stroke. |
2021-08-13 |
2023-08-13 |
human |
| Sheng-Jun Wen, Xi-Min Zheng, Li-Fen Liu, Na-Na Li, Hai-An Mao, Liang Huang, Qiong-Lan Yua. Effects of primary microglia and astrocytes on neural stem cells in Neural regeneration research. vol 16. issue 9. 2021-08-10. PMID:33510055. |
effects of primary microglia and astrocytes on neural stem cells in transplantation of neural stem cells (nscs) can protect neurons in animal stroke models; however, their low rates of survival and neuronal differentiation limit their clinical application. |
2021-08-10 |
2023-08-13 |
rat |