| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Cheng, Yue Geng, Yeting Chen, Yongjie Zhang, Runjie Guo, Hong Xu, Jianfeng Liang, Jiajun Xie, Zean Zhang, Xuesong Tia. δ-Opioid receptor activation ameliorates lipopolysaccharide-induced inflammation and apoptosis by inhibiting the MAPK/caspase-3 pathway in BV2 microglial cells. Experimental brain research. vol 239. issue 2. 2021-07-28. PMID:33206235. |
however, the role of dor in microglia in ischaemic stroke has not yet been fully investigated. |
2021-07-28 |
2023-08-13 |
mouse |
| Vivien Häußler, Tristan Daehn, Björn Rissiek, Vanessa Roth, Christian Gerloff, Thiruma V Arumugam, Tim Magnus, Mathias Gelderblo. Intravenous Immunoglobulin (IVIg) Induce a Protective Phenotype in Microglia Preventing Neuronal Cell Death in Ischaemic Stroke. Neuromolecular medicine. vol 22. issue 1. 2021-07-23. PMID:31559534. |
intravenous immunoglobulin (ivig) induce a protective phenotype in microglia preventing neuronal cell death in ischaemic stroke. |
2021-07-23 |
2023-08-13 |
Not clear |
| Vivien Häußler, Tristan Daehn, Björn Rissiek, Vanessa Roth, Christian Gerloff, Thiruma V Arumugam, Tim Magnus, Mathias Gelderblo. Intravenous Immunoglobulin (IVIg) Induce a Protective Phenotype in Microglia Preventing Neuronal Cell Death in Ischaemic Stroke. Neuromolecular medicine. vol 22. issue 1. 2021-07-23. PMID:31559534. |
although neuroprotective effects of ivig in vivo and in vitro have been established in previous studies, we were able to show for the first time, that ivig modulates the polarization of microglia during the pathogenesis of stroke. |
2021-07-23 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
microglia, the main immune cell in the cerebrum, possess therapeutic potential for strokes as its specific anti-inflammatory phenotype can reduce inflammation and promote neuron regeneration. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
however, the on-demand anti-inflammatory polarization of microglia at the stroke site is uncontrollable for therapeutic application. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
here, we develop a platelet hybrid microglia platform which can specifically polarize to the anti-inflammatory phenotype by ultrasound irradiation for targeted cerebrum repair after stroke. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
the intravenously injected microglia platform showed anti-inflammatory polarization at the stroke site with insonation, and accelerated the m2-type polarization of endogenous microglia for long-term stroke recovery. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
satisfied prognoses were achieved with reduced apoptosis, promoted neurogenesis, and functional recovery, indicating the implications of the microglia platform for stroke therapy. |
2021-07-20 |
2023-08-13 |
Not clear |
| Rui Dong, Renxuan Huang, Jiaoqi Wang, Hongyu Liu, Zhongxin X. Effects of Microglial Activation and Polarization on Brain Injury After Stroke. Frontiers in neurology. vol 12. 2021-07-20. PMID:34276530. |
microglia, the innate immune cells of the central nervous system (cns), can be activated and polarized to take on different phenotypes in response to stimulations associated with stroke, including pro-inflammatory and anti-inflammatory phenotypes, which affect the prognosis of stroke. |
2021-07-20 |
2023-08-13 |
Not clear |
| Rui Dong, Renxuan Huang, Jiaoqi Wang, Hongyu Liu, Zhongxin X. Effects of Microglial Activation and Polarization on Brain Injury After Stroke. Frontiers in neurology. vol 12. 2021-07-20. PMID:34276530. |
therefore, investigation of the activation and polarizing mechanisms of microglia plays a critical role in treating stroke. |
2021-07-20 |
2023-08-13 |
Not clear |
| Rui Dong, Renxuan Huang, Jiaoqi Wang, Hongyu Liu, Zhongxin X. Effects of Microglial Activation and Polarization on Brain Injury After Stroke. Frontiers in neurology. vol 12. 2021-07-20. PMID:34276530. |
the aim of this article was to investigate the significance of microglial phenotype regulation in stroke treatment by summarizing the activation, polarizing mechanisms, and general microglia characteristics. |
2021-07-20 |
2023-08-13 |
Not clear |
| Lalita Subedi, Bhakta Prasad Gair. Phytochemicals as regulators of microglia/macrophages activation in cerebral ischemia. Pharmacological research. vol 165. 2021-07-16. PMID:33450385. |
the latest studies in animal stroke models demonstrate that this group of bioactive phytochemicals exerts their anti-inflammatory effects via attenuation of brain proinflammatory microglia and macrophages m1 polarization while promoting anti-inflammatory microglial and macrophages m2 polarization. |
2021-07-16 |
2023-08-13 |
Not clear |
| Zongping Fang, Di Wu, Jiao Deng, Qianzi Yang, Xijing Zhang, Jian Chen, Shiquan Wang, Sijun Hu, Wugang Hou, Siming Ning, Yi Ding, Zhongmin Fan, Zhenhua Jiang, Junjun Kang, Yingying Liu, Jinlin Miao, Xunming Ji, Hailong Dong, Lize Xion. An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke. Science translational medicine. vol 13. issue 597. 2021-07-12. PMID:34108252. |
here, we report that the expression of myeloid differentiation protein 2 (md2), which is traditionally regarded to be expressed only in microglia in the normal brain, was markedly increased in cortical neurons after stroke. |
2021-07-12 |
2023-08-13 |
mouse |
| Dongxue Wang, Fei Liu, Liyun Zhu, Ping Lin, Fanyi Han, Xue Wang, Xianxi Tan, Li Lin, Ye Xion. FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. Journal of neuroinflammation. vol 17. issue 1. 2021-07-09. PMID:32867781. |
therefore, we investigated whether rhfgf21 improves ischemic outcomes in experimental stroke by targeting microglia and macrophages. |
2021-07-09 |
2023-08-13 |
human |
| Ling-Zhi Li, Yu-You Huang, Zhen-Hong Yang, Si-Jia Zhang, Zi-Ping Han, Yu-Min Lu. Potential microglia-based interventions for stroke. CNS neuroscience & therapeutics. vol 26. issue 3. 2021-06-30. PMID:32064759. |
microglia are the principal immune cells in the brain and are the first line of defense against the pathophysiology induced by stroke. |
2021-06-30 |
2023-08-13 |
human |
| Ling-Zhi Li, Yu-You Huang, Zhen-Hong Yang, Si-Jia Zhang, Zi-Ping Han, Yu-Min Lu. Potential microglia-based interventions for stroke. CNS neuroscience & therapeutics. vol 26. issue 3. 2021-06-30. PMID:32064759. |
increasing evidence has suggested that microglia play diverse roles that depend on dynamic interactions with neurons, astrocytes, and other neighboring cells both in the normal brain and under pathological conditions, including stroke. |
2021-06-30 |
2023-08-13 |
human |
| Débora D S Vogel, Nancy N Ortiz-Villatoro, Noemi S Araújo, Márcia Jonathas Guimarães Marques, Flavio Aimbire, Fúlvio A Scorza, Carla A Scorza, Regiane Albertin. Transcranial low-level laser therapy in an in vivo model of stroke: Relevance to the brain infarct, microglia activation and neuroinflammation. Journal of biophotonics. vol 14. issue 6. 2021-06-28. PMID:33580734. |
transcranial low-level laser therapy in an in vivo model of stroke: relevance to the brain infarct, microglia activation and neuroinflammation. |
2021-06-28 |
2023-08-13 |
rat |
| Cristina Barca, Amanda J Kiliaan, Claudia Foray, Lydia Wachsmuth, Sven Hermann, Cornelius Faber, Michael Schaefers, Maximilian Wiesmann, Andreas H Jacobs, Bastian Zinnhard. A longitudinal PET/MR imaging study of colony stimulating factor-1 receptor-mediated microglia depletion in experimental stroke. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2021-06-25. PMID:34168016. |
a longitudinal pet/mr imaging study of colony stimulating factor-1 receptor-mediated microglia depletion in experimental stroke. |
2021-06-25 |
2023-08-13 |
Not clear |
| Gonzalo Garcia-Martin, Berta Alcover-Sanchez, Francisco Wandosell, Beatriz Cubelo. Pathways involved in remyelination after cerebral ischemia. Current neuropharmacology. 2021-06-21. PMID:34151767. |
for this reason, we will put some context into how microglia and astrocytes react against stroke and influence oligodendrogenesis to highlight the relevance of remyelination in the ischemic brain. |
2021-06-21 |
2023-08-13 |
Not clear |
| Max Rudolph, Christian W Schmeer, Madlen Günther, Florus Woitke, Carolin Kathner-Schaffert, Lina Karapetow, Julia Lindner, Thomas Lehmann, Gustav Jirikowski, Otto W Witte, Christoph Redecker, Silke Keine. Microglia-mediated phagocytosis of apoptotic nuclei is impaired in the adult murine hippocampus after stroke. Glia. vol 69. issue 8. 2021-06-09. PMID:33942391. |
here, we evaluated the effect of a prefrontal stroke lesion on the phagocytic activity of microglia in the dentate gyrus (dg) of the hippocampus. |
2021-06-09 |
2023-08-13 |
mouse |