| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng-Ting Jiang, Wan-Feng Wu, Yi-Hui Deng, Jin-Wen G. Modulators of microglia activation and polarization in ischemic stroke (Review). Molecular medicine reports. vol 21. issue 5. 2021-02-16. PMID:32323760. |
it has been shown that m1 microglia promote secondary brain damage, whilst m2 microglia facilitate recovery following stroke. |
2021-02-16 |
2023-08-13 |
Not clear |
| Lu Lian, Yunsha Zhang, Lu Liu, Liji Yang, Yichen Cai, Junping Zhang, Shixin X. Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia. Frontiers in molecular neuroscience. vol 13. 2021-01-26. PMID:33488360. |
during the acute phase of stroke onset, m2 microglia are the dominant phenotype and exert protective effects on neuronal cells, whereas permanent m1 microglia contribute to prolonged inflammation and are detrimental to brain tissue. |
2021-01-26 |
2023-08-13 |
Not clear |
| Lu Lian, Yunsha Zhang, Lu Liu, Liji Yang, Yichen Cai, Junping Zhang, Shixin X. Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia. Frontiers in molecular neuroscience. vol 13. 2021-01-26. PMID:33488360. |
thus, we briefly reviewed the dynamic response of microglia after a stroke and assessed how specific mirnas affect the behavior of reactive microglia. |
2021-01-26 |
2023-08-13 |
Not clear |
| Shengxiang Zhan. Microglial activation after ischaemic stroke. Stroke and vascular neurology. vol 4. issue 2. 2021-01-25. PMID:31338213. |
ischaemic stroke can induce rapid activation of microglia. |
2021-01-25 |
2023-08-13 |
Not clear |
| Wan Zhang, Tian Tian, Shao-Xin Gong, Wen-Qian Huang, Qin-Yi Zhou, Ai-Ping Wang, Ying Tia. Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke. Neural regeneration research. vol 16. issue 1. 2021-01-23. PMID:32788440. |
therefore, it is clinically important to study the role and regulation of microglia in stroke. |
2021-01-23 |
2023-08-13 |
Not clear |
| Eileen Gülke, Mathias Gelderblom, Tim Magnu. Danger signals in stroke and their role on microglia activation after ischemia. Therapeutic advances in neurological disorders. vol 11. 2021-01-08. PMID:29854002. |
danger signals in stroke and their role on microglia activation after ischemia. |
2021-01-08 |
2023-08-13 |
Not clear |
| Tongshuai Zhang, Dandan Wang, Xuan Li, Yixiang Jiang, Chao Wang, Yao Zhang, Qingfei Kong, Chao Tian, Yongfeng Dai, Wei Zhao, Mingyue Jiang, Yanzhong Chang, Guangyou Wan. Excess salt intake promotes M1 microglia polarization via a p38/MAPK/AR-dependent pathway after cerebral ischemia in mice. International immunopharmacology. vol 81. 2021-01-07. PMID:32044667. |
the administration of either the ar inhibitor epalrestat or a p38-neutralizing antibody blocked the polarization of microglia and alleviated stroke injury. |
2021-01-07 |
2023-08-13 |
mouse |
| Tongshuai Zhang, Dandan Wang, Xuan Li, Yixiang Jiang, Chao Wang, Yao Zhang, Qingfei Kong, Chao Tian, Yongfeng Dai, Wei Zhao, Mingyue Jiang, Yanzhong Chang, Guangyou Wan. Excess salt intake promotes M1 microglia polarization via a p38/MAPK/AR-dependent pathway after cerebral ischemia in mice. International immunopharmacology. vol 81. 2021-01-07. PMID:32044667. |
in conclusion, hsd promotes polarization in pro-inflammatory m1 microglia by upregulating the expression of the ar protein via p38/mapk, thereby exacerbating the development of ischemia stroke. |
2021-01-07 |
2023-08-13 |
mouse |
| Pranay Srivastava, Chunxia G Cronin, Victoria L Scranton, Kenneth A Jacobson, Bruce T Liang, Rajkumar Verm. Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke. Experimental neurology. vol 329. 2020-12-24. PMID:32289314. |
p2x4r, a receptor for adenosine triphosphate (atp), regulates activation of myeloid immune cells (infiltrating monocytes/macrophages and brain-resident microglia) after stroke injury. |
2020-12-24 |
2023-08-13 |
mouse |
| Tsogzolmaa Ganbold, Qingming Bao, Jargalmaa Zandan, Agula Hasi, Huricha Baigud. Modulation of Microglia Polarization through Silencing of NF-κB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi. ACS applied materials & interfaces. vol 12. issue 10. 2020-11-30. PMID:32073249. |
inhibition of proinflammatory (m1) polarization and promotion of anti-inflammatory (m2) polarization of microglia are potential therapeutic strategies for inflammation reduction and neuronal recovery after stroke. |
2020-11-30 |
2023-08-13 |
Not clear |
| Ashley McDonough, Jonathan R Weinstei. The role of microglia in ischemic preconditioning. Glia. vol 68. issue 3. 2020-11-19. PMID:31386233. |
although there are technological challenges and gaps in knowledge to overcome, the targeting of specific molecular signaling pathways in microglia is a promising direction for development of novel and effective pharmacotherapies for stroke. |
2020-11-19 |
2023-08-13 |
Not clear |
| Franziska M Collmann, Rory Pijnenburg, Somayyeh Hamzei-Taj, Anuka Minassian, Kat Folz-Donahue, Christian Kukat, Markus Aswendt, Mathias Hoeh. Individual Frontiers in immunology. vol 10. 2020-10-28. PMID:31214190. |
the modulation of microglia polarization is an appealing neurotherapeutic strategy for stroke and other brain lesions, as well as neurodegenerative diseases. |
2020-10-28 |
2023-08-13 |
Not clear |
| Zong-Jian Liu, Yuan-Yuan Ran, Shu-Yan Qie, Wei-Jun Gong, Fu-Hai Gao, Zi-Tong Ding, Jia-Ning X. Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway. CNS neuroscience & therapeutics. vol 25. issue 12. 2020-10-26. PMID:31793209. |
however, the effect of melatonin on microglia polarization after stroke and underlying mechanisms remain unknown. |
2020-10-26 |
2023-08-13 |
Not clear |
| Supriya Ramesha, Sruti Rayaprolu, Srikant Rangaraj. Flow Cytometry Approach to Characterize Phagocytic Properties of Acutely-Isolated Adult Microglia and Brain Macrophages In Vitro. Journal of visualized experiments : JoVE. issue 160. 2020-10-22. PMID:32658196. |
microglia and central nervous system (cns)-infiltrating macrophages, collectively called cns mononuclear phagocytes (cns-mps), play central roles in neurological diseases including neurodegeneration and stroke. |
2020-10-22 |
2023-08-13 |
mouse |
| Hao Zhang, Minyi Lu, Xiaofeng Zhang, Yihe Kuai, Ying Mei, Qiwen Tan, Kailun Zhong, Xiaoou Sun, Wen Ta. Isosteviol Sodium Protects against Ischemic Stroke by Modulating Microglia/Macrophage Polarization via Disruption of GAS5/miR-146a-5p sponge. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:31434993. |
stv-na has a profound regulatory effect on microglia response after stroke. |
2020-10-20 |
2023-08-13 |
Not clear |
| Nassir U Al-Khishman, Qi Qi, Austyn D Roseborough, Alexander Levit, Brian L Allman, Udunna C Anazodo, Matthew S Fox, Shawn N Whitehead, Jonathan D Thiesse. TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat. EJNMMI research. vol 10. issue 1. 2020-10-16. PMID:32990808. |
this study aimed to test the ability of tspo to detect activated wm microglia that are immunohistochemically positive for mhcii in rat models of prodromal alzheimer's disease and acute subcortical stroke. |
2020-10-16 |
2023-08-13 |
rat |
| Wei Cai, Xuejiao Dai, Jie Chen, Jingyan Zhao, Mingyue Xu, Lili Zhang, Boyu Yang, Wenting Zhang, Marcelo Rocha, Toshimasa Nakao, Julia Kofler, Yejie Shi, R Anne Stetler, Xiaoming Hu, Jun Che. STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice. JCI insight. vol 4. issue 20. 2020-10-15. PMID:31619589. |
efferocytosis, or phagocytic clearance of dead/dying cells by brain-resident microglia and/or infiltrating macrophages, is instrumental for inflammation resolution and restoration of brain homeostasis after stroke. |
2020-10-15 |
2023-08-13 |
mouse |
| Wujun Geng, Hongli Tang, Shan Luo, Ya Lv, Dongdong Liang, Xianhui Kang, Wandong Hon. Exosomes from miRNA-126-modified ADSCs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation. American journal of translational research. vol 11. issue 2. 2020-10-01. PMID:30899379. |
exosomes from mirna-126-modified adscs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation. |
2020-10-01 |
2023-08-13 |
rat |
| Walace Gomes-Lea. Why microglia kill neurons after neural disorders? The friendly fire hypothesis. Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089039. |
according to this notion, microglia may cause bystander neuronal damage with a kind of blind "friendly fire", fighting against a non-existing infection during non-infectious disorders, like stroke and trauma. |
2020-10-01 |
2023-08-13 |
rat |
| Steffanie Heindl, Benno Gesierich, Corinne Benakis, Gemma Llovera, Marco Duering, Arthur Lies. Automated Morphological Analysis of Microglia After Stroke. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:29725290. |
automated morphological analysis of microglia after stroke. |
2020-09-30 |
2023-08-13 |
mouse |