| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shanshan Wang, Brian P Hea. Caveolin-1 in Stroke Neuropathology and Neuroprotection: A Novel Molecular Therapeutic Target for Ischemic-Related Injury. Current vascular pharmacology. vol 17. issue 1. 2020-01-21. PMID:29412114. |
this review focuses on the 1) pathophysiology of stroke (neuronal cell loss, defective blood brain barrier, microglia activation, and inflammation), 2) the role of the membrane protein caveolin- 1 (cav-1) in normal brain physiology and stroke-induced changes, and, 3) we briefly discussed the potential therapeutic role of cav-1 in recovery following stroke. |
2020-01-21 |
2023-08-13 |
Not clear |
| Reza Rahimian, Starlee Lively, Essam Abdelhamid, Melanie Lalancette-Hebert, Lyanne Schlichter, Sachiko Sato, Jasna Kri. Delayed Galectin-3-Mediated Reprogramming of Microglia After Stroke is Protective. Molecular neurobiology. vol 56. issue 9. 2020-01-13. PMID:30798442. |
delayed galectin-3-mediated reprogramming of microglia after stroke is protective. |
2020-01-13 |
2023-08-13 |
Not clear |
| Abdullah Al Mamun, Haifu Yu, Mehwish A Mirza, Sharmeen Romana, Louise D McCullough, Fudong Li. Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy. Neurochemistry international. vol 127. 2020-01-02. PMID:30586599. |
previously we have reported that irf4 signaling is closely correlated with anti-inflammatory polarization of microglia in adult mice after stroke. |
2020-01-02 |
2023-08-13 |
mouse |
| Yang-Ye Hu, Yuan Wang, Shuang Liang, Xue-Li Yu, Lei Zhang, Lin-Yin Feng, Yi Fen. Senkyunolide I attenuates oxygen-glucose deprivation/reoxygenation-induced inflammation in microglial cells. Brain research. vol 1649. issue Pt A. 2019-11-20. PMID:27524398. |
over-activated microglia during stroke has been documented to aggravate brain damage. |
2019-11-20 |
2023-08-13 |
rat |
| Daojing Li, Wenjing Lang, Chen Zhou, Chao Wu, Fang Zhang, Qiang Liu, Shuang Yang, Junwei Ha. Upregulation of Microglial ZEB1 Ameliorates Brain Damage after Acute Ischemic Stroke. Cell reports. vol 22. issue 13. 2019-11-05. PMID:29590624. |
understanding these mechanisms may ultimately reduce disease burden and allow the manipulation of microglia responses to shape the outcomes of stroke. |
2019-11-05 |
2023-08-13 |
mouse |
| Ioanna Sandvig, Ingrid Lovise Augestad, Asta Kristine Håberg, Axel Sandvi. Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks. The European journal of neuroscience. vol 47. issue 12. 2019-11-04. PMID:29786167. |
experimental evidence suggests that microglia in response to injury can rapidly modify neuronal activity and modulate synaptic function, as well as be beneficial for the proliferation and integration of neural progenitor cells (npcs) from endogenous neurogenic niches into functional networks thereby supporting stroke recovery. |
2019-11-04 |
2023-08-13 |
Not clear |
| Ioanna Sandvig, Ingrid Lovise Augestad, Asta Kristine Håberg, Axel Sandvi. Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks. The European journal of neuroscience. vol 47. issue 12. 2019-11-04. PMID:29786167. |
in this review, we first introduce some of the key cellular and molecular mechanisms underlying neuroplasticity in stroke and then proceed to discuss the crosstalk between microglia and endogenous neuroplasticity in response to brain ischaemia with special focus on the engagement of synapses and neural networks and their implications for grey matter integrity and function in stroke repair. |
2019-11-04 |
2023-08-13 |
Not clear |
| Abdullah Al Mamun, Anjali Chauhan, Haifu Yu, Yan Xu, Romana Sharmeen, Fudong Li. Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice. The European journal of neuroscience. vol 47. issue 2. 2019-10-16. PMID:29131464. |
our results revealed that the irf5 mrna level in sorted microglia increased at 3 days of stroke; whereas irf4 mrna level exhibited biphasic increases, with a transient rise at 24 h and a peak at 10 days. |
2019-10-16 |
2023-08-13 |
mouse |
| Xin Wang, Wei Xuan, Zi-Yu Zhu, Yan Li, Hao Zhu, Ling Zhu, Dan-Yun Fu, Li-Qun Yang, Pei-Ying Li, Wei-Feng Y. The evolving role of neuro-immune interaction in brain repair after cerebral ischemic stroke. CNS neuroscience & therapeutics. vol 24. issue 12. 2019-10-14. PMID:30350341. |
alternatively, activated microglia, monocytes, and neutrophils in the innate immune system, traditionally considered as major damaging factors after stroke, have been suggested to be extensively involved in brain repair after stroke. |
2019-10-14 |
2023-08-13 |
Not clear |
| Isabella Wimmer, Tobias Zrzavy, Hans Lassman. Neuroinflammatory responses in experimental and human stroke lesions. Journal of neuroimmunology. vol 323. 2019-10-03. PMID:30196821. |
finally, human stroke lesions develop on a basis of age-dependent microglia pre-activation, which may have major impact on the further activation and functional differentiation of these cells. |
2019-10-03 |
2023-08-13 |
human |
| Haoran Zhao, Lihua Wan, Yan Chen, He Zhang, Yun Xu, Shuwei Qi. FasL incapacitation alleviates CD4 Journal of neuroimmunology. vol 318. 2019-09-30. PMID:29395324. |
fasl incapacitation alleviates cd4 inflammation responses involving the crosstalk between infiltrated t cells and microglia play crucial roles in ischemia stroke. |
2019-09-30 |
2023-08-13 |
Not clear |
| Jyoti Gautam, Yao Ya. Roles of Pericytes in Stroke Pathogenesis. Cell transplantation. vol 27. issue 12. 2019-09-19. PMID:29845887. |
in addition to the well-established functions of astrocytes and microglia in stroke pathogenesis, pericytes also play an important role in stroke progression and recovery. |
2019-09-19 |
2023-08-13 |
Not clear |
| Christiane Charriaut-Marlangue, Claire Leconte, Zsolt Csaba, Linda Chafa, Julien Pansiot, Mustapha Talatizi, Kristin Simon, Raffaella Moretti, Catherine Marchand-Leroux, Olivier Baud, Valérie C Besso. Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29852289. |
the bases for these sex differences are poorly understood but might include the number, morphology and activation of microglia in the developing brain when subjected to stroke. |
2019-08-06 |
2023-08-13 |
mouse |
| Tobias Zrzavy, Joana Machado-Santos, Sheren Christine, Christoph Baumgartner, Howard L Weiner, Oleg Butovsky, Hans Lassman. Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain pathology (Zurich, Switzerland). vol 28. issue 6. 2019-05-28. PMID:29222823. |
inflammatory mechanisms, involving granulocytes, t-cells, b-cells, macrophages and activated microglia, have been suggested to play a pathogenic role in experimental models of stroke and may be targets for therapeutic intervention. |
2019-05-28 |
2023-08-13 |
human |
| Bastian Zinnhardt, Maximilian Wiesmann, Lisa Honold, Cristina Barca, Michael Schäfers, Amanda J Kiliaan, Andreas H Jacob. Theranostics. vol 8. issue 10. 2019-05-13. PMID:29774062. |
here, we highlight the recent developments in preclinical and clinical molecular imaging biomarkers of neuroinflammation (endothelial markers, microglia, mmps, cell labeling, future developments) in stroke and outline how imaging biomarkers can be used in overcoming current translational roadblocks and attrition in order to advance new immunomodulatory compounds within the clinical pipeline. |
2019-05-13 |
2023-08-13 |
Not clear |
| Adi Moshe, Sivan Izraely, Orit Sagi-Assif, Roshini Prakash, Alona Telerman, Tsipi Meshel, Thomas Carmichael, Isaac P Wit. Cystatin C takes part in melanoma-microglia cross-talk: possible implications for brain metastasis. Clinical & experimental metastasis. vol 35. issue 5-6. 2019-04-15. PMID:29722001. |
the similarities between melanoma brain metastasis and stroke with respect to cysc expression by and secretion from microglia cells suggest that cysc may be involved in shared pathways between brain metastasis and post-stroke regeneration. |
2019-04-15 |
2023-08-13 |
mouse |
| Wai Ping Yew, Natalia D Djukic, Jaya S P Jayaseelan, Frederick R Walker, Karl A A Roos, Timothy K Chataway, Hakan Muyderman, Neil R Sim. Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes. Journal of neuroinflammation. vol 16. issue 1. 2019-04-15. PMID:30626393. |
early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes. |
2019-04-15 |
2023-08-13 |
rat |
| Wai Ping Yew, Natalia D Djukic, Jaya S P Jayaseelan, Frederick R Walker, Karl A A Roos, Timothy K Chataway, Hakan Muyderman, Neil R Sim. Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes. Journal of neuroinflammation. vol 16. issue 1. 2019-04-15. PMID:30626393. |
this study tested the ability of minocycline treatment early after stroke to modify reactive responses in microglia and astrocytes and improve recovery. |
2019-04-15 |
2023-08-13 |
rat |
| Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoeh. Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke. Journal of neuroinflammation. vol 15. issue 1. 2019-04-10. PMID:29866203. |
targeted intracerebral delivery of the anti-inflammatory cytokine il13 promotes alternative activation of both microglia and macrophages after stroke. |
2019-04-10 |
2023-08-13 |
mouse |
| Lars Karlsson, María Nazareth González-Alvarado, Mar Larrosa-Flor, Ahmed Osman, Mats Börjesson, Klas Blomgren, Hans Georg Kuh. Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke. Neuroscience. vol 384. 2019-02-21. PMID:29859976. |
in the stroke model, muscular overexpression of pgc-1α resulted in an increased infarct size without any changes in microglia activation or reactive astrocytosis. |
2019-02-21 |
2023-08-13 |
mouse |