| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roxana Surugiu, Daniela Glavan, Mircea Popescu, Otilia Margaritescu, Radu Eugen, Aurel Popa-Wagne. Vasculature Remodeling in a Rat Model of Cerebral Ischemia. The Fate of the BrdU-Labeled Cells Prior to Stroke. Frontiers in neurology. vol 9. 2020-09-29. PMID:30542320. |
in this study, using brdu-labeling of proliferating cells and immunofluorescence of pre- and post-stroke rats, we found that, (i) brdu administered before stroke was incorporated preferentially into the nuclei of endothelial cells lining the lumen of existing blood vessels and newly born neurons in the dentate gyrus but not in the subventricular zone or proliferating microglia, (ii) brdu injection prior to stroke led to the patchy distribution of the newly incorporated endothelial cells into existing blood vessels of the adult rat brain, (iii) brdu injection prior to stroke specifically labeled neuronal precursors cells in a region of soft tissue beyond the inhibitory scar, which seems to be permissive to regenerative events, (iv) brdu injection after stroke led to labeling of endothelial cells crossing or detaching from the disintegrating blood vessels and their incorporation into new blood vessels in the stroke region, scar tissue and the region beyond, (v) brdu injection after stroke led to specific incorporation of brdu-positive nuclei into the "pinwheel" architecture of the ventricular epithelium, (vi) blood vessels in remote areas relative to the infarct core and in the contralateral non-lesioned cortex, showed co-labeled brdu/reca |
2020-09-29 |
2023-08-13 |
rat |
| Xu Zhao, Jing Li, Haitao Su. CD200-CD200R Interaction: An Important Regulator After Stroke. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31440137. |
because of their vital functions in the regulation of neuroinflammation, microglia constitute an important target for stroke. |
2020-09-29 |
2023-08-13 |
human |
| Pascal Gervois, Ivo Lambricht. The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke. Frontiers in immunology. vol 10. 2020-09-28. PMID:31379859. |
microglia play a key role in the inflammatory stroke microenvironment as they can adapt a disease-promoting pro-inflammatory- or pro-regenerative phenotype thereby contributing to the exacerbation or alleviation of ischemic damage, respectively. |
2020-09-28 |
2023-08-13 |
Not clear |
| Charlotte Rawlinson, Stuart Jenkins, Laura Thei, Mark L Dallas, Ruoli Che. Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain sciences. vol 10. issue 3. 2020-09-28. PMID:32168831. |
post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Charlotte Rawlinson, Stuart Jenkins, Laura Thei, Mark L Dallas, Ruoli Che. Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain sciences. vol 10. issue 3. 2020-09-28. PMID:32168831. |
microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke. |
2020-09-28 |
2023-08-13 |
Not clear |
| Charlotte Rawlinson, Stuart Jenkins, Laura Thei, Mark L Dallas, Ruoli Che. Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain sciences. vol 10. issue 3. 2020-09-28. PMID:32168831. |
a major developmental challenge for clinical translation will be the selective suppression of the deleterious effects of microglial activity after stroke whilst retaining (or enhancing) the neurovascular repair and remodelling responses of microglia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Man Cheng, Liu Yang, Zhiping Dong, Mengying Wang, Yan Sun, Huan Liu, Xuan Wang, Na Sai, Guowei Huang, Xumei Zhan. Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells. Journal of cellular and molecular medicine. vol 23. issue 7. 2020-08-06. PMID:31087489. |
however, whether fd is involved in the activation of microglia and the neuroinflammation after experimental stroke and the underlying mechanism is still unclear. |
2020-08-06 |
2023-08-13 |
rat |
| Benjamin Maïer, Nathalie Kubi. Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview. Neural plasticity. vol 2019. 2020-07-27. PMID:31737062. |
here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron connectivity and neurogenesis, and phenotype modification of microglia and astrocytes. |
2020-07-27 |
2023-08-13 |
Not clear |
| Wael Eldahshan, Susan C Fagan, Adviye Ergu. Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery. Pharmacological research. vol 147. 2020-07-21. PMID:31315064. |
inflammation within the neurovascular unit: focus on microglia for stroke injury and recovery. |
2020-07-21 |
2023-08-13 |
Not clear |
| Mei-Juan Zhang, Qiu-Chen Zhao, Ming-Xu Xia, Jian Chen, Yan-Ting Chen, Xiang Cao, Yi Liu, Zeng-Qiang Yuan, Xiao-Ying Wang, Yun X. The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 1. 2020-07-07. PMID:31914678. |
here, we investigated the potential contributions of hdac3 to inflammasome activation in primary cultured microglia and experimental stroke models. |
2020-07-07 |
2023-08-13 |
mouse |
| Mei-Juan Zhang, Qiu-Chen Zhao, Ming-Xu Xia, Jian Chen, Yan-Ting Chen, Xiang Cao, Yi Liu, Zeng-Qiang Yuan, Xiao-Ying Wang, Yun X. The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 1. 2020-07-07. PMID:31914678. |
in this study, we documented that hdac3 expression was increased in microglia of mouse experimental stroke model. |
2020-07-07 |
2023-08-13 |
mouse |
| Shun-Ming Ting, Xiurong Zhao, Guanghua Sun, Lidiya Obertas, Mercedes Ricote, Jaroslaw Aronowsk. Brain Cleanup as a Potential Target for Poststroke Recovery: The Role of RXR (Retinoic X Receptor) in Phagocytes. Stroke. vol 51. issue 3. 2020-06-22. PMID:31914884. |
background and purpose- phagocytic cells, such as microglia and blood-derived macrophages, are a key biological modality responsible for phagocytosis-mediated clearance of damaged, dead, or displaced cells that are compromised during senescence or pathological processes, including after stroke. |
2020-06-22 |
2023-08-13 |
mouse |
| Akriti Srivastava, Pranay Srivastava, Rajkumar Verm. Role of bone marrow-derived macrophages (BMDMs) in neurovascular interactions during stroke. Neurochemistry international. vol 129. 2020-06-01. PMID:31145968. |
after stroke onset, microglia - the brain-resident macrophage immune cells - and peripheral immune cells affect stoke injury/recovery by releasing pro-inflammatory and/or anti-inflammatory cytokines depending on their microenvironment. |
2020-06-01 |
2023-08-13 |
Not clear |
| Chuwen Li, Yaqi Bian, Yu Feng, Fan Tang, Liang Wang, Maggie Pui Man Hoi, Dan Ma, Chao Zhao, Simon Ming Yuen Le. Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization. ACS chemical neuroscience. vol 10. issue 5. 2020-05-29. PMID:30839193. |
neuroprotective effects of bhdpc, a novel neuroprotectant, on experimental stroke by modulating microglia polarization. |
2020-05-29 |
2023-08-13 |
mouse |
| Degang Song, Xiangjian Zhang, Junmin Chen, Xiaoxia Liu, Jing Xue, Lan Zhang, Xifa La. Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke. Journal of neuroinflammation. vol 16. issue 1. 2020-05-27. PMID:31810470. |
here, we explored whether wnt/β-catenin pathway activator tws119 facilitated long-term neurological recovery via modulating microglia polarization after experimental stroke. |
2020-05-27 |
2023-08-13 |
Not clear |
| Jun-Long Huang, Wen-Wu Liu, Anatol Manaenko, Xue-Jun Sun, Qi-Yong Mei, Qin H. Hydrogen inhibits microglial activation and regulates microglial phenotype in a mouse middle cerebral artery occlusion model. Medical gas research. vol 9. issue 3. 2020-05-25. PMID:31552875. |
microglia participate in bi-directional control of brain repair after stroke. |
2020-05-25 |
2023-08-13 |
mouse |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
however, myeloid cells participating in stroke pathology include both brain resident microglia and circulating macrophages. |
2020-05-18 |
2023-08-13 |
mouse |
| Murielle G Kluge, Mahmoud Abdolhoseini, Katarzyna Zalewska, Lin Kooi Ong, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 12. 2020-05-05. PMID:30204044. |
in this study, we combine a photothrombotic stroke model in mice, acute slice and fluorescent imaging to analyse the loss of microglia process responsiveness. |
2020-05-05 |
2023-08-13 |
mouse |
| Yves Werner, Elvira Mass, Praveen Ashok Kumar, Thomas Ulas, Kristian Händler, Arik Horne, Kathrin Klee, Amelie Lupp, Dagmar Schütz, Friederike Saaber, Christoph Redecker, Joachim L Schultze, Frederic Geissmann, Ralf Stum. Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke. Nature neuroscience. vol 23. issue 3. 2020-04-13. PMID:32042176. |
cxcr4 distinguishes hsc-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke. |
2020-04-13 |
2023-08-13 |
Not clear |
| Ke Ning, Wen-Wu Liu, Jun-Long Huang, Hong-Tao Lu, Xue-Jun Su. Effects of hydrogen on polarization of macrophages and microglia in a stroke model. Medical gas research. vol 8. issue 4. 2020-02-25. PMID:30713668. |
effects of hydrogen on polarization of macrophages and microglia in a stroke model. |
2020-02-25 |
2023-08-13 |
human |