| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessio Facciolà, Giuseppa Visalli, Sebastiano La Maestra, Manuela Ceccarelli, Francesco D'Aleo, Giuseppe Nunnari, Giovanni Francesco Pellicanò, Angela Di Pietr. Carbon nanotubes and central nervous system: Environmental risks, toxicological aspects and future perspectives. Environmental toxicology and pharmacology. vol 65. 2019-02-13. PMID:30500734. |
after their entrance, cnts reach the cns where they may cause cytotoxicity of selected neurons in several cns regions, impairing molecular pathways and contributing to the onset and progression of chronic brain inflammation, microglia activation and white matter abnormalities with an increased risk for autism spectrum disorders, lower iq in children, neurodegenerative diseases and stroke. |
2019-02-13 |
2023-08-13 |
human |
| Melissa A Lopes Pinheiro, Gijs Kooij, Mark R Mizee, Alwin Kamermans, Gaby Enzmann, Ruth Lyck, Markus Schwaninger, Britta Engelhardt, Helga E de Vrie. Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke. Biochimica et biophysica acta. vol 1862. issue 3. 2019-01-24. PMID:26527183. |
in ms and stroke the blood-brain barrier is disrupted allowing bone marrow-derived macrophages to invade the brain in support of the resident microglia. |
2019-01-24 |
2023-08-13 |
Not clear |
| Kecheng Zhou, Jiayu Wu, Jie Chen, Ye Zhou, Xiaolong Chen, Qiaoyun Wu, Yangxinzi Xu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Songhe Jian. Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells. Journal of pharmacological sciences. vol 139. issue 1. 2019-01-24. PMID:30528467. |
neuroinflammation plays a major role in the development of ischemic stroke, and regulation of the proinflammatory tlr4 signaling pathway in microglia stands to be a promising therapeutic strategy for stroke intervention. |
2019-01-24 |
2023-08-13 |
mouse |
| Hai M Nguyen, Linda V Blomster, Palle Christophersen, Heike Wulf. Potassium channel expression and function in microglia: Plasticity and possible species variations. Channels (Austin, Tex.). vol 11. issue 4. 2018-11-22. PMID:28277939. |
potassium channels play important roles in microglia functions and thus constitute potential targets for the treatment of neurodegenerative diseases like alzheimer, parkinson and stroke. |
2018-11-22 |
2023-08-13 |
mouse |
| Reza Rahimian, Louis-Charles Béland, Jasna Kri. Galectin-3: mediator of microglia responses in injured brain. Drug discovery today. vol 23. issue 2. 2018-11-07. PMID:29133191. |
given its putative role as a dynamic fine-tuner of microglia, activation of galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. |
2018-11-07 |
2023-08-13 |
Not clear |
| Ji Wang, Hongyi Xing, Lin Wan, Xingjun Jiang, Chen Wang, Yan W. Treatment targets for M2 microglia polarization in ischemic stroke. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 105. 2018-11-06. PMID:29883947. |
therefore, methods for promoting the differentiation of microglia into the m2 polarized form to alleviate harmful reactions after stroke have become a topic of interest in recent years. |
2018-11-06 |
2023-08-13 |
Not clear |
| Ji Wang, Hongyi Xing, Lin Wan, Xingjun Jiang, Chen Wang, Yan W. Treatment targets for M2 microglia polarization in ischemic stroke. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 105. 2018-11-06. PMID:29883947. |
in the present review, we discussed the neuroprotective effects of microglia m2 polarization and the potential mechanisms and drugs by which microglia can be transformed into the m2 polarized type after stroke. |
2018-11-06 |
2023-08-13 |
Not clear |
| Liqiang Liu, Xiangrong Liu, Rongliang Wang, Feng Yan, Yumin Luo, Ankush Chandra, Yuchuan Ding, Xunming J. Mild focal hypothermia regulates the dynamic polarization of microglia after ischemic stroke in mice. Neurological research. vol 40. issue 6. 2018-10-15. PMID:29619889. |
this transformation of polarity of microglia has influence on the degree of damage following a stroke. |
2018-10-15 |
2023-08-13 |
mouse |
| Gergely Szalay, Bernadett Martinecz, Nikolett Lénárt, Zsuzsanna Környei, Barbara Orsolits, Linda Judák, Eszter Császár, Rebeka Fekete, Brian L West, Gergely Katona, Balázs Rózsa, Ádám Déne. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nature communications. vol 7. 2018-09-24. PMID:27139776. |
microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. |
2018-09-24 |
2023-08-13 |
Not clear |
| E S Savchenko, I B Pevzner, L D Zorova, D N Silachev, V A Babenko, V N Manskikh, M V Gulyaev, Yu A Pirogov, E Yu Plotnikov, D B Zoro. CHANGES IN THE NUMBER OF NEURONS, ASTROCYTES AND MICROGLIA IN THE BRAIN AFTER ISCHEMIC STROKE ASSESSED BY IMMUNOHISTOCHEMISTRY AND IMMUNOBLOTTING. Tsitologiia. vol 58. issue 7. 2018-09-24. PMID:30198664. |
it is known that the mechanisms of damage in the brain after stroke are regulated by combination of severaltypes of cells, primarily of neurons, astrocytes, endothelium and microglia. |
2018-09-24 |
2023-08-13 |
Not clear |
| Rui Liu, Junjian Diao, Shucheng He, Binbin Li, Yuxiang Fei, Yunman Li, Weirong Fan. XQ-1H protects against ischemic stroke by regulating microglia polarization through PPARγ pathway in mice. International immunopharmacology. vol 57. 2018-09-10. PMID:29475098. |
in conclusion, the present study demonstrates that xq-1h alleviated ischemic stroke by regulating balance of pro-/anti-inflammatory microglia polarization through pparγ pathway both in vivo and in vitro, offering an alternative medication for stroke associated with inflammation. |
2018-09-10 |
2023-08-13 |
mouse |
| Yunjie Wang, Yun Huang, Yazhou Xu, Wenchen Ruan, Haojie Wang, Yihua Zhang, Juan M Saavedra, Luyong Zhang, Zhangjian Huang, Tao Pan. A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization. Antioxidants & redox signaling. vol 28. issue 2. 2018-07-27. PMID:28747068. |
a dual ampk/nrf2 activator reduces brain inflammation after stroke by enhancing microglia m2 polarization. |
2018-07-27 |
2023-08-13 |
Not clear |
| Yunjie Wang, Wenchen Ruan, Junru Mi, Jingzi Xu, Haojie Wang, Zhengyu Cao, Juan M Saavedra, Luyong Zhang, Hansen Lin, Tao Pan. Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28803158. |
promoting the anti-inflammatory activation of microglia might be an effective treatment of stroke. |
2018-07-11 |
2023-08-13 |
mouse |
| K A Jones, S Maltby, M W Plank, M Kluge, M Nilsson, P S Foster, F R Walke. Peripheral immune cells infiltrate into sites of secondary neurodegeneration after ischemic stroke. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28911981. |
experimental stroke leads to microglia activation and progressive neuronal loss at sites of secondary neurodegeneration (snd). |
2018-07-11 |
2023-08-13 |
Not clear |
| Radhika Patnala, Thiruma V Arumugam, Neelima Gupta, S Thameem Dhee. HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke. Molecular neurobiology. vol 54. issue 8. 2018-07-09. PMID:27722928. |
cerebral ischemia leads to neuroinflammation and activation of microglia which further contribute to stroke pathology. |
2018-07-09 |
2023-08-13 |
mouse |
| Roland G W Staal, Jonathan R Weinstein, Megan Nattini, Manuel Cajina, Gamini Chandresana, Thomas Mölle. Senicapoc: Repurposing a Drug to Target Microglia K Neurochemical research. vol 42. issue 9. 2018-07-09. PMID:28364331. |
senicapoc: repurposing a drug to target microglia k stroke is the leading cause of serious long-term disability and the fifth leading cause of death in the united states. |
2018-07-09 |
2023-08-13 |
Not clear |
| Roland G W Staal, Jonathan R Weinstein, Megan Nattini, Manuel Cajina, Gamini Chandresana, Thomas Mölle. Senicapoc: Repurposing a Drug to Target Microglia K Neurochemical research. vol 42. issue 9. 2018-07-09. PMID:28364331. |
neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. |
2018-07-09 |
2023-08-13 |
Not clear |
| Jenni E Anttila, Keith W Whitaker, Emily S Wires, Brandon K Harvey, Mikko Airavaar. Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt A. 2018-07-06. PMID:27389423. |
role of microglia in ischemic focal stroke and recovery: focus on toll-like receptors. |
2018-07-06 |
2023-08-13 |
Not clear |
| Jenni E Anttila, Keith W Whitaker, Emily S Wires, Brandon K Harvey, Mikko Airavaar. Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt A. 2018-07-06. PMID:27389423. |
this division encompasses the spatial and temporal dynamics of microglia as they participate in the pathophysiological changes that contribute to the symptoms and sequela of a stroke. |
2018-07-06 |
2023-08-13 |
Not clear |
| Jenni E Anttila, Keith W Whitaker, Emily S Wires, Brandon K Harvey, Mikko Airavaar. Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt A. 2018-07-06. PMID:27389423. |
increasing evidence shows that microglia have a complex role in stroke pathophysiology, and they mediate both detrimental and beneficial effects on stroke outcome. |
2018-07-06 |
2023-08-13 |
Not clear |