| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
stroke activates microglia pro-inflammatory response that not only induces the early neuronal injuries but also causes the secondary brain infarction. |
2021-06-08 |
2023-08-13 |
mouse |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
yet, the underlying mechanisms for how microglia become activated in stroke are still unknown. |
2021-06-08 |
2023-08-13 |
mouse |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
inhibition of either hmgb2 or ctss blocks microglia pro-inflammatory response and protects against brain damages and improves the neurological functions of stroke mice. |
2021-06-08 |
2023-08-13 |
mouse |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
this study uncovers hmgb2 and ctss as the major microglia inflammatory response mediators in stroke and hence warrants the promising targets for stroke therapies. |
2021-06-08 |
2023-08-13 |
mouse |
| Bella M Gonzales-Portillo, Jea-Young Lee, Arthur A Vandenbark, Halina Offner, Cesario V Borlonga. Major histocompatibility complex Class II-based therapy for stroke. Brain circulation. vol 7. issue 1. 2021-06-05. PMID:34084976. |
drmq was observed to attenuate behavioral deficits and decrease microglia activation and proinflammatory cytokines, illustrating its ability to mitigate the secondary cell death following stroke. |
2021-06-05 |
2023-08-13 |
Not clear |
| Wenguang Xie, Xiao-Ting Gong, Xiaofeng Cheng, Jingjing Cao, Jin Zhao, Hao-Li Zhang, Shengxiang Zhan. LIMPID: a versatile method for visualization of brain vascular networks. Biomaterials science. vol 9. issue 7. 2021-05-14. PMID:33595547. |
we have successfully applied this method to acquire cortical vasculature images simultaneously with the neurons or microglia, as well as to evaluate vascular damage in a mouse model of stroke. |
2021-05-14 |
2023-08-13 |
mouse |
| Li-Rong Liu, Jia-Chen Liu, Jin-Shuang Bao, Qin-Qin Bai, Gai-Qing Wan. Interaction of Microglia and Astrocytes in the Neurovascular Unit. Frontiers in immunology. vol 11. 2021-05-05. PMID:32733433. |
during neuroinflammation, induced by stroke or lipopolysaccharides, microglia are more sensitive to pathogens, or damage; they are thus initially activated into the m1 phenotype and produce common inflammatory signals such as il-1 and tnf-α to trigger reactive astrocytes into the a1 phenotype. |
2021-05-05 |
2023-08-13 |
Not clear |
| Yang Jiao, Jianjian Wang, Huixue Zhang, Yuze Cao, Yang Qu, Siyu Huang, Xiaotong Kong, Chang Song, Jie Li, Qian Li, Heping Ma, Xiaoyu Lu, Lihua Wan. Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke. Journal of cellular and molecular medicine. vol 24. issue 21. 2021-05-04. PMID:32990414. |
microglia are rapidly activated following ischaemic stroke and participate in the induction of neuroinflammation, which exacerbates the injury of ischaemic stroke. |
2021-05-04 |
2023-08-13 |
human |
| Jung Hak Kim, So Young Kim, Bokyung Kim, Sang Rae Lee, Sang Hoon Cha, Dong Seok Lee, Hong Jun Le. Prospects of Therapeutic Target and Directions for Ischemic Stroke. Pharmaceuticals (Basel, Switzerland). vol 14. issue 4. 2021-05-02. PMID:33916253. |
these cytokines lead to severe neurotoxicity via the overactivation of microglia in prolonged and lasting insults such as stroke. |
2021-05-02 |
2023-08-13 |
Not clear |
| Abdulhameed Bakreen, Miia Juntunen, Yannick Dunlop, Irene F Ugidos, Tarja Malm, Susanna Miettinen, Jukka Jolkkone. Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats. International journal of molecular sciences. vol 22. issue 4. 2021-04-20. PMID:33546370. |
additive behavioral improvement after combined cell therapy and rehabilitation despite long-term microglia presence in stroke rats. |
2021-04-20 |
2023-08-13 |
rat |
| Lu Jiang, Hongfeng Mu, Fei Xu, Di Xie, Wei Su, Jing Xu, Zeyu Sun, Silvia Liu, Jianhua Luo, Yejie Shi, Rehana K Leak, Lawrence R Wechsler, Jun Chen, Xiaoming H. Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32065074. |
transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery. |
2021-03-23 |
2023-08-13 |
Not clear |
| Lu Jiang, Hongfeng Mu, Fei Xu, Di Xie, Wei Su, Jing Xu, Zeyu Sun, Silvia Liu, Jianhua Luo, Yejie Shi, Rehana K Leak, Lawrence R Wechsler, Jun Chen, Xiaoming H. Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32065074. |
here, we compared the transcriptional profiles of young versus aged microglia during stroke recovery. |
2021-03-23 |
2023-08-13 |
Not clear |
| Ligen Shi, Marcelo Rocha, Wenting Zhang, Ming Jiang, Sicheng Li, Qing Ye, Sulaiman H Hassan, Liqiang Liu, Maya N Adair, Jing Xu, Jianhua Luo, Xiaoming Hu, Lawrence R Wechsler, Jun Chen, Yejie Sh. Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32438860. |
senescence-associated alterations in microglia may have profound impact on cerebral homeostasis and stroke outcomes. |
2021-03-23 |
2023-08-13 |
mouse |
| Ligen Shi, Marcelo Rocha, Wenting Zhang, Ming Jiang, Sicheng Li, Qing Ye, Sulaiman H Hassan, Liqiang Liu, Maya N Adair, Jing Xu, Jianhua Luo, Xiaoming Hu, Lawrence R Wechsler, Jun Chen, Yejie Sh. Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32438860. |
gene clusters with functional implications in immune inflammatory responses, immune cell chemotaxis, tissue remodeling, and cell-cell interactions were markedly activated in microglia of young but not aged stroke mice. |
2021-03-23 |
2023-08-13 |
mouse |
| Wenjun Deng, Emiri Mandeville, Yasukazu Terasaki, Wenlu Li, Julie Holder, Aaron Tt Chuang, Mingming Ning, Ken Arai, Eng H Lo, Changhong Xin. Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:33208001. |
microglia are key regulators of inflammatory response after stroke and brain injury. |
2021-03-23 |
2023-08-13 |
rat |
| Ladonya Jackson, Selin Dumanli, Maribeth H Johnson, Susan C Fagan, Adviye Ergu. Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke. Journal of neuroinflammation. vol 17. issue 1. 2021-03-19. PMID:32345303. |
microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke. |
2021-03-19 |
2023-08-13 |
Not clear |
| Masahiro Hatakeyama, Itaru Ninomiya, Yutaka Otsu, Kaoru Omae, Yasuko Kimura, Osamu Onodera, Masanori Fukushima, Takayoshi Shimohata, Masato Kanazaw. Cell Therapies under Clinical Trials and Polarized Cell Therapies in Pre-Clinical Studies to Treat Ischemic Stroke and Neurological Diseases: A Literature Review. International journal of molecular sciences. vol 21. issue 17. 2021-02-22. PMID:32867222. |
polarized microglia or peripheral blood mononuclear cells might provide promising therapeutic strategies after stroke because they have pleiotropic effects. |
2021-02-22 |
2023-08-13 |
Not clear |
| Cheng-Ting Jiang, Wan-Feng Wu, Yi-Hui Deng, Jin-Wen G. Modulators of microglia activation and polarization in ischemic stroke (Review). Molecular medicine reports. vol 21. issue 5. 2021-02-16. PMID:32323760. |
it has been shown that m1 microglia promote secondary brain damage, whilst m2 microglia facilitate recovery following stroke. |
2021-02-16 |
2023-08-13 |
Not clear |
| Lu Lian, Yunsha Zhang, Lu Liu, Liji Yang, Yichen Cai, Junping Zhang, Shixin X. Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia. Frontiers in molecular neuroscience. vol 13. 2021-01-26. PMID:33488360. |
during the acute phase of stroke onset, m2 microglia are the dominant phenotype and exert protective effects on neuronal cells, whereas permanent m1 microglia contribute to prolonged inflammation and are detrimental to brain tissue. |
2021-01-26 |
2023-08-13 |
Not clear |
| Lu Lian, Yunsha Zhang, Lu Liu, Liji Yang, Yichen Cai, Junping Zhang, Shixin X. Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia. Frontiers in molecular neuroscience. vol 13. 2021-01-26. PMID:33488360. |
thus, we briefly reviewed the dynamic response of microglia after a stroke and assessed how specific mirnas affect the behavior of reactive microglia. |
2021-01-26 |
2023-08-13 |
Not clear |