| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ursula Heldmann, Yutaka Mine, Zaal Kokaia, Christine T Ekdahl, Olle Lindval. Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21419118. |
these findings indicate that the mac-1-expressing microglia in the svz do not play a major role either for the number of neuroblasts which exit the svz or their migration in the striatum early following stroke. |
2011-08-05 |
2023-08-12 |
rat |
| D Arsene, Florina Vasilescu, C Toader, Adina Bălan, C Popa, Carmen Ardelean. Clinico-pathological correlations in fatal ischemic stroke. An immunohistochemical study of human brain penumbra. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 52. issue 1. 2011-07-21. PMID:21424029. |
microglia appears active in stroke and stimulating methods directed to it could be useful. |
2011-07-21 |
2023-08-12 |
human |
| Alexander Thiel, Wolf-Dieter Heis. Imaging of microglia activation in stroke. Stroke. vol 42. issue 2. 2011-03-02. PMID:21164114. |
imaging of microglia activation in stroke. |
2011-03-02 |
2023-08-12 |
human |
| Vladimer Darsalia, Susan J Allison, Carlo Cusulin, Emanuela Monni, Daniela Kuzdas, Therése Kallur, Olle Lindvall, Zaal Kokai. Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 1. 2011-02-03. PMID:20531461. |
a substantial number of activated microglia was observed at 48 hours after the insult in the injured striatum, but reached maximum levels 1 to 6 weeks after stroke. |
2011-02-03 |
2023-08-12 |
human |
| Midori A Yenari, Tiina M Kauppinen, Raymond A Swanso. Microglial activation in stroke: therapeutic targets. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 7. issue 4. 2011-01-24. PMID:20880502. |
effective agents are now available for blocking both microglial receptor activation and the microglia effector responses that drive the inflammatory response after stroke. |
2011-01-24 |
2023-08-12 |
Not clear |
| V A Dinapoli, S A Benkovic, X Li, K A Kelly, D B Miller, C L Rosen, J D Huber, J P O'Callagha. Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20633608. |
while activation of perilesional astrocytes and microglia following ischemic brain injury is well documented, the influence of age on these cellular responses after stroke is unclear. |
2011-01-20 |
2023-08-12 |
rat |
| D Famer, L-O Wahlund, M Crisb. Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD. Biochemical and biophysical research communications. vol 402. issue 2. 2010-12-28. PMID:20946880. |
rosuvastatin reduces microglia in the brain of wild type and apoe knockout mice on a high cholesterol diet; implications for prevention of stroke and ad. |
2010-12-28 |
2023-08-12 |
mouse |
| Catherine E Downes, Peter J Crac. Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? British journal of pharmacology. vol 160. issue 8. 2010-11-08. PMID:20649586. |
over the past 20 years, researchers examining brain tissue at various time intervals after stroke observed the presence of inflammatory cells, neutrophils and monocytes at the site of injury, as well as the activation of endogenous glia and microglia. |
2010-11-08 |
2023-08-12 |
Not clear |
| Amjad Shehadah, Jieli Chen, Xu Cui, Cynthia Roberts, Mei Lu, Michael Chop. Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. Journal of the neurological sciences. vol 294. issue 1-2. 2010-10-21. PMID:20451219. |
in this study we examined the effect of combination treatment of experimental stroke with niaspan, a prolonged-release formulation of niacin (vitamin b3), and simvastatin, a cholesterol-lowering drug, on functional outcome, axonal damage, axonal density and the of iba-1 immunoreactive microglia expression in the ischemic brain of rats. |
2010-10-21 |
2023-08-12 |
rat |
| Amjad Shehadah, Jieli Chen, Xu Cui, Cynthia Roberts, Mei Lu, Michael Chop. Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. Journal of the neurological sciences. vol 294. issue 1-2. 2010-10-21. PMID:20451219. |
decreased expression of the ngr and reduced activated microglia may contribute to functional recovery after stroke. |
2010-10-21 |
2023-08-12 |
rat |
| Alexander Thiel, Basia A Radlinska, Caroline Paquette, Michael Sidel, Jean-Paul Soucy, Ralf Schirrmacher, Jeffrey Minu. The temporal dynamics of poststroke neuroinflammation: a longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51. issue 9. 2010-09-27. PMID:20720039. |
animal experiments suggest that 2 different types of activated microglia (amg) cells occur in the brain after a stroke: local amg in the area of the infarct and remote amg, which occurs along affected fiber tracts. |
2010-09-27 |
2023-08-12 |
Not clear |
| Rong Jin, Shiyong Yu, Zifang Song, Joseph W Quillin, Daniel P Deasis, Josef M Penninger, Anil Nanda, D Neil Granger, Guohong L. Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. Biochemical and biophysical research communications. vol 399. issue 3. 2010-09-14. PMID:20678469. |
phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. |
2010-09-14 |
2023-08-12 |
mouse |
| J J Li, L H Wu, Q Cao, Y Yuan, L Yang, Z Y Guo, C Kaur, V Sivakumar, E A Ling, C Y W. Endothelins-1/3 and endothelin-A/B receptors expressing glial cells with special reference to activated microglia in experimentally induced cerebral ischemia in the adult rats. Neuroscience. vol 167. issue 3. 2010-06-29. PMID:20206236. |
however, dissecting the role of individual component of the endothelin system in the various glial cells, notably activated microglia, would be vital in designing of an effective therapeutic strategy for clinical treatment of stroke in which microglial cells have been implicated. |
2010-06-29 |
2023-08-12 |
rat |
| Jack Rocky-Jay Rivers, John Clive Ashto. The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies. Central nervous system agents in medicinal chemistry. vol 10. issue 1. 2010-06-07. PMID:20236042. |
we first discuss the role of microglia in the healthy brain, and then the role of microglia in chronic neuroinflammatory disorders, including alzheimer's disease and parkinson's disease, as well as in neuroinflammation following acute brain injury such as stroke and global hypoxia. |
2010-06-07 |
2023-08-12 |
Not clear |
| Taïssia Lelekov-Boissard, Guillemette Chapuisat, Jean-Pierre Boissel, Emmanuel Grenier, Marie-Aimée Dronn. Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. vol 367. issue 1908. 2010-03-04. PMID:19884176. |
the inflammatory process during stroke consists of activation of resident brain microglia and recruitment of leucocytes, namely neutrophils and monocytes/macrophages. |
2010-03-04 |
2023-08-12 |
Not clear |
| Basia A Radlinska, Sasan A Ghinani, Paul Lyon, Dean Jolly, Jean-Paul Soucy, Jeffrey Minuk, Ralf Schirrmacher, Alexander Thie. Multimodal microglia imaging of fiber tracts in acute subcortical stroke. Annals of neurology. vol 66. issue 6. 2010-01-18. PMID:20035510. |
multimodal microglia imaging of fiber tracts in acute subcortical stroke. |
2010-01-18 |
2023-08-12 |
Not clear |
| Basia A Radlinska, Sasan A Ghinani, Paul Lyon, Dean Jolly, Jean-Paul Soucy, Jeffrey Minuk, Ralf Schirrmacher, Alexander Thie. Multimodal microglia imaging of fiber tracts in acute subcortical stroke. Annals of neurology. vol 66. issue 6. 2010-01-18. PMID:20035510. |
case series with (11)c-pk11195 and positron emission tomography (pet) in stroke patients suggest that activated microglia may be detected in remote brain regions with fiber tract connections to the lesion site as an indicator of poststroke neuroinflammation. |
2010-01-18 |
2023-08-12 |
Not clear |
| Fransisca Indraswari, Peter T H Wong, Elgin Yap, Y K Ng, S Thameem Dhee. Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Neurochemistry international. vol 55. issue 4. 2009-09-02. PMID:19524114. |
therefore, this study was aimed to investigate the temporal expression of dpysl2 and spna2 genes in normal and stroke rat brain and to characterize stroke brains for cell areas, apoptosis, and microglia cells. |
2009-09-02 |
2023-08-12 |
rat |
| Fransisca Indraswari, Peter T H Wong, Elgin Yap, Y K Ng, S Thameem Dhee. Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Neurochemistry international. vol 55. issue 4. 2009-09-02. PMID:19524114. |
characterization of stroke brain for apoptosis and microglia cells showed apoptotic cells and activated microglia, mainly in the infarct core of ipsilateral cortex and striatum of stroke brain. |
2009-09-02 |
2023-08-12 |
rat |
| M Schilling, J-K Strecker, W-R Schäbitz, E B Ringelstein, R Kiefe. Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19374937. |
however, the remarkable predominance of activated microglia and the additional attenuation of invading macrophages suggest that different mechanisms than macrophage recruitment are responsible for the mcp-1-mediated neuroprotective effects after experimental stroke. |
2009-08-24 |
2023-08-12 |
mouse |