| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander Thiel, Basia A Radlinska, Caroline Paquette, Michael Sidel, Jean-Paul Soucy, Ralf Schirrmacher, Jeffrey Minu. The temporal dynamics of poststroke neuroinflammation: a longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51. issue 9. 2010-09-27. PMID:20720039. |
animal experiments suggest that 2 different types of activated microglia (amg) cells occur in the brain after a stroke: local amg in the area of the infarct and remote amg, which occurs along affected fiber tracts. |
2010-09-27 |
2023-08-12 |
Not clear |
| Rong Jin, Shiyong Yu, Zifang Song, Joseph W Quillin, Daniel P Deasis, Josef M Penninger, Anil Nanda, D Neil Granger, Guohong L. Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. Biochemical and biophysical research communications. vol 399. issue 3. 2010-09-14. PMID:20678469. |
phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. |
2010-09-14 |
2023-08-12 |
mouse |
| J J Li, L H Wu, Q Cao, Y Yuan, L Yang, Z Y Guo, C Kaur, V Sivakumar, E A Ling, C Y W. Endothelins-1/3 and endothelin-A/B receptors expressing glial cells with special reference to activated microglia in experimentally induced cerebral ischemia in the adult rats. Neuroscience. vol 167. issue 3. 2010-06-29. PMID:20206236. |
however, dissecting the role of individual component of the endothelin system in the various glial cells, notably activated microglia, would be vital in designing of an effective therapeutic strategy for clinical treatment of stroke in which microglial cells have been implicated. |
2010-06-29 |
2023-08-12 |
rat |
| Jack Rocky-Jay Rivers, John Clive Ashto. The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies. Central nervous system agents in medicinal chemistry. vol 10. issue 1. 2010-06-07. PMID:20236042. |
we first discuss the role of microglia in the healthy brain, and then the role of microglia in chronic neuroinflammatory disorders, including alzheimer's disease and parkinson's disease, as well as in neuroinflammation following acute brain injury such as stroke and global hypoxia. |
2010-06-07 |
2023-08-12 |
Not clear |
| Taïssia Lelekov-Boissard, Guillemette Chapuisat, Jean-Pierre Boissel, Emmanuel Grenier, Marie-Aimée Dronn. Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. vol 367. issue 1908. 2010-03-04. PMID:19884176. |
the inflammatory process during stroke consists of activation of resident brain microglia and recruitment of leucocytes, namely neutrophils and monocytes/macrophages. |
2010-03-04 |
2023-08-12 |
Not clear |
| Basia A Radlinska, Sasan A Ghinani, Paul Lyon, Dean Jolly, Jean-Paul Soucy, Jeffrey Minuk, Ralf Schirrmacher, Alexander Thie. Multimodal microglia imaging of fiber tracts in acute subcortical stroke. Annals of neurology. vol 66. issue 6. 2010-01-18. PMID:20035510. |
multimodal microglia imaging of fiber tracts in acute subcortical stroke. |
2010-01-18 |
2023-08-12 |
Not clear |
| Basia A Radlinska, Sasan A Ghinani, Paul Lyon, Dean Jolly, Jean-Paul Soucy, Jeffrey Minuk, Ralf Schirrmacher, Alexander Thie. Multimodal microglia imaging of fiber tracts in acute subcortical stroke. Annals of neurology. vol 66. issue 6. 2010-01-18. PMID:20035510. |
case series with (11)c-pk11195 and positron emission tomography (pet) in stroke patients suggest that activated microglia may be detected in remote brain regions with fiber tract connections to the lesion site as an indicator of poststroke neuroinflammation. |
2010-01-18 |
2023-08-12 |
Not clear |
| Fransisca Indraswari, Peter T H Wong, Elgin Yap, Y K Ng, S Thameem Dhee. Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Neurochemistry international. vol 55. issue 4. 2009-09-02. PMID:19524114. |
therefore, this study was aimed to investigate the temporal expression of dpysl2 and spna2 genes in normal and stroke rat brain and to characterize stroke brains for cell areas, apoptosis, and microglia cells. |
2009-09-02 |
2023-08-12 |
rat |
| Fransisca Indraswari, Peter T H Wong, Elgin Yap, Y K Ng, S Thameem Dhee. Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Neurochemistry international. vol 55. issue 4. 2009-09-02. PMID:19524114. |
characterization of stroke brain for apoptosis and microglia cells showed apoptotic cells and activated microglia, mainly in the infarct core of ipsilateral cortex and striatum of stroke brain. |
2009-09-02 |
2023-08-12 |
rat |
| M Schilling, J-K Strecker, W-R Schäbitz, E B Ringelstein, R Kiefe. Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19374937. |
however, the remarkable predominance of activated microglia and the additional attenuation of invading macrophages suggest that different mechanisms than macrophage recruitment are responsible for the mcp-1-mediated neuroprotective effects after experimental stroke. |
2009-08-24 |
2023-08-12 |
mouse |
| Pär Thored, Ursula Heldmann, Walace Gomes-Leal, Ramiro Gisler, Vladimer Darsalia, Jalal Taneera, Jens M Nygren, Sten-Eirik W Jacobsen, Christine T Ekdahl, Zaal Kokaia, Olle Lindval. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia. vol 57. issue 8. 2009-07-09. PMID:19053043. |
long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. |
2009-07-09 |
2023-08-12 |
rat |
| Pär Thored, Ursula Heldmann, Walace Gomes-Leal, Ramiro Gisler, Vladimer Darsalia, Jalal Taneera, Jens M Nygren, Sten-Eirik W Jacobsen, Christine T Ekdahl, Zaal Kokaia, Olle Lindval. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia. vol 57. issue 8. 2009-07-09. PMID:19053043. |
elevated numbers of igf-1-expressing microglia were found in svz at 2, 6, and 16 weeks after stroke. |
2009-07-09 |
2023-08-12 |
rat |
| Pär Thored, Ursula Heldmann, Walace Gomes-Leal, Ramiro Gisler, Vladimer Darsalia, Jalal Taneera, Jens M Nygren, Sten-Eirik W Jacobsen, Christine T Ekdahl, Zaal Kokaia, Olle Lindval. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia. vol 57. issue 8. 2009-07-09. PMID:19053043. |
the long-term accumulation of microglia with proneurogenic phenotype in the svz implies a supportive role of these cells for the continuous neurogenesis after stroke. |
2009-07-09 |
2023-08-12 |
rat |
| Robert E Iosif, Henrik Ahlenius, Christine T Ekdahl, Vladimer Darsalia, Pär Thored, Stefan Jovinge, Zaal Kokaia, Olle Lindval. Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 9. 2008-10-06. PMID:18493257. |
here we show that the increased proliferation 1 week after stroke occurred concomitantly with elevated microglia numbers and tnf-alpha and tnf receptor-1 (tnf-r1) gene expression in the svz of wild-type mice. |
2008-10-06 |
2023-08-12 |
mouse |
| A Popa-Wagner, Irina Badan, Raluca Vintilescu, L Walker, C Kessle. Premature cellular proliferation following cortical infarct in aged rats. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 47. issue 3. 2007-05-18. PMID:17308679. |
since most proliferating cells at the infarct site are microglia or nestin-positive cells derived from the vascular wall, we conclude that the vasculature plays a hitherto unrecognized role as a source of proliferating neuroepithelial cells after stroke. |
2007-05-18 |
2023-08-12 |
human |
| Sheryl P Denker, Shaoquan Ji, Andra Dingman, Sarah Y Lee, Nikita Derugin, Michael F Wendland, Zinaida S Vexle. Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke. Journal of neurochemistry. vol 100. issue 4. 2007-04-10. PMID:17212701. |
macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke. |
2007-04-10 |
2023-08-12 |
rat |
| Mélanie Lalancette-Hébert, Geneviève Gowing, Alain Simard, Yuan Cheng Weng, Jasna Kri. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 10. 2007-04-09. PMID:17344397. |
more importantly, our results revealed a marked neuroprotective potential of proliferating microglia serving as an endogenous pool of neurotrophic molecules such as igf-1, which may open new therapeutic avenues in the treatment of stroke and other neurological disorders. |
2007-04-09 |
2023-08-12 |
mouse |
| Mohamed G Bani-Hani, David Greenstein, Brian E Mann, Colin J Green, Roberto Motterlin. Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. The Journal of pharmacology and experimental therapeutics. vol 318. issue 3. 2006-10-10. PMID:16772536. |
these results suggest that the anti-inflammatory activity of corm-3 could be exploited to mitigate microglia activity in stroke and other neuroinflammatory diseases. |
2006-10-10 |
2023-08-12 |
Not clear |
| Aaron Y Lai, Kathryn G Tod. Microglia in cerebral ischemia: molecular actions and interactions. Canadian journal of physiology and pharmacology. vol 84. issue 1. 2006-08-23. PMID:16845890. |
the precise role of microglia in stroke and cerebral ischemia has been the subject of debate for a number of years. |
2006-08-23 |
2023-08-12 |
human |
| Elena Fonfria, Cesar Mattei, Kerstin Hill, Jon T Brown, Andrew Randall, Christopher D Benham, Stephen D Skaper, Colin A Campbell, Barry Crook, Paul R Murdock, Jennifer M Wilson, Frank P Maurio, Davina E Owen, Paula L Tilling, Shaun McNult. TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. Journal of receptor and signal transduction research. vol 26. issue 3. 2006-07-31. PMID:16777714. |
trpm2 is elevated in the tmcao stroke model, transcriptionally regulated, and functionally expressed in c13 microglia. |
2006-07-31 |
2023-08-12 |
human |