| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeynep Sena Agim, Melda Esendal, Laurent Briollais, Ozgun Uyan, Mehran Meschian, Luis Antonio Mendoza Martinez, Yongmei Ding, A Nazli Basak, Hilmi Ozceli. Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. PloS one. vol 8. issue 1. 2013-08-20. PMID:23301017. |
discovery, validation and characterization of erbb4 and nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. |
2013-08-20 |
2023-08-12 |
human |
| Zeynep Sena Agim, Melda Esendal, Laurent Briollais, Ozgun Uyan, Mehran Meschian, Luis Antonio Mendoza Martinez, Yongmei Ding, A Nazli Basak, Hilmi Ozceli. Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. PloS one. vol 8. issue 1. 2013-08-20. PMID:23301017. |
recent association studies have revealed genomic regions of nrg1 and erbb4, which are significantly associated with risk of developing schizophrenia; however, inconsistencies exist in terms of validation of findings between distinct populations. |
2013-08-20 |
2023-08-12 |
human |
| Zeynep Sena Agim, Melda Esendal, Laurent Briollais, Ozgun Uyan, Mehran Meschian, Luis Antonio Mendoza Martinez, Yongmei Ding, A Nazli Basak, Hilmi Ozceli. Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. PloS one. vol 8. issue 1. 2013-08-20. PMID:23301017. |
in nrg1, a significant 25-kb block, between 32,291,552 and 32,317,192, was associated with risk of schizophrenia in all catie, gain, and nongain datasets (p = 0.0005, 0.0589, and 0.0143, respectively). |
2013-08-20 |
2023-08-12 |
human |
| Dong-Min Yin, Yong-Jun Chen, Yi-Sheng Lu, Jonathan C Bean, Anupama Sathyamurthy, Chengyong Shen, Xihui Liu, Thiri W Lin, Clifford A Smith, Wen-Cheng Xiong, Lin Me. Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1. Neuron. vol 78. issue 4. 2013-08-05. PMID:23719163. |
these observations demonstrate that synaptic dysfunction and behavioral deficits in ctonrg1 mice require continuous nrg1 abnormality in adulthood, suggesting that relevant schizophrenia may benefit from therapeutic intervention to restore nrg1 signaling. |
2013-08-05 |
2023-08-12 |
mouse |
| Adam R Taylor, Sara B Taylor, James I Koeni. The involvement of Type II Neuregulin-1 in rat visuospatial learning and memory. Neuroscience letters. vol 531. issue 2. 2013-07-22. PMID:23098760. |
here, we have utilized a rat model (nrg1(tn)), which is hypomorphic for the neuregulin-1 (nrg1) gene, to test whether reduced type ii nrg1 in the rat brain leads to cognitive deficits relevant to schizophrenia. |
2013-07-22 |
2023-08-12 |
rat |
| Hirotake Hida, Akihiro Mouri, Yukihiro Nod. Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors. Journal of pharmacological sciences. vol 121. issue 3. 2013-06-21. PMID:23449491. |
genetic [e.g., disrupted-in-schizophrenia 1 (disc1), neuregulin-1 (nrg1)] and environmental factors (e.g., maternal viral infection, obstetric complications, social stress) may act during the developmental period to increase the incidence of schizophrenia. |
2013-06-21 |
2023-08-12 |
mouse |
| Basant K Tiwar. The severity of mental disorders is linked to interaction among candidate genes. Integrative biology : quantitative biosciences from nano to macro. vol 4. issue 9. 2013-04-03. PMID:22777684. |
a gene coexpression network was developed based on a mutual information approach including four candidate genes (nrg1, disc1, bdnf and comt) along with other coexpressing genes in unipolar disorder, bipolar disorder and schizophrenia. |
2013-04-03 |
2023-08-12 |
Not clear |
| Basant K Tiwar. The severity of mental disorders is linked to interaction among candidate genes. Integrative biology : quantitative biosciences from nano to macro. vol 4. issue 9. 2013-04-03. PMID:22777684. |
disc1 and nrg1 are key hub genes in the unipolar disorder network and the bipolar disorder network but have lost the role of hub genes in schizophrenia network, despite their significant association with schizophrenia. |
2013-04-03 |
2023-08-12 |
Not clear |
| Seyed Ali Mohamad Shariati, Mehrdad Behmanesh, Hamid Galehdar. A Study of the Association between SNP8NRG241930 in the 5' End of Neuroglin 1 Gene with Schizophrenia in a Group of Iranian Patients. Cell journal. vol 13. issue 2. 2013-03-20. PMID:23508206. |
neuregulin1 (nrg1) gene is among the most promising candidate genes for schizophrenia. |
2013-03-20 |
2023-08-12 |
Not clear |
| Seyed Ali Mohamad Shariati, Mehrdad Behmanesh, Hamid Galehdar. A Study of the Association between SNP8NRG241930 in the 5' End of Neuroglin 1 Gene with Schizophrenia in a Group of Iranian Patients. Cell journal. vol 13. issue 2. 2013-03-20. PMID:23508206. |
however, some studies have failed to confirm the role of nrg1 gene in the pathogenesis of schizophrenia. |
2013-03-20 |
2023-08-12 |
Not clear |
| Seyed Ali Mohamad Shariati, Mehrdad Behmanesh, Hamid Galehdar. A Study of the Association between SNP8NRG241930 in the 5' End of Neuroglin 1 Gene with Schizophrenia in a Group of Iranian Patients. Cell journal. vol 13. issue 2. 2013-03-20. PMID:23508206. |
in the current study, we attempt to examine the association of snp8nrg241930 from the nrg1 gene with schizophrenia in an iranian population. |
2013-03-20 |
2023-08-12 |
Not clear |
| Seyed Ali Mohamad Shariati, Mehrdad Behmanesh, Hamid Galehdar. A Study of the Association between SNP8NRG241930 in the 5' End of Neuroglin 1 Gene with Schizophrenia in a Group of Iranian Patients. Cell journal. vol 13. issue 2. 2013-03-20. PMID:23508206. |
it is noteworthy that there has been no report on the nrg1 association with schizophrenia in a population from the middle east region. |
2013-03-20 |
2023-08-12 |
Not clear |
| Jarrah R Spencer, Keturah M E Darbyshire, Aurelie A Boucher, Jonathon C Arnol. Adolescent neuregulin 1 heterozygous mice display enhanced behavioural sensitivity to methamphetamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 2. 2013-03-19. PMID:22850204. |
in the current study we investigated whether adolescent mice heterozygous for the schizophrenia susceptibility gene neuregulin 1 (nrg1 het mice) exhibit altered behavioural responses to methamphetamine (0.6 or 2.4mg/kg) in schizophrenia-relevant paradigms. |
2013-03-19 |
2023-08-12 |
mouse |
| Jurjen J Luykx, Christiaan H Vinkers, Steven C Bakker, Wouter F Visser, Loes van Boxmeer, Eric Strengman, Kristel R van Eijk, Judith A Lens, Paul Borgdorff, Peter Keijzers, Teus H Kappen, Eric P A van Dongen, Peter Bruins, Nanda M Verhoeven, Tom J de Koning, René S Kahn, Roel A Ophof. A common variant in ERBB4 regulates GABA concentrations in human cerebrospinal fluid. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 9. 2013-03-17. PMID:22549119. |
the neuregulin 1 (nrg1) receptor erbb4 is involved in the development of cortical inhibitory gabaergic circuits and nrg1-erbb4 signaling has been implicated in schizophrenia (scz). |
2013-03-17 |
2023-08-12 |
human |
| Seung-Ae Yan. Association between a Missense Polymorphism (rs3924999, Arg253Gln) of Neuregulin 1 and Schizophrenia in Korean Population. Experimental neurobiology. vol 21. issue 4. 2013-03-14. PMID:23319876. |
neuregulin 1 (nrg1) is associated with the pathogenesis of schizophrenia through controlling activation and signaling of neurotransmitter receptors. |
2013-03-14 |
2023-08-12 |
human |
| Seung-Ae Yan. Association between a Missense Polymorphism (rs3924999, Arg253Gln) of Neuregulin 1 and Schizophrenia in Korean Population. Experimental neurobiology. vol 21. issue 4. 2013-03-14. PMID:23319876. |
influence to schizophrenia development by the nrg1 gene may differ in individuals, and genetic polymorphism is one of the factors affecting their differences. |
2013-03-14 |
2023-08-12 |
human |
| Seung-Ae Yan. Association between a Missense Polymorphism (rs3924999, Arg253Gln) of Neuregulin 1 and Schizophrenia in Korean Population. Experimental neurobiology. vol 21. issue 4. 2013-03-14. PMID:23319876. |
association between three single nucleotide polymorphisms (snps) (rs7014762, -1174 a/t; rs11998176, -788 a/t; rs3924999, arg253gln) of nrg1 and the development of schizophrenia was analyzed in 221 schizophrneia and 359 control subjects. |
2013-03-14 |
2023-08-12 |
human |
| Seung-Ae Yan. Association between a Missense Polymorphism (rs3924999, Arg253Gln) of Neuregulin 1 and Schizophrenia in Korean Population. Experimental neurobiology. vol 21. issue 4. 2013-03-14. PMID:23319876. |
the results suggest that rs3924999 of the nrg1 gene may be associated with schizophrenia susceptibility. |
2013-03-14 |
2023-08-12 |
human |
| C S Weickert, Y Tiwari, P R Schofield, B J Mowry, J M Fullerto. Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity. Translational psychiatry. vol 2. 2013-03-04. PMID:22832904. |
excitement and controversy have followed neuregulin (nrg1) since its discovery as a putative schizophrenia susceptibility gene; however, the mechanism of action of the associated risk haplotype (hapice) has not been identified, and specific genetic variations, which may increase risk to schizophrenia have remained elusive. |
2013-03-04 |
2023-08-12 |
Not clear |
| C S Weickert, Y Tiwari, P R Schofield, B J Mowry, J M Fullerto. Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity. Translational psychiatry. vol 2. 2013-03-04. PMID:22832904. |
we propose that the hapice risk haplotype increases expression of the most brain-abundant form of nrg1, which in turn, elicits an earlier clinical presentation, thus providing a novel mechanism through which this genetic association may increase risk of schizophrenia. |
2013-03-04 |
2023-08-12 |
Not clear |