| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ketan K Marballi, Robert E McCullumsmith, Stefani Yates, Michael A Escamilla, Robin J Leach, Henriette Raventos, Consuelo Walss-Bas. Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 5. 2014-12-12. PMID:24380930. |
these results show that perturbing nrg1 icd formation has major effects on cell signaling, including inflammatory and neurite formation pathways, and may contribute significantly to schizophrenia pathophysiology. |
2014-12-12 |
2023-08-12 |
Not clear |
| Clare Paterson, Yanhong Wang, Joel E Kleinman, Amanda J La. Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. The American journal of psychiatry. vol 171. issue 9. 2014-11-21. PMID:24935406. |
effects of schizophrenia risk variation in the nrg1 gene on nrg1-iv splicing during fetal and early postnatal human neocortical development. |
2014-11-21 |
2023-08-13 |
human |
| Clare Paterson, Yanhong Wang, Joel E Kleinman, Amanda J La. Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. The American journal of psychiatry. vol 171. issue 9. 2014-11-21. PMID:24935406. |
neuregulin 1 (nrg1) is a multifunctional neurotrophin that mediates neurodevelopment and schizophrenia risk. |
2014-11-21 |
2023-08-13 |
human |
| J R Spencer, T W Chohan, T Karl, J C Arnol. Female neuregulin 1 heterozygous mice require repeated exposure to Δ⁹-tetrahydrocannabinol to alter sensorimotor gating function. Pharmacopsychiatry. vol 46. issue 7. 2014-11-15. PMID:24105081. |
the schizophrenia susceptibility gene neuregulin 1 (nrg1) confers vulnerability to the neurobehavioural eff ects of cannabinoids differently across sexes. |
2014-11-15 |
2023-08-12 |
mouse |
| Tariq W Chohan, An Nguyen, Stephanie M Todd, Maxwell R Bennett, Paul Callaghan, Jonathon C Arnol. Partial genetic deletion of neuregulin 1 and adolescent stress interact to alter NMDA receptor binding in the medial prefrontal cortex. Frontiers in behavioral neuroscience. vol 8. 2014-10-17. PMID:25324742. |
we have recently shown that partial genetic deletion of the schizophrenia susceptibility gene neuregulin 1 (nrg1) and adolescent stress interact to disturb sensorimotor gating, neuroendocrine activity and dendritic morphology in mice. |
2014-10-17 |
2023-08-13 |
mouse |
| X-J Hou, K-M Ni, J-M Yang, X-M L. Neuregulin 1/ErbB4 enhances synchronized oscillations of prefrontal cortex neurons via inhibitory synapses. Neuroscience. vol 261. 2014-09-19. PMID:24374327. |
both neuregulin 1 (nrg1) and its receptor erbb4 are susceptibility genes for schizophrenia. |
2014-09-19 |
2023-08-12 |
mouse |
| Mohammad M Ghahramani Seno, Fuad G Gwadry, Pingzhao Hu, Stephen W Schere. Neuregulin 1-alpha regulates phosphorylation, acetylation, and alternative splicing in lymphoblastoid cells. Genome. vol 56. issue 10. 2014-06-30. PMID:24237343. |
abnormal expression and (or) genomic variations of some of these molecules, such as nrg1, have been associated with disease conditions such as cancer and schizophrenia. |
2014-06-30 |
2023-08-12 |
Not clear |
| Mohammad M Ghahramani Seno, Fuad G Gwadry, Pingzhao Hu, Stephen W Schere. Neuregulin 1-alpha regulates phosphorylation, acetylation, and alternative splicing in lymphoblastoid cells. Genome. vol 56. issue 10. 2014-06-30. PMID:24237343. |
these processes have fundamental roles in proper development and function of various tissues including the central nervous system (cns)--a fact that may explain conditions associated with nrg1 dysregulations such as schizophrenia. |
2014-06-30 |
2023-08-12 |
Not clear |
| Aleksandra Szczepankiewic. Evidence for single nucleotide polymorphisms and their association with bipolar disorder. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24143106. |
the review of association data reveals evidence for several genes (slc6a4/5-htt [serotonin transporter gene], bdnf [brain-derived neurotrophic factor], daoa [d-amino acid oxidase activator], dtnbp1 [dysbindin], nrg1 [neuregulin 1], disc1 [disrupted in schizophrenia 1]) to be crucial candidates in bd, whereas numerous genome-wide association studies conducted in bd indicate polymorphisms in two genes (cacna1c [calcium channel, voltage-dependent, l type, alpha 1c subunit], ank3 [ankyrin 3]) replicated for association with bd in most of these studies. |
2014-06-24 |
2023-08-12 |
Not clear |
| Ju-Chun Pei, Chih-Min Liu, Wen-Sung La. Distinct phenotypes of new transmembrane-domain neuregulin 1 mutant mice and the rescue effects of valproate on the observed schizophrenia-related cognitive deficits. Frontiers in behavioral neuroscience. vol 8. 2014-04-30. PMID:24782733. |
accumulating evidence suggests that neuregulin 1 (nrg1) might be involved in the neurodevelopment, neural plasticity, gabaergic neurotransmission, and pathogenesis of schizophrenia. |
2014-04-30 |
2023-08-13 |
mouse |
| Ju-Chun Pei, Chih-Min Liu, Wen-Sung La. Distinct phenotypes of new transmembrane-domain neuregulin 1 mutant mice and the rescue effects of valproate on the observed schizophrenia-related cognitive deficits. Frontiers in behavioral neuroscience. vol 8. 2014-04-30. PMID:24782733. |
because the transmembrane domain of nrg1 is vital for both forward and reverse signaling cascades, new nrg1-deficient mice that carry a truncation of the transmembrane domain of the nrg1 gene were characterized and used in this study to test a nrg1 loss-of-function hypothesis for schizophrenia. |
2014-04-30 |
2023-08-13 |
mouse |
| S B Taylor, A R Taylor, J I Koeni. The interaction of disrupted type II neuregulin 1 and chronic adolescent stress on adult anxiety- and fear-related behaviors. Neuroscience. vol 249. 2014-04-11. PMID:23022220. |
neuregulin 1 (nrg1) is a frequently identified schizophrenia susceptibility gene that has also been associated with the psychotic features of bipolar disorder. |
2014-04-11 |
2023-08-12 |
rat |
| Dong-Min Yin, Xiang-Dong Sun, Jonathan C Bean, Thiri W Lin, Anupama Sathyamurthy, Wen-Cheng Xiong, Tian-Ming Gao, Yong-Jun Chen, Lin Me. Regulation of spine formation by ErbB4 in PV-positive interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 49. 2014-01-31. PMID:24305825. |
the trophic factor neuregulin 1 (nrg1) and its receptor erbb4 are schizophrenia candidate genes. |
2014-01-31 |
2023-08-12 |
mouse |
| Ji-Tao Li, Yu Feng, Yun-Ai Su, Xiao-Dong Wang, Tian-Mei S. Enhanced interaction among ErbB4, PSD-95 and NMDAR by chronic MK-801 treatment is associated with behavioral abnormalities. Pharmacology, biochemistry, and behavior. vol 108. 2014-01-02. PMID:23603030. |
the neuregulin 1 (nrg1)-erbb4 signaling pathway has been implicated in the pathophysiology of schizophrenia. |
2014-01-02 |
2023-08-12 |
rat |
| K A Newell, T Karl, X F Huan. A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice. Neuroscience. vol 248. 2013-12-31. PMID:23811072. |
these data indicate that a nrg1 transmembrane mutation produces selective imbalances in glutamatergic and dopaminergic neurotransmission, which are two key systems believed to contribute to schizophrenia pathogenesis. |
2013-12-31 |
2023-08-12 |
mouse |
| Michael E Cahill, Christine Remmers, Kelly A Jones, Zhong Xie, Robert A Sweet, Peter Penze. Neuregulin1 signaling promotes dendritic spine growth through kalirin. Journal of neurochemistry. vol 126. issue 5. 2013-10-28. PMID:23742124. |
the biological functions of the neuregulin 1 (nrg1) and erbb4 genes have received much recent attention due to several studies showing associations between these genes and schizophrenia. |
2013-10-28 |
2023-08-12 |
Not clear |
| Leonora E Long, Rose Chesworth, Xu-Feng Huang, Iain S McGregor, Jonathon C Arnold, Tim Kar. Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence. The international journal of neuropsychopharmacology. vol 16. issue 1. 2013-10-17. PMID:22226049. |
to test whether the schizophrenia candidate gene neuregulin 1 (nrg1) modulates the effects of cannabinoids in adolescence, we tested male adolescent heterozygous transmembrane domain nrg1 mutant (nrg1 tm het) mice and wild type-like littermates (wt) for their neurobehavioural response to repeated Δ(9)-tetrahydrocannabinol (thc, 10 mg/kg i.p. |
2013-10-17 |
2023-08-12 |
mouse |
| Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huan. Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway. Psychopharmacology. vol 226. issue 2. 2013-09-10. PMID:23389757. |
evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (nrg1)-erbb4 signalling as a schizophrenia susceptibility pathway. |
2013-09-10 |
2023-08-12 |
mouse |
| Tim Kar. Neuregulin 1: a prime candidate for research into gene-environment interactions in schizophrenia? Insights from genetic rodent models. Frontiers in behavioral neuroscience. vol 7. 2013-08-22. PMID:23966917. |
this mini review will focus on recent advancements in the field made by challenging mutant and transgenic rodent models for the schizophrenia candidate gene neuregulin 1 (nrg1) with particular environmental factors. |
2013-08-22 |
2023-08-12 |
mouse |
| Tim Kar. Neuregulin 1: a prime candidate for research into gene-environment interactions in schizophrenia? Insights from genetic rodent models. Frontiers in behavioral neuroscience. vol 7. 2013-08-22. PMID:23966917. |
these studies suggest nrg1 as a prime candidate for gxe interactions in schizophrenia rodent models and that the use of rodent models will enable a better understanding of gxe interactions and the underlying mechanisms. |
2013-08-22 |
2023-08-12 |
mouse |