| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tim Karl, Jonathon C Arnol. What does a mouse tell us about neuregulin 1-cannabis interactions? Frontiers in cellular neuroscience. vol 7. 2013-03-01. PMID:23447438. |
here we review the effects of cannabinoids on a mutant mouse model for the schizophrenia candidate gene neuregulin 1 (nrg1). |
2013-03-01 |
2023-08-12 |
mouse |
| Jarrah R Spencer, Keturah M E Darbyshire, Aurelie A Boucher, Mohammed A Kashem, Leonora E Long, Iain S McGregor, Tim Karl, Jonathon C Arnol. Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice. Frontiers in cellular neuroscience. vol 7. 2013-03-01. PMID:23447498. |
neuregulin 1 (nrg1) is linked to an increased risk of developing schizophrenia and cannabis dependence. |
2013-03-01 |
2023-08-12 |
mouse |
| Jarrah R Spencer, Keturah M E Darbyshire, Aurelie A Boucher, Mohammed A Kashem, Leonora E Long, Iain S McGregor, Tim Karl, Jonathon C Arnol. Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice. Frontiers in cellular neuroscience. vol 7. 2013-03-01. PMID:23447498. |
comparison of wt and nrg1 het mice identified proteins linked to molecular changes in schizophrenia that have not been previously associated with nrg1. |
2013-03-01 |
2023-08-12 |
mouse |
| Jeong-Hyun Kim, Byung-Lae Park, Charisse Flerida A Pasaje, Joon Seol Bae, Chul Soo Park, Boseok Cha, Bong-Jo Kim, Migyung Lee, Woo Hyuk Choi, Tae-Min Shin, Ihn-Geun Choi, Jaeuk Hwang, Insong Koh, Sung-Il Woo, Hyoung Doo Shi. Lack of associations of neuregulin 1 variations with schizophrenia and smooth pursuit eye movement abnormality in a Korean population. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21858616. |
the human neuregulin 1 (nrg1) on 8p12 has been implicated as a candidate gene for schizophrenia. |
2013-02-25 |
2023-08-12 |
human |
| Jeong-Hyun Kim, Byung-Lae Park, Charisse Flerida A Pasaje, Joon Seol Bae, Chul Soo Park, Boseok Cha, Bong-Jo Kim, Migyung Lee, Woo Hyuk Choi, Tae-Min Shin, Ihn-Geun Choi, Jaeuk Hwang, Insong Koh, Sung-Il Woo, Hyoung Doo Shi. Lack of associations of neuregulin 1 variations with schizophrenia and smooth pursuit eye movement abnormality in a Korean population. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21858616. |
however, controversial results of the associations of nrg1 polymorphisms with schizophrenia and related phenotypes have been reported. |
2013-02-25 |
2023-08-12 |
human |
| Jeong-Hyun Kim, Byung-Lae Park, Charisse Flerida A Pasaje, Joon Seol Bae, Chul Soo Park, Boseok Cha, Bong-Jo Kim, Migyung Lee, Woo Hyuk Choi, Tae-Min Shin, Ihn-Geun Choi, Jaeuk Hwang, Insong Koh, Sung-Il Woo, Hyoung Doo Shi. Lack of associations of neuregulin 1 variations with schizophrenia and smooth pursuit eye movement abnormality in a Korean population. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21858616. |
in this study, four nrg1 single nucleotide polymorphisms, three in the promoter region, and one nonsynonymous in coding region, were genotyped in a total of 825 subject including 435 schizophrenia cases and 390 normal controls of korean ethnicity. |
2013-02-25 |
2023-08-12 |
human |
| Jeong-Hyun Kim, Byung-Lae Park, Charisse Flerida A Pasaje, Joon Seol Bae, Chul Soo Park, Boseok Cha, Bong-Jo Kim, Migyung Lee, Woo Hyuk Choi, Tae-Min Shin, Ihn-Geun Choi, Jaeuk Hwang, Insong Koh, Sung-Il Woo, Hyoung Doo Shi. Lack of associations of neuregulin 1 variations with schizophrenia and smooth pursuit eye movement abnormality in a Korean population. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21858616. |
although logistic association analysis of nrg1 polymorphisms and haplotypes with schizophrenia showed a nominal association in rs4623364g > c (p = 0.04), the significance disappeared after corrections for multiple testing (corrected p > 0.05). |
2013-02-25 |
2023-08-12 |
human |
| Jeong-Hyun Kim, Byung-Lae Park, Charisse Flerida A Pasaje, Joon Seol Bae, Chul Soo Park, Boseok Cha, Bong-Jo Kim, Migyung Lee, Woo Hyuk Choi, Tae-Min Shin, Ihn-Geun Choi, Jaeuk Hwang, Insong Koh, Sung-Il Woo, Hyoung Doo Shi. Lack of associations of neuregulin 1 variations with schizophrenia and smooth pursuit eye movement abnormality in a Korean population. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21858616. |
additional case/control and multiple regression analyses in schizophrenia patients using a method that measures the smooth pursuit eye movement (spem) function globally based on natural logarithmic values of the signal/noise ratio also showed no association between nrg1 variants and spem abnormality among patients with schizophrenia (p > 0.05). |
2013-02-25 |
2023-08-12 |
human |
| Jeong-Hyun Kim, Byung-Lae Park, Charisse Flerida A Pasaje, Joon Seol Bae, Chul Soo Park, Boseok Cha, Bong-Jo Kim, Migyung Lee, Woo Hyuk Choi, Tae-Min Shin, Ihn-Geun Choi, Jaeuk Hwang, Insong Koh, Sung-Il Woo, Hyoung Doo Shi. Lack of associations of neuregulin 1 variations with schizophrenia and smooth pursuit eye movement abnormality in a Korean population. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21858616. |
despite the need for further replications in other cohorts, our findings provide additional supporting information that four variants in nrg1 investigated in this study may not be associated with schizophrenia and its related spem function in a korean population. |
2013-02-25 |
2023-08-12 |
human |
| Teresa Marie du Bois, Kelly Anne Newell, Xu-Feng Huan. Perinatal phencyclidine treatment alters neuregulin 1/erbB4 expression and activation in later life. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 5. 2013-01-22. PMID:21962913. |
moreover, genetic linkage and post mortem studies strongly suggest a role for altered neuregulin 1 (nrg1)/erbb4 signaling in schizophrenia pathology. |
2013-01-22 |
2023-08-12 |
rat |
| Inga H Deakin, Wiebke Nissen, Amanda J Law, Tracy Lane, Riam Kanso, Markus H Schwab, Klaus-Armin Nave, Karri P Lamsa, Ole Paulsen, David M Bannerman, Paul J Harriso. Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 7. 2012-11-13. PMID:21878485. |
it is a schizophrenia candidate gene, and hippocampal expression of the nrg1 type i isoform is increased in the disorder. |
2012-11-13 |
2023-08-12 |
mouse |
| Inga H Deakin, Wiebke Nissen, Amanda J Law, Tracy Lane, Riam Kanso, Markus H Schwab, Klaus-Armin Nave, Karri P Lamsa, Ole Paulsen, David M Bannerman, Paul J Harriso. Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 7. 2012-11-13. PMID:21878485. |
the effects are likely mediated via inhibitory interneurons and may be relevant to the involvement of nrg1 in schizophrenia. |
2012-11-13 |
2023-08-12 |
mouse |
| Dawei Li, Guang He, Yifeng Xu, Yun Duan, Niufan Gu, Xingwang Li, Yongyong Shi, Wei Qin, Guoyin Feng, Lin H. Schizophrenia is not associated with the ERBB3 gene in a Han Chinese population sample: Results from case-control and family-based studies. Genetics and molecular biology. vol 32. issue 4. 2012-10-04. PMID:21637446. |
erbb3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3), encoding a receptor of neuregulin-1 (nrg1), has been considered a functional candidate gene for schizophrenia susceptibility. |
2012-10-04 |
2023-08-12 |
Not clear |
| Francesco Papaleo, Barbara K Lipska, Daniel R Weinberge. Mouse models of genetic effects on cognition: relevance to schizophrenia. Neuropharmacology. vol 62. issue 3. 2012-09-27. PMID:21557953. |
we also consider other risk-associated genes for schizophrenia such as dysbindin (dtnbp1), neuregulin (nrg1), disrupted-in-schizophrenia1 (disc1), reelin and proline dehydrogenase (prodh). |
2012-09-27 |
2023-08-12 |
mouse |
| Ketan Marballi, Dianne Cruz, Peter Thompson, Consuelo Walss-Bas. Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings. PloS one. vol 7. issue 5. 2012-09-19. PMID:22590542. |
neuregulin 1 (nrg1) is a key candidate susceptibility gene for both schizophrenia (scz) and bipolar disorder (bpd). |
2012-09-19 |
2023-08-12 |
mouse |
| ChuanYuan Kang, XiaoBin Yang, XiuFeng Xu, Hua Liu, Ping Su, JianZhong Yan. Association study of neuregulin 1 gene polymorphisms with auditory P300 in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 4. 2012-09-04. PMID:22467496. |
neuregulin 1 (nrg1), a gene involved with myelin production has been shown to have a positive correlation with schizophrenia. |
2012-09-04 |
2023-08-12 |
human |
| ChuanYuan Kang, XiaoBin Yang, XiuFeng Xu, Hua Liu, Ping Su, JianZhong Yan. Association study of neuregulin 1 gene polymorphisms with auditory P300 in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 4. 2012-09-04. PMID:22467496. |
the present study investigated the association of nrg1 genotypes with p300 in schizophrenia. |
2012-09-04 |
2023-08-12 |
human |
| ChuanYuan Kang, XiaoBin Yang, XiuFeng Xu, Hua Liu, Ping Su, JianZhong Yan. Association study of neuregulin 1 gene polymorphisms with auditory P300 in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 4. 2012-09-04. PMID:22467496. |
nrg1 gene is a susceptible gene for chinese han schizophrenia and at haplotype might have the protective role in the schizophrenia. |
2012-09-04 |
2023-08-12 |
human |
| Lieve Desbonnet, Colm O'Tuathaigh, Gerard Clarke, Claire O'Leary, Emilie Petit, Niamh Clarke, Orna Tighe, Donna Lai, Richard Harvey, John F Cryan, Timothy G Dinan, John L Waddingto. Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction. Brain, behavior, and immunity. vol 26. issue 4. 2012-08-30. PMID:22426432. |
this study examined the individual and combined effects of chronic social stress during adolescence and deletion of the schizophrenia risk gene neuregulin-1 (nrg1) on adult mouse phenotype. |
2012-08-30 |
2023-08-12 |
mouse |
| Sarah Tosato, Marcella Bellani, Chiara Bonetto, Mirella Ruggeri, Cinzia Perlini, Antonio Lasalvia, Veronica Marinelli, Gianluca Rambaldelli, Doriana Cristofalo, Mariaelena Bertani, Martina Zanoni, Lorenza Lazzarotto, Roberto Cerini, Roberto Pozzi Mucelli, Michele Tansella, Paola Dazzan, Marta Di Forti, Robin M Murray, David A Collier, Paolo Brambill. Is neuregulin 1 involved in determining cerebral volumes in schizophrenia? Preliminary results showing a decrease in superior temporal gyrus volume. Neuropsychobiology. vol 65. issue 3. 2012-08-27. PMID:22378022. |
in this study, the association between nrg1 and stg anatomy in patients with schizophrenia was explored for the first time. |
2012-08-27 |
2023-08-12 |
Not clear |