| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergi Papiol, Martin Begemann, Albert Rosenberger, Heidi Friedrichs, Katja Ribbe, Sabrina Grube, Markus H Schwab, Henriette Jahn, Stefan Gunkel, Fritz Benseler, Klaus-Armin Nave, Hannelore Ehrenreic. A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 3. 2011-07-12. PMID:21234898. |
the gras data collection as a prerequisite for pgas has enabled us to associate protective nrg1 genotypes with later onset and milder course of schizophrenia. |
2011-07-12 |
2023-08-12 |
mouse |
| Taisuke Kato, Atsushi Kasai, Makoto Mizuno, Liang Fengyi, Norihito Shintani, Sadaaki Maeda, Minesuke Yokoyama, Miwako Ozaki, Hiroyuki Naw. Phenotypic characterization of transgenic mice overexpressing neuregulin-1. PloS one. vol 5. issue 12. 2011-07-05. PMID:21151609. |
neuregulin-1 (nrg1) is one of the susceptibility genes for schizophrenia and implicated in the neurotrophic regulation of gabaergic and dopaminergic neurons, myelination, and nmda receptor function. |
2011-07-05 |
2023-08-12 |
mouse |
| Yuichi Abe, Hisaaki Namba, Taisuke Kato, Yuriko Iwakura, Hiroyuki Naw. Neuregulin-1 signals from the periphery regulate AMPA receptor sensitivity and expression in GABAergic interneurons in developing neocortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 15. 2011-06-13. PMID:21490211. |
neuregulin-1 (nrg1) signaling is thought to contribute to both neuronal development and schizophrenia neuropathology. |
2011-06-13 |
2023-08-12 |
mouse |
| T Kato, Y Abe, H Sotoyama, A Kakita, R Kominami, S Hirokawa, M Ozaki, H Takahashi, H Naw. Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia. Molecular psychiatry. vol 16. issue 3. 2011-06-03. PMID:20142818. |
collectively, our findings provide novel insights into neurotrophic contribution of nrg1 to dopaminergic maldevelopment and schizophrenia pathogenesis. |
2011-06-03 |
2023-08-12 |
mouse |
| Graham M Pitcher, Lorraine V Kalia, David Ng, Nathalie M Goodfellow, Kathleen T Yee, Evelyn K Lambe, Michael W Salte. Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors. Nature medicine. vol 17. issue 4. 2011-06-02. PMID:21441918. |
for the schizophrenia-linked genes nrg1 and erbb4, nmdar hypofunction is thus considered a key detrimental consequence of the excessive nrg1-erbb4 signaling found in people with schizophrenia. |
2011-06-02 |
2023-08-12 |
Not clear |
| Panos Roussos, Stella G Giakoumaki, Eva Adamaki, Panos Bitsio. The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males. Biological psychiatry. vol 69. issue 5. 2011-05-31. PMID:21035784. |
neuregulin-1 (nrg1) variations have been shown to modulate schizophrenia candidate endophenotypes related to brain structure and function. |
2011-05-31 |
2023-08-12 |
Not clear |
| Panos Roussos, Stella G Giakoumaki, Eva Adamaki, Panos Bitsio. The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males. Biological psychiatry. vol 69. issue 5. 2011-05-31. PMID:21035784. |
the objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the nrg1 gene identified as promising schizophrenia risk genes (rs6994992, snp8nrg221132, snp8nrg241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (ppi) of the acoustic startle reflex, a well validated schizophrenia endophenotype. |
2011-05-31 |
2023-08-12 |
Not clear |
| Yong-Jun Chen, Meng Zhang, Dong-Min Yin, Lei Wen, Annie Ting, Pu Wang, Yi-Sheng Lu, Xin-Hong Zhu, Shu-Ji Li, Cui-Ying Wu, Xue-Ming Wang, Cary Lai, Wen-Cheng Xiong, Lin Mei, Tian-Ming Ga. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 50. 2011-05-12. PMID:21106764. |
considering that nrg1 and erbb4 are susceptibility genes of schizophrenia, these observations contribute to a better understanding of how abnormal nrg1/erbb4 signaling may be involved in the pathogenesis of schizophrenia. |
2011-05-12 |
2023-08-12 |
mouse |
| Maria-Mercè Garcia-Barceló, Xiaoping Miao, Clara S Tang, Hon-Cheong So, Waikiu Tang, Thomas Y Y Leon, Manting So, Benjamin Yip, Ronald Y L Chen, Eric F C Cheung, Eric Y H Chen, Tao Li, Paul Tam, Stacey S Cherny, Pak C Sha. No NRG1 V266L in Chinese patients with schizophrenia. Psychiatric genetics. vol 21. issue 1. 2011-05-09. PMID:20978455. |
no nrg1 v266l in chinese patients with schizophrenia. |
2011-05-09 |
2023-08-12 |
Not clear |
| Maria-Mercè Garcia-Barceló, Xiaoping Miao, Clara S Tang, Hon-Cheong So, Waikiu Tang, Thomas Y Y Leon, Manting So, Benjamin Yip, Ronald Y L Chen, Eric F C Cheung, Eric Y H Chen, Tao Li, Paul Tam, Stacey S Cherny, Pak C Sha. No NRG1 V266L in Chinese patients with schizophrenia. Psychiatric genetics. vol 21. issue 1. 2011-05-09. PMID:20978455. |
nrg1 is one of the best-supported schizophrenia (sz) susceptibility genes. |
2011-05-09 |
2023-08-12 |
Not clear |
| Adel Barakat, Brian Dean, Elizabeth Scarr, Geneviève Evi. Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia. Schizophrenia research. vol 124. issue 1-3. 2011-04-19. PMID:20926259. |
neuregulin 1 (nrg1) is a susceptibility gene for schizophrenia. |
2011-04-19 |
2023-08-12 |
human |
| Adel Barakat, Brian Dean, Elizabeth Scarr, Geneviève Evi. Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia. Schizophrenia research. vol 124. issue 1-3. 2011-04-19. PMID:20926259. |
there was no correlation between the levels of either full-length nrg1, nrg1-ctf, or bace1 and the final recorded doses of antipsychotic drugs for the subjects with schizophrenia. |
2011-04-19 |
2023-08-12 |
human |
| Adel Barakat, Brian Dean, Elizabeth Scarr, Geneviève Evi. Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia. Schizophrenia research. vol 124. issue 1-3. 2011-04-19. PMID:20926259. |
these data suggest that the proteolytic processing of nrg1 is impaired in schizophrenia. |
2011-04-19 |
2023-08-12 |
human |
| Riccardo Zuliani, T William J Moorhead, Mark E Bastin, Eve C Johnstone, Stephen M Lawrie, Paolo Brambilla, Michael C O'Donovan, Michael J Owen, Jeremy Hall, Andrew M McIntos. Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry research. vol 191. issue 2. 2011-04-06. PMID:21232925. |
we hypothesised that variation in the gene encoding the nrg1 receptor, erbb4, would also be associated with reduced alic integrity and with cognitive impairments characteristic of individuals with bipolar disorder and schizophrenia. |
2011-04-06 |
2023-08-12 |
Not clear |
| Ketan Marballi, Marlon P Quinones, Fabio Jimenez, Michael A Escamilla, Henriette Raventós, Maria Clara Soto-Bernardini, Seema S Ahuja, Consuelo Walss-Bas. In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation. Journal of molecular medicine (Berlin, Germany). vol 88. issue 11. 2011-02-23. PMID:20625696. |
neuregulin 1 (nrg1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. |
2011-02-23 |
2023-08-12 |
Not clear |
| Ketan Marballi, Marlon P Quinones, Fabio Jimenez, Michael A Escamilla, Henriette Raventós, Maria Clara Soto-Bernardini, Seema S Ahuja, Consuelo Walss-Bas. In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation. Journal of molecular medicine (Berlin, Germany). vol 88. issue 11. 2011-02-23. PMID:20625696. |
this study could contribute towards understanding the role of nrg1 in the pathogenesis of schizophrenia and other disorders in which inflammation plays an important role. |
2011-02-23 |
2023-08-12 |
Not clear |
| Annie K Ting, Yongjun Chen, Lei Wen, Dong-Min Yin, Chengyong Shen, Yanmei Tao, Xihui Liu, Wen-Cheng Xiong, Lin Me. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 1. 2011-02-04. PMID:21209185. |
neuregulin 1 (nrg1) and its receptor erbb4 are both susceptibility genes of schizophrenia. |
2011-02-04 |
2023-08-12 |
Not clear |
| Annie K Ting, Yongjun Chen, Lei Wen, Dong-Min Yin, Chengyong Shen, Yanmei Tao, Xihui Liu, Wen-Cheng Xiong, Lin Me. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 1. 2011-02-04. PMID:21209185. |
in light of the association of the genes of both nrg1 and erbb4 with schizophrenia and dysfunction of gabaergic system in this disorder, these results provide insight into its potential pathological mechanism. |
2011-02-04 |
2023-08-12 |
Not clear |
| L Duffy, E Cappas, D Lai, A A Boucher, T Kar. Cognition in transmembrane domain neuregulin 1 mutant mice. Neuroscience. vol 170. issue 3. 2011-01-11. PMID:20678553. |
the heterozygous transmembrane domain nrg1 mutant mouse (nrg1 tm het) exhibits a neurobehavioural phenotype relevant for schizophrenia research, characterized by the development of locomotor hyperactivity, social withdrawal, increased sensitivity to environmental manipulation, and changes to the serotonergic system. |
2011-01-11 |
2023-08-12 |
mouse |
| Anamika Banerjee, Mathew L Macdonald, Karin E Borgmann-Winter, Chang-Gyu Hah. Neuregulin 1-erbB4 pathway in schizophrenia: From genes to an interactome. Brain research bulletin. vol 83. issue 3-4. 2011-01-06. PMID:20433909. |
this article aims to re-evaluate the evidence for the role of neuregulin 1 (nrg1)-erbb4 signaling in schizophrenia by focusing on its interactions with other candidate susceptibility, pathways. |
2011-01-06 |
2023-08-12 |
Not clear |