| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yachi Chen, Melissa L Hancock, Lorna W Role, David A Talmag. Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610754. |
together, these results support the proposal that aberrant intramembranous processing and defective signaling via the intracellular domain of type iii nrg1 impair a subset of nrg1 functions in cortical development and contribute to abnormal neuroconnectivity implicated in schizophrenia. |
2010-08-16 |
2023-08-12 |
Not clear |
| Alon Shamir, Andres Buonann. Molecular and cellular characterization of Neuregulin-1 type IV isoforms. Journal of neurochemistry. vol 113. issue 5. 2010-07-08. PMID:20218976. |
numerous genetic studies associated the neuregulin 1 (nrg1) icelandic haplotype (hap(ice)), and its single nucleotide polymorphism snp8nrg243177 [t/t], with schizophrenia. |
2010-07-08 |
2023-08-12 |
human |
| Maarten van den Buuse, Lena Wischhof, Ruo Xi Lee, Sally Martin, Tim Kar. Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation. The international journal of neuropsychopharmacology. vol 12. issue 10. 2010-06-29. PMID:19400983. |
neuregulin 1 (nrg1) has been widely recognized as a candidate gene for schizophrenia. |
2010-06-29 |
2023-08-12 |
mouse |
| Maarten van den Buuse, Lena Wischhof, Ruo Xi Lee, Sally Martin, Tim Kar. Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation. The international journal of neuropsychopharmacology. vol 12. issue 10. 2010-06-29. PMID:19400983. |
these studies add to the knowledge about behavioural effects in this mouse model of impaired nrg1 function and suggest that a number of the behavioural tests with relevance to schizophrenia are normal in these mice. |
2010-06-29 |
2023-08-12 |
mouse |
| János M Réthelyi, Steven C Bakker, Patrícia Polgár, Pál Czobor, Eric Strengman, Péter I Pásztor, René S Kahn, István Bitte. Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 3. 2010-06-23. PMID:19937977. |
association study of nrg1, dtnbp1, rgs4, g72/g30, and pip5k2a with schizophrenia and symptom severity in a hungarian sample. |
2010-06-23 |
2023-08-12 |
Not clear |
| János M Réthelyi, Steven C Bakker, Patrícia Polgár, Pál Czobor, Eric Strengman, Péter I Pásztor, René S Kahn, István Bitte. Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 3. 2010-06-23. PMID:19937977. |
a homogeneous sample of 280 schizophrenia patients and 230 healthy controls of hungarian, caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes nrg1, dtnbp1, rgs4, g72/g30, and pip5k2a. |
2010-06-23 |
2023-08-12 |
Not clear |
| János M Réthelyi, Steven C Bakker, Patrícia Polgár, Pál Czobor, Eric Strengman, Péter I Pásztor, René S Kahn, István Bitte. Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 3. 2010-06-23. PMID:19937977. |
although these results replicate earlier findings about the genetic background of sz-nd and sz-d only partially, our data seem to confirm previously reported association of nrg1 with schizophrenia without prominent negative symptoms. |
2010-06-23 |
2023-08-12 |
Not clear |
| Chih-Fong Chou, Miwako Ozak. In silico analysis of neuregulin 1 evolution in vertebrates. Bioscience reports. vol 30. issue 4. 2010-06-22. PMID:19681757. |
particularly in neurobiology, nrg1 signalling is associated with synaptic transmission, myelination of schwann cells and the human disease of schizophrenia. |
2010-06-22 |
2023-08-12 |
human |
| Pietro Fazzari, Ana V Paternain, Manuel Valiente, Ramón Pla, Rafael Luján, Kent Lloyd, Juan Lerma, Oscar Marín, Beatriz Ric. Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature. vol 464. issue 7293. 2010-06-15. PMID:20393464. |
altogether, our results indicate that nrg1 and erbb4 signalling is required for the wiring of gaba-mediated circuits in the postnatal cortex, providing a new perspective to the involvement of these genes in the aetiology of schizophrenia. |
2010-06-15 |
2023-08-12 |
mouse |
| Eleni Parlapani, Andrea Schmitt, Oliver Wirths, Manfred Bauer, Clemens Sommer, Udo Rueb, Markus H Skowronek, Jens Treutlein, Georg A Petroianu, Marcella Rietschel, Peter Falka. Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 2 Pt 2. 2010-06-14. PMID:20218788. |
one important risk gene in schizophrenia is neuregulin-1 (nrg1), which is expressed in different isoforms in the brain. |
2010-06-14 |
2023-08-12 |
human |
| Eleni Parlapani, Andrea Schmitt, Oliver Wirths, Manfred Bauer, Clemens Sommer, Udo Rueb, Markus H Skowronek, Jens Treutlein, Georg A Petroianu, Marcella Rietschel, Peter Falka. Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 2 Pt 2. 2010-06-14. PMID:20218788. |
compared to controls, gene expression of the nrg1 isoform i was decreased and isoform ii increased in the prefrontal cortex (ba10) of schizophrenia patients. |
2010-06-14 |
2023-08-12 |
human |
| Andrea Mechelli, Essi Viding, Atul Kumar, Stefania Tognin, Fergus Kane, Philip McGuir. Influence of neuregulin1 genotype on neural substrate of perceptual matching in children. Behavior genetics. vol 40. issue 2. 2010-06-08. PMID:19967439. |
we examined the impact of neuregulin1 (nrg1), a probable susceptibility gene for schizophrenia and bipolar disorder, on brain function in a sample of 102 healthy 10-12 year old boys including 18 pairs of monozygotic twins, 24 pairs of dizygotic twins and 18 singletons. |
2010-06-08 |
2023-08-12 |
human |
| Shi-Zhong Bian, Wei-Li Liu, Zhi-Xiang Zhang, Zhen-Lun Gu, Xiao-Gang Jiang, Ci-Yi Gu. [The correlation between ketamine-induced schizophrenia-like signs in mice and the expressions of NRG1, ErbB4 mRNA]. Fa yi xue za zhi. vol 25. issue 5. 2010-06-03. PMID:20000043. |
to explore the correlation between signs similar to schizophrenia in mice after ketamine administration and the expressions of nrg1 and erbb4 mrna in order to explain the possible pathogenesis of schizophrenia. |
2010-06-03 |
2023-08-12 |
mouse |
| Saurav Seshadri, Atsushi Kamiya, Yukako Yokota, Ingrid Prikulis, Shin-ichi Kano, Akiko Hayashi-Takagi, Amelia Stanco, Tae-Yeon Eom, Sarada Rao, Koko Ishizuka, Philip Wong, Carsten Korth, E S Anton, Akira Saw. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 12. 2010-04-16. PMID:20212127. |
neuregulin-1 (nrg1) and disrupted-in-schizophrenia-1 (disc1) are promising susceptibility factors for schizophrenia. |
2010-04-16 |
2023-08-12 |
mouse |
| Saurav Seshadri, Atsushi Kamiya, Yukako Yokota, Ingrid Prikulis, Shin-ichi Kano, Akiko Hayashi-Takagi, Amelia Stanco, Tae-Yeon Eom, Sarada Rao, Koko Ishizuka, Philip Wong, Carsten Korth, E S Anton, Akira Saw. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 12. 2010-04-16. PMID:20212127. |
these findings may connect nrg1, erbbs, akt, and disc1 in a common pathway, which may regulate neurodevelopment and contribute to susceptibility to schizophrenia. |
2010-04-16 |
2023-08-12 |
mouse |
| Alessio Squassina, Paola Piccardi, Maria Del Zompo, Alessandro Rossi, Antonio Vita, Stefano Pini, Armida Mucci, Silvana Galderis. NRG1 and BDNF genes in schizophrenia: an association study in an Italian case-control sample. Psychiatry research. vol 176. issue 1. 2010-04-12. PMID:20061032. |
nrg1 and bdnf genes in schizophrenia: an association study in an italian case-control sample. |
2010-04-12 |
2023-08-12 |
human |
| Alessio Squassina, Paola Piccardi, Maria Del Zompo, Alessandro Rossi, Antonio Vita, Stefano Pini, Armida Mucci, Silvana Galderis. NRG1 and BDNF genes in schizophrenia: an association study in an Italian case-control sample. Psychiatry research. vol 176. issue 1. 2010-04-12. PMID:20061032. |
we tested for associations between five single nucleotide polymorphisms (snps) located in the area containing the neuregulin 1 gene (nrg1) and three snps within the brain-derived neutrophic factor gene (bdnf) in an italian sample consisting of 171 schizophrenia subjects and 349 controls. |
2010-04-12 |
2023-08-12 |
human |
| Lei Wen, Yi-Sheng Lu, Xin-Hong Zhu, Xiao-Ming Li, Ran-Sook Woo, Yong-Jun Chen, Dong-Min Yin, Cary Lai, Alvin V Terry, Almira Vazdarjanova, Wen-Cheng Xiong, Lin Me. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 3. 2010-03-26. PMID:20080551. |
because both nrg1 and erbb4 are susceptibility genes of schizophrenia, our study provides insight into potential pathogenic mechanisms of schizophrenia and suggests that pv-erbb4(-/-) mice may serve as a model in the study of this and relevant brain disorders. |
2010-03-26 |
2023-08-12 |
mouse |
| A Schosser, S Cohen-Woods, D Gaysina, P C Chow, L Martucci, A Farmer, A Korszun, C Gunashinghe, J Gray, L Jones, N Craddock, M J Owen, I W Craig, P McGuffi. NRG1 gene in recurrent major depression: no association in a large-scale case-control association study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 1. 2010-03-23. PMID:19367584. |
the neuregulin 1 (nrg1) gene was initially implicated in schizophrenia (sz) and has recently been associated with bipolar disorder (bpd) in two studies. |
2010-03-23 |
2023-08-12 |
Not clear |
| Tomo Okochi, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoko Kinoshita, Kunihiro Kawashima, Takenori Okumura, Tomoko Tsunoka, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Nakao Iwat. Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 5. 2010-03-12. PMID:19394386. |
the neuregulin 1 gene (nrg1) has been identified as a candidate gene for schizophrenia in a linkage study in the icelandic population. |
2010-03-12 |
2023-08-12 |
human |