| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ignacio Mata, Rocio Perez-Iglesias, Roberto Roiz-Santiañez, Diana Tordesillas-Gutierrez, Andres Gonzalez-Mandly, Ana Berja, Jose L Vazquez-Barquero, Benedicto Crespo-Facorr. Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:19913623. |
additive effect of nrg1 and disc1 genes on lateral ventricle enlargement in first episode schizophrenia. |
2011-01-03 |
2023-08-12 |
mouse |
| Ignacio Mata, Rocio Perez-Iglesias, Roberto Roiz-Santiañez, Diana Tordesillas-Gutierrez, Andres Gonzalez-Mandly, Ana Berja, Jose L Vazquez-Barquero, Benedicto Crespo-Facorr. Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:19913623. |
we have previously reported an association between the t allele of the rs6994992 snp within nrg1 gene and lateral ventricle (lv) enlargement in first-episode schizophrenia patients. |
2011-01-03 |
2023-08-12 |
mouse |
| Ignacio Mata, Rocio Perez-Iglesias, Roberto Roiz-Santiañez, Diana Tordesillas-Gutierrez, Andres Gonzalez-Mandly, Ana Berja, Jose L Vazquez-Barquero, Benedicto Crespo-Facorr. Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:19913623. |
in this study, we examined the possible interactive effects of nrg1 and disc1 on brain volumes in a sample of first-episode schizophrenia patients. |
2011-01-03 |
2023-08-12 |
mouse |
| Ignacio Mata, Rocio Perez-Iglesias, Roberto Roiz-Santiañez, Diana Tordesillas-Gutierrez, Andres Gonzalez-Mandly, Ana Berja, Jose L Vazquez-Barquero, Benedicto Crespo-Facorr. Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:19913623. |
our findings suggest that nrg1 and disc1 genes may be associated with brain abnormalities in schizophrenia through their influence on related pathways of brain development. |
2011-01-03 |
2023-08-12 |
mouse |
| Axel Krug, Valentin Markov, Sören Krach, Andreas Jansen, Klaus Zerres, Thomas Eggermann, Tony Stöcker, N Jon Shah, Markus M Nöthen, Jens Treutlein, Marcella Rietschel, Tilo Kirche. The effect of Neuregulin 1 on neural correlates of episodic memory encoding and retrieval. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:20036336. |
neuregulin 1 (nrg1) has been found to be associated with schizophrenia. |
2011-01-03 |
2023-08-12 |
human |
| Unn Kristin Haukvik, Peter Saetre, Thomas McNeil, Petr S Bjerkan, Ole A Andreassen, Thomas Werge, Erik G Jönsson, Ingrid Agart. An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 7. 2010-12-29. PMID:20638435. |
we investigated putative independent and interaction effects of severe hypoxia-related ocs and variation in four hypoxia-regulated schizophrenia susceptibility genes (bdnf, dtnbp1, grm3 and nrg1) on hippocampal volume in schizophrenia patients and healthy controls. |
2010-12-29 |
2023-08-12 |
Not clear |
| A Schmechtig, E Vassos, V Kumari, S B Hutton, D A Collier, R G Morris, S C R Williams, U Ettinge. Association of Neuregulin 1 rs3924999 genotype with antisaccades and smooth pursuit eye movements. Genes, brain, and behavior. vol 9. issue 6. 2010-12-27. PMID:20497232. |
neuregulin 1 (nrg1) has been identified as one of the leading candidate genes for schizophrenia. |
2010-12-27 |
2023-08-12 |
human |
| A Schmechtig, E Vassos, V Kumari, S B Hutton, D A Collier, R G Morris, S C R Williams, U Ettinge. Association of Neuregulin 1 rs3924999 genotype with antisaccades and smooth pursuit eye movements. Genes, brain, and behavior. vol 9. issue 6. 2010-12-27. PMID:20497232. |
these findings indicate that nrg1 rs3924999 affects spatial accuracy on the as task, suggesting an influence of the gene on the neural mechanisms underlying visuospatial sensorimotor transformations, a mechanism that has been previously found to be impaired in patients with schizophrenia and their relatives. |
2010-12-27 |
2023-08-12 |
human |
| Imola Seres, Oguz Kelemen, György Benedek, Szabolcs Kér. Neuregulin 1-induced AKT phosphorylation in monozygotic twins discordant for schizophrenia. Neurochemistry international. vol 56. issue 8. 2010-11-29. PMID:20371257. |
patients with schizophrenia exhibit decreased neuregulin 1 (nrg1)-stimulated akt phosphorylation in peripheral lymphoblasts. |
2010-11-29 |
2023-08-12 |
Not clear |
| Wee-Tin Kao, Yanhong Wang, Joel E Kleinman, Barbara K Lipska, Thomas M Hyde, Daniel R Weinberger, Amanda J La. Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 35. 2010-11-15. PMID:20713722. |
several genes in the nrg-erbb signaling pathway including nrg1 and erbb4 have been implicated in genetic predisposition to schizophrenia. |
2010-11-15 |
2023-08-12 |
human |
| M Shibuya, E Komi, R Wang, T Kato, Y Watanabe, M Sakai, M Ozaki, T Someya, H Naw. Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia: an influence of its genetic polymorphism. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 7. 2010-10-25. PMID:20526724. |
these findings suggest that serum nrg1 levels are decreased in patients with chronic schizophrenia and influenced by their snp8nrg243177 alleles. |
2010-10-25 |
2023-08-12 |
human |
| Kristin K Nicodemus, Amanda J Law, Eugenia Radulescu, Augustin Luna, Bhaskar Kolachana, Radhakrishna Vakkalanka, Dan Rujescu, Ina Giegling, Richard E Straub, Kate McGee, Bert Gold, Michael Dean, Pierandrea Muglia, Joseph H Callicott, Hao-Yang Tan, Daniel R Weinberge. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Archives of general psychiatry. vol 67. issue 10. 2010-10-25. PMID:20921115. |
biological validation of increased schizophrenia risk with nrg1, erbb4, and akt1 epistasis via functional neuroimaging in healthy controls. |
2010-10-25 |
2023-08-12 |
Not clear |
| Kristin K Nicodemus, Amanda J Law, Eugenia Radulescu, Augustin Luna, Bhaskar Kolachana, Radhakrishna Vakkalanka, Dan Rujescu, Ina Giegling, Richard E Straub, Kate McGee, Bert Gold, Michael Dean, Pierandrea Muglia, Joseph H Callicott, Hao-Yang Tan, Daniel R Weinberge. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Archives of general psychiatry. vol 67. issue 10. 2010-10-25. PMID:20921115. |
nrg1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. |
2010-10-25 |
2023-08-12 |
Not clear |
| Leonora E Long, Rose Chesworth, Jonathon C Arnold, Tim Kar. A follow-up study: acute behavioural effects of Delta(9)-THC in female heterozygous neuregulin 1 transmembrane domain mutant mice. Psychopharmacology. vol 211. issue 3. 2010-10-15. PMID:20571781. |
we report data from a follow-up study in female nrg1 het mice, investigating thc effects on behaviours with some relevance to schizophrenia. |
2010-10-15 |
2023-08-12 |
mouse |
| Fiona Middle, Antonia L Pritchard, Herlina Handoko, Sayeed Haque, Roger Holder, Peter Bentham, Corinne L Lendo. No association between neuregulin 1 and psychotic symptoms in Alzheimer's disease patients. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182055. |
variants within the neuregulin-1 (nrg1) gene have been investigated both in early onset psychiatric disorders, such as schizophrenia and recently in ad patients with psychosis. |
2010-09-07 |
2023-08-12 |
Not clear |
| Yoshitatsu Sei, Zhen Li, Jian Song, Renee Ren-Patterson, Elizabeth M Tunbridge, Yukihiko Iizuka, Masahiro Inoue, Berenice T Alfonso, Senda Beltaifa, Yoko Nakai, Bhaskar S Kolachana, Jingshan Chen, Daniel R Weinberge. Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. PloS one. vol 5. issue 5. 2010-09-07. PMID:20520724. |
neuregulin1 (nrg1)-erbb signaling has been implicated in the pathogenesis of cancer and schizophrenia. |
2010-09-07 |
2023-08-12 |
Not clear |
| Yu Feng, Xiao-Dong Wang, Chun-Mei Guo, Yang Yang, Ji-Tao Li, Yun-Ai Su, Tian-Mei S. Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration. Journal of biomedicine & biotechnology. vol 2010. 2010-08-30. PMID:20467458. |
recent human genetic studies and postmortem brain examinations of schizophrenia patients strongly indicate that dysregulation of nrg1 and erbb4 may be important pathogenic factors of schizophrenia. |
2010-08-30 |
2023-08-12 |
human |
| Yu Feng, Xiao-Dong Wang, Chun-Mei Guo, Yang Yang, Ji-Tao Li, Yun-Ai Su, Tian-Mei S. Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration. Journal of biomedicine & biotechnology. vol 2010. 2010-08-30. PMID:20467458. |
in this study we quantitatively examined nrg1 and erbb4 protein expressions by immunohistochemistry and western blot in the brain of a rat schizophrenia model induced by chronic administration of mk-801 (a noncompetitive nmda receptor antagonist). |
2010-08-30 |
2023-08-12 |
human |
| Yu Feng, Xiao-Dong Wang, Chun-Mei Guo, Yang Yang, Ji-Tao Li, Yun-Ai Su, Tian-Mei S. Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration. Journal of biomedicine & biotechnology. vol 2010. 2010-08-30. PMID:20467458. |
these findings suggest that altered expressions of nrg1 and erbb4 might be attributed to the schizophrenia. |
2010-08-30 |
2023-08-12 |
human |
| Yachi Chen, Melissa L Hancock, Lorna W Role, David A Talmag. Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610754. |
in particular, substitutions at valine 321, previously linked to schizophrenia risks, result in nrg1 proteins that fail to undergo gamma-secretase-mediated nuclear localization and transcriptional activation. |
2010-08-16 |
2023-08-12 |
Not clear |