| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriel Corfas, Kristine Roy, Joseph D Buxbau. Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nature neuroscience. vol 7. issue 6. 2004-07-20. PMID:15162166. |
recently, the gene that encodes neuregulin-1 (nrg1) has been identified as a potential susceptibility gene for schizophrenia, and defects in the expression of erbb3, one of the nrg1 receptors, have been shown to occur in the prefrontal cortex of schizophrenic patients, suggesting that nrg1-erbb signaling is involved in the pathogenesis of schizophrenia. |
2004-07-20 |
2023-08-12 |
Not clear |
| Masayoshi Okada, Gabriel Corfa. Neuregulin1 downregulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse. Hippocampus. vol 14. issue 3. 2004-07-06. PMID:15132433. |
these results suggest that nrg1 may contribute to the reduction in gabaergic synaptic activity in hippocampal ca1 pyramidal neurons that normally occurs during early postnatal development, and that alterations in nrg1 signaling in the hippocampus may contribute to schizophrenia and epilepsy. |
2004-07-06 |
2023-08-12 |
Not clear |
| Michael C O'Donovan, Nigel M Williams, Michael J Owe. Recent advances in the genetics of schizophrenia. Human molecular genetics. vol 12 Spec No 2. 2004-06-04. PMID:12952866. |
currently, the weight of evidence supports nrg1 and dtnbp1 as schizophrenia susceptibility loci, though work remains before we understand precisely how genetic variation at each locus confers susceptibility and protection. |
2004-06-04 |
2023-08-12 |
Not clear |
| Hreinn Stefansson, Valgerdur Steinthorsdottir, Thorgeir E Thorgeirsson, Jeffrey R Gulcher, Kari Stefansso. Neuregulin 1 and schizophrenia. Annals of medicine. vol 36. issue 1. 2004-05-27. PMID:15000348. |
we discuss in this review the role of the neuregulin (nrg1) gene in schizophrenia. |
2004-05-27 |
2023-08-12 |
Not clear |
| Hreinn Stefansson, Valgerdur Steinthorsdottir, Thorgeir E Thorgeirsson, Jeffrey R Gulcher, Kari Stefansso. Neuregulin 1 and schizophrenia. Annals of medicine. vol 36. issue 1. 2004-05-27. PMID:15000348. |
nrg1 contributes to the genetics of schizophrenia in both icelandic and scottish schizophrenia patients. |
2004-05-27 |
2023-08-12 |
Not clear |
| Hreinn Stefansson, Valgerdur Steinthorsdottir, Thorgeir E Thorgeirsson, Jeffrey R Gulcher, Kari Stefansso. Neuregulin 1 and schizophrenia. Annals of medicine. vol 36. issue 1. 2004-05-27. PMID:15000348. |
the discovery that defects in nrg1 signaling may be involved in some cases of schizophrenia, not only implicates nrg1, but suggests that its biological pathway, active both at developing and mature synapses, is worth inspecting further in a search for other schizophrenia genes possibly in epistasis with nrg1. |
2004-05-27 |
2023-08-12 |
Not clear |
| J Z Yang, T M Si, Y Ruan, Y S Ling, Y H Han, X L Wang, M Zhou, H Y Zhang, Q M Kong, C Liu, D R Zhang, Y Q Yu, S Z Liu, G Z Ju, L Shu, D L Ma, D Zhan. Association study of neuregulin 1 gene with schizophrenia. Molecular psychiatry. vol 8. issue 7. 2004-04-20. PMID:12874607. |
in this region, the candidate gene of interest, neuregulin 1 (nrg1), may play a role in the pathogenesis of schizophrenia. |
2004-04-20 |
2023-08-12 |
Not clear |
| J Z Yang, T M Si, Y Ruan, Y S Ling, Y H Han, X L Wang, M Zhou, H Y Zhang, Q M Kong, C Liu, D R Zhang, Y Q Yu, S Z Liu, G Z Ju, L Shu, D L Ma, D Zhan. Association study of neuregulin 1 gene with schizophrenia. Molecular psychiatry. vol 8. issue 7. 2004-04-20. PMID:12874607. |
then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (snps: rs3924999, rs2954041, snp8nrg221533) on nrg1 gene and schizophrenia in 246 chinese han schizophrenic family trios using pcr-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography. |
2004-04-20 |
2023-08-12 |
Not clear |
| W Maier, A Zobel, M Rietsche. Genetics of schizophrenia and affective disorders. Pharmacopsychiatry. vol 36 Suppl 3. 2004-02-27. PMID:14677079. |
several disposition genes for schizophrenia (dtnbp1, nrg1, g72) were identified, whereas evidence for specific disposition genes in bipolar disorder is more limited. |
2004-02-27 |
2023-08-12 |
Not clear |
| Hreinn Stefansson, Jane Sarginson, Augustine Kong, Phil Yates, Valgerdur Steinthorsdottir, Einar Gudfinnsson, Steinunn Gunnarsdottir, Nicholas Walker, Hannes Petursson, Caroline Crombie, Andres Ingason, Jeffrey R Gulcher, Kari Stefansson, David St Clai. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. American journal of human genetics. vol 72. issue 1. 2003-02-21. PMID:12478479. |
recently, we identified neuregulin 1 (nrg1) as a susceptibility gene for schizophrenia in the icelandic population, by a combined linkage and association approach. |
2003-02-21 |
2023-08-12 |
human |
| Hreinn Stefansson, Jane Sarginson, Augustine Kong, Phil Yates, Valgerdur Steinthorsdottir, Einar Gudfinnsson, Steinunn Gunnarsdottir, Nicholas Walker, Hannes Petursson, Caroline Crombie, Andres Ingason, Jeffrey R Gulcher, Kari Stefansson, David St Clai. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. American journal of human genetics. vol 72. issue 1. 2003-02-21. PMID:12478479. |
here, we report the first study evaluating the relevance of nrg1 to schizophrenia in a population outside iceland. |
2003-02-21 |
2023-08-12 |
human |
| Hreinn Stefansson, Jane Sarginson, Augustine Kong, Phil Yates, Valgerdur Steinthorsdottir, Einar Gudfinnsson, Steinunn Gunnarsdottir, Nicholas Walker, Hannes Petursson, Caroline Crombie, Andres Ingason, Jeffrey R Gulcher, Kari Stefansson, David St Clai. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. American journal of human genetics. vol 72. issue 1. 2003-02-21. PMID:12478479. |
this direct replication of haplotype association in a second population further implicates nrg1 as a factor that contributes to the etiology of schizophrenia. |
2003-02-21 |
2023-08-12 |
human |
| Hreinn Stefansson, Engilbert Sigurdsson, Valgerdur Steinthorsdottir, Soley Bjornsdottir, Thordur Sigmundsson, Shyamali Ghosh, Jon Brynjolfsson, Steinunn Gunnarsdottir, Omar Ivarsson, Thomas T Chou, Omar Hjaltason, Birgitta Birgisdottir, Helgi Jonsson, Vala G Gudnadottir, Elsa Gudmundsdottir, Asgeir Bjornsson, Brynjolfur Ingvarsson, Andres Ingason, Sigmundur Sigfusson, Hronn Hardardottir, Richard P Harvey, Donna Lai, Mingdong Zhou, Daniela Brunner, Vincent Mutel, Acuna Gonzalo, Greg Lemke, Jesus Sainz, Gardar Johannesson, Thorkell Andresson, Daniel Gudbjartsson, Andrei Manolescu, Michael L Frigge, Mark E Gurney, Augustine Kong, Jeffrey R Gulcher, Hannes Petursson, Kari Stefansso. Neuregulin 1 and susceptibility to schizophrenia. American journal of human genetics. vol 71. issue 4. 2002-10-28. PMID:12145742. |
extensive fine-mapping of the 8p locus and haplotype-association analysis, supplemented by a transmission/disequilibrium test, identifies neuregulin 1 (nrg1) as a candidate gene for schizophrenia. |
2002-10-28 |
2023-08-12 |
mouse |
| Hreinn Stefansson, Engilbert Sigurdsson, Valgerdur Steinthorsdottir, Soley Bjornsdottir, Thordur Sigmundsson, Shyamali Ghosh, Jon Brynjolfsson, Steinunn Gunnarsdottir, Omar Ivarsson, Thomas T Chou, Omar Hjaltason, Birgitta Birgisdottir, Helgi Jonsson, Vala G Gudnadottir, Elsa Gudmundsdottir, Asgeir Bjornsson, Brynjolfur Ingvarsson, Andres Ingason, Sigmundur Sigfusson, Hronn Hardardottir, Richard P Harvey, Donna Lai, Mingdong Zhou, Daniela Brunner, Vincent Mutel, Acuna Gonzalo, Greg Lemke, Jesus Sainz, Gardar Johannesson, Thorkell Andresson, Daniel Gudbjartsson, Andrei Manolescu, Michael L Frigge, Mark E Gurney, Augustine Kong, Jeffrey R Gulcher, Hannes Petursson, Kari Stefansso. Neuregulin 1 and susceptibility to schizophrenia. American journal of human genetics. vol 71. issue 4. 2002-10-28. PMID:12145742. |
mutant mice heterozygous for either nrg1 or its receptor, erbb4, show a behavioral phenotype that overlaps with mouse models for schizophrenia. |
2002-10-28 |
2023-08-12 |
mouse |
| Hreinn Stefansson, Engilbert Sigurdsson, Valgerdur Steinthorsdottir, Soley Bjornsdottir, Thordur Sigmundsson, Shyamali Ghosh, Jon Brynjolfsson, Steinunn Gunnarsdottir, Omar Ivarsson, Thomas T Chou, Omar Hjaltason, Birgitta Birgisdottir, Helgi Jonsson, Vala G Gudnadottir, Elsa Gudmundsdottir, Asgeir Bjornsson, Brynjolfur Ingvarsson, Andres Ingason, Sigmundur Sigfusson, Hronn Hardardottir, Richard P Harvey, Donna Lai, Mingdong Zhou, Daniela Brunner, Vincent Mutel, Acuna Gonzalo, Greg Lemke, Jesus Sainz, Gardar Johannesson, Thorkell Andresson, Daniel Gudbjartsson, Andrei Manolescu, Michael L Frigge, Mark E Gurney, Augustine Kong, Jeffrey R Gulcher, Hannes Petursson, Kari Stefansso. Neuregulin 1 and susceptibility to schizophrenia. American journal of human genetics. vol 71. issue 4. 2002-10-28. PMID:12145742. |
we also demonstrate that the behavioral phenotypes of the nrg1 hypomorphs are partially reversible with clozapine, an atypical antipsychotic drug used to treat schizophrenia. |
2002-10-28 |
2023-08-12 |
mouse |