| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Tosato, Paola Dazzan, David Collie. Association between the neuregulin 1 gene and schizophrenia: a systematic review. Schizophrenia bulletin. vol 31. issue 3. 2005-12-07. PMID:16081509. |
overall, there is convincing but not yet compelling evidence for a role for nrg1 in susceptibility to schizophrenia. |
2005-12-07 |
2023-08-12 |
human |
| T L Petryshen, F A Middleton, A Kirby, K A Aldinger, S Purcell, A R Tahl, C P Morley, L McGann, K L Gentile, G N Rockwell, H M Medeiros, C Carvalho, A Macedo, A Dourado, J Valente, C P Ferreira, N J Patterson, M H Azevedo, M J Daly, C N Pato, M T Pato, P Skla. Support for involvement of neuregulin 1 in schizophrenia pathophysiology. Molecular psychiatry. vol 10. issue 4. 2005-07-12. PMID:15545978. |
we investigated nrg1 for association in schizophrenia patients of portuguese descent to determine whether this gene is a risk factor in this population. |
2005-07-12 |
2023-08-12 |
Not clear |
| T L Petryshen, F A Middleton, A Kirby, K A Aldinger, S Purcell, A R Tahl, C P Morley, L McGann, K L Gentile, G N Rockwell, H M Medeiros, C Carvalho, A Macedo, A Dourado, J Valente, C P Ferreira, N J Patterson, M H Azevedo, M J Daly, C N Pato, M T Pato, P Skla. Support for involvement of neuregulin 1 in schizophrenia pathophysiology. Molecular psychiatry. vol 10. issue 4. 2005-07-12. PMID:15545978. |
comparison of nrg1 transcript expression in peripheral leukocytes from schizophrenia patients and unaffected siblings identified 3.8-fold higher levels of the smdf variant in patients (p=0.039). |
2005-07-12 |
2023-08-12 |
Not clear |
| T L Petryshen, F A Middleton, A Kirby, K A Aldinger, S Purcell, A R Tahl, C P Morley, L McGann, K L Gentile, G N Rockwell, H M Medeiros, C Carvalho, A Macedo, A Dourado, J Valente, C P Ferreira, N J Patterson, M H Azevedo, M J Daly, C N Pato, M T Pato, P Skla. Support for involvement of neuregulin 1 in schizophrenia pathophysiology. Molecular psychiatry. vol 10. issue 4. 2005-07-12. PMID:15545978. |
in summary, our results suggest that haplotypes across nrg1 and multiple nrg1 variants are involved in schizophrenia. |
2005-07-12 |
2023-08-12 |
Not clear |
| Elaine K Green, Rachel Raybould, Stuart Macgregor, Katherine Gordon-Smith, Jess Heron, Sally Hyde, Detelina Grozeva, Marian Hamshere, Nigel Williams, Michael J Owen, Michael C O'Donovan, Lisa Jones, Ian Jones, George Kirov, Nick Craddoc. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Archives of general psychiatry. vol 62. issue 6. 2005-06-15. PMID:15939841. |
several studies have provided evidence that variation at the neuregulin 1 (nrg1) gene on chromosome 8p12 influences susceptibility to schizophrenia. |
2005-06-15 |
2023-08-12 |
human |
| Chih-Min Liu, Hai-Gwo Hwu, Cathy S J Fann, Chin-Yu Lin, Yu-Li Liu, Wen-Chen Ou-Yang, Sandy F-C Le. Linkage evidence of schizophrenia to loci near neuregulin 1 gene on chromosome 8p21 in Taiwanese families. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 134B. issue 1. 2005-05-09. PMID:15704228. |
the marker d8s1222 was about 400 kbp distal to the exon 1 of glial growth factor 2 (ggf2), an isoform of neuregulin 1 gene (nrg1), which has been highly suggested to be a candidate gene for schizophrenia. |
2005-05-09 |
2023-08-12 |
Not clear |
| Chih-Min Liu, Hai-Gwo Hwu, Cathy S J Fann, Chin-Yu Lin, Yu-Li Liu, Wen-Chen Ou-Yang, Sandy F-C Le. Linkage evidence of schizophrenia to loci near neuregulin 1 gene on chromosome 8p21 in Taiwanese families. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 134B. issue 1. 2005-05-09. PMID:15704228. |
the results provide suggestive linkage evidence of schizophrenia to loci near nrg1 on chromosome 8p21 in an ethnically distinct taiwanese sample. |
2005-05-09 |
2023-08-12 |
Not clear |
| D L Thiselton, B T Webb, B M Neale, R C Ribble, F A O'Neill, D Walsh, B P Riley, K S Kendle. No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). Molecular psychiatry. vol 9. issue 8. 2005-03-07. PMID:15197397. |
no evidence for linkage or association of neuregulin-1 (nrg1) with disease in the irish study of high-density schizophrenia families (ishdsf). |
2005-03-07 |
2023-08-12 |
Not clear |
| D L Thiselton, B T Webb, B M Neale, R C Ribble, F A O'Neill, D Walsh, B P Riley, K S Kendle. No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). Molecular psychiatry. vol 9. issue 8. 2005-03-07. PMID:15197397. |
the neuregulin-1 gene (nrg1) at chromosome 8p21-22 has been implicated as a schizophrenia susceptibility gene in icelandic, scottish, irish and mixed uk populations. |
2005-03-07 |
2023-08-12 |
Not clear |
| D L Thiselton, B T Webb, B M Neale, R C Ribble, F A O'Neill, D Walsh, B P Riley, K S Kendle. No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). Molecular psychiatry. vol 9. issue 8. 2005-03-07. PMID:15197397. |
the shared ancestry between these populations led us to investigate the nrg1 polymorphisms and appropriate marker haplotypes for linkage and/or association to schizophrenia in the irish study of high-density schizophrenia families (ishdsf). |
2005-03-07 |
2023-08-12 |
Not clear |
| T Li, H Stefansson, E Gudfinnsson, G Cai, X Liu, R M Murray, V Steinthorsdottir, D Januel, V G Gudnadottir, H Petursson, A Ingason, J R Gulcher, K Stefansson, D A Collie. Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Molecular psychiatry. vol 9. issue 7. 2005-01-04. PMID:15007393. |
to determine if neuregulin 1 (nrg1) is associated with schizophrenia in asian populations, we investigated a han chinese population using both a family trio design and a case-control design. |
2005-01-04 |
2023-08-12 |
Not clear |
| T Li, H Stefansson, E Gudfinnsson, G Cai, X Liu, R M Murray, V Steinthorsdottir, D Januel, V G Gudnadottir, H Petursson, A Ingason, J R Gulcher, K Stefansson, D A Collie. Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Molecular psychiatry. vol 9. issue 7. 2005-01-04. PMID:15007393. |
a total of 25 microsatellite markers and single nucleotide polymorphisms (snps) were genotyped spanning the 1.1 mb nrg1 gene including markers of a seven-marker haplotype at the 5' end of the gene found to be in excess in icelandic and scottish schizophrenia patients. |
2005-01-04 |
2023-08-12 |
Not clear |
| T Li, H Stefansson, E Gudfinnsson, G Cai, X Liu, R M Murray, V Steinthorsdottir, D Januel, V G Gudnadottir, H Petursson, A Ingason, J R Gulcher, K Stefansson, D A Collie. Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Molecular psychiatry. vol 9. issue 7. 2005-01-04. PMID:15007393. |
we conclude that different haplotypes within the boundaries of the nrg1 gene may be associated with schizophrenia in the han chinese. |
2005-01-04 |
2023-08-12 |
Not clear |
| D Hall, J A Gogos, M Karayiorgo. The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations. Genes, brain, and behavior. vol 3. issue 4. 2004-10-05. PMID:15248869. |
here we characterize and compare the contribution of three recently identified strong candidate schizophrenia susceptibility genes; g72, neuregulin 1 (nrg1) and dystrobrevin-binding protein 1 (dtnbp1) in two independent datasets of patients with distinct genetic backgrounds. |
2004-10-05 |
2023-08-12 |
Not clear |
| A P Corvin, D W Morris, K McGhee, S Schwaiger, P Scully, J Quinn, D Meagher, D St Clair, J L Waddington, M Gil. Confirmation and refinement of an 'at-risk' haplotype for schizophrenia suggests the EST cluster, Hs.97362, as a potential susceptibility gene at the Neuregulin-1 locus. Molecular psychiatry. vol 9. issue 2. 2004-09-27. PMID:14966480. |
two recent association studies have implicated the neuregulin-1 gene (nrg1) at chromosome 8p21-22 as a susceptibility gene for schizophrenia. |
2004-09-27 |
2023-08-12 |
Not clear |
| Chen-Jee Hong, Sheue-Jane Huo, Ding-Lieh Liao, Kuenlin Lee, Jia-Yan Wu, Shih-Jen Tsa. Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia. Neuroscience letters. vol 366. issue 2. 2004-08-25. PMID:15276238. |
genetic variations in the neuregulin 1 (nrg1), a critical gene in neuronal development, have been reported to be associated with schizophrenia in several reports. |
2004-08-25 |
2023-08-12 |
Not clear |
| Chen-Jee Hong, Sheue-Jane Huo, Ding-Lieh Liao, Kuenlin Lee, Jia-Yan Wu, Shih-Jen Tsa. Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia. Neuroscience letters. vol 366. issue 2. 2004-08-25. PMID:15276238. |
association has been reported between a non-synonymous nrg1 polymorphism (arg38gln) and schizophrenia in a chinese family-based association study; however, this finding is not yet confirmed by other research findings analyzed using independent sample. |
2004-08-25 |
2023-08-12 |
Not clear |
| Chen-Jee Hong, Sheue-Jane Huo, Ding-Lieh Liao, Kuenlin Lee, Jia-Yan Wu, Shih-Jen Tsa. Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia. Neuroscience letters. vol 366. issue 2. 2004-08-25. PMID:15276238. |
to replicate this finding and assess the association between age at onset of schizophrenia and the nrg1 arg38gln polymorphism, we investigated the prevalence of this polymorphism in a chinese population (228 schizophrenic disorder patients and 269 controls). |
2004-08-25 |
2023-08-12 |
Not clear |
| Chen-Jee Hong, Sheue-Jane Huo, Ding-Lieh Liao, Kuenlin Lee, Jia-Yan Wu, Shih-Jen Tsa. Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia. Neuroscience letters. vol 366. issue 2. 2004-08-25. PMID:15276238. |
we were unable, however, to demonstrate a significant association between the nrg1 arg38gln polymorphism and schizophrenia (p = 0.869 for genotype and p = 0.597 for allelic frequencies) or age at onset (p = 0.940). |
2004-08-25 |
2023-08-12 |
Not clear |
| Chen-Jee Hong, Sheue-Jane Huo, Ding-Lieh Liao, Kuenlin Lee, Jia-Yan Wu, Shih-Jen Tsa. Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia. Neuroscience letters. vol 366. issue 2. 2004-08-25. PMID:15276238. |
on the basis of the contrast between the findings of other study and our family-based study and the negative findings of our case-control association study, we conclude that nrg1 arg38gln polymorphism is not likely to play a major role in the pathogenesis of schizophrenia in chinese populations. |
2004-08-25 |
2023-08-12 |
Not clear |