| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jubao Duan, Maria Martinez, Alan R Sanders, Cuiping Hou, Aaron J Krasner, Daniel B Schwartz, Pablo V Gejma. Neuregulin 1 (NRG1 ) and schizophrenia: analysis of a US family sample and the evidence in the balance. Psychological medicine. vol 35. issue 11. 2006-06-09. PMID:16219118. |
neuregulin 1 (nrg1 ) and schizophrenia: analysis of a us family sample and the evidence in the balance. |
2006-06-09 |
2023-08-12 |
Not clear |
| Jong Won Kim, Yu-Sang Lee, Eun-Young Cho, Yong Lee Jang, Dong Yeon Park, Kyeong-Sook Choi, Hyun Ok Jeun, Seung-Hee Cho, Sue-Yon Jang, Kyung Sue Hon. Linkage and association of schizophrenia with genetic variations in the locus of neuregulin 1 in Korean population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 3. 2006-05-30. PMID:16526041. |
after neuregulin 1 (nrg1) was identified as a positional candidate gene for schizophrenia in this locus, several independent association studies have reported controversial results. |
2006-05-30 |
2023-08-12 |
Not clear |
| Jong Won Kim, Yu-Sang Lee, Eun-Young Cho, Yong Lee Jang, Dong Yeon Park, Kyeong-Sook Choi, Hyun Ok Jeun, Seung-Hee Cho, Sue-Yon Jang, Kyung Sue Hon. Linkage and association of schizophrenia with genetic variations in the locus of neuregulin 1 in Korean population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 3. 2006-05-30. PMID:16526041. |
this study provides additional suggestive evidence for both the linkage and association of genetic variations on 8p12, a locus of nrg1, with schizophrenia. |
2006-05-30 |
2023-08-12 |
Not clear |
| Jong Won Kim, Yu-Sang Lee, Eun-Young Cho, Yong Lee Jang, Dong Yeon Park, Kyeong-Sook Choi, Hyun Ok Jeun, Seung-Hee Cho, Sue-Yon Jang, Kyung Sue Hon. Linkage and association of schizophrenia with genetic variations in the locus of neuregulin 1 in Korean population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 3. 2006-05-30. PMID:16526041. |
nrg1 might either play a role in the predisposition to schizophrenia or be in linkage disequilibrium (ld) with a causal locus of this illness. |
2006-05-30 |
2023-08-12 |
Not clear |
| Gilad Silberberg, Ariel Darvasi, Ronit Pinkas-Kramarski, Ruth Navo. The involvement of ErbB4 with schizophrenia: association and expression studies. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 2. 2006-05-01. PMID:16402353. |
neuregulin 1 (nrg1) has been found to be associated with schizophrenia in several populations. |
2006-05-01 |
2023-08-12 |
mouse |
| Gilad Silberberg, Ariel Darvasi, Ronit Pinkas-Kramarski, Ruth Navo. The involvement of ErbB4 with schizophrenia: association and expression studies. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 2. 2006-05-01. PMID:16402353. |
consistently, mutant mice heterozygous for either nrg1 or its receptor, erbb4, show a behavioral phenotype that overlaps with mouse models for schizophrenia. |
2006-05-01 |
2023-08-12 |
mouse |
| Gilad Silberberg, Ariel Darvasi, Ronit Pinkas-Kramarski, Ruth Navo. The involvement of ErbB4 with schizophrenia: association and expression studies. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 2. 2006-05-01. PMID:16402353. |
we propose that nrg1 and its receptor erbb4 are components of a biological pathway, involved in the pathophysiology of schizophrenia. |
2006-05-01 |
2023-08-12 |
mouse |
| Naoki Fukui, Tatsuyuki Muratake, Naoshi Kaneko, Hideki Amagane, Toshiyuki Somey. Supportive evidence for neuregulin 1 as a susceptibility gene for schizophrenia in a Japanese population. Neuroscience letters. vol 396. issue 2. 2006-04-25. PMID:16326006. |
identified neuregulin 1 (nrg1) on 8p12 as a susceptibility gene for schizophrenia in the icelandic population. |
2006-04-25 |
2023-08-12 |
Not clear |
| Naoki Fukui, Tatsuyuki Muratake, Naoshi Kaneko, Hideki Amagane, Toshiyuki Somey. Supportive evidence for neuregulin 1 as a susceptibility gene for schizophrenia in a Japanese population. Neuroscience letters. vol 396. issue 2. 2006-04-25. PMID:16326006. |
since then several independent studies have supported the association of nrg1 with schizophrenia. |
2006-04-25 |
2023-08-12 |
Not clear |
| Naoki Fukui, Tatsuyuki Muratake, Naoshi Kaneko, Hideki Amagane, Toshiyuki Somey. Supportive evidence for neuregulin 1 as a susceptibility gene for schizophrenia in a Japanese population. Neuroscience letters. vol 396. issue 2. 2006-04-25. PMID:16326006. |
our data support the hypothesis that nrg1 gene is a susceptibility gene for schizophrenia. |
2006-04-25 |
2023-08-12 |
Not clear |
| M Gardner, A González-Neira, O Lao, F Calafell, J Bertranpetit, D Coma. Extreme population differences across Neuregulin 1 gene, with implications for association studies. Molecular psychiatry. vol 11. issue 1. 2006-04-17. PMID:16189508. |
neuregulin 1 (nrg1) is one of the most exciting candidate genes for schizophrenia in recent years since its first association with the disease in an icelandic population. |
2006-04-17 |
2023-08-12 |
human |
| N Craddock, M C O'Donovan, M J Owe. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. Journal of medical genetics. vol 42. issue 3. 2006-03-31. PMID:15744031. |
current evidence supports nrg1, dtnbp1, disc1, daoa(g72), dao, and rgs4 as schizophrenia susceptibility loci. |
2006-03-31 |
2023-08-12 |
Not clear |
| N Craddock, M C O'Donovan, M J Owe. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. Journal of medical genetics. vol 42. issue 3. 2006-03-31. PMID:15744031. |
increasing evidence suggests an overlap in genetic susceptibility across the traditional classification systems that dichotomised psychotic disorders into schizophrenia or bipolar disorder, most notably with association findings at daoa(g72), disc1, and nrg1. |
2006-03-31 |
2023-08-12 |
Not clear |
| Nadine Norton, Valentina Moskvina, Derek W Morris, Nicholas J Bray, Stanley Zammit, Nigel M Williams, Hywel J Williams, Anna C Preece, Sarah Dwyer, Jennifer C Wilkinson, Gillian Spurlock, George Kirov, Paul Buckland, John L Waddington, Michael Gill, Aiden P Corvin, Michael J Owen, Michael C O'Donova. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 1. 2006-03-28. PMID:16249994. |
there is now strong evidence that neuregulin 1 (nrg1) is a susceptibility gene for schizophrenia. |
2006-03-28 |
2023-08-12 |
mouse |
| Nadine Norton, Valentina Moskvina, Derek W Morris, Nicholas J Bray, Stanley Zammit, Nigel M Williams, Hywel J Williams, Anna C Preece, Sarah Dwyer, Jennifer C Wilkinson, Gillian Spurlock, George Kirov, Paul Buckland, John L Waddington, Michael Gill, Aiden P Corvin, Michael J Owen, Michael C O'Donova. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 1. 2006-03-28. PMID:16249994. |
nrg1 mediates some of its effects through the tyrosine kinase receptor erbb4, and analysis of gene knock-out animals suggests that the functional interaction of nrg1 and erbb4 mediates behaviors that may model some aspects of the schizophrenia phenotype in mice. |
2006-03-28 |
2023-08-12 |
mouse |
| Nadine Norton, Valentina Moskvina, Derek W Morris, Nicholas J Bray, Stanley Zammit, Nigel M Williams, Hywel J Williams, Anna C Preece, Sarah Dwyer, Jennifer C Wilkinson, Gillian Spurlock, George Kirov, Paul Buckland, John L Waddington, Michael Gill, Aiden P Corvin, Michael J Owen, Michael C O'Donova. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 1. 2006-03-28. PMID:16249994. |
however, we did find evidence for a significant interaction between the nrg1 "icelandic" schizophrenia risk haplotype and erbb4 (p = 0.019). |
2006-03-28 |
2023-08-12 |
mouse |
| Nadine Norton, Valentina Moskvina, Derek W Morris, Nicholas J Bray, Stanley Zammit, Nigel M Williams, Hywel J Williams, Anna C Preece, Sarah Dwyer, Jennifer C Wilkinson, Gillian Spurlock, George Kirov, Paul Buckland, John L Waddington, Michael Gill, Aiden P Corvin, Michael J Owen, Michael C O'Donova. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 1. 2006-03-28. PMID:16249994. |
our data require independent replication, but tentatively suggest that nrg1 may mediate its effects on schizophrenia susceptibility through functional interaction with erbb4, and that genetic interaction between variants at the two loci increases susceptibility to schizophrenia. |
2006-03-28 |
2023-08-12 |
mouse |
| Herbert M Lachman, Erika Pedrosa, Karen A Nolan, Max Glass, Kenny Ye, Takuya Sait. Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 1. 2006-03-28. PMID:16287046. |
linkage analysis and association studies have pointed to neuregulin 1 (nrg1) as the prime candidate for 8p-linked schizophrenia (sz). |
2006-03-28 |
2023-08-12 |
rat |
| Nick Craddock, Michael C O'Donovan, Michael J Owe. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia bulletin. vol 32. issue 1. 2006-03-07. PMID:16319375. |
for example, disc1 and nrg1 may confer susceptibility to a form of illness with mixed features of schizophrenia and mania. |
2006-03-07 |
2023-08-12 |
Not clear |
| Rodney C P Go, Rodney T Perry, Howard Wiener, Susan S Bassett, Deborah Blacker, Bernie Devlin, Robert A Swee. Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 139B. issue 1. 2006-01-27. PMID:16082692. |
associations with nrg1 snps have also been found in other schizophrenia populations from scotland, ireland, and china. |
2006-01-27 |
2023-08-12 |
Not clear |