| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shiny V Mathew, Amanda J Law, Barbara K Lipska, Martha I Dávila-García, Eduardo D Zamora, Shruti N Mitkus, Radhakrishna Vakkalanka, Richard E Straub, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyd. Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Human molecular genetics. vol 16. issue 23. 2008-01-22. PMID:17884806. |
studies in cell culture and in animals suggest that neuregulin 1 (nrg1), a probable schizophrenia susceptibility gene, regulates the expression of the alpha7 nicotinic acetylcholine receptors (nachrs). |
2008-01-22 |
2023-08-12 |
human |
| Shiny V Mathew, Amanda J Law, Barbara K Lipska, Martha I Dávila-García, Eduardo D Zamora, Shruti N Mitkus, Radhakrishna Vakkalanka, Richard E Straub, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyd. Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Human molecular genetics. vol 16. issue 23. 2008-01-22. PMID:17884806. |
we examined the effects of four disease-associated single-nucleotide polymorphisms (snps) in the 5' region of the nrg1 gene on nachr alpha7 mrna transcript expression in both the dorsolateral prefrontal cortex (dlpfc) and hippocampus of normal controls and patients with schizophrenia using quantitative real-time pcr. |
2008-01-22 |
2023-08-12 |
human |
| Shiny V Mathew, Amanda J Law, Barbara K Lipska, Martha I Dávila-García, Eduardo D Zamora, Shruti N Mitkus, Radhakrishna Vakkalanka, Richard E Straub, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyd. Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Human molecular genetics. vol 16. issue 23. 2008-01-22. PMID:17884806. |
together, these results suggest that the molecular mechanism of the association between nrg1 risk alleles and schizophrenia may include down-regulation of nachr alpha7 expression. |
2008-01-22 |
2023-08-12 |
human |
| Y Sei, R Ren-Patterson, Z Li, E M Tunbridge, M F Egan, B S Kolachana, D R Weinberge. Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms. Molecular psychiatry. vol 12. issue 10. 2008-01-04. PMID:17440436. |
this study demonstrates that the migratory response of schizophrenia-derived cells to nrg1 is impaired and is associated with genetic variations in more than one schizophrenia susceptibility gene, providing a novel insight into potential neurodevelopmental mechanisms of schizophrenia. |
2008-01-04 |
2023-08-12 |
Not clear |
| Undine E Lang, Imke Puls, Daniel J Muller, Nathalie Strutz-Seebohm, Jurgen Gallina. Molecular mechanisms of schizophrenia. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 6. 2007-12-19. PMID:17982252. |
the glutamatergic hypothesis of schizophrenia lead recently to a first successful mglu2/3 receptor agonistic drug and is underpinned by significant findings in genes regulating the glutamatergic system (slc1a6, slc1a2 grin1, grin2a, gria1, nrg1, erbb4, dtnbp1, daao, g72/30, grm3). |
2007-12-19 |
2023-08-12 |
Not clear |
| Araceli Rosa, M Gardner, M J Cuesta, V Peralta, M Fatjó-Vilas, S Miret, M E Navarro, D Comas, L Fañaná. Family-based association study of neuregulin-1 gene and psychosis in a Spanish sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503451. |
neuregulin 1 (nrg1) is one of the most exciting candidate genes for schizophrenia since its first association with the disorder in an icelandic population. |
2007-12-06 |
2023-08-12 |
Not clear |
| Araceli Rosa, M Gardner, M J Cuesta, V Peralta, M Fatjó-Vilas, S Miret, M E Navarro, D Comas, L Fañaná. Family-based association study of neuregulin-1 gene and psychosis in a Spanish sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503451. |
we tested eight snps across 1.2 mb along nrg1 including regions previously associated to schizophrenia in association studies. |
2007-12-06 |
2023-08-12 |
Not clear |
| Araceli Rosa, M Gardner, M J Cuesta, V Peralta, M Fatjó-Vilas, S Miret, M E Navarro, D Comas, L Fañaná. Family-based association study of neuregulin-1 gene and psychosis in a Spanish sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503451. |
these results do not seem to suggest that the investigated nrg1 markers play a role in schizophrenia in the spanish population, although the finding of a trend for association with one snp in the 3'of the gene warrants further investigation. |
2007-12-06 |
2023-08-12 |
Not clear |
| T Karl, L Duffy, A Scimone, R P Harvey, P R Schofiel. Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia. Genes, brain, and behavior. vol 6. issue 7. 2007-11-20. PMID:17309661. |
human genetic studies have shown that neuregulin 1 (nrg1) is a potential susceptibility gene for schizophrenia. |
2007-11-20 |
2023-08-12 |
mouse |
| T Karl, L Duffy, A Scimone, R P Harvey, P R Schofiel. Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia. Genes, brain, and behavior. vol 6. issue 7. 2007-11-20. PMID:17309661. |
nrg1 influences various neurodevelopmental processes, which are potentially related to schizophrenia. |
2007-11-20 |
2023-08-12 |
mouse |
| T Karl, L Duffy, A Scimone, R P Harvey, P R Schofiel. Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia. Genes, brain, and behavior. vol 6. issue 7. 2007-11-20. PMID:17309661. |
the behavioural phenotype detected in heterozygous nrg1 mutant mice is not specific to schizophrenia per se, but the increased sensitivity of mutant mice to exogenous factors is consistent with the pathophysiology of schizophrenia and the neurodevelopmental theory. |
2007-11-20 |
2023-08-12 |
mouse |
| T Karl, L Duffy, A Scimone, R P Harvey, P R Schofiel. Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia. Genes, brain, and behavior. vol 6. issue 7. 2007-11-20. PMID:17309661. |
thus, nrg1 hets may, in combination with other genetic and drug models, help to clarify pathophysiological mechanisms behind schizophrenia. |
2007-11-20 |
2023-08-12 |
mouse |
| Wei Tan, Yanhong Wang, Bert Gold, Jingshan Chen, Michael Dean, Paul J Harrison, Daniel R Weinberger, Amanda J La. Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. The Journal of biological chemistry. vol 282. issue 33. 2007-10-19. PMID:17565985. |
molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (nrg1) isoform and identification of a functional promoter variant associated with schizophrenia. |
2007-10-19 |
2023-08-12 |
human |
| Wei Tan, Yanhong Wang, Bert Gold, Jingshan Chen, Michael Dean, Paul J Harrison, Daniel R Weinberger, Amanda J La. Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. The Journal of biological chemistry. vol 282. issue 33. 2007-10-19. PMID:17565985. |
neuregulin 1 (nrg1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. |
2007-10-19 |
2023-08-12 |
human |
| Wei Tan, Yanhong Wang, Bert Gold, Jingshan Chen, Michael Dean, Paul J Harrison, Daniel R Weinberger, Amanda J La. Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. The Journal of biological chemistry. vol 282. issue 33. 2007-10-19. PMID:17565985. |
our data suggest that type iv is a unique brain-specific nrg1 that is differentially expressed and processed during early development, is translated, and its expression regulated by a schizophrenia risk-associated functional promoter or single nucleotide polymorphism (snp). |
2007-10-19 |
2023-08-12 |
human |
| C M P O'Tuathaigh, D Babovic, G J O'Sullivan, J J Clifford, O Tighe, D T Croke, R Harvey, J L Waddingto. Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1. Neuroscience. vol 147. issue 1. 2007-10-16. PMID:17512671. |
neuregulin-1 (nrg1) has been identified as a candidate susceptibility gene for schizophrenia. |
2007-10-16 |
2023-08-12 |
mouse |
| Michael J Owen, Nick Craddock, Assen Jablensk. The genetic deconstruction of psychosis. Schizophrenia bulletin. vol 33. issue 4. 2007-10-11. PMID:17551090. |
for example, variation in disrupted in schizophrenia 1 (disc1) and neuregulin 1 (nrg1) may confer susceptibility to a form of illness with mixed features of schizophrenia and mania. |
2007-10-11 |
2023-08-12 |
Not clear |
| A Bello. New genes associated with schizophrenia in neurite formation: a review of cell culture experiments. Molecular psychiatry. vol 12. issue 7. 2007-08-28. PMID:17440437. |
new genes consistently associated with schizophrenia include nrg1, akt, disc-1 and dysbindin-1. |
2007-08-28 |
2023-08-12 |
Not clear |
| Isabel Benzel, Aruna Bansal, Brian L Browning, Nicholas W Galwey, Peter R Maycox, Ralph McGinnis, Devi Smart, David St Clair, Phillip Yates, Ian Purvi. Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia. Behavioral and brain functions : BBF. vol 3. 2007-08-13. PMID:17598910. |
evidence of genetic association between the nrg1 (neuregulin-1) gene and schizophrenia is now well-documented. |
2007-08-13 |
2023-08-12 |
Not clear |
| A A Boucher, J C Arnold, L Duffy, P R Schofield, J Micheau, T Kar. Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Delta9-tetrahydrocannabinol. Psychopharmacology. vol 192. issue 3. 2007-08-09. PMID:17333138. |
human and animal research indicates that neuregulin 1 (nrg1) is a susceptibility gene for schizophrenia. |
2007-08-09 |
2023-08-12 |
mouse |