| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victor Z Chong, Mia Thompson, Senda Beltaifa, Maree J Webster, Amanda J Law, Cynthia Shannon Weicker. Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients. Schizophrenia research. vol 100. issue 1-3. 2008-08-01. PMID:18243664. |
our investigation suggests that schizophrenia-associated nrg1 and erbb4 mrna elevations also occur at the protein level and may be specific to schizophrenia. |
2008-08-01 |
2023-08-12 |
human |
| Lin Mei, Wen-Cheng Xion. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nature reviews. Neuroscience. vol 9. issue 6. 2008-06-16. PMID:18478032. |
the past few years have witnessed exciting progress in our knowledge of nrg1 and erbb4 functions and the biological basis of the increased risk for schizophrenia that is potentially conferred by polymorphisms in the two genes. |
2008-06-16 |
2023-08-12 |
Not clear |
| Lin Mei, Wen-Cheng Xion. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nature reviews. Neuroscience. vol 9. issue 6. 2008-06-16. PMID:18478032. |
an improved understanding of the mechanisms by which altered function of nrg1 and erbb4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics. |
2008-06-16 |
2023-08-12 |
Not clear |
| A V Savonenko, T Melnikova, F M Laird, K-A Stewart, D L Price, P C Won. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 14. 2008-06-10. PMID:18385378. |
although nrg1 has been genetically linked to schizophrenia and nrg1(+/-) mice exhibit a number of schizophrenia-like behavioral traits, it is not known whether altered bace1-dependent nrg1 signaling can cause similar behavioral abnormalities. |
2008-06-10 |
2023-08-12 |
mouse |
| A V Savonenko, T Melnikova, F M Laird, K-A Stewart, D L Price, P C Won. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 14. 2008-06-10. PMID:18385378. |
to test this hypothesis, we analyze the behaviors considered to be rodent analogs of clinical features of schizophrenia in bace1(-/-) mice with impaired processing of nrg1. |
2008-06-10 |
2023-08-12 |
mouse |
| Colm M P O'Tuathaigh, Anne-Marie O'Connor, Gerard J O'Sullivan, Donna Lai, Richard Harvey, David T Croke, John L Waddingto. Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 2. 2008-05-30. PMID:17980471. |
clinical genetic studies have implicated neuregulin-1 [nrg1] as a leading susceptibility gene for schizophrenia. |
2008-05-30 |
2023-08-12 |
mouse |
| Colm M P O'Tuathaigh, Anne-Marie O'Connor, Gerard J O'Sullivan, Donna Lai, Richard Harvey, David T Croke, John L Waddingto. Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 2. 2008-05-30. PMID:17980471. |
nrg1 is known to play a significant role in the developing brain, which is consistent with the prevailing neurodevelopmental model of schizophrenia. |
2008-05-30 |
2023-08-12 |
mouse |
| Alan R Sanders, Jubao Duan, Douglas F Levinson, Jianxin Shi, Deli He, Cuiping Hou, Gregory J Burrell, John P Rice, Deborah A Nertney, Ann Olincy, Pablo Rozic, Sophia Vinogradov, Nancy G Buccola, Bryan J Mowry, Robert Freedman, Farooq Amin, Donald W Black, Jeremy M Silverman, William F Byerley, Raymond R Crowe, C Robert Cloninger, Maria Martinez, Pablo V Gejma. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. The American journal of psychiatry. vol 165. issue 4. 2008-05-14. PMID:18198266. |
the authors carried out a genetic association study of 14 schizophrenia candidate genes (rgs4, disc1, dtnbp1, stx7, taar6, ppp3cc, nrg1, drd2, htr2a, daoa, akt1, chrna7, comt, and arvcf). |
2008-05-14 |
2023-08-12 |
Not clear |
| Elisabet Vilella, Javier Costas, Julio Sanjuan, Míriam Guitart, Yolanda De Diego, Angel Carracedo, Lourdes Martorell, Joaquín Valero, Antonio Labad, Rosa De Frutos, Carmen Nájera, M Dolores Moltó, Ivette Toirac, Roser Guillamat, Anna Brunet, Vicenç Vallès, Lucía Pérez, Melquíades Leon, Fernando Rodríguez de Fonseca, Christopher Phillips, María Torre. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. Journal of psychiatric research. vol 42. issue 4. 2008-04-29. PMID:17408693. |
association of schizophrenia with dtnbp1 but not with dao, daoa, nrg1 and rgs4 nor their genetic interaction. |
2008-04-29 |
2023-08-12 |
human |
| Elisabet Vilella, Javier Costas, Julio Sanjuan, Míriam Guitart, Yolanda De Diego, Angel Carracedo, Lourdes Martorell, Joaquín Valero, Antonio Labad, Rosa De Frutos, Carmen Nájera, M Dolores Moltó, Ivette Toirac, Roser Guillamat, Anna Brunet, Vicenç Vallès, Lucía Pérez, Melquíades Leon, Fernando Rodríguez de Fonseca, Christopher Phillips, María Torre. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. Journal of psychiatric research. vol 42. issue 4. 2008-04-29. PMID:17408693. |
recent reports indicate that dao, daoa, dtnbp1, nrg1 and rgs4 are some of the most-replicated genes implicated in susceptibility to schizophrenia. |
2008-04-29 |
2023-08-12 |
human |
| Elisabet Vilella, Javier Costas, Julio Sanjuan, Míriam Guitart, Yolanda De Diego, Angel Carracedo, Lourdes Martorell, Joaquín Valero, Antonio Labad, Rosa De Frutos, Carmen Nájera, M Dolores Moltó, Ivette Toirac, Roser Guillamat, Anna Brunet, Vicenç Vallès, Lucía Pérez, Melquíades Leon, Fernando Rodríguez de Fonseca, Christopher Phillips, María Torre. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. Journal of psychiatric research. vol 42. issue 4. 2008-04-29. PMID:17408693. |
however, no association was found between dao, daoa, nrg1 and rgs4 and schizophrenia. |
2008-04-29 |
2023-08-12 |
human |
| S M Lawrie, J Hall, A M McIntosh, D G Cunningham-Owens, E C Johnston. Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential. British journal of pharmacology. vol 153 Suppl 1. 2008-04-28. PMID:18193072. |
the nrg1 gene appears to be a risk factor for an extended or intermediate phenotype, while the comt val allele, which decreases the rate at which cortical dopamine is degraded compared to the met allele, is associated with an increased risk of schizophrenia in subjects at increased familial risk. |
2008-04-28 |
2023-08-12 |
human |
| Nicholas J Bray, Peter A Holmans, Marianne B van den Bree, Lesley Jones, Lyn A Elliston, Gareth Hughes, Alexander L Richards, Nigel M Williams, Nick Craddock, Michael J Owen, Michael C O'Donova. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human molecular genetics. vol 17. issue 8. 2008-04-21. PMID:18182443. |
the region of linkage to dtnbp1 expression on chromosome 8 is contiguous with linkage findings based upon the clinical schizophrenia phenotype, and contains another well-supported schizophrenia susceptibility gene, neuregulin-1 (nrg1). |
2008-04-21 |
2023-08-12 |
Not clear |
| Andreas Konrad, Georg Wintere. Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? Schizophrenia bulletin. vol 34. issue 1. 2008-04-03. PMID:17485733. |
there is also growing evidence for abnormal expression of myelin-related genes in schizophrenia: neuregulin (nrg1) is important for oligodendrocyte development and function, and altered expression of erbb3, one of the nrg1 receptors, has been shown in schizophrenia patients. |
2008-04-03 |
2023-08-12 |
Not clear |
| Andreas Konrad, Georg Wintere. Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? Schizophrenia bulletin. vol 34. issue 1. 2008-04-03. PMID:17485733. |
this is consistent with recent genetic studies suggesting that nrg1 may contribute to the genetic risk for schizophrenia. |
2008-04-03 |
2023-08-12 |
Not clear |
| Marcus R Munafò, Angela S Attwood, Jonathan Flin. Neuregulin 1 genotype and schizophrenia. Schizophrenia bulletin. vol 34. issue 1. 2008-04-03. PMID:18032396. |
the neuregulin 1 (nrg1) gene has been the subject of considerable excitement within the psychiatric genetics literature since it was originally identified as a potential susceptibility locus for schizophrenia. |
2008-04-03 |
2023-08-12 |
human |
| Marcus R Munafò, Angela S Attwood, Jonathan Flin. Neuregulin 1 genotype and schizophrenia. Schizophrenia bulletin. vol 34. issue 1. 2008-04-03. PMID:18032396. |
case-control and family-based genetic association studies of the nrg1 gene in healthy control groups and clinically diagnosed schizophrenia patients were included. |
2008-04-03 |
2023-08-12 |
human |
| A A Boucher, G E Hunt, T Karl, J Micheau, I S McGregor, J C Arnol. Heterozygous neuregulin 1 mice display greater baseline and Delta(9)-tetrahydrocannabinol-induced c-Fos expression. Neuroscience. vol 149. issue 4. 2008-03-28. PMID:17905522. |
neuregulin 1 (nrg1) is a schizophrenia susceptibility gene and mutant mice heterozygous for the transmembrane domain of this gene (nrg1 het mice) exhibit a schizophrenia-related phenotype. |
2008-03-28 |
2023-08-12 |
mouse |
| L Elliot Hong, Ikwunga Wonodi, O Colin Stine, Braxton D Mitchell, Gunvant K Thake. Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biological psychiatry. vol 63. issue 1. 2008-02-27. PMID:17631867. |
neuregulin 1 (nrg1) is one of the leading candidate genes in schizophrenia. |
2008-02-27 |
2023-08-12 |
Not clear |
| L Elliot Hong, Ikwunga Wonodi, O Colin Stine, Braxton D Mitchell, Gunvant K Thake. Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biological psychiatry. vol 63. issue 1. 2008-02-27. PMID:17631867. |
rodents with nrg1 knock-out showed significantly impaired prepulse inhibition (ppi) in the original report linking nrg1 to schizophrenia. |
2008-02-27 |
2023-08-12 |
Not clear |