| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sae Shiota, Mamoru Tochigi, Hiroko Shimada, Jun Ohashi, Kiyoto Kasai, Nobumasa Kato, Katsushi Tokunaga, Tsukasa Sasak. Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population. Journal of human genetics. vol 53. issue 10. 2008-11-18. PMID:18704261. |
however, it is equally possible that one or more genes interacting with nrg1 may also be implicated in schizophrenia and attribute to the inconsistency. |
2008-11-18 |
2023-08-12 |
Not clear |
| Sae Shiota, Mamoru Tochigi, Hiroko Shimada, Jun Ohashi, Kiyoto Kasai, Nobumasa Kato, Katsushi Tokunaga, Tsukasa Sasak. Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population. Journal of human genetics. vol 53. issue 10. 2008-11-18. PMID:18704261. |
to test the hypothesis, we conducted an interaction analysis between nrg1 and one of its receptor's (erbb4) polymorphisms as well as the association analysis of the two genes associated with schizophrenia in japanese. |
2008-11-18 |
2023-08-12 |
Not clear |
| Sae Shiota, Mamoru Tochigi, Hiroko Shimada, Jun Ohashi, Kiyoto Kasai, Nobumasa Kato, Katsushi Tokunaga, Tsukasa Sasak. Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population. Journal of human genetics. vol 53. issue 10. 2008-11-18. PMID:18704261. |
thus, our results suggest the possibility that interaction between variants in nrg1 and erbb4 might contribute to susceptibility for schizophrenia in a japanese population. |
2008-11-18 |
2023-08-12 |
Not clear |
| Liesl Duffy, Emily Cappas, Anna Scimone, Peter R Schofield, Tim Kar. Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1. Behavioral neuroscience. vol 122. issue 4. 2008-11-05. PMID:18729627. |
human genetic studies have demonstrated that the neuregulin 1 gene (nrg1) is involved in the development of schizophrenia. |
2008-11-05 |
2023-08-12 |
mouse |
| Lyudmila Georgieva, Albena Dimitrova, Dobril Ivanov, Ivan Nikolov, Nigel M Williams, Detelina Grozeva, Irina Zaharieva, Draga Toncheva, Michael J Owen, George Kirov, Michael C O'Donova. Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia. Biological psychiatry. vol 64. issue 5. 2008-11-03. PMID:18466881. |
there is support that neuregulin 1 (nrg1) plays a role in susceptibility to schizophrenia but limited evidence for its involvement in bipolar disorder. |
2008-11-03 |
2023-08-12 |
Not clear |
| Lyudmila Georgieva, Albena Dimitrova, Dobril Ivanov, Ivan Nikolov, Nigel M Williams, Detelina Grozeva, Irina Zaharieva, Draga Toncheva, Michael J Owen, George Kirov, Michael C O'Donova. Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia. Biological psychiatry. vol 64. issue 5. 2008-11-03. PMID:18466881. |
we wished to investigate further the involvement of nrg1 in schizophrenia and bipolar disorder. |
2008-11-03 |
2023-08-12 |
Not clear |
| Chongbo Zhong, Chuang Du, Melissa Hancock, Marjolijn Mertz, David A Talmage, Lorna W Rol. Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784291. |
both the neuregulin 1 (nrg1) and alpha7 nicotinic acetylcholine receptor (alpha7*nachrs) genes have been linked to schizophrenia and associated sensory-motor gating deficits. |
2008-11-03 |
2023-08-12 |
Not clear |
| Guolian Kang, Weihua Yue, Jifeng Zhang, Marianne Huebner, Handi Zhang, Yan Ruan, Tianlan Lu, Yansu Ling, Yijun Zuo, Dai Zhan. Two-stage designs to identify the effects of SNP combinations on complex diseases. Journal of human genetics. vol 53. issue 8. 2008-10-14. PMID:18584117. |
the results suggest that there may be interactive effects for schizophrenia among variants of the genes neuregulin 1 (nrg1, 8p22-p11), g72 (13q34), the regulator of g-protein signaling-4 (rgs4, 1q21-q22) and frizzled 3 (fzd3, 8p21). |
2008-10-14 |
2023-08-12 |
Not clear |
| Elvira Bramon, Emma Dempster, Sophia Frangou, Madiha Shaikh, Muriel Walshe, Francesca M Filbey, Colm McDonald, Pak Sham, David A Collier, Robin Murra. Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype. Schizophrenia research. vol 103. issue 1-3. 2008-09-26. PMID:18571900. |
neuregulin-1 (nrg1) has been put forward as a susceptibility gene for schizophrenia. |
2008-09-26 |
2023-08-12 |
Not clear |
| T Dejaegere, L Serneels, M K Schäfer, J Van Biervliet, K Horré, C Depboylu, D Alvarez-Fischer, A Herreman, M Willem, C Haass, G U Höglinger, R D'Hooge, B De Stroope. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 28. 2008-09-03. PMID:18626010. |
this finding suggests that dysregulation of intramembrane proteolysis of nrg1 could increase risk for schizophrenia and related disorders. |
2008-09-03 |
2023-08-12 |
mouse |
| Masashi Ikeda, Nagahide Takahashi, Shinichi Saito, Branko Aleksic, Yuichiro Watanabe, Ayako Nunokawa, Yoshio Yamanouchi, Tsuyoshi Kitajima, Yoko Kinoshita, Taro Kishi, Kunihiro Kawashima, Ryota Hashimoto, Hiroshi Ujike, Toshiya Inada, Toshiyuki Someya, Masatoshi Takeda, Norio Ozaki, Nakao Iwat. Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample. Schizophrenia research. vol 101. issue 1-3. 2008-08-13. PMID:18282690. |
failure to replicate the association between nrg1 and schizophrenia using japanese large sample. |
2008-08-13 |
2023-08-12 |
Not clear |
| Masashi Ikeda, Nagahide Takahashi, Shinichi Saito, Branko Aleksic, Yuichiro Watanabe, Ayako Nunokawa, Yoshio Yamanouchi, Tsuyoshi Kitajima, Yoko Kinoshita, Taro Kishi, Kunihiro Kawashima, Ryota Hashimoto, Hiroshi Ujike, Toshiya Inada, Toshiyuki Someya, Masatoshi Takeda, Norio Ozaki, Nakao Iwat. Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample. Schizophrenia research. vol 101. issue 1-3. 2008-08-13. PMID:18282690. |
systematic linkage disequilibrium (ld) mapping of 8p12-21 in the icelandic population identified neuregulin 1 (nrg1) as a prime candidate gene for schizophrenia. |
2008-08-13 |
2023-08-12 |
Not clear |
| Masashi Ikeda, Nagahide Takahashi, Shinichi Saito, Branko Aleksic, Yuichiro Watanabe, Ayako Nunokawa, Yoshio Yamanouchi, Tsuyoshi Kitajima, Yoko Kinoshita, Taro Kishi, Kunihiro Kawashima, Ryota Hashimoto, Hiroshi Ujike, Toshiya Inada, Toshiyuki Someya, Masatoshi Takeda, Norio Ozaki, Nakao Iwat. Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample. Schizophrenia research. vol 101. issue 1-3. 2008-08-13. PMID:18282690. |
therefore, we designed this study with the aim of assessing this putative association between schizophrenia and nrg1 (especially hap(ice) region and exon region) using a gene-based association approach in the japanese population. |
2008-08-13 |
2023-08-12 |
Not clear |
| Masashi Ikeda, Nagahide Takahashi, Shinichi Saito, Branko Aleksic, Yuichiro Watanabe, Ayako Nunokawa, Yoshio Yamanouchi, Tsuyoshi Kitajima, Yoko Kinoshita, Taro Kishi, Kunihiro Kawashima, Ryota Hashimoto, Hiroshi Ujike, Toshiya Inada, Toshiyuki Someya, Masatoshi Takeda, Norio Ozaki, Nakao Iwat. Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample. Schizophrenia research. vol 101. issue 1-3. 2008-08-13. PMID:18282690. |
these results indicate that the positionally and functionally attractive regions of nrg1 are unlikely to contribute to susceptibility to schizophrenia in the japanese population. |
2008-08-13 |
2023-08-12 |
Not clear |
| Ying-Jiun J Chen, Madeleine A Johnson, Michael D Lieberman, Rose E Goodchild, Scott Schobel, Nicole Lewandowski, Gorazd Rosoklija, Ruei-Che Liu, Jay A Gingrich, Scott Small, Holly Moore, Andrew J Dwork, David A Talmage, Lorna W Rol. Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 27. 2008-08-12. PMID:18596162. |
the nrg1 gene is a schizophrenia susceptibility gene. |
2008-08-12 |
2023-08-12 |
mouse |
| Christopher G Kanakry, Zhen Li, Yoko Nakai, Yoshitatsu Sei, Daniel R Weinberge. Neuregulin-1 regulates cell adhesion via an ErbB2/phosphoinositide-3 kinase/Akt-dependent pathway: potential implications for schizophrenia and cancer. PloS one. vol 2. issue 12. 2008-08-08. PMID:18159252. |
neuregulin-1 (nrg1) is a putative schizophrenia susceptibility gene involved extensively in central nervous system development as well as cancer invasion and metastasis. |
2008-08-08 |
2023-08-12 |
Not clear |
| Christopher G Kanakry, Zhen Li, Yoko Nakai, Yoshitatsu Sei, Daniel R Weinberge. Neuregulin-1 regulates cell adhesion via an ErbB2/phosphoinositide-3 kinase/Akt-dependent pathway: potential implications for schizophrenia and cancer. PloS one. vol 2. issue 12. 2008-08-08. PMID:18159252. |
using a b lymphoblast cell model, we previously demonstrated impairment in nrg1alpha-mediated migration in cells derived from patients with schizophrenia as well as effects of risk alleles in nrg1 and catechol-o-methyltransferase (comt), a second gene implicated both in schizophrenia susceptibility and in cancer. |
2008-08-08 |
2023-08-12 |
Not clear |
| Andrés Buonanno, Oh-Bin Kwon, Leqin Yan, Carmen Gonzalez, Marines Longart, Dax Hoffman, Detlef Vullhors. Neuregulins and neuronal plasticity: possible relevance in schizophrenia. Novartis Foundation symposium. vol 289. 2008-08-07. PMID:18497102. |
polymorphisms in the neuregulin 1 (nrg1) and erbb4 receptor genes have been associated with schizophrenia in numerous cohort and family studies, and biochemical measurements from postmortem prefrontal cortex homogenates suggest that nrg/erbb signalling is altered in schizophrenia. |
2008-08-07 |
2023-08-12 |
Not clear |
| Y C Chagnon, M-A Roy, A Bureau, C Mérette, M Maziad. Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes. Schizophrenia research. vol 100. issue 1-3. 2008-08-01. PMID:18234478. |
the dystrobrevin binding protein 1 (dtnbp1) and neuregulin 1 (nrg1) genes have been related to schizophrenia (sz) and bipolar disorder (bp) by several whole-genome linkage and associations studies. |
2008-08-01 |
2023-08-12 |
human |
| Victor Z Chong, Mia Thompson, Senda Beltaifa, Maree J Webster, Amanda J Law, Cynthia Shannon Weicker. Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients. Schizophrenia research. vol 100. issue 1-3. 2008-08-01. PMID:18243664. |
neuregulin-1 (nrg1) and its receptor, erbb4, have been implicated in schizophrenia at both gene and transcript levels. |
2008-08-01 |
2023-08-12 |
human |