| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Dutt, C McDonald, E Dempster, D Prata, M Shaikh, I Williams, K Schulze, N Marshall, M Walshe, M Allin, D Collier, R Murray, E Bramo. The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis. Psychological medicine. vol 39. issue 11. 2010-02-17. PMID:19573260. |
genetic epidemiological studies support an overlap between schizophrenia and bipolar disorder, and comt, bdnf, 5-htt, nrg1 and dtnbp1 genes have been implicated in the aetiology of both these disorders. |
2010-02-17 |
2023-08-12 |
Not clear |
| Andrea Mechelli, Essi Viding, William Pettersson-Yeo, Stefania Tognin, Philip K McGuir. Genetic variation in neuregulin1 is associated with differences in prefrontal engagement in children. Human brain mapping. vol 30. issue 12. 2010-02-02. PMID:19449332. |
we examined the impact of neuregulin1 (nrg1), a probable susceptibility gene for schizophrenia and bipolar disorder, on brain function in a sample of 102 ten- to twelve-year-old children. |
2010-02-02 |
2023-08-12 |
human |
| Inga H Deakin, Amanda J Law, Peter L Oliver, Markus H Schwab, Klaus Armin Nave, Paul J Harrison, David M Bannerma. Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice. Neuroreport. vol 20. issue 17. 2010-02-02. PMID:19829162. |
the pattern of results shows both similarities and differences to those reported in hypomorphic nrg1 mice, and may be relevant for interpreting the increased nrg1 type i expression observed in schizophrenia. |
2010-02-02 |
2023-08-12 |
mouse |
| Richard S Ehrlichman, Steven N Luminais, Samantha L White, Noam D Rudnick, Nan Ma, Holly C Dow, Arati S Kreibich, Ted Abel, Edward S Brodkin, Chang-Gyu Hahn, Steven J Siege. Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions. Brain research. vol 1294. 2010-01-12. PMID:19643092. |
neuregulin-1 (nrg1) is one of susceptibility genes for schizophrenia and plays critical roles in glutamatergic, dopaminergic and gabaergic signaling. |
2010-01-12 |
2023-08-12 |
mouse |
| Richard S Ehrlichman, Steven N Luminais, Samantha L White, Noam D Rudnick, Nan Ma, Holly C Dow, Arati S Kreibich, Ted Abel, Edward S Brodkin, Chang-Gyu Hahn, Steven J Siege. Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions. Brain research. vol 1294. 2010-01-12. PMID:19643092. |
using mutant mice heterozygous for nrg1 (nrg1(+/-)) we studied the effects of nrg1 signaling on behavioral and electrophysiological measures relevant to schizophrenia. |
2010-01-12 |
2023-08-12 |
mouse |
| Tilo Kircher, Axel Krug, Valentin Markov, Carin Whitney, Sören Krach, Klaus Zerres, Thomas Eggermann, Tony Stöcker, Nadim Jon Shah, Jens Treutlein, Markus M Nöthen, Tim Becker, Marcella Rietsche. Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals. Human brain mapping. vol 30. issue 10. 2009-11-30. PMID:19350564. |
since schizophrenia has a high heritability, it is of interest whether susceptibility genes for the disorder, such as nrg1, modulate verbal fluency performance and its neural correlates. |
2009-11-30 |
2023-08-12 |
human |
| K K Nicodemus, A J Law, A Luna, R Vakkalanka, R E Straub, J E Kleinman, D R Weinberge. A 5' promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression. Molecular psychiatry. vol 14. issue 8. 2009-11-30. PMID:19626024. |
a 5' promoter region snp in nrg1 is associated with schizophrenia risk and type iii isoform expression. |
2009-11-30 |
2023-08-12 |
Not clear |
| Ricardo Cáceda, Becky Kinkead, Charles B Nemerof. Involvement of neuropeptide systems in schizophrenia: human studies. International review of neurobiology. vol 78. 2009-11-13. PMID:17349866. |
the strongest genetic evidence supporting a role for neuropeptides in schizophrenia are those studies linking polymorphisms in nrg1 and the ccka receptor with schizophrenia. |
2009-11-13 |
2023-08-12 |
human |
| Erika Pedrosa, Karen A Nolan, Radu Stefanescu, Pnina Herskovits, Pnina Hershcovitz, Tomas Novak, Ilja Zukov, Pavla Stopkova, Herbert M Lachma. Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia. Neuropsychobiology. vol 59. issue 4. 2009-10-26. PMID:19521112. |
neuregulin 1 (nrg1) is a positional candidate gene in schizophrenia (sz). |
2009-10-26 |
2023-08-12 |
Not clear |
| Detlef Vullhorst, Jörg Neddens, Irina Karavanova, Ludovic Tricoire, Ronald S Petralia, Chris J McBain, Andres Buonann. Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 39. 2009-10-13. PMID:19793984. |
nrg1 and erbb4 have emerged as some of the most reproducible schizophrenia risk genes. |
2009-10-13 |
2023-08-12 |
mouse |
| Erik G Jönsson, Peter Saetre, Maria Vares, Dimitrios Andreou, Kristina Larsson, Sally Timm, Henrik B Rasmussen, Srdjan Djurovic, Ingrid Melle, Ole A Andreassen, Ingrid Agartz, Thomas Werge, Håkan Hall, Lars Tereniu. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. Neuropsychobiology. vol 59. issue 3. 2009-09-16. PMID:19439994. |
dtnbp1, nrg1, daoa, dao and grm3 polymorphisms and schizophrenia: an association study. |
2009-09-16 |
2023-08-12 |
Not clear |
| Erik G Jönsson, Peter Saetre, Maria Vares, Dimitrios Andreou, Kristina Larsson, Sally Timm, Henrik B Rasmussen, Srdjan Djurovic, Ingrid Melle, Ole A Andreassen, Ingrid Agartz, Thomas Werge, Håkan Hall, Lars Tereniu. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. Neuropsychobiology. vol 59. issue 3. 2009-09-16. PMID:19439994. |
several studies of the dystrobrevin-binding protein 1 gene (dtnbp1), neuregulin 1 (nrg1), d-amino-acid oxidase (dao), dao activator (daoa, g72), and metabotropic glutamate receptor 3 (grm3) genes have suggested an association between variants of these genes and schizophrenia. |
2009-09-16 |
2023-08-12 |
Not clear |
| Yann Le Strat, Nicolas Ramoz, Philip Gorwoo. The role of genes involved in neuroplasticity and neurogenesis in the observation of a gene-environment interaction (GxE) in schizophrenia. Current molecular medicine. vol 9. issue 4. 2009-08-28. PMID:19519407. |
several candidate genes have been suggested, with the strongest evidences for genes encoding dystrobrevin binding protein 1 (dtnbp1), neuregulin 1 (nrg1), neuregulin 1 receptor (erbb4) and disrupted in schizophrenia 1 (disc1), as well as several neurotrophic factors. |
2009-08-28 |
2023-08-12 |
Not clear |
| Y G Gong, C N Wu, Q H Xing, X Z Zhao, J Zhu, L H. A two-method meta-analysis of Neuregulin 1(NRG1) association and heterogeneity in schizophrenia. Schizophrenia research. vol 111. issue 1-3. 2009-08-25. PMID:19362450. |
a two-method meta-analysis of neuregulin 1(nrg1) association and heterogeneity in schizophrenia. |
2009-08-25 |
2023-08-12 |
Not clear |
| Y G Gong, C N Wu, Q H Xing, X Z Zhao, J Zhu, L H. A two-method meta-analysis of Neuregulin 1(NRG1) association and heterogeneity in schizophrenia. Schizophrenia research. vol 111. issue 1-3. 2009-08-25. PMID:19362450. |
nrg1 is one of the most researched genes associated with schizophrenia. |
2009-08-25 |
2023-08-12 |
Not clear |
| Y G Gong, C N Wu, Q H Xing, X Z Zhao, J Zhu, L H. A two-method meta-analysis of Neuregulin 1(NRG1) association and heterogeneity in schizophrenia. Schizophrenia research. vol 111. issue 1-3. 2009-08-25. PMID:19362450. |
the study reveals that one snp of the nrg1 gene does not contribute significantly to schizophrenia and that population stratification is evident. |
2009-08-25 |
2023-08-12 |
Not clear |
| Maaike Alaerts, Shana Ceulemans, Diego Forero, Lotte N Moens, Sonia De Zutter, Lien Heyrman, An-Sofie Lenaerts, Karl-Fredrik Norrback, Peter De Rijk, Lars-Göran Nilsson, Dirk Goossens, Rolf Adolfsson, Jurgen Del-Faver. Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population. Archives of general psychiatry. vol 66. issue 8. 2009-08-11. PMID:19652122. |
support for nrg1 as a susceptibility factor for schizophrenia in a northern swedish isolated population. |
2009-08-11 |
2023-08-12 |
Not clear |
| Maaike Alaerts, Shana Ceulemans, Diego Forero, Lotte N Moens, Sonia De Zutter, Lien Heyrman, An-Sofie Lenaerts, Karl-Fredrik Norrback, Peter De Rijk, Lars-Göran Nilsson, Dirk Goossens, Rolf Adolfsson, Jurgen Del-Faver. Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population. Archives of general psychiatry. vol 66. issue 8. 2009-08-11. PMID:19652122. |
neuregulin 1 (nrg1), a growth factor involved in neurodevelopment, myelination, neurotransmitter receptor expression, and synaptic plasticity, first joined the list of candidate genes for schizophrenia when a 7-marker haplotype at the 5' end of the gene (hap(ice)) was shown to be associated with the disorder in the icelandic population. |
2009-08-11 |
2023-08-12 |
Not clear |
| Maaike Alaerts, Shana Ceulemans, Diego Forero, Lotte N Moens, Sonia De Zutter, Lien Heyrman, An-Sofie Lenaerts, Karl-Fredrik Norrback, Peter De Rijk, Lars-Göran Nilsson, Dirk Goossens, Rolf Adolfsson, Jurgen Del-Faver. Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population. Archives of general psychiatry. vol 66. issue 8. 2009-08-11. PMID:19652122. |
since then, more genetic and functional evidence has emerged, which supports a role for nrg1 in the development of schizophrenia. |
2009-08-11 |
2023-08-12 |
Not clear |
| Fei Wang, Tianzi Jiang, Zhiguo Sun, Siew-Leng Teng, Xingguang Luo, Zhongjun Zhu, Yufeng Zang, Handi Zhang, Weihua Yue, Mei Qu, Tianlan Lu, Nan Hong, Haiyan Huang, Hilary P Blumberg, Dai Zhan. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. Journal of psychiatry & neuroscience : JPN. vol 34. issue 3. 2009-07-30. PMID:19448847. |
neuregulin1 (nrg1) influences the development of white matter connectivity and is implicated in genetic susceptibility to schizophrenia. |
2009-07-30 |
2023-08-12 |
human |