| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy Hall, Heather C Whalley, Dominic E Job, Ben J Baig, Andrew M McIntosh, Kathryn L Evans, Pippa A Thomson, David J Porteous, David G Cunningham-Owens, Eve C Johnstone, Stephen M Lawri. A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nature neuroscience. vol 9. issue 12. 2007-02-20. PMID:17072305. |
here we investigate the effects of a variant in the human nrg1 promoter region in subjects at high risk of schizophrenia. |
2007-02-20 |
2023-08-12 |
human |
| Paul D Morrison, Lyn S Pilowsk. Schizophrenia: more evidence for less glutamate. Expert review of neurotherapeutics. vol 7. issue 1. 2007-01-16. PMID:17187494. |
this is important given that nrg1 is a convincing susceptibility gene in schizophrenia. |
2007-01-16 |
2023-08-12 |
Not clear |
| Lyudmila Georgieva, Valentina Moskvina, Tim Peirce, Nadine Norton, Nicholas J Bray, Lesley Jones, Peter Holmans, Stuart Macgregor, Stanley Zammit, Jennifer Wilkinson, Hywel Williams, Ivan Nikolov, Nigel Williams, Dobril Ivanov, Kenneth L Davis, Vahram Haroutunian, Joseph D Buxbaum, Nick Craddock, George Kirov, Michael J Owen, Michael C O'Donova. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 33. 2006-11-07. PMID:16891421. |
to obtain independent support for this association, we sought evidence for genetic interaction between olig2 and three genes of relevance to oligodendrocyte function for which we have reported evidence for association with schizophrenia: cnp, nrg1, and erbb4. |
2006-11-07 |
2023-08-12 |
mouse |
| M R Munafò, D L Thiselton, T G Clark, J Flin. Association of the NRG1 gene and schizophrenia: a meta-analysis. Molecular psychiatry. vol 11. issue 6. 2006-10-10. PMID:16520822. |
association of the nrg1 gene and schizophrenia: a meta-analysis. |
2006-10-10 |
2023-08-12 |
Not clear |
| M R Munafò, D L Thiselton, T G Clark, J Flin. Association of the NRG1 gene and schizophrenia: a meta-analysis. Molecular psychiatry. vol 11. issue 6. 2006-10-10. PMID:16520822. |
we investigated the association of the nrg1 gene and schizophrenia using meta-analytic techniques, combining all published data while restricting our analysis to studies investigating the most commonly reported single marker (snp8nrg221533). |
2006-10-10 |
2023-08-12 |
Not clear |
| M R Munafò, D L Thiselton, T G Clark, J Flin. Association of the NRG1 gene and schizophrenia: a meta-analysis. Molecular psychiatry. vol 11. issue 6. 2006-10-10. PMID:16520822. |
our meta-analysis provides support for the association of nrg1 with schizophrenia, but indicates that firmly establishing the role of nrg1 gene in schizophrenia by genetic association requires much larger sample sizes than have hitherto been reported. |
2006-10-10 |
2023-08-12 |
Not clear |
| Jane Winantea, My Ngo Hoang, Stefanie Ohlraun, Marcella Rietschel, Sven Cichon, Peter Propping, Markus M Nöthen, Jan Freudenberg, Yun Freudenberg-Hu. A summary statistic approach to sequence variation in noncoding regions of six schizophrenia-associated gene loci. European journal of human genetics : EJHG. vol 14. issue 9. 2006-09-26. PMID:16736033. |
in order to explore the role of noncoding variants in the genetics of schizophrenia, we sequenced 27 kb of noncoding dna from the gene loci rac-alpha serine/threonine-protein kinase (akt1), brain-derived neurotrophic factor (bdnf), dopamine receptor-3 (drd3), dystrobrevin binding protein-1 (dtnbp1), neuregulin-1 (nrg1) and regulator of g-protein signaling-4 (rgs4) in 37 schizophrenia patients and 25 healthy controls. |
2006-09-26 |
2023-08-12 |
Not clear |
| Chang-Gyu Hahn, Hoau-Yan Wang, Dan-Sung Cho, Konrad Talbot, Raquel E Gur, Wade H Berrettini, Kalindi Bakshi, Joshua Kamins, Karin E Borgmann-Winter, Steven J Siegel, Robert J Gallop, Steven E Arnol. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nature medicine. vol 12. issue 7. 2006-09-14. PMID:16767099. |
recent molecular genetics studies implicate neuregulin 1 (nrg1) and its receptor erbb in the pathophysiology of schizophrenia. |
2006-09-14 |
2023-08-12 |
human |
| Chang-Gyu Hahn, Hoau-Yan Wang, Dan-Sung Cho, Konrad Talbot, Raquel E Gur, Wade H Berrettini, Kalindi Bakshi, Joshua Kamins, Karin E Borgmann-Winter, Steven J Siegel, Robert J Gallop, Steven E Arnol. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nature medicine. vol 12. issue 7. 2006-09-14. PMID:16767099. |
levels of nrg1 and erbb4, however, did not differ between schizophrenia and control groups. |
2006-09-14 |
2023-08-12 |
human |
| Chang-Gyu Hahn, Hoau-Yan Wang, Dan-Sung Cho, Konrad Talbot, Raquel E Gur, Wade H Berrettini, Kalindi Bakshi, Joshua Kamins, Karin E Borgmann-Winter, Steven J Siegel, Robert J Gallop, Steven E Arnol. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nature medicine. vol 12. issue 7. 2006-09-14. PMID:16767099. |
therefore, these findings suggest that enhanced nrg1 signaling may contribute to nmda hypofunction in schizophrenia. |
2006-09-14 |
2023-08-12 |
human |
| Paul J Harrison, Amanda J La. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biological psychiatry. vol 60. issue 2. 2006-08-28. PMID:16442083. |
neuregulin 1 (nrg1) is a leading schizophrenia susceptibility gene. |
2006-08-28 |
2023-08-12 |
Not clear |
| Paul J Harrison, Amanda J La. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biological psychiatry. vol 60. issue 2. 2006-08-28. PMID:16442083. |
the nrg1 locus on chromosome 8p shows linkage to the disorder, and genetic association has been found between schizophrenia and various non-coding polymorphisms and haplotypes, especially at the 5' end of the nrg1 gene, in many but not all case-control and family studies. |
2006-08-28 |
2023-08-12 |
Not clear |
| Paul J Harrison, Amanda J La. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biological psychiatry. vol 60. issue 2. 2006-08-28. PMID:16442083. |
understanding the neurobiology of nrg1 and its involvement in schizophrenia is challenged by the complexity of the gene, which gives rise to multiple functionally distinct isoforms, including six "types" of nrg1 defined by 5' exon usage. |
2006-08-28 |
2023-08-12 |
Not clear |
| Paul J Harrison, Amanda J La. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biological psychiatry. vol 60. issue 2. 2006-08-28. PMID:16442083. |
we review the structure and functions of nrg1, consider the evidence for and against it being a schizophrenia susceptibility gene, and discuss mechanisms that might underlie the contribution of nrg1 to disease pathophysiology. |
2006-08-28 |
2023-08-12 |
Not clear |
| Károly Mirnics, Pat Levitt, David A Lewi. Critical appraisal of DNA microarrays in psychiatric genomics. Biological psychiatry. vol 60. issue 2. 2006-08-28. PMID:16616896. |
for example, gad67, rgs4, dtnbp1, nrg1, and gabrab2 show expression alterations in the postmortem brain of subjects with schizophrenia, and these genes have been also implicated as putative, heritable schizophrenia susceptibility genes. |
2006-08-28 |
2023-08-12 |
human |
| Dawei Li, David A Collier, Lin H. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Human molecular genetics. vol 15. issue 12. 2006-08-10. PMID:16687441. |
meta-analysis shows strong positive association of the neuregulin 1 (nrg1) gene with schizophrenia. |
2006-08-10 |
2023-08-12 |
Not clear |
| Wolfgang Maier, Astrid Zobel, Kai-Uwe Küh. Clinical impact of recently detected susceptibility genes for schizophrenia. Dialogues in clinical neuroscience. vol 8. issue 1. 2006-06-28. PMID:16640117. |
thus, there are now at least three very strong candidates: the gene for dysbindin (dtnbp1), the gene for neuregulin-1 (nrg1), and a less well-understood gene locus, g72/g30, which are likely to influence manifestations of schizophrenia. |
2006-06-28 |
2023-08-12 |
Not clear |
| Amanda J Law, Barbara K Lipska, Cynthia Shannon Weickert, Thomas M Hyde, Richard E Straub, Ryota Hashimoto, Paul J Harrison, Joel E Kleinman, Daniel R Weinberge. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 17. 2006-06-15. PMID:16618933. |
genetic variation in neuregulin 1 (nrg1) is associated with schizophrenia. |
2006-06-15 |
2023-08-12 |
human |
| Amanda J Law, Barbara K Lipska, Cynthia Shannon Weickert, Thomas M Hyde, Richard E Straub, Ryota Hashimoto, Paul J Harrison, Joel E Kleinman, Daniel R Weinberge. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 17. 2006-06-15. PMID:16618933. |
these data implicate variation in isoform expression as a molecular mechanism for the genetic association of nrg1 with schizophrenia. |
2006-06-15 |
2023-08-12 |
human |
| Nagafumi Doi, Chie Usu. Are high-risk haplotypes in DTNBP1 and NRG1 resistance genes for schizophrenia? The American journal of psychiatry. vol 163. issue 5. 2006-06-12. PMID:16648345. |
are high-risk haplotypes in dtnbp1 and nrg1 resistance genes for schizophrenia? |
2006-06-12 |
2023-08-12 |
Not clear |