| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nikolaos Smyrnis, Emmanouil Kattoulas, Nicholas C Stefanis, Dimitrios Avramopoulos, Costas N Stefanis, Ioannis Evdokimidi. Schizophrenia-related neuregulin-1 single-nucleotide polymorphisms lead to deficient smooth eye pursuit in a large sample of young men. Schizophrenia bulletin. vol 37. issue 4. 2011-11-14. PMID:19965935. |
neuregulin-1 (nrg1) variations have been shown to modulate schizophrenia candidate endophenotypes related to brain structure and function. |
2011-11-14 |
2023-08-12 |
Not clear |
| Nikolaos Smyrnis, Emmanouil Kattoulas, Nicholas C Stefanis, Dimitrios Avramopoulos, Costas N Stefanis, Ioannis Evdokimidi. Schizophrenia-related neuregulin-1 single-nucleotide polymorphisms lead to deficient smooth eye pursuit in a large sample of young men. Schizophrenia bulletin. vol 37. issue 4. 2011-11-14. PMID:19965935. |
the aim of this study was to determine the effect of nrg1 on several oculomotor schizophrenia endophenotypes. |
2011-11-14 |
2023-08-12 |
Not clear |
| Malcolm W Nason, Avishek Adhikari, Marjan Bozinoski, Joshua A Gordon, Lorna W Rol. Disrupted activity in the hippocampal-accumbens circuit of type III neuregulin 1 mutant mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 2. 2011-11-14. PMID:20927045. |
neuregulin 1 (nrg1), a schizophrenia susceptibility gene, is involved in fundamental aspects of neurodevelopment. |
2011-11-14 |
2023-08-12 |
mouse |
| T Karl, T H J Burne, M Van den Buuse, R Cheswort. Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit? Behavioural brain research. vol 223. issue 2. 2011-10-24. PMID:21605597. |
evidence suggests that the heterozygous transmembrane domain mutant mouse model for the schizophrenia candidate gene neuregulin 1 (nrg1 het) exhibits a deficit in prepulse inhibition (ppi). |
2011-10-24 |
2023-08-12 |
mouse |
| S B Taylor, A R Taylor, J A Markham, A M Geurts, B Z Kanaskie, J I Koeni. Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. Physiology & behavior. vol 104. issue 2. 2011-10-14. PMID:21092742. |
neuregulin 1 (nrg1) is a susceptibility gene for schizophrenia and is also associated with psychotic bipolar disorder. |
2011-10-14 |
2023-08-12 |
rat |
| Fernando S Goes, Michael Rongione, Yun-Ching Chen, Rachel Karchin, Eran Elhaik, James B Potas. Exonic DNA sequencing of ERBB4 in bipolar disorder. PloS one. vol 6. issue 5. 2011-09-29. PMID:21637803. |
however, recent genome-wide association analyses have not provided evidence for common variation in nrg1 or erbb4 influencing schizophrenia or bipolar disorder susceptibility. |
2011-09-29 |
2023-08-12 |
Not clear |
| Beatriz Rico, Oscar Marí. Neuregulin signaling, cortical circuitry development and schizophrenia. Current opinion in genetics & development. vol 21. issue 3. 2011-09-16. PMID:21295966. |
neuregulin-1 (nrg1) and its receptor erbb4 are encoded by genes that have been repeatedly linked to schizophrenia. |
2011-09-16 |
2023-08-12 |
mouse |
| M V Alfimova, L I Abramova, E V Aksenova, S A Golubev, L F Frolova, T K Ganisheva, T K Shemiakina, V A Orlov, V E Golimbe. [The association between the NRG1 gene polymorphism and cognitive functions in patients with schizophrenia and healthy controls]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 111. issue 6. 2011-09-15. PMID:21716252. |
[the association between the nrg1 gene polymorphism and cognitive functions in patients with schizophrenia and healthy controls]. |
2011-09-15 |
2023-08-12 |
Not clear |
| M V Alfimova, L I Abramova, E V Aksenova, S A Golubev, L F Frolova, T K Ganisheva, T K Shemiakina, V A Orlov, V E Golimbe. [The association between the NRG1 gene polymorphism and cognitive functions in patients with schizophrenia and healthy controls]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 111. issue 6. 2011-09-15. PMID:21716252. |
nrg1 is a strong candidate for schizophrenia though its role in the pathogenesis of the disease remains unknown. |
2011-09-15 |
2023-08-12 |
Not clear |
| M V Alfimova, L I Abramova, E V Aksenova, S A Golubev, L F Frolova, T K Ganisheva, T K Shemiakina, V A Orlov, V E Golimbe. [The association between the NRG1 gene polymorphism and cognitive functions in patients with schizophrenia and healthy controls]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 111. issue 6. 2011-09-15. PMID:21716252. |
one of the approaches to study mechanisms underlying the association between nrg1 and schizophrenia is to investigate the association between a gene and an endophenotype of schizophrenia, e.g., cognitive dysfunctions. |
2011-09-15 |
2023-08-12 |
Not clear |
| Amy E Geddes, Xu-Feng Huang, Kelly A Newel. Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21371516. |
both the n-methyl-d-aspartate receptor (nmdar) and neuregulin1 (nrg1) are key molecules involved in normal brain development that have been linked to schizophrenia pathology and aetiology. |
2011-09-13 |
2023-08-12 |
human |
| Amy E Geddes, Xu-Feng Huang, Kelly A Newel. Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21371516. |
altered nr2 gene and protein expression has been found in human post-mortem schizophrenia brain tissue together with changes in nrg1 and its receptor erbb4. |
2011-09-13 |
2023-08-12 |
human |
| Amy E Geddes, Xu-Feng Huang, Kelly A Newel. Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21371516. |
however little is known about the possible effects of nmdar dysfunction on nrg1 signalling, which is important with regards to schizophrenia aetiology as numerous risk factors for the disorder can alter nmdar functioning during early brain development. |
2011-09-13 |
2023-08-12 |
human |
| Amy E Geddes, Xu-Feng Huang, Kelly A Newel. Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21371516. |
this review focuses on the role of the nmda receptor subunits and nrg1 signalling in schizophrenia and proposes a mechanism by which a disruption to the nmdar, particularly via altering the balance of nr2 subunits during early development, could influence nrg1 signalling. |
2011-09-13 |
2023-08-12 |
human |
| Bo Pan, Xu-Feng Huang, Chao Den. Antipsychotic treatment and neuregulin 1-ErbB4 signalling in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21513767. |
evidence from genetic, transgenic and post-mortem studies has strongly supported the critical role that neuregulin 1 (nrg1) and its erbb4 receptor plays in the pathophysiology of schizophrenia. |
2011-09-13 |
2023-08-12 |
mouse |
| Xihui Liu, Ryan Bates, Dong-Min Yin, Chengyong Shen, Fay Wang, Nan Su, Sergei A Kirov, Yuling Luo, Jian-Zhi Wang, Wen-Cheng Xiong, Lin Me. Specific regulation of NRG1 isoform expression by neuronal activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 23. 2011-09-01. PMID:21653853. |
these results indicate that expression of nrg1 isoforms is regulated by distinct mechanisms, which may contribute to versatile functions of nrg1 and pathologic mechanisms of brain disorders such as schizophrenia. |
2011-09-01 |
2023-08-12 |
human |
| Sheryl S Moy, H Troy Ghashghaei, Randal J Nonneman, Jill M Weimer, Yukako Yokota, Daekee Lee, Cary Lai, David W Threadgill, E S Anto. Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia. Journal of neurodevelopmental disorders. vol 1. issue 4. 2011-07-14. PMID:21547722. |
nrg1 and its receptors, erbb3 and erbb4, have been implicated in genetic susceptibility for schizophrenia. |
2011-07-14 |
2023-08-12 |
mouse |
| Sergi Papiol, Martin Begemann, Albert Rosenberger, Heidi Friedrichs, Katja Ribbe, Sabrina Grube, Markus H Schwab, Henriette Jahn, Stefan Gunkel, Fritz Benseler, Klaus-Armin Nave, Hannelore Ehrenreic. A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 3. 2011-07-12. PMID:21234898. |
by pure endpoint diagnosis of the disease, the risk of developing schizophrenia has been repeatedly associated with specific variants of the neuregulin1 (nrg1) gene. |
2011-07-12 |
2023-08-12 |
mouse |
| Sergi Papiol, Martin Begemann, Albert Rosenberger, Heidi Friedrichs, Katja Ribbe, Sabrina Grube, Markus H Schwab, Henriette Jahn, Stefan Gunkel, Fritz Benseler, Klaus-Armin Nave, Hannelore Ehrenreic. A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 3. 2011-07-12. PMID:21234898. |
however, the role of nrg1 in the etiology of schizophrenia has remained unclear. |
2011-07-12 |
2023-08-12 |
mouse |
| Sergi Papiol, Martin Begemann, Albert Rosenberger, Heidi Friedrichs, Katja Ribbe, Sabrina Grube, Markus H Schwab, Henriette Jahn, Stefan Gunkel, Fritz Benseler, Klaus-Armin Nave, Hannelore Ehrenreic. A phenotype-based genetic association study reveals the contribution of neuregulin1 gene variants to age of onset and positive symptom severity in schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 3. 2011-07-12. PMID:21234898. |
we analyzed 1,071 comprehensively phenotyped schizophrenic/schizoaffective patients, diagnosed according to dsm-iv-tr, from the gras (göttingen research association for schizophrenia) data collection for genetic variability in the icelandic region of risk in the nrg1 gene. |
2011-07-12 |
2023-08-12 |
mouse |