| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Chen, Jianhua Chen, Ke Huang, Weidong Ji, Ti Wang, Tao Li, Yang Wang, Hankun Wang, Lin He, Guoyin Feng, Yongyong Sh. Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population. Progress in neuro-psychopharmacology & biological psychiatry. vol 36. issue 1. 2012-08-20. PMID:21993442. |
neuregulin-1 (nrg1) is associated with schizophrenia. |
2012-08-20 |
2023-08-12 |
Not clear |
| Peng Chen, Jianhua Chen, Ke Huang, Weidong Ji, Ti Wang, Tao Li, Yang Wang, Hankun Wang, Lin He, Guoyin Feng, Yongyong Sh. Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population. Progress in neuro-psychopharmacology & biological psychiatry. vol 36. issue 1. 2012-08-20. PMID:21993442. |
as one of the receptors of nrg1, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (erbb4) has also been reported to be associated with schizophrenia. |
2012-08-20 |
2023-08-12 |
Not clear |
| Thomas W Rösler, Candan Depboylu, Oscar Arias-Carrión, Wojciech Wozny, Thomas Carlsson, Matthias Höllerhage, Wolfgang H Oertel, André Schrattenholz, Günter U Höglinge. Biodistribution and brain permeability of the extracellular domain of neuregulin-1-β1. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21903113. |
genetic association of nrg1 within brain disorders such as alzheimer's disease, schizophrenia and neuroprotective properties of certain nrg1 isoforms have led to a variety of studies in corresponding disease models. |
2012-08-01 |
2023-08-12 |
mouse |
| András Szamosi, Oguz Kelemen, Szabolcs Kér. Hippocampal volume and the AKT signaling system in first-episode schizophrenia. Journal of psychiatric research. vol 46. issue 3. 2012-07-23. PMID:22209534. |
evidence suggests that neuregulin 1 (nrg1) induces decreased akt phosphorylation in schizophrenia relative to healthy controls, which may be related to dysfunctional neurodevelopment and neuroplasticity. |
2012-07-23 |
2023-08-12 |
Not clear |
| András Szamosi, Oguz Kelemen, Szabolcs Kér. Hippocampal volume and the AKT signaling system in first-episode schizophrenia. Journal of psychiatric research. vol 46. issue 3. 2012-07-23. PMID:22209534. |
the aim of this study was to investigate the relationship between nrg1--induced akt phosphorylation and hippocampal volume in schizophrenia. |
2012-07-23 |
2023-08-12 |
Not clear |
| Jessica L Yokley, Konasale M Prasad, Kodavali V Chowdari, Michael E Talkowski, Joel Wood, Ruben C Gur, Raquel E Gur, Laura Almasy, Vishwajit L Nimgaonkar, Michael F Pogue-Geil. Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families. Psychiatric genetics. vol 22. issue 2. 2012-06-22. PMID:22183611. |
recent work shows promising associations between schizophrenia and polymorphisms in neuregulin-1 (nrg1) and a large literature also finds strong familial relationships between schizophrenia and cognitive deficits. |
2012-06-22 |
2023-08-12 |
Not clear |
| Jessica L Yokley, Konasale M Prasad, Kodavali V Chowdari, Michael E Talkowski, Joel Wood, Ruben C Gur, Raquel E Gur, Laura Almasy, Vishwajit L Nimgaonkar, Michael F Pogue-Geil. Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families. Psychiatric genetics. vol 22. issue 2. 2012-06-22. PMID:22183611. |
given the role of nrg1 in glutamate regulation and glutamate's effect on cognition, we hypothesized that cognitive deficits may be related to variation within nrg1, providing a possible mechanism to increase risk for schizophrenia. |
2012-06-22 |
2023-08-12 |
Not clear |
| Tiffany A Greenwood, Gregory A Light, Neal R Swerdlow, Allen D Radant, David L Braf. Association analysis of 94 candidate genes and schizophrenia-related endophenotypes. PloS one. vol 7. issue 1. 2012-05-29. PMID:22253750. |
among these genes were erbb4 and nrg1, providing further support for a role of these genes in schizophrenia susceptibility. |
2012-05-29 |
2023-08-12 |
human |
| Jörg Neddens, Andrés Buonann. Expression of the neuregulin receptor ErbB4 in the brain of the rhesus monkey (Macaca mulatta). PloS one. vol 6. issue 11. 2012-05-18. PMID:22087295. |
this interpretation is functionally consistent with the genetic association of nrg1 and erbb4 with schizophrenia. |
2012-05-18 |
2023-08-12 |
monkey |
| Hong-xing Zhang, Wen-qiang Li, Hai-san Zhang, Yan Zhang, Jing-ping Zhao, Lu-xian Lv, Ge Yan. [Expressional changes of neuregulin-1 gene mRNA in peripheral blood from schizophrenia patients]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 28. issue 6. 2012-04-12. PMID:22161091. |
to explore the effect of anti-psychotic treatment on the expression of neuregulin-1 (nrg1) mrna in the peripheral blood lymphocytes of schizophrenia patients. |
2012-04-12 |
2023-08-12 |
Not clear |
| June G Allison, Partha M Das, Jingjing Ma, Fiona M Inglis, Frank E Jone. The ERBB4 intracellular domain (4ICD) regulates NRG1-induced gene expression in hippocampal neurons. Neuroscience research. vol 70. issue 2. 2012-04-09. PMID:21352860. |
the nrg1 growth factor and erbb4 receptor have been identified as leading schizophrenia risk genes. |
2012-04-09 |
2023-08-12 |
rat |
| Andrea Vereczkei, Karoly Mirnic. Genetic predisposition to schizophrenia: what did we learn and what does the future hold? Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 13. issue 4. 2012-03-20. PMID:22184188. |
vulnerability in disc1, nrg1, dtnbp1, rgs4, kcnh2, comt, akt1 and other putative schizophrenia genes, together with copy number variants, leave unexplained the vast majority of diseased cases. |
2012-03-20 |
2023-08-12 |
Not clear |
| M R Bennet. Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss. Progress in neurobiology. vol 95. issue 3. 2012-03-01. PMID:21907759. |
several molecules such as neuregulin-1 (nrg1) and its erbb4 receptor are encoded by candidate susceptibility genes for schizophrenia. |
2012-03-01 |
2023-08-12 |
Not clear |
| Rose Chesworth, Laura Downey, Warren Logge, Simon Killcross, Tim Kar. Cognition in female transmembrane domain neuregulin 1 mutant mice. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21944941. |
neuregulin 1 (nrg1) has been implicated in the development of schizophrenia and influences key neurodevelopmental processes such as myelination and neuronal migration. |
2012-02-09 |
2023-08-12 |
mouse |
| Rose Chesworth, Laura Downey, Warren Logge, Simon Killcross, Tim Kar. Cognition in female transmembrane domain neuregulin 1 mutant mice. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21944941. |
the heterozygous transmembrane domain nrg1 mutant mouse (nrg1 tm het) exhibits a sex-specific phenotype relevant for schizophrenia research, which is characterized by the development of locomotor hyperactivity, social withdrawal, and changes to the serotonergic system. |
2012-02-09 |
2023-08-12 |
mouse |
| Rose Chesworth, Laura Downey, Warren Logge, Simon Killcross, Tim Kar. Cognition in female transmembrane domain neuregulin 1 mutant mice. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21944941. |
cognitive impairments are characteristic of schizophrenia patients and male nrg1 tm het mice exhibit cognitive deficits in novel object recognition and contextual fear conditioning. |
2012-02-09 |
2023-08-12 |
mouse |
| Aurélie A Boucher, Glenn E Hunt, Jacques Micheau, Xufeng Huang, Iain S McGregor, Tim Karl, Jonathon C Arnol. The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. The international journal of neuropsychopharmacology. vol 14. issue 5. 2012-01-06. PMID:20701826. |
in this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (nrg1) modulates the development of tolerance to cannabinoids in mice. |
2012-01-06 |
2023-08-12 |
mouse |
| Emily Moon, Brandi Rollins, Andrea Mesén, Adolfo Sequeira, Richard M Myers, Huda Akil, Stanley J Watson, Jack Barchas, Edward G Jones, Alan Schatzberg, William E Bunney, Lynn E DeLisi, William Byerley, Marquis P Vawte. Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population. Schizophrenia research. vol 131. issue 1-3. 2011-12-23. PMID:21745728. |
lack of association to a nrg1 missense polymorphism in schizophrenia or bipolar disorder in a costa rican population. |
2011-12-23 |
2023-08-12 |
human |
| Emily Moon, Brandi Rollins, Andrea Mesén, Adolfo Sequeira, Richard M Myers, Huda Akil, Stanley J Watson, Jack Barchas, Edward G Jones, Alan Schatzberg, William E Bunney, Lynn E DeLisi, William Byerley, Marquis P Vawte. Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population. Schizophrenia research. vol 131. issue 1-3. 2011-12-23. PMID:21745728. |
a missense polymorphism in the nrg1 gene, val>leu in exon 11, was reported to increase the risk of schizophrenia in selected families from the central valley region of costa rica (cvcr). |
2011-12-23 |
2023-08-12 |
human |
| Emily Moon, Brandi Rollins, Andrea Mesén, Adolfo Sequeira, Richard M Myers, Huda Akil, Stanley J Watson, Jack Barchas, Edward G Jones, Alan Schatzberg, William E Bunney, Lynn E DeLisi, William Byerley, Marquis P Vawte. Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population. Schizophrenia research. vol 131. issue 1-3. 2011-12-23. PMID:21745728. |
subjects with bipolar disorder (bd, n=358), schizophrenia (sz, n=273), or unrelated controls (co, n=479) were genotyped for three nrg1 variants. |
2011-12-23 |
2023-08-12 |
human |