| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rukhsana Nawaz, Huma Asif, Asifullah Khan, Hina Ishtiaq, Fatima Shad, Sonia Siddiqu. Drugs targeting SNPrs35753505 of the NRG1 gene may prevent the association of neurological disorder schizophrenia in a Pakistani population. CNS & neurological disorders drug targets. vol 13. issue 9. 2015-08-19. PMID:25106628. |
the neuregulin 1 (nrg1) gene has been associated with schizophrenia in several populations, and all four types of nrg1 genes are linked with neurotransmitters activities. |
2015-08-19 |
2023-08-13 |
Not clear |
| Rukhsana Nawaz, Huma Asif, Asifullah Khan, Hina Ishtiaq, Fatima Shad, Sonia Siddiqu. Drugs targeting SNPrs35753505 of the NRG1 gene may prevent the association of neurological disorder schizophrenia in a Pakistani population. CNS & neurological disorders drug targets. vol 13. issue 9. 2015-08-19. PMID:25106628. |
in this study for the first time we have demonstrated an association between nrg1 mutation and schizophrenia in pakistani population. |
2015-08-19 |
2023-08-13 |
Not clear |
| Rukhsana Nawaz, Huma Asif, Asifullah Khan, Hina Ishtiaq, Fatima Shad, Sonia Siddiqu. Drugs targeting SNPrs35753505 of the NRG1 gene may prevent the association of neurological disorder schizophrenia in a Pakistani population. CNS & neurological disorders drug targets. vol 13. issue 9. 2015-08-19. PMID:25106628. |
our results suggest that snp rs35753505 of nrg1 plays an important role in conferring susceptibility to the schizophrenia in a pakistani population. |
2015-08-19 |
2023-08-13 |
Not clear |
| Chao Deng, Bo Pan, Chang-Hua Hu, Mei Han, Xu-Feng Huan. Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain. Psychiatry research. vol 225. issue 3. 2015-07-30. PMID:25576368. |
neuregulin-1 (nrg1) and erbb4 genes have been identified as candidate genes for schizophrenia. |
2015-07-30 |
2023-08-13 |
human |
| Pietro Fazzari, An Snellinx, Victor Sabanov, Tariq Ahmed, Lutgarde Serneels, Annette Gartner, S Ali M Shariati, Detlef Balschun, Bart De Stroope. Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling. eLife. vol 3. 2015-07-28. PMID:24891237. |
neuregulin 1 (nrg1) and the γ-secretase subunit aph1b have been previously implicated as genetic risk factors for schizophrenia and schizophrenia relevant deficits have been observed in rodent models with loss of function mutations in either gene. |
2015-07-28 |
2023-08-13 |
mouse |
| Pietro Fazzari, An Snellinx, Victor Sabanov, Tariq Ahmed, Lutgarde Serneels, Annette Gartner, S Ali M Shariati, Detlef Balschun, Bart De Stroope. Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling. eLife. vol 3. 2015-07-28. PMID:24891237. |
in conclusion, our study sheds light on the physiological role of aph1b-γ-secretase in brain and provides a new mechanistic perspective on the relevance of nrg1 processing in schizophrenia. |
2015-07-28 |
2023-08-13 |
mouse |
| Sarah Tosato, Martina Zanoni, Chiara Bonetto, Federica Tozzi, Clyde Francks, Elisa Ira, Simona Tomassi, Mariaelena Bertani, Dan Rujescu, Ina Giegling, David St Clair, Michele Tansella, Mirella Ruggeri, Pierandrea Mugli. No association between NRG1 and ErbB4 genes and psychopathological symptoms of schizophrenia. Neuromolecular medicine. vol 16. issue 4. 2015-07-20. PMID:25142529. |
no association between nrg1 and erbb4 genes and psychopathological symptoms of schizophrenia. |
2015-07-20 |
2023-08-13 |
human |
| Sarah Tosato, Martina Zanoni, Chiara Bonetto, Federica Tozzi, Clyde Francks, Elisa Ira, Simona Tomassi, Mariaelena Bertani, Dan Rujescu, Ina Giegling, David St Clair, Michele Tansella, Mirella Ruggeri, Pierandrea Mugli. No association between NRG1 and ErbB4 genes and psychopathological symptoms of schizophrenia. Neuromolecular medicine. vol 16. issue 4. 2015-07-20. PMID:25142529. |
neuregulin 1 (nrg1) and v-erb-a erythroblastic leukemia viral oncogene homolog 4 (erbb4) have been extensively studied in schizophrenia susceptibility because of their pivotal role in key neurodevelopmental processes. |
2015-07-20 |
2023-08-13 |
human |
| Sarah Tosato, Martina Zanoni, Chiara Bonetto, Federica Tozzi, Clyde Francks, Elisa Ira, Simona Tomassi, Mariaelena Bertani, Dan Rujescu, Ina Giegling, David St Clair, Michele Tansella, Mirella Ruggeri, Pierandrea Mugli. No association between NRG1 and ErbB4 genes and psychopathological symptoms of schizophrenia. Neuromolecular medicine. vol 16. issue 4. 2015-07-20. PMID:25142529. |
in the present study we tested, in a large cohort of 461 schizophrenia patients recruited in scotland, whether several snps in nrg1 and/or erbb4 are associated with schizophrenia symptom dimensions as evaluated by the positive and negative syndrome scale (panss). |
2015-07-20 |
2023-08-13 |
human |
| Sarah Tosato, Martina Zanoni, Chiara Bonetto, Federica Tozzi, Clyde Francks, Elisa Ira, Simona Tomassi, Mariaelena Bertani, Dan Rujescu, Ina Giegling, David St Clair, Michele Tansella, Mirella Ruggeri, Pierandrea Mugli. No association between NRG1 and ErbB4 genes and psychopathological symptoms of schizophrenia. Neuromolecular medicine. vol 16. issue 4. 2015-07-20. PMID:25142529. |
these findings suggest that some regions of nrg1 and erbb4 are functionally involved in biological processes that underlie some of the phenotypic manifestations of schizophrenia. |
2015-07-20 |
2023-08-13 |
human |
| Tariq W Chohan, Aurelie A Boucher, Jarrah R Spencer, Mustafa S Kassem, Areeg A Hamdi, Tim Karl, Sandra Y Fok, Maxwell R Bennett, Jonathon C Arnol. Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice. Schizophrenia bulletin. vol 40. issue 6. 2015-06-19. PMID:24442851. |
genetic variation in neuregulin 1 (nrg1) increases the risk of developing schizophrenia and may help predict which high-risk individuals will transition to psychosis. |
2015-06-19 |
2023-08-12 |
mouse |
| Tariq W Chohan, Aurelie A Boucher, Jarrah R Spencer, Mustafa S Kassem, Areeg A Hamdi, Tim Karl, Sandra Y Fok, Maxwell R Bennett, Jonathon C Arnol. Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice. Schizophrenia bulletin. vol 40. issue 6. 2015-06-19. PMID:24442851. |
nrg1 also modulates sensorimotor gating, a schizophrenia endophenotype. |
2015-06-19 |
2023-08-12 |
mouse |
| Tariq W Chohan, Aurelie A Boucher, Jarrah R Spencer, Mustafa S Kassem, Areeg A Hamdi, Tim Karl, Sandra Y Fok, Maxwell R Bennett, Jonathon C Arnol. Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice. Schizophrenia bulletin. vol 40. issue 6. 2015-06-19. PMID:24442851. |
we used an animal model to demonstrate that partial genetic deletion of nrg1 interacts with stress to promote neurobehavioral deficits of relevance to schizophrenia. |
2015-06-19 |
2023-08-12 |
mouse |
| C O'Leary, L Desbonnet, N Clarke, E Petit, O Tighe, D Lai, R Harvey, J L Waddington, C O'Tuathaig. Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1. Neuroscience. vol 277. 2015-06-08. PMID:24969132. |
neuregulin 1 (nrg1) is a schizophrenia risk gene, hence any interaction with environmental adversity, such as maternal infection, may provide further insights into the basis of the disease. |
2015-06-08 |
2023-08-13 |
mouse |
| C O'Leary, L Desbonnet, N Clarke, E Petit, O Tighe, D Lai, R Harvey, J L Waddington, C O'Tuathaig. Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1. Neuroscience. vol 277. 2015-06-08. PMID:24969132. |
this study examined the individual and combined effects of prenatal immune activation with polyriboinosinic-polyribocytidilic acid (poly i:c) and disruption of the schizophrenia risk gene nrg1 on the expression of behavioral phenotypes related to schizophrenia. |
2015-06-08 |
2023-08-13 |
mouse |
| Amit Agarwal, Mingyue Zhang, Irina Trembak-Duff, Tilmann Unterbarnscheidt, Konstantin Radyushkin, Payam Dibaj, Daniel Martins de Souza, Susann Boretius, Magdalena M Brzózka, Heinz Steffens, Sebastian Berning, Zenghui Teng, Maike N Gummert, Martesa Tantra, Peter C Guest, Katrin I Willig, Jens Frahm, Stefan W Hell, Sabine Bahn, Moritz J Rossner, Klaus-Armin Nave, Hannelore Ehrenreich, Weiqi Zhang, Markus H Schwa. Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity. Cell reports. vol 8. issue 4. 2015-05-26. PMID:25131210. |
neuregulin-1 (nrg1) gene variants are associated with increased genetic risk for schizophrenia. |
2015-05-26 |
2023-08-13 |
mouse |
| Amit Agarwal, Mingyue Zhang, Irina Trembak-Duff, Tilmann Unterbarnscheidt, Konstantin Radyushkin, Payam Dibaj, Daniel Martins de Souza, Susann Boretius, Magdalena M Brzózka, Heinz Steffens, Sebastian Berning, Zenghui Teng, Maike N Gummert, Martesa Tantra, Peter C Guest, Katrin I Willig, Jens Frahm, Stefan W Hell, Sabine Bahn, Moritz J Rossner, Klaus-Armin Nave, Hannelore Ehrenreich, Weiqi Zhang, Markus H Schwa. Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity. Cell reports. vol 8. issue 4. 2015-05-26. PMID:25131210. |
it is unclear whether risk haplotypes cause elevated or decreased expression of nrg1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. |
2015-05-26 |
2023-08-13 |
mouse |
| W Logge, J Kingham, T Kar. Do individually ventilated cage systems generate a problem for genetic mouse model research? Genes, brain, and behavior. vol 13. issue 7. 2015-05-22. PMID:24920375. |
thus, in this study, we systematically compared the established behavioural phenotype of a validated mouse model for the schizophrenia risk gene neuregulin 1 (tm nrg1 het) kept in filter housing with nrg1 mutant mice raised in ivc systems. |
2015-05-22 |
2023-08-13 |
mouse |
| Xiaoyang Luo, Wanxia He, Xiangyou Hu, Riqiang Ya. Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice. Biological psychiatry. vol 76. issue 2. 2015-02-19. PMID:24210810. |
neuregulin-1 (nrg1) is a pleiotropic signaling molecule that regulates neural development, and mutation of nrg1 is a risk factor for schizophrenia. |
2015-02-19 |
2023-08-12 |
mouse |
| Jonathan C Bean, Thiri W Lin, Anupama Sathyamurthy, Fang Liu, Dong-Min Yin, Wen-Cheng Xiong, Lin Me. Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 40. 2015-01-20. PMID:25274830. |
neuregulin 1 (nrg1) and its receptor erbb4 are schizophrenia risk genes. |
2015-01-20 |
2023-08-13 |
mouse |