| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan C Olaya, Carrie L Heusner, Mitsuyuki Matsumoto, Duncan Sinclair, Mari A Kondo, Tim Karl, Cynthia Shannon Weicker. Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice. Schizophrenia bulletin. vol 44. issue 4. 2019-01-09. PMID:28981869. |
importantly, nrg1 type iii (nrg1 iii) mrna is increased in humans inheriting a schizophrenia risk haplotype for the nrg1 gene (hapice), and nrg1 protein levels can be elevated in schizophrenia. |
2019-01-09 |
2023-08-13 |
mouse |
| Juan C Olaya, Carrie L Heusner, Mitsuyuki Matsumoto, Cynthia Shannon Weickert, Tim Kar. Schizophrenia-relevant behaviours of female mice overexpressing neuregulin 1 type III. Behavioural brain research. vol 353. 2018-11-26. PMID:29559337. |
elevated levels of the type iii (iii) isoforms of neuregulin 1 (nrg1) have been observed in the brains of schizophrenia patients that carry nrg1 hap |
2018-11-26 |
2023-08-13 |
mouse |
| Harleen Chhabra, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anushree Bose, Sri Mahavir Agarwal, Vanteemar S Sreeraj, Damodharan Dinakaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramania. Gene polymorphisms and response to transcranial direct current stimulation for auditory verbal hallucinations in schizophrenia. Acta neuropsychiatrica. vol 30. issue 4. 2018-11-15. PMID:29559020. |
of the many snps, nrg1 rs35753505 and catechol-o-methyl transferase (comt) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia. |
2018-11-15 |
2023-08-13 |
Not clear |
| Qingsheng Zhang, Dorna Esrafilzadeh, Jeremy M Crook, Robert Kapsa, Elise M Stewart, Eva Tomaskovic-Crook, Gordon G Wallace, Xu-Feng Huan. Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice. Scientific reports. vol 7. 2018-11-05. PMID:28198409. |
deficits in neurite outgrowth, possibly involving dysregulation of risk genes neuregulin-1 (nrg1) and disrupted in schizophrenia 1 (disc1) have been implicated in psychiatric disorders including schizophrenia. |
2018-11-05 |
2023-08-13 |
mouse |
| Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana, Suresh Sundram, Cynthia Shannon Weickert, Christos Pantelis, Ian Everall, Chad Bousma. Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients. Translational psychiatry. vol 7. issue 12. 2018-07-13. PMID:29225331. |
elevated peripheral expression of neuregulin-1 (nrg1) mrna isoforms in clozapine-treated schizophrenia patients. |
2018-07-13 |
2023-08-13 |
Not clear |
| Colm M P O'Tuathaigh, Naina Mathur, Matthew J O'Callaghan, Lynsey MacIntyre, Richard Harvey, Donna Lai, John L Waddington, Benjamin S Pickard, David G Watson, Paula M Mora. Specialized Information Processing Deficits and Distinct Metabolomic Profiles Following TM-Domain Disruption of Nrg1. Schizophrenia bulletin. vol 43. issue 5. 2018-05-28. PMID:28338897. |
mutant mice containing disruption of the transmembrane (tm) domain of the nrg1 gene constitute a heuristic model for dysregulation of nrg1-erbb4 signaling in schizophrenia. |
2018-05-28 |
2023-08-13 |
mouse |
| Colm M P O'Tuathaigh, Naina Mathur, Matthew J O'Callaghan, Lynsey MacIntyre, Richard Harvey, Donna Lai, John L Waddington, Benjamin S Pickard, David G Watson, Paula M Mora. Specialized Information Processing Deficits and Distinct Metabolomic Profiles Following TM-Domain Disruption of Nrg1. Schizophrenia bulletin. vol 43. issue 5. 2018-05-28. PMID:28338897. |
across 2 different sites and protocols, nrg1 mutants demonstrated deficits in prepulse inhibition, a measure of sensorimotor gating, that is, disrupted in schizophrenia; these deficits were partially reversed by acute treatment with second, but not first-, generation antipsychotic drugs. |
2018-05-28 |
2023-08-13 |
mouse |
| Colm M P O'Tuathaigh, Naina Mathur, Matthew J O'Callaghan, Lynsey MacIntyre, Richard Harvey, Donna Lai, John L Waddington, Benjamin S Pickard, David G Watson, Paula M Mora. Specialized Information Processing Deficits and Distinct Metabolomic Profiles Following TM-Domain Disruption of Nrg1. Schizophrenia bulletin. vol 43. issue 5. 2018-05-28. PMID:28338897. |
however, nrg1 mutants did not show a specific deficit in latent inhibition, a measure of selective attention that is also disrupted in schizophrenia. |
2018-05-28 |
2023-08-13 |
mouse |
| Michael C Wehr, Wilko Hinrichs, Magdalena M Brzózka, Tilmann Unterbarnscheidt, Alexander Herholt, Jan P Wintgens, Sergi Papiol, Maria Clara Soto-Bernardini, Mykola Kravchenko, Mingyue Zhang, Klaus-Armin Nave, Sven P Wichert, Peter Falkai, Weiqi Zhang, Markus H Schwab, Moritz J Rossne. Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice. EMBO molecular medicine. vol 9. issue 10. 2018-05-24. PMID:28743784. |
transgenic mice overexpressing nrg1 type iii display cortical erbb4 hyperphosphorylation, a condition observed in postmortem brains from schizophrenia patients. |
2018-05-24 |
2023-08-13 |
mouse |
| Aosa Kamezaki, Fuminori Sato, Kazuhiro Aoki, Kazuhide Asakawa, Koichi Kawakami, Fumio Matsuzaki, Atsuko Sehara-Fujisaw. Visualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo. Scientific reports. vol 6. 2018-05-15. PMID:27364328. |
neuregulin1 (nrg1) plays diverse developmental roles and is likely involved in several neurological disorders including schizophrenia. |
2018-05-15 |
2023-08-13 |
zebrafish |
| Lieve Desbonnet, Rachel Cox, Orna Tighe, Donna Lai, Richard P Harvey, John L Waddington, Colm M P O'Tuathaig. Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1. Behavioural brain research. vol 320. 2017-12-26. PMID:27916686. |
simultaneous disruption of the developmental genes and schizophrenia risk factors neuregulin-1 (nrg1) and disrupted-in-schizophrenia 1 (disc1) in mice has been shown to produce disease-relevant and domain-specific phenotypic profiles different from that observed following disruption of either gene alone. |
2017-12-26 |
2023-08-13 |
mouse |
| Silvia Schneider, Katja Götz, Carmen Birchmeier, Herbert Schwegler, Thomas Roskode. Neuregulin-1 mutant mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28089851. |
a relation between nrg1 and schizophrenia is assumed. |
2017-12-01 |
2023-08-13 |
mouse |
| Silvia Schneider, Katja Götz, Carmen Birchmeier, Herbert Schwegler, Thomas Roskode. Neuregulin-1 mutant mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28089851. |
in conclusion, this analyzed nrg1 mutant mice model did not serve as a complete schizophrenia model. |
2017-12-01 |
2023-08-13 |
mouse |
| Silvia Schneider, Katja Götz, Carmen Birchmeier, Herbert Schwegler, Thomas Roskode. Neuregulin-1 mutant mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28089851. |
particular aspects of schizophrenia disease in locomotor and sensory behavior deficits could represent in this nrg1 mutant mice. |
2017-12-01 |
2023-08-13 |
mouse |
| Silvia Schneider, Katja Götz, Carmen Birchmeier, Herbert Schwegler, Thomas Roskode. Neuregulin-1 mutant mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28089851. |
beside several different models could nrg1 deficiency represent an endophenotype of schizophrenia disease. |
2017-12-01 |
2023-08-13 |
mouse |
| M S Mostaid, S G Mancuso, C Liu, S Sundram, C Pantelis, I P Everall, C A Bousma. Meta-analysis reveals associations between genetic variation in the 5' and 3' regions of Neuregulin-1 and schizophrenia. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28094814. |
genetic, post-mortem and neuroimaging studies repeatedly implicate neuregulin-1 (nrg1) as a critical component in the pathophysiology of schizophrenia. |
2017-11-16 |
2023-08-13 |
Not clear |
| M S Mostaid, S G Mancuso, C Liu, S Sundram, C Pantelis, I P Everall, C A Bousma. Meta-analysis reveals associations between genetic variation in the 5' and 3' regions of Neuregulin-1 and schizophrenia. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28094814. |
our results suggest genetic variation at the 5' and 3' ends of nrg1 are associated with schizophrenia and provide renewed justification for further investigation of nrg1's role in the pathophysiology of schizophrenia. |
2017-11-16 |
2023-08-13 |
Not clear |
| Chongbo Zhong, Wendy Akmentin, Chuang Du, Lorna W Role, David A Talmag. Axonal Type III Nrg1 Controls Glutamate Synapse Formation and GluA2 Trafficking in Hippocampal-Accumbens Connections. eNeuro. vol 4. issue 1. 2017-10-30. PMID:28275713. |
altered neuregulin 1 (nrg1)/erbb signaling and glutamatergic hypofunction have been implicated in the pathophysiology of schizophrenia. |
2017-10-30 |
2023-08-13 |
mouse |
| Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousma. Neuregulin-1 and schizophrenia in the genome-wide association study era. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27283360. |
clinical and pre-clinical evidence has implicated neuregulin 1 (nrg1) as a critical component in the pathophysiology of schizophrenia. |
2017-10-24 |
2023-08-13 |
Not clear |
| Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousma. Neuregulin-1 and schizophrenia in the genome-wide association study era. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27283360. |
however, the arrival of the genome-wide association study (gwas) era has yielded results that challenge the relevance of nrg1 in schizophrenia due to the absence of a genome-wide significant nrg1 variant associated with schizophrenia. |
2017-10-24 |
2023-08-13 |
Not clear |