| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| JianZhong Yang, ChuanYuan Kang, Changjiang Wu, Yuanyuan Lin, Lei Zeng, Jing Yuan, Yan Zhang, YuJun Wei, Li Xu, Fang Zho. Pharmacogenetic associations of NRG1 polymorphisms with neurocognitive performance and clinical symptom response to risperidone in the untreated schizophrenia. Schizophrenia research. vol 231. 2021-07-05. PMID:33770628. |
to explore pharmacogenetic relationships of nrg1 genotypes with neurocognitive performance and clinical symptoms after 12 week treatment of risperidone in chinese han first-episode schizophrenia. |
2021-07-05 |
2023-08-13 |
Not clear |
| Jill R Crittenden, Theresa A Gipson, Anne C Smith, Hilary A Bowden, Ferah Yildirim, Kyle B Fischer, Michael Yim, David E Housman, Ann M Graybie. Striatal transcriptome changes linked to drug-induced repetitive behaviors. The European journal of neuroscience. vol 53. issue 8. 2021-06-29. PMID:33759265. |
nrg1 is known to be a schizophrenia and autism susceptibility gene that encodes a ligand for erb-b receptors, which are involved in neuronal migration, myelination, and cell survival, including that of dopamine-containing neurons. |
2021-06-29 |
2023-08-13 |
mouse |
| François Mouton-Liger, Julien Dumurgier, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Hugo Vanderstichele, Eugeen Vanmechelen, Elodie Bouaziz-Amar, Kaj Blennow, Jacques Hugon, Claire Paque. CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32690068. |
the presynaptic protein neuregulin1 (nrg1) is cleaved by beta-site app cleaving enzyme 1 (bace1) in a similar way as amyloid precursor protein (app) nrg1 can activate post-synaptic receptor tyrosine-protein kinase erbb4 (erbb4) and was linked to schizophrenia. |
2021-06-24 |
2023-08-13 |
Not clear |
| Ashwini Rajasekaran, Venkataram Shivakumar, Sunil V Kalmady, Rujuta Parlikar, Harleen Chhabra, Ananya Prabhu, Manjula Subbanna, Deepthi Venugopal, Anekal C Amaresha, Sri Mahavir Agarwal, Anushree Bose, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramania. Impact of NRG1 HapICE gene variants on digit ratio and dermatoglyphic measures in schizophrenia. Asian journal of psychiatry. vol 54. 2021-06-21. PMID:33271685. |
impact of nrg1 hapice gene variants on digit ratio and dermatoglyphic measures in schizophrenia. |
2021-06-21 |
2023-08-13 |
Not clear |
| Ashwini Rajasekaran, Venkataram Shivakumar, Sunil V Kalmady, Rujuta Parlikar, Harleen Chhabra, Ananya Prabhu, Manjula Subbanna, Deepthi Venugopal, Anekal C Amaresha, Sri Mahavir Agarwal, Anushree Bose, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramania. Impact of NRG1 HapICE gene variants on digit ratio and dermatoglyphic measures in schizophrenia. Asian journal of psychiatry. vol 54. 2021-06-21. PMID:33271685. |
multiple lines of evidence have suggested a potential role of neuregulin-1 (nrg1) in the neurodevelopmental pathogenesis of schizophrenia. |
2021-06-21 |
2023-08-13 |
Not clear |
| Ashwini Rajasekaran, Venkataram Shivakumar, Sunil V Kalmady, Rujuta Parlikar, Harleen Chhabra, Ananya Prabhu, Manjula Subbanna, Deepthi Venugopal, Anekal C Amaresha, Sri Mahavir Agarwal, Anushree Bose, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramania. Impact of NRG1 HapICE gene variants on digit ratio and dermatoglyphic measures in schizophrenia. Asian journal of psychiatry. vol 54. 2021-06-21. PMID:33271685. |
we examined the role of two well-replicated polymorphisms of nrg1 (snp8nrg221533 and snp8nrg243177) on schizophrenia risk and its probable impact on the digit ratio and dermatoglyphic measures in patients (n = 221) and healthy controls (n = 200). |
2021-06-21 |
2023-08-13 |
Not clear |
| Ashwini Rajasekaran, Venkataram Shivakumar, Sunil V Kalmady, Rujuta Parlikar, Harleen Chhabra, Ananya Prabhu, Manjula Subbanna, Deepthi Venugopal, Anekal C Amaresha, Sri Mahavir Agarwal, Anushree Bose, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramania. Impact of NRG1 HapICE gene variants on digit ratio and dermatoglyphic measures in schizophrenia. Asian journal of psychiatry. vol 54. 2021-06-21. PMID:33271685. |
in schizophrenia patients, but not in healthy controls, a significant association between nrg1 snp8nrg221533 c/c genotype with lower left 2d:4d ratio, as well as with higher fa_t |
2021-06-21 |
2023-08-13 |
Not clear |
| Miguel Skirzewski, Marie E Cronin, Ricardo Murphy, Wambura Fobbs, Alexxai V Kravitz, Andres Buonann. ErbB4 Null Mice Display Altered Mesocorticolimbic and Nigrostriatal Dopamine Levels as well as Deficits in Cognitive and Motivational Behaviors. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32354758. |
natural genetic variants of neuregulin1 (nrg1) and its cognate receptor erbb4 are associated with a risk for schizophrenia. |
2021-06-18 |
2023-08-13 |
mouse |
| Jia Xu, Cuiping Guo, Yi Liu, Gang Wu, Dan Ke, Qun Wang, Jing Mao, Jian-Zhi Wang, Rong Liu, Xiaochuan Wan. Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32703967. |
increasing evidence indicates that neuregulin 1 (nrg1) plays an important role in psychiatric illnesses, including depression, schizophrenia and bipolar disorder. |
2021-06-18 |
2023-08-13 |
mouse |
| Jitendra Vohr. Sudden Cardiac Death in Schizophrenia: A Review. Heart, lung & circulation. vol 29. issue 10. 2021-05-05. PMID:32800442. |
it also mentions the reported association for nonsynonymous genetic polymorphism rs10503929 within the neuregulin 1 gene (nrg1) and the minor allele c and its role in the risk of sudden cardiac death in schizophrenia. |
2021-05-05 |
2023-08-13 |
Not clear |
| Jerzy Zieba, Margaret J Morris, Cynthia Shannon Weickert, Tim Kar. Behavioural effects of high fat diet in adult Nrg1 type III transgenic mice. Behavioural brain research. vol 377. 2021-04-23. PMID:31499092. |
neuregulin 1 (nrg1) is a risk gene for schizophrenia and a recently developed transgenic mouse model for nrg1 type iii demonstrates a schizophrenia-relevant phenotype. |
2021-04-23 |
2023-08-13 |
mouse |
| Jerzy Zieba, Margaret J Morris, Cynthia Shannon Weickert, Tim Kar. Behavioural effects of high fat diet in adult Nrg1 type III transgenic mice. Behavioural brain research. vol 377. 2021-04-23. PMID:31499092. |
male and female nrg1 iii and control littermates (n = 13-24) were exposed during adulthood to either hfd or standard chow diet (chow) for eight weeks before being tested in behavioural domains relevant to schizophrenia. |
2021-04-23 |
2023-08-13 |
mouse |
| Jerzy Zieba, Margaret J Morris, Cynthia Shannon Weickert, Tim Kar. Behavioural effects of high fat diet in adult Nrg1 type III transgenic mice. Behavioural brain research. vol 377. 2021-04-23. PMID:31499092. |
thus, our preclinical data suggest that genetic predisposition to the schizophrenia risk gene nrg1 may modulate detrimental behavioural effects of diets. |
2021-04-23 |
2023-08-13 |
mouse |
| Yao-Yi Wang, Bing Zhao, Meng-Meng Wu, Xiao-Li Zheng, Longnian Lin, Dong-Min Yi. Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition. Nature communications. vol 12. issue 1. 2021-01-21. PMID:33436636. |
to mimic increased expression of nrg1, a schizophrenia susceptibility gene in gabaergic interneurons from patients with schizophrenia, we generated gtonrg1 mice with overexpression of nrg1 in gabaergic interneurons. |
2021-01-21 |
2023-08-13 |
mouse |
| Zhengrong Zhang, Yuhong Li, Fan He, Yonghua Cui, Yi Zheng, Rena L. Sex differences in circulating neuregulin1-β1 and β-secretase 1 expression in childhood-onset schizophrenia. Comprehensive psychiatry. vol 100. 2020-10-16. PMID:32430144. |
however, circulating neuregulin1-β1 (nrg1-β1), an isoform of nrg1, and its cleavage enzyme bace1 have not been studied in early-onset patients with schizophrenia. |
2020-10-16 |
2023-08-13 |
Not clear |
| Zhengrong Zhang, Jing Huang, Yong Shen, Rena L. BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28993723. |
recent studies have shown that neuregulin-1 (nrg1) is a candidate gene for schizophrenia. |
2020-10-01 |
2023-08-13 |
human |
| Zhengrong Zhang, Jing Huang, Yong Shen, Rena L. BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28993723. |
while changes in nrg1 expression levels in schizophrenia still remain controversial, understanding the bace1-cleaved nrg1-ntf and nrg1/erbb4 signaling in schizophrenia neuropathogenesis is essential and important. |
2020-10-01 |
2023-08-13 |
human |
| Zhengrong Zhang, Jing Huang, Yong Shen, Rena L. BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28993723. |
in this review paper, we included three major parts: (1) nrg1 structure and cleavage pattern by bace1; (2) bace1-dependent nrg1 cleavage associated with schizophrenia in human studies; and (3) animal studies of nrg1 and bace1 mutations with behavioral observations. |
2020-10-01 |
2023-08-13 |
human |
| Zhengrong Zhang, Jing Huang, Yong Shen, Rena L. BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28993723. |
our review will provide a better understanding of nrg1 in schizophrenia and a potential strategy for using bace1 cleavage of nrg1 as a unique biomarker for diagnosis, as well as a new therapeutic target, of schizophrenia. |
2020-10-01 |
2023-08-13 |
human |
| Dan Wang, Tingting Guo, Qi Guo, Shun Zhang, Jinghuan Zhang, Jing Lu. The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects. Frontiers in psychology. vol 10. 2020-10-01. PMID:31649580. |
to further explore the potential genetic link between schizophrenia and creativity, in a sample of 580 healthy han chinese subjects, this study aimed to (1) validate the role of neuregulin 1 (nrg1) rs6994992 (one schizophrenia risk variant that has been previously linked to creativity in the european population) in the relationship between schizophrenia and creativity and (2) explore the associations between 10 other schizophrenia risk variants and creativity. |
2020-10-01 |
2023-08-13 |
human |