| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Venkataramaiah Chintha, Rajendra Wudayagir. Bioavailability and Neuroprotectivity of 3-(3, 4-dimethoxy phenyl)-1-4 (methoxy phenyl) prop-2-en-1-one against Schizophrenia: an Journal of receptor and signal transduction research. vol 39. issue 5-6. 2020-06-17. PMID:31829066. |
in addition mutations in genes other than the dopa genes such as rgs4, nrg1, comt, akt1 and dtnbp1 (set 2) have also been implicated in the pathogenesis of schizophrenia. |
2020-06-17 |
2023-08-13 |
Not clear |
| D Fleck, A N Garratt, C Haass, M Wille. BACE1 Dependent Neuregulin Proteolysis. Current Alzheimer research. 2019-11-20. PMID:21605034. |
there is strong evidence that deregulation of nrg1 is involved in breast cancer and schizophrenia. |
2019-11-20 |
2023-08-12 |
mouse |
| Paula Suárez-Pinilla, Roberto Roíz-Santiañez, Ignacio Mata, Victor Ortiz-García de la Foz, Paolo Brambilla, Lourdes Fañanas, Natalia Valle-San Román, Benedicto Crespo-Facorr. Progressive Structural Brain Changes and NRG1 Gene Variants in First-Episode Nonaffective Psychosis. Neuropsychobiology. vol 71. issue 2. 2019-11-20. PMID:25871612. |
the neuregulin 1 gene (nrg1), influencing neurodevelopment and neuroplasticity, has been associated with schizophrenia. |
2019-11-20 |
2023-08-13 |
Not clear |
| Vinita Jagannath, Miriam Gerstenberg, Christoph U Correll, Susanne Walitza, Edna Grünblat. A systematic meta-analysis of the association of Neuregulin 1 (NRG1), D-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 1. 2019-09-30. PMID:28864885. |
a systematic meta-analysis of the association of neuregulin 1 (nrg1), d-amino acid oxidase (dao), and dao activator (daoa)/g72 polymorphisms with schizophrenia. |
2019-09-30 |
2023-08-13 |
Not clear |
| Vinita Jagannath, Miriam Gerstenberg, Christoph U Correll, Susanne Walitza, Edna Grünblat. A systematic meta-analysis of the association of Neuregulin 1 (NRG1), D-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 1. 2019-09-30. PMID:28864885. |
the glutamate hypothesis of schizophrenia is related to the proposed dysregulation of d-amino acid oxidase (dao), dao activator (daoa)/g72, and neuregulin 1 (nrg1) genes. |
2019-09-30 |
2023-08-13 |
Not clear |
| Vinita Jagannath, Miriam Gerstenberg, Christoph U Correll, Susanne Walitza, Edna Grünblat. A systematic meta-analysis of the association of Neuregulin 1 (NRG1), D-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 1. 2019-09-30. PMID:28864885. |
genetic studies have shown significant associations between dao, daoa, nrg1 single-nucleotide polymorphisms (snps), and schizophrenia. |
2019-09-30 |
2023-08-13 |
Not clear |
| Vinita Jagannath, Miriam Gerstenberg, Christoph U Correll, Susanne Walitza, Edna Grünblat. A systematic meta-analysis of the association of Neuregulin 1 (NRG1), D-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 1. 2019-09-30. PMID:28864885. |
we conducted meta-analyses of 20, 23, and 48 case-control studies, respectively, to comprehensively evaluate the association of 8 dao, 12 daoa, and 14 nrg1 snps with schizophrenia. |
2019-09-30 |
2023-08-13 |
Not clear |
| Vinita Jagannath, Miriam Gerstenberg, Christoph U Correll, Susanne Walitza, Edna Grünblat. A systematic meta-analysis of the association of Neuregulin 1 (NRG1), D-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 1. 2019-09-30. PMID:28864885. |
after adding new reports, the t-allele of nrg1 snp8nrg241930 (rs62510682) across all studies (or = 0.95, 95% ci = 0.91-0.997, p = 0.04, n = 22,898) and in caucasian samples (or = 0.95, 95% ci = 0.90-0.99, p = 0.03, n = 16,014), and the c-allele of nrg1 rs10503929 across all studies (or = 0.89, 95% ci = 0.81-0.97, p = 0.01, n = 6844) and in caucasian samples (or = 0.89, 95% ci = 0.81-0.98, p = 0.01, n = 6414) were protective against schizophrenia. |
2019-09-30 |
2023-08-13 |
Not clear |
| Vinita Jagannath, Miriam Gerstenberg, Christoph U Correll, Susanne Walitza, Edna Grünblat. A systematic meta-analysis of the association of Neuregulin 1 (NRG1), D-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 1. 2019-09-30. PMID:28864885. |
our systematic meta-analysis is the most updated one for the association of dao, daoa, and nrg1 snps with schizophrenia. |
2019-09-30 |
2023-08-13 |
Not clear |
| Dimitrios Avramopoulo. Neuregulin 3 and its roles in schizophrenia risk and presentation. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 177. issue 2. 2019-05-28. PMID:28556469. |
they were first implicated in schizophrenia in 2002 with the detection of linkage and association at the nrg1 locus followed after a few years by nrg3. |
2019-05-28 |
2023-08-13 |
Not clear |
| C A Bousman, V Cropley, P Klauser, J L Hess, A Pereira, R Idrizi, J Bruggemann, M S Mostaid, R Lenroot, T W Weickert, S J Glatt, I P Everall, S Sundram, A Zalesky, C S Weickert, C Panteli. Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia. Psychological medicine. vol 48. issue 5. 2019-05-03. PMID:28826413. |
neuregulin-1 (nrg1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia. |
2019-05-03 |
2023-08-13 |
Not clear |
| Zhengrong Zhang, Jie Cui, Feng Gao, Yuhong Li, Guofu Zhang, Min Liu, Riqiang Yan, Yong Shen, Rena L. Elevated cleavage of neuregulin-1 by beta-secretase 1 in plasma of schizophrenia patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 90. 2019-04-22. PMID:30500411. |
neuregulin 1 (nrg1) is a key candidate susceptibility gene for schizophrenia. |
2019-04-22 |
2023-08-13 |
human |
| Zhengrong Zhang, Jie Cui, Feng Gao, Yuhong Li, Guofu Zhang, Min Liu, Riqiang Yan, Yong Shen, Rena L. Elevated cleavage of neuregulin-1 by beta-secretase 1 in plasma of schizophrenia patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 90. 2019-04-22. PMID:30500411. |
in the current study, we used a newly developed enzymatic assay to detect bace1-nrg1 activity in the human plasma and investigated the levels of cleavage of nrg1 by bace1 in the plasma from schizophrenia patients. |
2019-04-22 |
2023-08-13 |
human |
| L Yan, A Shamir, M Skirzewski, E Leiva-Salcedo, O B Kwon, I Karavanova, D Paredes, O Malkesman, K R Bailey, D Vullhorst, J N Crawley, A Buonann. Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders. Molecular psychiatry. vol 23. issue 5. 2019-03-27. PMID:28322273. |
numerous genetic and functional studies implicate variants of neuregulin-1 (nrg1) and its neuronal receptor erbb4 in schizophrenia and many of its endophenotypes. |
2019-03-27 |
2023-08-13 |
mouse |
| Jun Ju, Luping Liu, Yujie Zhang, Qiang Zho. Effect of age onset on schizophrenia-like phenotypes and underlying mechanisms in model mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30025793. |
to understand whether schizophrenia with either adolescence- or adult-onset have distinct phenotypes and cellular mechanisms in schizophrenia model mice, we altered nrg1 signaling during either adolescence or adult mice via injection of anti-nrg1 antibodies. |
2019-03-25 |
2023-08-13 |
mouse |
| David Lloyd, David Talmage, Cynthia Shannon Weickert, Tim Kar. Reduced type III neuregulin 1 expression does not modulate the behavioural sensitivity of mice to acute Δ Pharmacology, biochemistry, and behavior. vol 170. 2019-03-22. PMID:29750976. |
reduced type iii neuregulin 1 expression does not modulate the behavioural sensitivity of mice to acute Δ mice with a mutation in the transmembrane domain of the schizophrenia risk gene, neuregulin 1 (nrg1 tm het), are more susceptible to the neuro-behavioural effects of Δ |
2019-03-22 |
2023-08-13 |
mouse |
| Samane Abbasy, Fazlollah Shahraki, Arvin Haghighatfard, Masoume Ghasemzadeh Qazvini, Sahel Towfigh Rafiei, Elnaz Noshadirad, Mahdi Farhadi, Horie Rezvani Asl, Atena Alsadat Shiryazdi, Rana Ghamari, Zeinab Tabrizi, Rashed Mehrfard, Fereshteh Esmaili Kakroudi, Mahsima Azarnoosh, Faeghe Younesi, Narges Parsamehr, Nooriyeh Garaei, Soroush Abyari, Maede Salehi, Maryam Gholami, Pardis Zolfaghari, Seyede Mahsa Bagheri, Melika Pourmehrabi, Elham Rastegarimogaddam, Elnaz Nobakht, Elmira Nobakht, Rayan Partov. Neuregulin1 types mRNA level changes in autism spectrum disorder, and is associated with deficit in executive functions. EBioMedicine. vol 37. 2019-03-12. PMID:30415889. |
neuregulin1 (nrg1) gene, located in 8p12 is involved in development of central nervous system and was indicated as candidate gene in schizophrenia. |
2019-03-12 |
2023-08-13 |
Not clear |
| Cunyan Li, Huai Tao, Xiudeng Yang, Xianghui Zhang, Yong Liu, Yamei Tang, Aiguo Tan. Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia. International journal of medical sciences. vol 15. issue 9. 2019-01-21. PMID:30008602. |
together, our findings highlight that altered expression of nrg1, erbb4, bdnf, dnmt1 and tet1 are involved in schizophrenia development and they may serve as potential biomarkers for the diagnosis of the schizophrenia. |
2019-01-21 |
2023-08-13 |
Not clear |
| Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeia. Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry research. vol 265. 2019-01-16. PMID:29680514. |
genes with known strong relationships with this disease include bdnf, catechol-o-methyltransferase (comt), regulator of g-protein signaling 4 (rgs4), dystrobrevin-binding protein 1 (dtnbp1), neuregulin 1 (nrg1), reelin (reln), selenium-binding protein 1 (selenbp1), glutamic acid decarboxylase 67 (gad 67), and disrupted in schizophrenia 1 (disc1). |
2019-01-16 |
2023-08-13 |
human |
| Juan C Olaya, Carrie L Heusner, Mitsuyuki Matsumoto, Duncan Sinclair, Mari A Kondo, Tim Karl, Cynthia Shannon Weicker. Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice. Schizophrenia bulletin. vol 44. issue 4. 2019-01-09. PMID:28981869. |
neuregulin 1 (nrg1) is a schizophrenia candidate gene whose protein product is involved in neuronal migration, survival, and synaptic plasticity via production of specific isoforms. |
2019-01-09 |
2023-08-13 |
mouse |