| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D-M Yin, Y-J Chen, S Liu, H Jiao, C Shen, A Sathyamurthy, T W Lin, W-C Xiong, B-M Li, L Mei, C Bergso. Calcyon stimulates neuregulin 1 maturation and signaling. Molecular psychiatry. vol 20. issue 10. 2016-08-01. PMID:25349163. |
both nrg1 and its receptor, erbb4, are well-established risk genes of schizophrenia. |
2016-08-01 |
2023-08-13 |
mouse |
| Sindre Rolstad, Erik Pålsson, Carl Johan Ekman, Elias Eriksson, Carl Sellgren, Mikael Landé. Polymorphisms of dopamine pathway genes NRG1 and LMX1A are associated with cognitive performance in bipolar disorder. Bipolar disorders. vol 17. issue 8. 2016-07-12. PMID:26534905. |
lim homeobox transcription factor 1, alpha (lmx1a) and neuregulin 1 (nrg1) are susceptibility genes for schizophrenia that have been implicated in the dopaminergic pathway and have been associated with altered cognitive functioning. |
2016-07-12 |
2023-08-13 |
Not clear |
| A Ledonne, A Nobili, E C Latagliata, V Cavallucci, E Guatteo, S Puglisi-Allegra, M D'Amelio, N B Mercur. Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Molecular psychiatry. vol 20. issue 8. 2016-04-26. PMID:25266126. |
despite the evidence that nrg1 and its receptors, erbb tyrosine kinases, are expressed in mesencephalic dopaminergic nuclei and their functional alterations are reported in schizophrenia and parkinson's disease, the role of nrg1/erbb signalling in dopaminergic neurons remains unclear. |
2016-04-26 |
2023-08-13 |
Not clear |
| A Ledonne, A Nobili, E C Latagliata, V Cavallucci, E Guatteo, S Puglisi-Allegra, M D'Amelio, N B Mercur. Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Molecular psychiatry. vol 20. issue 8. 2016-04-26. PMID:25266126. |
our results identify a novel role of nrg1 in the dopaminergic neurons, whose functional alteration might contribute to devastating diseases, such as schizophrenia and parkinson's disease. |
2016-04-26 |
2023-08-13 |
Not clear |
| Ran Wang, Yumei Wang, Rui Hu, Xingshi Chen, Mei Song, Xueyi Wan. Decreased plasma levels of neureglin-1 in drug naïve patients and chronic patients with schizophrenia. Neuroscience letters. vol 606. 2016-03-03. PMID:26365407. |
although the neuregulin-1 (nrg1) gene is one of the susceptibility genes for schizophrenia and various other psychiatric diseases, it remains unclear how individual psychiatric diseases affect the expression of the nrg1 protein in patients. |
2016-03-03 |
2023-08-13 |
human |
| Ran Wang, Yumei Wang, Rui Hu, Xingshi Chen, Mei Song, Xueyi Wan. Decreased plasma levels of neureglin-1 in drug naïve patients and chronic patients with schizophrenia. Neuroscience letters. vol 606. 2016-03-03. PMID:26365407. |
these findings suggest that nrg1 may serve as a relatively specific disease marker for schizophrenia. |
2016-03-03 |
2023-08-13 |
human |
| T Kato, Y Abe, S Hirokawa, Y Iwakura, M Mizuno, H Namba, H Naw. Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801. Current molecular medicine. vol 15. issue 3. 2016-02-12. PMID:25817857. |
neuregulin-1 (nrg1) is a well-recognized risk gene for schizophrenia and is often implicated in the neurodevelopmental hypothesis of this illness. |
2016-02-12 |
2023-08-13 |
mouse |
| Martin Engel, Peta Snikeris, Andrew Jenner, Tim Karl, Xu-Feng Huang, Elisabeth Fran. Neuregulin 1 Prevents Phencyclidine-Induced Behavioral Impairments and Disruptions to GABAergic Signaling in Mice. The international journal of neuropsychopharmacology. vol 18. issue 7. 2016-02-05. PMID:26478928. |
substantial evidence from human post-mortem and genetic studies has linked the neurotrophic factor neuregulin 1 (nrg1) to the pathophysiology of schizophrenia. |
2016-02-05 |
2023-08-13 |
mouse |
| Martin Engel, Peta Snikeris, Andrew Jenner, Tim Karl, Xu-Feng Huang, Elisabeth Fran. Neuregulin 1 Prevents Phencyclidine-Induced Behavioral Impairments and Disruptions to GABAergic Signaling in Mice. The international journal of neuropsychopharmacology. vol 18. issue 7. 2016-02-05. PMID:26478928. |
genetic animal models and in vitro experiments have suggested that altered nrg1 signaling, rather than protein changes, contributes to the symptomatology of schizophrenia. |
2016-02-05 |
2023-08-13 |
mouse |
| M S Farrell, T Werge, P Sklar, M J Owen, R A Ophoff, M C O'Donovan, A Corvin, S Cichon, P F Sulliva. Evaluating historical candidate genes for schizophrenia. Molecular psychiatry. vol 20. issue 5. 2016-01-19. PMID:25754081. |
in this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, comt, disc1, dtnbp1 and nrg1). |
2016-01-19 |
2023-08-13 |
Not clear |
| Youngah Cho, Seunghyong Ryu, Iksoo Huh, Eun Young Cho, Hyeji Oh, Yu-Sang Lee, Woo Kyeong Lee, Taesung Park, Jun Soo Kwon, Kyung Sue Hon. Effects of genetic variations in NRG1 on cognitive domains in patients with schizophrenia and healthy individuals. Psychiatric genetics. vol 25. issue 4. 2016-01-11. PMID:25967537. |
effects of genetic variations in nrg1 on cognitive domains in patients with schizophrenia and healthy individuals. |
2016-01-11 |
2023-08-13 |
Not clear |
| Youngah Cho, Seunghyong Ryu, Iksoo Huh, Eun Young Cho, Hyeji Oh, Yu-Sang Lee, Woo Kyeong Lee, Taesung Park, Jun Soo Kwon, Kyung Sue Hon. Effects of genetic variations in NRG1 on cognitive domains in patients with schizophrenia and healthy individuals. Psychiatric genetics. vol 25. issue 4. 2016-01-11. PMID:25967537. |
the neuregulin 1 (nrg1) gene has been investigated as a candidate susceptibility gene for schizophrenia. |
2016-01-11 |
2023-08-13 |
Not clear |
| J M Biernacka, K Sangkuhl, G Jenkins, R M Whaley, P Barman, A Batzler, R B Altman, V Arolt, J Brockmöller, C H Chen, K Domschke, D K Hall-Flavin, C J Hong, A Illi, Y Ji, O Kampman, T Kinoshita, E Leinonen, Y J Liou, T Mushiroda, S Nonen, M K Skime, L Wang, B T Baune, M Kato, Y L Liu, V Praphanphoj, J C Stingl, S J Tsai, M Kubo, T E Klein, R Weinshilbou. The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response. Translational psychiatry. vol 5. 2016-01-07. PMID:25897834. |
nrg1 is involved in many aspects of brain development, including neuronal maturation and variations in this gene have been shown to be associated with increased risk for mental disorders, particularly schizophrenia. |
2016-01-07 |
2023-08-13 |
human |
| Carlos G Perez-Garci. ErbB4 in Laminated Brain Structures: A Neurodevelopmental Approach to Schizophrenia. Frontiers in cellular neuroscience. vol 9. 2016-01-06. PMID:26733804. |
the susceptibility genes for schizophrenia neuregulin-1 (nrg1) and erbb4 have critical functions during brain development and in the adult. |
2016-01-06 |
2023-08-13 |
mouse |
| Lin-Lin Bi, Xiang-Dong Sun, Jie Zhang, Yi-Sheng Lu, Yi-Hua Chen, Jue Wang, Fei Geng, Fang Liu, Meng Zhang, Ji-Hong Liu, Xiao-Wen Li, Lin Mei, Tian-Ming Ga. Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25308353. |
because nrg1 and erbb4 are susceptibility genes of schizophrenia, our findings might also help to explain the potential mechanism of emotional abnormality in schizophrenia. |
2016-01-05 |
2023-08-13 |
mouse |
| Ajay Jajodia, Harpreet Kaur, Kalpana Kumari, Meenal Gupta, Ruchi Baghel, Ankit Srivastava, Mamta Sood, Rakesh Kumar Chadda, Sanjeev Jain, Ritushree Kukret. Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case-control and familial samples. Schizophrenia research. vol 162. issue 1-3. 2016-01-04. PMID:25579050. |
meta-analysis of this population of indo-european and dravidian ancestry identified three strongly associated variants with schizophrenia: stt3a (rs548181, p=1.47×10(-5)), nrg1 (rs17603876, p=8.66×10(-5)) and grm7 (rs3864075, p=4.06×10(-3)). |
2016-01-04 |
2023-08-13 |
Not clear |
| Tea Terzić, Matej Kastelic, Vita Dolžan, Blanka Kores Plesniča. Genetic variability testing of neurodevelopmental genes in schizophrenic patients. Journal of molecular neuroscience : MN. vol 56. issue 1. 2015-12-24. PMID:25529856. |
this study investigated the associations between single nucleotide polymorphisms in the neurodevelopmental disrupted in schizophrenia 1 (disc1 ), neuregulin 1 (nrg1), brain-derived neurotrophic factor (bdnf) and notch4 genes and the clinical symptoms and the occurrence of treatment-resistant schizophrenia in the slovenian population. |
2015-12-24 |
2023-08-13 |
human |
| Hee Jeong Yoo, Ran-Sook Woo, Soo-Churl Cho, Boong-Nyun Kim, Jae-Won Kim, Min-Sup Shin, Tae-Won Park, Jung-Woo Son, Un-Sun Chung, Subin Park, Mira Park, Soon Ae Ki. Genetic association analyses of neuregulin 1 gene polymorphism with endopheontype for sociality of Korean autism spectrum disorders family. Psychiatry research. vol 227. issue 2-3. 2015-11-03. PMID:25858800. |
to determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (asd) and neuregulin 1 (nrg1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (snps) in nrg1 using a family-based association test (fbat) in korean families with asd. |
2015-11-03 |
2023-08-13 |
Not clear |
| Thomas Nickl-Jockschat, Tony Stöcker, Axel Krug, Valentin Markov, Ruiwang Huang, Frank Schneider, Ute Habel, Simon B Eickhoff, Klaus Zerres, Markus M Nöthen, Jens Treutlein, Marcella Rietschel, Nadim Jon Shah, Tilo Kirche. A Neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects. Brain and behavior. vol 4. issue 2. 2015-10-21. PMID:24683514. |
neuregulin-1 (nrg1) is one of the best-validated schizophrenia susceptibility genes. |
2015-10-21 |
2023-08-12 |
human |
| Rukhsana Nawaz, Huma Asif, Asifullah Khan, Hina Ishtiaq, Fatima Shad, Sonia Siddiqu. Drugs targeting SNPrs35753505 of the NRG1 gene may prevent the association of neurological disorder schizophrenia in a Pakistani population. CNS & neurological disorders drug targets. vol 13. issue 9. 2015-08-19. PMID:25106628. |
drugs targeting snprs35753505 of the nrg1 gene may prevent the association of neurological disorder schizophrenia in a pakistani population. |
2015-08-19 |
2023-08-13 |
Not clear |