| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chongbo Zhong, Wendy Akmentin, Chuang Du, Lorna W Role, David A Talmag. Axonal Type III Nrg1 Controls Glutamate Synapse Formation and GluA2 Trafficking in Hippocampal-Accumbens Connections. eNeuro. vol 4. issue 1. 2017-10-30. PMID:28275713. |
altered neuregulin 1 (nrg1)/erbb signaling and glutamatergic hypofunction have been implicated in the pathophysiology of schizophrenia. |
2017-10-30 |
2023-08-13 |
mouse |
| Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousma. Neuregulin-1 and schizophrenia in the genome-wide association study era. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27283360. |
clinical and pre-clinical evidence has implicated neuregulin 1 (nrg1) as a critical component in the pathophysiology of schizophrenia. |
2017-10-24 |
2023-08-13 |
Not clear |
| Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousma. Neuregulin-1 and schizophrenia in the genome-wide association study era. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27283360. |
however, the arrival of the genome-wide association study (gwas) era has yielded results that challenge the relevance of nrg1 in schizophrenia due to the absence of a genome-wide significant nrg1 variant associated with schizophrenia. |
2017-10-24 |
2023-08-13 |
Not clear |
| Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousma. Neuregulin-1 and schizophrenia in the genome-wide association study era. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27283360. |
to assess nrg1's relevance to schizophrenia in the gwas era, we provide a targeted review of recent preclinical evidence on nrg1's role in regulating several aspects of excitatory/inhibitory neurotransmission and in turn schizophrenia risk. |
2017-10-24 |
2023-08-13 |
Not clear |
| Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousma. Neuregulin-1 and schizophrenia in the genome-wide association study era. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27283360. |
we also present a systematic review of the last decade of clinical research examining nrg1 in the context of schizophrenia. |
2017-10-24 |
2023-08-13 |
Not clear |
| Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousma. Neuregulin-1 and schizophrenia in the genome-wide association study era. Neuroscience and biobehavioral reviews. vol 68. 2017-10-24. PMID:27283360. |
we conclude with recommendations for future clinical and preclinical work that we hope will help prioritize a strategy forward to further advance our understanding of the relationship between nrg1 and schizophrenia. |
2017-10-24 |
2023-08-13 |
Not clear |
| Claudia S Barz, Thomas Bessaih, Ted Abel, Dirk Feldmeyer, Diego Contrera. Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1. Brain structure & function. vol 221. issue 9. 2017-10-13. PMID:26721794. |
the present study sought to elucidate the cellular basis of disease-related deficits in sensory resonance properties using mice heterozygous for the schizophrenia susceptibility gene neuregulin 1 (nrg1). |
2017-10-13 |
2023-08-13 |
mouse |
| David J Clarke, Jordyn Stuart, Iain S McGregor, Jonathon C Arnol. Endocannabinoid dysregulation in cognitive and stress-related brain regions in the Nrg1 mouse model of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 72. 2017-08-30. PMID:27521758. |
endocannabinoid dysregulation in cognitive and stress-related brain regions in the nrg1 mouse model of schizophrenia. |
2017-08-30 |
2023-08-13 |
mouse |
| Francesco Papaleo, Feng Yang, Clare Paterson, Sara Palumbo, Gregory V Carr, Yanhong Wang, Kirsten Floyd, Wenwei Huang, Craig J Thomas, Jingshan Chen, Daniel R Weinberger, Amanda J La. Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 17. 2017-06-19. PMID:27122041. |
neuregulin 1 (nrg1), a critical developmental neurotrophin, is associated with schizophrenia. |
2017-06-19 |
2023-08-13 |
mouse |
| Francesco Papaleo, Feng Yang, Clare Paterson, Sara Palumbo, Gregory V Carr, Yanhong Wang, Kirsten Floyd, Wenwei Huang, Craig J Thomas, Jingshan Chen, Daniel R Weinberger, Amanda J La. Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 17. 2017-06-19. PMID:27122041. |
the nrg1 gene undergoes extensive alternative splicing and, to date, little is known about the neurobiology of a novel nrg1 isoform, nrg1-iv, which is increased in the brains of individuals with schizophrenia and associated with genetic risk variation. |
2017-06-19 |
2023-08-13 |
mouse |
| Asuka Yoshimi, Akira Suda, Fumi Hayano, Motoaki Nakamura, Kumi Aoyama-Uehara, Jun Konishi, Takeshi Asami, Ikuko Kishida, Chiaki Kawanishi, Tomio Inoue, Robert W McCarley, Martha E Shenton, Yoshio Hirayas. Effects of NRG1 genotypes on orbitofrontal sulcogyral patterns in Japanese patients diagnosed with schizophrenia. Psychiatry and clinical neurosciences. vol 70. issue 7. 2017-02-27. PMID:26909665. |
effects of nrg1 genotypes on orbitofrontal sulcogyral patterns in japanese patients diagnosed with schizophrenia. |
2017-02-27 |
2023-08-13 |
Not clear |
| Bang-Shun He, Ling-Yun Zhang, Yu-Qin Pan, Kang Lin, Li-Li Zhang, Hui-Ling Sun, Tian-Yi Gao, Tai-Qin Su, Shu-Kui Wang, Cheng-Bin Zh. Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population. Gene. vol 590. issue 2. 2017-01-30. PMID:27236031. |
association of the disc1 and nrg1 genetic polymorphisms with schizophrenia in a chinese population. |
2017-01-30 |
2023-08-13 |
human |
| Bang-Shun He, Ling-Yun Zhang, Yu-Qin Pan, Kang Lin, Li-Li Zhang, Hui-Ling Sun, Tian-Yi Gao, Tai-Qin Su, Shu-Kui Wang, Cheng-Bin Zh. Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population. Gene. vol 590. issue 2. 2017-01-30. PMID:27236031. |
polymorphisms in disrupted-in-schizophrenia 1 (disc1) and neuregulin 1 (nrg1) might be associated with schizophrenia; however, the conclusions of relevant studies were inconsistent across different ethnic populations. |
2017-01-30 |
2023-08-13 |
human |
| Bang-Shun He, Ling-Yun Zhang, Yu-Qin Pan, Kang Lin, Li-Li Zhang, Hui-Ling Sun, Tian-Yi Gao, Tai-Qin Su, Shu-Kui Wang, Cheng-Bin Zh. Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population. Gene. vol 590. issue 2. 2017-01-30. PMID:27236031. |
for nrg1 polymorphisms, in the early onset subgroup (≤25years), the rs3924999 g/g genotype was susceptible to schizophrenia. |
2017-01-30 |
2023-08-13 |
human |
| Bang-Shun He, Ling-Yun Zhang, Yu-Qin Pan, Kang Lin, Li-Li Zhang, Hui-Ling Sun, Tian-Yi Gao, Tai-Qin Su, Shu-Kui Wang, Cheng-Bin Zh. Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population. Gene. vol 590. issue 2. 2017-01-30. PMID:27236031. |
the interaction of disc1 rs821616 t allele with the nrg1 rs3924999 a allele or that of disc1 rs821597 a allele with nrg1 rs3924999 a allele had synergic effects on the development of schizophrenia. |
2017-01-30 |
2023-08-13 |
human |
| Bang-Shun He, Ling-Yun Zhang, Yu-Qin Pan, Kang Lin, Li-Li Zhang, Hui-Ling Sun, Tian-Yi Gao, Tai-Qin Su, Shu-Kui Wang, Cheng-Bin Zh. Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population. Gene. vol 590. issue 2. 2017-01-30. PMID:27236031. |
this study concluded that carriers of the disc1 rs821616 t allele have increased risk for developing schizophrenia, and that the disc1 rs821597 a allele was susceptible to schizophrenia for the male, and that there are marked interactions between the disc1 rs821616 t and/or rs821597 a alleles and the nrg1 rs3924999 a allele for the development of schizophrenia. |
2017-01-30 |
2023-08-13 |
human |
| Hisaaki Namba, Takeshi Okubo, Hiroyuki Naw. Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling. Scientific reports. vol 6. 2017-01-04. PMID:26935991. |
aberrant neuregulin-1 (nrg1) signals are suggested to associate with the neuropathophysiology of schizophrenia. |
2017-01-04 |
2023-08-13 |
mouse |
| Hisaaki Namba, Takeshi Okubo, Hiroyuki Naw. Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling. Scientific reports. vol 6. 2017-01-04. PMID:26935991. |
employing a mouse schizophrenia model established by neonatal neuregulin-1 challenge, we analysed postpubertal consequence of the nrg1 pretreatment for the electrophysiological property of nigral dopamine neurons. |
2017-01-04 |
2023-08-13 |
mouse |
| Zujia Wen, Jianhua Chen, Raja Amjad Waheed Khan, Zhijian Song, Meng Wang, Zhiqiang Li, Jiawei Shen, Wenjin Li, Yongyong Sh. Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 171B. issue 3. 2016-12-13. PMID:26888291. |
to further investigate whether nrg1 is a shared risk gene for major depressive disorder, bipolar disorder as well as schizophrenia, we performed an association study among 1,248 schizophrenia cases, 1,056 major depression cases, 1,344 bipolar disorder cases, and 1,248 controls. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ruili Dang, Yujin Guo, Hualin Cai, Ranyao Yang, Donglou Liang, Chuanfeng Lv, Pei Jian. Effects of prolonged antipsychotic administration on neuregulin-1/ErbB signaling in rat prefrontal cortex and myocardium: implications for the therapeutic action and cardiac adverse effect. The Journal of toxicological sciences. vol 41. issue 2. 2016-12-13. PMID:26961615. |
patients with schizophrenia (scz) are at higher risk for developing cardiovascular disease (cvd) and neuregulin-1 (nrg1)/erbb signaling has been identified as a common susceptibility pathway for the comorbidity. |
2016-12-13 |
2023-08-13 |
rat |