| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiun-Tsai Lin, Wei-Cheng Chang, Hui-Mei Chen, Hsing-Lin Lai, Chih-Yeh Chen, Mi-Hua Tao, Yijuang Cher. Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease. Molecular and cellular biology. vol 33. issue 5. 2013-04-09. PMID:23275441. |
huntington's disease (hd) is a neurodegenerative disease caused by the expansion of a cag repeat in the huntingtin (htt) gene. |
2013-04-09 |
2023-08-12 |
mouse |
| Tz-Chuen Ju, Yow-Sien Lin, Yijuang Cher. Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB. Cellular and molecular life sciences : CMLS. vol 69. issue 24. 2013-02-18. PMID:22627493. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a cag trinucleotide expansion in the huntingtin (htt) gene. |
2013-02-18 |
2023-08-12 |
Not clear |
| Laura Ciarlo, Valeria Manganelli, Paola Matarrese, Tina Garofalo, Antonella Tinari, Lucrezia Gambardella, Matteo Marconi, Maria Grasso, Roberta Misasi, Maurizio Sorice, Walter Malorn. Raft-like microdomains play a key role in mitochondrial impairment in lymphoid cells from patients with Huntington's disease. Journal of lipid research. vol 53. issue 10. 2013-01-29. PMID:22773688. |
huntington's disease (hd) is a genetic neurodegenerative disease characterized by an exceedingly high number of contiguous glutamine residues in the translated protein, huntingtin (htt). |
2013-01-29 |
2023-08-12 |
human |
| James J Ritch, Antonio Valencia, Jonathan Alexander, Ellen Sapp, Leah Gatune, Gavin R Sangrey, Saurabh Sinha, Cally M Scherber, Scott Zeitlin, Ghazaleh Sadri-Vakili, Daniel Irimia, Marian Difiglia, Kimberly B Kege. Multiple phenotypes in Huntington disease mouse neural stem cells. Molecular and cellular neurosciences. vol 50. issue 1. 2012-11-09. PMID:22508027. |
hd is a heritable neurodegenerative disease caused by a mutation resulting in an increased number of glutamines (q) within a polyglutamine tract in huntingtin (htt). |
2012-11-09 |
2023-08-12 |
mouse |
| Verian Bader, Philipp Ottis, Martin Pum, Joseph P Huston, Carsten Kort. Generation, purification, and characterization of cell-invasive DISC1 protein species. Journal of visualized experiments : JoVE. issue 66. 2012-11-05. PMID:22952026. |
protein aggregation is seen as a general hallmark of chronic, degenerative brain conditions like, for example, in the neurodegenerative diseases alzheimer's disease (aβ, tau), parkinson's disease (α-synuclein), huntington's disease (polyglutamine, huntingtin), and others. |
2012-11-05 |
2023-08-12 |
Not clear |
| Neelima Mantha, Sudip K Das, Nandita G Da. RNAi-based therapies for Huntington's disease: delivery challenges and opportunities. Therapeutic delivery. vol 3. issue 9. 2012-11-01. PMID:23035592. |
huntington's disease (hd) is a polyglutamine neurodegenerative disease caused by a mutation in the htt gene coding for the huntingtin protein (htt). |
2012-11-01 |
2023-08-12 |
Not clear |
| Sabine Schipper-Krom, Katrin Juenemann, Eric A J Reit. The Ubiquitin-Proteasome System in Huntington's Disease: Are Proteasomes Impaired, Initiators of Disease, or Coming to the Rescue? Biochemistry research international. vol 2012. 2012-10-11. PMID:23050151. |
huntington's disease is a progressive neurodegenerative disease, caused by a polyglutamine expansion in the huntingtin protein. |
2012-10-11 |
2023-08-12 |
Not clear |
| Md N Islam, R Fujinaga, A Yanai, M R Jahan, Y Takeshita, K Kokubu, K Shinod. Characterization of the "sporadically lurking HAP1-immunoreactive (SLH) cells" in the hippocampus, with special reference to the expression of steroid receptors, GABA, and progenitor cell markers. Neuroscience. vol 210. 2012-09-21. PMID:22421101. |
huntingtin-associated protein 1 (hap1) is a neural huntingtin interactor that is widely expressed as a core molecule of the stigmoid body (a neurocytoplasmic inclusion) in the limbic and hypothalamic regions and has putative protective functions against some neurodegenerative diseases (hap1 protection hypothesis). |
2012-09-21 |
2023-08-12 |
rat |
| C Ruiz, M J Casarejos, I Rubio, S Gines, M Puigdellivol, J Alberch, M A Mena, J G de Yebene. The dopaminergic stabilizer, (-)-OSU6162, rescues striatal neurons with normal and expanded polyglutamine chains in huntingtin protein from exposure to free radicals and mitochondrial toxins. Brain research. vol 1459. 2012-09-18. PMID:22560595. |
huntington's disease (hd) is a neurodegenerative disease characterized by progressive motor, cognitive and psychiatric deficits, associated with predominant loss of striatal neurons and caused by a polyglutamine expansion in the huntingtin protein. |
2012-09-18 |
2023-08-12 |
mouse |
| Paul G Unschuld, Suresh E Joel, Xinyang Liu, Megan Shanahan, Russell L Margolis, Kevin M Biglan, Susan S Bassett, David J Schretlen, Graham W Redgrave, Peter C M van Zijl, James J Pekar, Christopher A Ros. Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease. Neuroscience letters. vol 514. issue 2. 2012-09-14. PMID:22425717. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag triplet-repeat expansion-mutation in the huntingtin gene. |
2012-09-14 |
2023-08-12 |
human |
| Zubeyde Bayram-Weston, Eduardo M Torres, Lesley Jones, Stephen B Dunnett, Simon P Brook. Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh(CAG)150 Huntington's disease knock-in mouse. Brain research bulletin. vol 88. issue 2-3. 2012-09-07. PMID:21511013. |
huntington's disease is an autosomal dominant, progressive neurodegenerative disease in which a single mutation in the gene responsible for the protein huntingtin leads to a primarily striatal and cortical neuronal loss, resulting progressive motor, cognitive and psychiatric disability and ultimately death. |
2012-09-07 |
2023-08-12 |
mouse |
| Zubeyde Bayram-Weston, Lesley Jones, Stephen B Dunnett, Simon P Brook. Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice. Brain research bulletin. vol 88. issue 2-3. 2012-09-07. PMID:21513775. |
huntington's disease (hd) is a fatally progressive neurodegenerative disease that is characterized anatomically by the abnormal accumulation of fragments of mutant huntingtin protein, within the glia and neurons of the brain. |
2012-09-07 |
2023-08-12 |
mouse |
| Zubeyde Bayram-Weston, Lesley Jones, Stephen B Dunnett, Simon P Brook. Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice. Brain research bulletin. vol 88. issue 2-3. 2012-09-07. PMID:21620935. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by the insertion of an expanded polyglutamine sequence within the huntingtin protein. |
2012-09-07 |
2023-08-12 |
mouse |
| Michael A Myr. Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum. Journal of biomedical science. vol 19. 2012-09-04. PMID:22489754. |
however, neurodegenerative disease genes, for example huntingtin (htt), the ataxins, the presenilins (psen1/psen2) are not simply localized to neurons but are ubiquitously expressed throughout peripheral tissues; it is therefore paramount to properly understand the earliest precipitating events leading to neuronal pathogenesis to develop effective long-term therapies. |
2012-09-04 |
2023-08-12 |
human |
| Mithun Sinha, Jayeeta Ghose, Nitai P Bhattarcharyy. Micro RNA -214,-150,-146a and-125b target Huntingtin gene. RNA biology. vol 8. issue 6. 2012-08-27. PMID:22048026. |
as genes involved in different neurodegenerative diseases are targeted by mirnas, we searched databases to find out whether huntingtin gene (htt), mutation to which causes hd, is a target of any mirna. |
2012-08-27 |
2023-08-12 |
mouse |
| Ningzhe Zhang, Bensheng Li, Ismael Al-Ramahi, Xin Cong, Jason M Held, Eugene Kim, Juan Botas, Bradford W Gibson, Lisa M Ellerb. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. The Journal of biological chemistry. vol 287. issue 25. 2012-08-24. PMID:22511757. |
huntington disease (hd) is a dominantly inherited neurodegenerative disease caused by a polyglutamine expansion in the protein huntingtin (htt). |
2012-08-24 |
2023-08-12 |
mouse |
| Zhiqiang Zheng, Marc I Diamon. Huntington disease and the huntingtin protein. Progress in molecular biology and translational science. vol 107. 2012-08-02. PMID:22482451. |
huntington disease (hd) is a devastating neurodegenerative disease that derives from cag repeat expansion in the huntingtin gene. |
2012-08-02 |
2023-08-12 |
mouse |
| Ming-Chang Chiang, Yijuang Chern, Rong-Nan Huan. PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21907283. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a cag trinucleotide expansion in the huntingtin (htt) gene. |
2012-07-23 |
2023-08-12 |
mouse |
| Veronica Costa, Luca Scorran. Shaping the role of mitochondria in the pathogenesis of Huntington's disease. The EMBO journal. vol 31. issue 8. 2012-06-11. PMID:22446390. |
intense research on the pathogenesis of huntington's disease (hd), a genetic neurodegenerative disease caused by a polyglutamine expansion in the huntingtin (htt) protein, revealed multiple potential mechanisms, among which mitochondrial alterations had emerged as key determinants of the natural history of the disease. |
2012-06-11 |
2023-08-12 |
Not clear |
| Harry Harris, David C Rubinsztei. Control of autophagy as a therapy for neurodegenerative disease. Nature reviews. Neurology. vol 8. issue 2. 2012-06-07. PMID:22187000. |
pharmacological induction of autophagy can enhance the clearance of intracytoplasmic aggregate-prone proteins, such as mutant forms of huntingtin, and ameliorate pathology in cell and animal models of neurodegenerative diseases. |
2012-06-07 |
2023-08-12 |
Not clear |