| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyunkyung Jeong, Florian Then, Thomas J Melia, Joseph R Mazzulli, Libin Cui, Jeffrey N Savas, Cindy Voisine, Paolo Paganetti, Naoko Tanese, Anne C Hart, Ai Yamamoto, Dimitri Krain. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. vol 137. issue 1. 2009-04-13. PMID:19345187. |
huntington's disease (hd) is an incurable neurodegenerative disease caused by neuronal accumulation of the mutant protein huntingtin. |
2009-04-13 |
2023-08-12 |
mouse |
| Tie-Shan Tang, Caixia Guo, Hongyu Wang, Xi Chen, Ilya Bezprozvann. Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 5. 2009-02-24. PMID:19193873. |
huntington's disease (hd) is a dominantly inherited, progressive neurodegenerative disease caused by an expanded polyglutamine tract in huntingtin protein (htt). |
2009-02-24 |
2023-08-12 |
mouse |
| Lu-Shiun Her, Lawrence S B Goldstei. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 50. 2009-01-23. PMID:19074039. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease linked to a polyq (polyglutamine) expansion in the huntingtin protein. |
2009-01-23 |
2023-08-12 |
mouse |
| Urszula Wojda, Elzbieta Salinska, Jacek Kuznick. Calcium ions in neuronal degeneration. IUBMB life. vol 60. issue 9. 2008-11-18. PMID:18478527. |
neurodegenerative diseases related to aging, such as alzheimer's disease, parkinson's disease, or huntington's disease, develop slowly and are characterized by the positive feedback between ca(2+) dyshomeostasis and the aggregation of disease-related proteins such as amyloid beta, alfa-synuclein, or huntingtin. |
2008-11-18 |
2023-08-12 |
Not clear |
| Timothy B Brown, Alexey I Bogush, Michelle E Ehrlic. Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse. Human molecular genetics. vol 17. issue 20. 2008-11-12. PMID:18632688. |
huntington's disease (hd) is an autosomal-dominant neurodegenerative disease caused by an expanded polyglutamine tract in the ubiquitously expressed huntingtin protein. |
2008-11-12 |
2023-08-12 |
mouse |
| Bin Huang, Johannes Schiefer, Christian Sass, Christoph M Kosinski, Stefan Kochane. Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion. The journal of gene medicine. vol 10. issue 3. 2008-08-07. PMID:18067195. |
huntington's disease (hd) is an inherited autosomal dominant neurodegenerative disease caused by the expansion of a cag trinucleotide repeat in exon 1 of the huntingtin (htt) gene. |
2008-08-07 |
2023-08-12 |
rat |
| Jieya Shao, William J Welch, Marc I Diamon. ROCK and PRK-2 mediate the inhibitory effect of Y-27632 on polyglutamine aggregation. FEBS letters. vol 582. issue 12. 2008-07-24. PMID:18423405. |
polyglutamine expansion in huntingtin (htt) and the androgen receptor (ar) causes untreatable neurodegenerative diseases. |
2008-07-24 |
2023-08-12 |
drosophila_melanogaster |
| Sara Imarisio, Jenny Carmichael, Viktor Korolchuk, Chien-Wen Chen, Shinji Saiki, Claudia Rose, Gauri Krishna, Janet E Davies, Evangelia Ttofi, Benjamin R Underwood, David C Rubinsztei. Huntington's disease: from pathology and genetics to potential therapies. The Biochemical journal. vol 412. issue 2. 2008-07-03. PMID:18466116. |
huntington's disease (hd) is a devastating autosomal dominant neurodegenerative disease caused by a cag trinucleotide repeat expansion encoding an abnormally long polyglutamine tract in the huntingtin protein. |
2008-07-03 |
2023-08-12 |
Not clear |
| Jodi L McBride, Ryan L Boudreau, Scott Q Harper, Patrick D Staber, Alex Mas Monteys, Inâs Martins, Brian L Gilmore, Haim Burstein, Richard W Peluso, Barry Polisky, Barrie J Carter, Beverly L Davidso. Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 15. 2008-06-13. PMID:18398004. |
huntington's disease (hd) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the hd gene, which encodes the huntingtin protein. |
2008-06-13 |
2023-08-12 |
mouse |
| Pritha Majumder, Swasti Raychaudhuri, Biswanath Chattopadhyay, Nitai P Bhattacharyy. Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range. Cellular and molecular neurobiology. vol 27. issue 8. 2008-05-01. PMID:17902043. |
(1) huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by the expansion of polymorphic cag repeats beyond 36 at exon 1 of huntingtin gene (htt). |
2008-05-01 |
2023-08-12 |
Not clear |
| Claire D Clelland, Roger A Barker, Colin Watt. Cell therapy in Huntington disease. Neurosurgical focus. vol 24. issue 3-4. 2008-04-17. PMID:18341412. |
huntington disease (hd), caused by polyglutamate expansions in the huntingtin protein, is a progressive neurodegenerative disease resulting in cognitive and motor impairments and death. |
2008-04-17 |
2023-08-12 |
Not clear |
| Erica Scappini, Tong-Wey Koh, Negin P Martin, John P O'Brya. Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Human molecular genetics. vol 16. issue 15. 2007-12-18. PMID:17550941. |
huntingon's disease is a progressive neurodegenerative disease arising from expansion of a polyglutamine (polyq) tract in the protein huntingtin (htt) resulting in aggregation of mutant htt into nuclear and/or cytosolic inclusions in neurons. |
2007-12-18 |
2023-08-12 |
drosophila_melanogaster |
| Vanita Chopra, Jonathan H Fox, Greg Lieberman, Kathryn Dorsey, Wayne Matson, Peter Waldmeier, David E Housman, Aleksey Kazantsev, Anne B Young, Steven Hersc. A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 42. 2007-12-13. PMID:17925440. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by a glutamine expansion within huntingtin protein. |
2007-12-13 |
2023-08-12 |
mouse |
| Ming-Chang Chiang, Chiun-Gung Juo, Hao-Hung Chang, Hui-Mei Chen, Eugene C Yi, Yijuang Cher. Systematic uncovering of multiple pathways underlying the pathology of Huntington disease by an acid-cleavable isotope-coded affinity tag approach. Molecular & cellular proteomics : MCP. vol 6. issue 5. 2007-12-12. PMID:17272267. |
huntington disease (hd) is an autosomal dominant neurodegenerative disease that results from a cag (glutamine) trinucleotide expansion in exon 1 of huntingtin (htt). |
2007-12-12 |
2023-08-12 |
mouse |
| Benjamin Dehay, Chantal Weber, Yvon Trottier, Anne Bertolott. Mapping of the epitope of monoclonal antibody 2B4 to the proline-rich region of human Huntingtin, a region critical for aggregation and toxicity. Biotechnology journal. vol 2. issue 5. 2007-09-04. PMID:17373643. |
huntington's disease is a neurodegenerative disease caused by a polyglutamine (polyq) expansion in huntingtin, which provokes aggregation of a proteolytic amino-terminal fragment of the affected protein encompassing the polyq expansion. |
2007-09-04 |
2023-08-12 |
human |
| Hirokazu Fukui, Carlos T Morae. Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates. Human molecular genetics. vol 16. issue 7. 2007-08-28. PMID:17356014. |
mitochondrial abnormalities represent a major cytopathology in huntington's disease (hd), a fatal neurodegenerative disease caused by cag repeat expansions in the gene encoding huntingtin (htt). |
2007-08-28 |
2023-08-12 |
human |
| Ming-Chang Chiang, Hui-Mei Chen, Yi-Hsin Lee, Hao-Hung Chang, Yi-Chih Wu, Bing-Wen Soong, Chiung-Mei Chen, Yih-Ru Wu, Chin-San Liu, Dau-Ming Niu, Jer-Yuarn Wu, Yuan-Tsong Chen, Yijuang Cher. Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. Human molecular genetics. vol 16. issue 5. 2007-07-16. PMID:17213233. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a cag trinucleotide expansion in the huntingtin (htt) gene. |
2007-07-16 |
2023-08-12 |
mouse |
| Bin Huang, Johannes Schiefer, Christian Sass, G Bernhard Landwehrmeyer, Christoph M Kosinski, Stefan Kochane. High-capacity adenoviral vector-mediated reduction of huntingtin aggregate load in vitro and in vivo. Human gene therapy. vol 18. issue 4. 2007-06-19. PMID:17472569. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by the expansion of a cag trinucleotide repeat in exon 1 of the huntingtin (htt) gene. |
2007-06-19 |
2023-08-12 |
mouse |
| Anne N T Strehlow, Jun Z Li, Richard M Myer. Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space. Human molecular genetics. vol 16. issue 4. 2007-04-26. PMID:17189290. |
huntington disease (hd) is an autosomal dominant neurodegenerative disease caused by an expanded cag trinucleotide repeat in the first exon of the hd gene, which results in a toxic polyglutamine stretch within huntingtin, the protein it encodes. |
2007-04-26 |
2023-08-12 |
human |
| Branka Cajavec, Hanspeter Herzel, Samuel Bernar. Death of neuronal clusters contributes to variance of age at onset in Huntington's disease. Neurogenetics. vol 7. issue 1. 2007-03-27. PMID:16416264. |
huntington's disease (hd) is a fatal neurodegenerative disease caused by an expanded polyglutamine (polyq) repeat in the protein huntingtin. |
2007-03-27 |
2023-08-12 |
Not clear |