| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Fan, Clare M Gladding, Liang Wang, Lily Y J Zhang, Alexandra M Kaufman, Austen J Milnerwood, Lynn A Raymon. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiology of disease. vol 45. issue 3. 2012-06-07. PMID:22198502. |
huntington disease (hd) is a dominantly inherited neurodegenerative disease caused by a polyglutamine (polyq) expansion in the protein huntingtin (htt). |
2012-06-07 |
2023-08-12 |
mouse |
| Youngnam N Jin, Woong Y Hwang, Chulman Jo, Gail V W Johnso. Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276192. |
impairments in mitochondria and transcription are important factors in the pathogenesis of huntington disease (hd), a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. |
2012-06-04 |
2023-08-12 |
Not clear |
| Pavan K Krishnamurthy, Einar M Sigurdsso. Therapeutic applications of antibodies in non-infectious neurodegenerative diseases. New biotechnology. vol 28. issue 5. 2012-05-15. PMID:21473943. |
neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease, huntington's disease (hd) or amyotrophic lateral sclerosis (als) are all characterised histologically by the presence of deposits of misfolded proteins, tau and amyloid-β, α-synuclein, huntingtin or superoxide dismutase, respectively. |
2012-05-15 |
2023-08-12 |
Not clear |
| David K Stiles, Zhiming Zhang, Pei Ge, Brian Nelson, Richard Grondin, Yi Ai, Peter Hardy, Peter T Nelson, Andrei P Guzaev, Mark T Butt, Klaus Charisse, Verbena Kosovrasti, Lubomir Tchangov, Michael Meys, Martin Maier, Lubomir Nechev, Muthiah Manoharan, William F Kaemmerer, Douglas Gwost, Gregory R Stewart, Don M Gash, Dinah W Y Sa. Widespread suppression of huntingtin with convection-enhanced delivery of siRNA. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22119622. |
huntington's disease is an autosomal dominant neurodegenerative disease caused by a toxic gain of function mutation in the huntingtin gene (htt). |
2012-03-25 |
2023-08-12 |
Not clear |
| Monica Hoyos Fligh. Neurodegenerative disease: Preventing 'SIRTain' death by mutant huntingtin. Nature reviews. Neuroscience. vol 13. issue 2. 2012-03-06. PMID:22251960. |
neurodegenerative disease: preventing 'sirtain' death by mutant huntingtin. |
2012-03-06 |
2023-08-12 |
Not clear |
| Jose Luis López-Sendón, Ana Royuela, Patricia Trigo, Michael Orth, Herwig Lange, Ralf Reilmann, Jennifer Keylock, Hugh Rickards, Silvia Piacentini, Ferdinando Squitieri, Bernhard Landwehrmeyer, Marie-Noelle Witjes-Ane, Caroline K Jurgens, Raymund A C Roos, Victor Abraira, Justo G de Yébene. What is the impact of education on Huntington's disease? Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 8. 2012-02-29. PMID:21432905. |
huntington's disease (hd) is a neurodegenerative disease caused by a cytosine adenosine guanine (cag) expansion in the huntingtin gene. |
2012-02-29 |
2023-08-12 |
Not clear |
| Peter O Bauer, Roman Hudec, Shoichiro Ozaki, Misako Okuno, Etsuko Ebisui, Katsuhiko Mikoshiba, Nobuyuki Nukin. Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation. Biochemical and biophysical research communications. vol 416. issue 1-2. 2012-01-27. PMID:22056561. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by an expansion of the polyglutamine (polyq) stretch in huntingtin (htt). |
2012-01-27 |
2023-08-12 |
Not clear |
| Undine Kruegel, Brett Robison, Thomas Dange, Günther Kahlert, Joe R Delaney, Soumya Kotireddy, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Christopher J Murakami, Jennifer Schleit, George Sutphin, Daniel Carr, Krisztina Tar, Gunnar Dittmar, Matt Kaeberlein, Brian K Kennedy, Marion Schmid. Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS genetics. vol 7. issue 9. 2012-01-23. PMID:21931558. |
moreover, since elevated proteasome capacity results in improved clearance of toxic huntingtin fragments in a yeast model for neurodegenerative diseases, we speculate that the observed lifespan extension originates from prolonged elimination of damaged proteins in old mother cells. |
2012-01-23 |
2023-08-12 |
rat |
| Nai-Kuei Huang, Jung-Hsin Lin, Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Chun-Jung Lin, Wan-Ping Chen, Yuh-Chiang Shen, Hui-Mei Chen, Jhih-Bin Chen, Hsing-Lin Lai, Chieh-Wen Yang, Ming-Chang Chiang, Yu-Shuo Wu, Chen Chang, Jiang-Fan Chen, Jim-Min Fang, Yun-Lian Lin, Yijuang Cher. A new drug design targeting the adenosinergic system for Huntington's disease. PloS one. vol 6. issue 6. 2011-11-21. PMID:21713039. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag trinucleotide expansion in the huntingtin (htt) gene. |
2011-11-21 |
2023-08-12 |
Not clear |
| Ming-Chang Chiang, Yijuang Chern, Chiun-Gung Ju. The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease. Biochimica et biophysica acta. vol 1812. issue 9. 2011-09-15. PMID:21651979. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a cag trinucleotide expansion in the huntingtin (htt) gene. |
2011-09-15 |
2023-08-12 |
mouse |
| Cara K Bradley, Heather A Scott, Omar Chami, Teija T Peura, Biljana Dumevska, Uli Schmidt, Tomas Stojano. Derivation of Huntington's disease-affected human embryonic stem cell lines. Stem cells and development. vol 20. issue 3. 2011-09-02. PMID:20649476. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by an expansion of cytosine-adenine-guanine (cag) repeats in the huntingtin gene htt. |
2011-09-02 |
2023-08-12 |
human |
| Lise Munsie, Nicholas Caron, Randy Singh Atwal, Ian Marsden, Edward J Wild, James R Bamburg, Sarah J Tabrizi, Ray Truan. Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease. Human molecular genetics. vol 20. issue 10. 2011-08-09. PMID:21355047. |
mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease. |
2011-08-09 |
2023-08-12 |
Not clear |
| Lise Munsie, Nicholas Caron, Randy Singh Atwal, Ian Marsden, Edward J Wild, James R Bamburg, Sarah J Tabrizi, Ray Truan. Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease. Human molecular genetics. vol 20. issue 10. 2011-08-09. PMID:21355047. |
these data support a direct role for huntingtin in nuclear actin re-organization, and describe a new pathogenic mechanism for aberrant tg2 enzymatic hyperactivity in neurodegenerative diseases. |
2011-08-09 |
2023-08-12 |
Not clear |
| Katrina Ra. Neurodegenerative disease: Mitochondria, huntingtin and HD. Nature reviews. Neurology. vol 7. issue 4. 2011-07-29. PMID:21468118. |
neurodegenerative disease: mitochondria, huntingtin and hd. |
2011-07-29 |
2023-08-12 |
Not clear |
| Andrew T N Tebbenkamp, Debbie Swing, Lino Tessarollo, David R Borchel. Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment. Human molecular genetics. vol 20. issue 8. 2011-07-21. PMID:21307087. |
huntington's disease (hd) is a fatal neurodegenerative disease characterized pathologically by aggregates composed of n-terminal fragments of the mutant form of the protein huntingtin (htt). |
2011-07-21 |
2023-08-12 |
mouse |
| Ningzhe Zhang, Mahru C An, Daniel Montoro, Lisa M Ellerb. Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells. PLoS currents. vol 2. 2011-07-14. PMID:21037797. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by a cag repeat expansion in the first exon of the gene huntingtin (htt). |
2011-07-14 |
2023-08-12 |
human |
| Elahe Taherzadeh-Fard, Carsten Saft, Denis A Akkad, Stefan Wieczorek, Aiden Haghikia, Andrew Chan, Jörg T Epplen, Larissa Arnin. PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21595933. |
huntington disease (hd) is an inherited neurodegenerative disease caused by an abnormal expansion of a cag repeat in the huntingtin htt (hd) gene. |
2011-07-14 |
2023-08-12 |
Not clear |
| Beate Winner, Zacharias Kohl, Fred H Gag. Neurodegenerative disease and adult neurogenesis. The European journal of neuroscience. vol 33. issue 6. 2011-06-24. PMID:21395858. |
genes that are key players in neurodegenerative diseases (α-synuclein, presenilin-1, tau, huntingtin) are also physiologically involved in modulating brain plasticity. |
2011-06-24 |
2023-08-12 |
human |
| Veronica Costa, Marta Giacomello, Roman Hudec, Raffaele Lopreiato, Gennady Ermak, Dmitri Lim, Walter Malorni, Kelvin J A Davies, Ernesto Carafoli, Luca Scorran. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO molecular medicine. vol 2. issue 12. 2011-03-23. PMID:21069748. |
huntington's disease (hd), a genetic neurodegenerative disease caused by a polyglutamine expansion in the huntingtin (htt) protein, is accompanied by multiple mitochondrial alterations. |
2011-03-23 |
2023-08-12 |
Not clear |
| Juan S Jiméne. Protein-DNA interaction at the origin of neurological diseases: a hypothesis. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20847445. |
a number of neurodegenerative diseases, including alzheimer's disease, tauopathies, parkinson's disease, and synucleinopathies, polyglutamine diseases, including huntington's disease, amyotrophic lateral sclerosis, and transmissible spongiform encephalopathy, are characterized by the existence of a protein or peptide prone to aggregation specific to the disease: amyloid-β, tau protein, α-synuclein, atrophin 1, androgen receptor, prion protein, copper-zinc superoxide dismutase, α 1a subunit of cav2.1, tata-box binding protein, huntingtin, and ataxins 1, 2, 3, and 7. |
2011-03-09 |
2023-08-12 |
Not clear |