| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Regina M Murph. Peptide aggregation in neurodegenerative disease. Annual review of biomedical engineering. vol 4. 2002-10-28. PMID:12117755. |
in this review, we focus attention on three polypeptides: beta-amyloid, prion, and huntingtin, which are linked to three feared neurodegenerative diseases: alzheimer's, "mad cow," and huntington's disease, respectively. |
2002-10-28 |
2023-08-12 |
Not clear |
| Anthone W Dunah, Hyunkyung Jeong, April Griffin, Yong-Man Kim, David G Standaert, Steven M Hersch, M Maral Mouradian, Anne B Young, Naoko Tanese, Dimitri Krain. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science (New York, N.Y.). vol 296. issue 5576. 2002-07-23. PMID:11988536. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by expansion of a polyglutamine tract in the huntingtin protein. |
2002-07-23 |
2023-08-12 |
mouse |
| J A Parker, J B Connolly, C Wellington, M Hayden, J Dausset, C Ner. Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 23. 2001-12-07. PMID:11687635. |
huntington's disease (hd) is a dominant neurodegenerative disease caused by polyglutamine (polyq) expansion in the protein huntingtin (htt). |
2001-12-07 |
2023-08-12 |
human |
| A B Meriin, K Mabuchi, V L Gabai, J A Yaglom, A Kazantsev, M Y Sherma. Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1. The Journal of cell biology. vol 153. issue 4. 2001-06-21. PMID:11352944. |
in several neurodegenerative diseases, such ibs can be formed by proteins with expanded polyglutamine (polyq) domains (e.g., huntingtin). |
2001-06-21 |
2023-08-12 |
Not clear |
| S Holbert, I Denghien, T Kiechle, A Rosenblatt, C Wellington, M R Hayden, R L Margolis, C A Ross, J Dausset, R J Ferrante, C Nér. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172033. |
huntington's disease (hd) is a neurodegenerative disease caused by polyglutamine expansion in the protein huntingtin (htt). |
2001-04-19 |
2023-08-12 |
human |
| A S Hackam, A S Yassa, R Singaraja, M Metzler, C A Gutekunst, L Gan, S Warby, C L Wellington, J Vaillancourt, N Chen, F G Gervais, L Raymond, D W Nicholson, M R Hayde. Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. The Journal of biological chemistry. vol 275. issue 52. 2001-01-26. PMID:11007801. |
huntington disease is a devastating neurodegenerative disease caused by the expansion of a polymorphic glutamine tract in huntingtin. |
2001-01-26 |
2023-08-12 |
Not clear |
| M Metzler, C D Helgason, I Dragatsis, T Zhang, L Gan, N Pineault, S O Zeitlin, R K Humphries, M R Hayde. Huntingtin is required for normal hematopoiesis. Human molecular genetics. vol 9. issue 3. 2000-05-04. PMID:10655548. |
huntington's disease (hd) is a neurodegenerative disease associated with polyglutamine expansion in huntingtin, a widely expressed protein. |
2000-05-04 |
2023-08-12 |
mouse |
| S J Tabrizi, J Workman, P E Hart, L Mangiarini, A Mahal, G Bates, J M Cooper, A H Schapir. Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse. Annals of neurology. vol 47. issue 1. 2000-02-16. PMID:10632104. |
huntington's disease is a progressive neurodegenerative disease caused by an abnormally expanded (>36) cag repeat within the iti5 gene encoding a widely expressed 349-kd protein, huntingtin. |
2000-02-16 |
2023-08-12 |
mouse |
| K L Moulder, O Onodera, J R Burke, W J Strittmatter, E M Johnso. Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 2. 1999-02-16. PMID:9880591. |
recent evidence suggests that, in huntingtin and many other proteins, polyglutamine repeats are a toxic stimulus in neurodegenerative diseases. |
1999-02-16 |
2023-08-12 |
rat |
| S K Singhrao, P Thomas, J D Wood, J C MacMillan, J W Neal, P S Harper, A L Jone. Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases. Experimental neurology. vol 150. issue 2. 1998-05-22. PMID:9527890. |
huntingtin protein colocalizes with lesions of neurodegenerative diseases: an investigation in huntington's, alzheimer's, and pick's diseases. |
1998-05-22 |
2023-08-12 |
Not clear |
| S K Singhrao, P Thomas, J D Wood, J C MacMillan, J W Neal, P S Harper, A L Jone. Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases. Experimental neurology. vol 150. issue 2. 1998-05-22. PMID:9527890. |
our findings suggest huntingtin selectively accumulates in association with abnormal intracytoplasmic and cytoskeletal filaments of neurons and glia in neurodegenerative diseases such as hd, ad, and pid. |
1998-05-22 |
2023-08-12 |
Not clear |
| S Engelender, A H Sharp, V Colomer, M K Tokito, A Lanahan, P Worley, E L Holzbaur, C A Ros. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Human molecular genetics. vol 6. issue 13. 1998-03-18. PMID:9361024. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by expansion of a polyglutamine repeat in the hd protein huntingtin. |
1998-03-18 |
2023-08-12 |
Not clear |
| J R Burke, J J Enghild, M E Martin, Y S Jou, R M Myers, A D Roses, J M Vance, W J Strittmatte. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature medicine. vol 2. issue 3. 1996-06-05. PMID:8612237. |
at least five adult-onset neurodegenerative diseases, including huntingtin disease (hd), and dentatorubral-pallidoluysian atrophy (drpla) are produced by genes containing a variably increased cag repeat within the coding region. |
1996-06-05 |
2023-08-12 |
Not clear |