| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beate Winner, Zacharias Kohl, Fred H Gag. Neurodegenerative disease and adult neurogenesis. The European journal of neuroscience. vol 33. issue 6. 2011-06-24. PMID:21395858. |
genes that are key players in neurodegenerative diseases (α-synuclein, presenilin-1, tau, huntingtin) are also physiologically involved in modulating brain plasticity. |
2011-06-24 |
2023-08-12 |
human |
| Veronica Costa, Marta Giacomello, Roman Hudec, Raffaele Lopreiato, Gennady Ermak, Dmitri Lim, Walter Malorni, Kelvin J A Davies, Ernesto Carafoli, Luca Scorran. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO molecular medicine. vol 2. issue 12. 2011-03-23. PMID:21069748. |
huntington's disease (hd), a genetic neurodegenerative disease caused by a polyglutamine expansion in the huntingtin (htt) protein, is accompanied by multiple mitochondrial alterations. |
2011-03-23 |
2023-08-12 |
Not clear |
| Juan S Jiméne. Protein-DNA interaction at the origin of neurological diseases: a hypothesis. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20847445. |
a number of neurodegenerative diseases, including alzheimer's disease, tauopathies, parkinson's disease, and synucleinopathies, polyglutamine diseases, including huntington's disease, amyotrophic lateral sclerosis, and transmissible spongiform encephalopathy, are characterized by the existence of a protein or peptide prone to aggregation specific to the disease: amyloid-β, tau protein, α-synuclein, atrophin 1, androgen receptor, prion protein, copper-zinc superoxide dismutase, α 1a subunit of cav2.1, tata-box binding protein, huntingtin, and ataxins 1, 2, 3, and 7. |
2011-03-09 |
2023-08-12 |
Not clear |
| Ming-Chang Chiang, Chiung-Mei Chen, Maw-Rong Lee, Hsiao-Wen Chen, Hui-Mei Chen, Yu-Shuo Wu, Cheng-Han Hung, Jheng-Jie Kang, Ching-Pang Chang, Chen Chang, Yih-Ru Wu, Yau-Sheng Tsai, Yijuang Cher. Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma. Human molecular genetics. vol 19. issue 20. 2011-03-01. PMID:20668093. |
huntington's disease (hd) is a neurodegenerative disease caused by the expansion of a cag trinucleotide repeat in exon 1 of the huntingtin (htt) gene. |
2011-03-01 |
2023-08-12 |
mouse |
| Mathuravani A Thevandavakkam, Robert Schwarcz, Paul J Muchowski, Flaviano Giorgin. Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease. CNS & neurological disorders drug targets. vol 9. issue 6. 2011-02-28. PMID:20942784. |
huntington's disease (hd) is an adult onset neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. |
2011-02-28 |
2023-08-12 |
Not clear |
| Keith T Gagnon, Hannah M Pendergraff, Glen F Deleavey, Eric E Swayze, Pierre Potier, John Randolph, Eric B Roesch, Jyoti Chattopadhyaya, Masad J Damha, C Frank Bennett, Christophe Montaillier, Marc Lemaitre, David R Core. Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry. vol 49. issue 47. 2010-12-30. PMID:21028906. |
huntington's disease (hd) is a currently incurable neurodegenerative disease caused by the expansion of a cag trinucleotide repeat within the huntingtin (htt) gene. |
2010-12-30 |
2023-08-12 |
Not clear |
| Linda S Kaltenbach, M McLean Bolton, Bijal Shah, Patrick M Kanju, Gwendolyn M Lewis, Gregory J Turmel, Jennifer C Whaley, O Joseph Trask, Donald C L. Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions. Journal of biomolecular screening. vol 15. issue 7. 2010-12-01. PMID:20581077. |
huntington's disease (hd) is a fatal neurodegenerative disease characterized by progressive cognitive, behavioral, and motor deficits and caused by expansion of a polyglutamine repeat in the huntingtin protein (htt). |
2010-12-01 |
2023-08-12 |
Not clear |
| Stephen D Skaper, Pietro Giust. Transgenic mouse models of Parkinson's disease and Huntington's disease. CNS & neurological disorders drug targets. vol 9. issue 4. 2010-11-09. PMID:20522011. |
hd, on the other hand, is one of the few neurodegenerative diseases with a known genetic cause, namely an expanded cag repeat mutation, extending a polyglutamine tract in the huntingtin protein. |
2010-11-09 |
2023-08-12 |
mouse |
| Abigail Snyder-Keller, Julie A McLear, Tyisha Hathorn, Anne Messe. Early or late-stage anti-N-terminal Huntingtin intrabody gene therapy reduces pathological features in B6.HDR6/1 mice. Journal of neuropathology and experimental neurology. vol 69. issue 10. 2010-10-15. PMID:20838238. |
huntington disease (hd) is a progressive neurodegenerative disease caused by an expansion of a polyglutamine sequence in mutant huntingtin (mhtt) that produces abnormal folding and aggregation that results in the formation of nuclear and cytoplasmic neuronal inclusion bodies. |
2010-10-15 |
2023-08-12 |
mouse |
| Youngnam N Jin, Gail V W Johnso. The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease. Journal of bioenergetics and biomembranes. vol 42. issue 3. 2010-10-08. PMID:20556492. |
huntington disease (hd) is an inherited neurodegenerative disease caused by an abnormal expansion of the cag repeat region in the huntingtin (htt) gene. |
2010-10-08 |
2023-08-12 |
Not clear |
| Claudia Rose, Fiona M Menzies, Maurizio Renna, Abraham Acevedo-Arozena, Silvia Corrochano, Oana Sadiq, Steve D Brown, David C Rubinsztei. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Human molecular genetics. vol 19. issue 11. 2010-09-22. PMID:20190273. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a polyglutamine expansion in huntingtin. |
2010-09-22 |
2023-08-12 |
mouse |
| Nichole L Dudek, Ying Dai, Nancy A Mum. Neuroprotective effects of calmodulin peptide 76-121aa: disruption of calmodulin binding to mutant huntingtin. Brain pathology (Zurich, Switzerland). vol 20. issue 1. 2010-07-30. PMID:19338577. |
huntington's disease (hd) is a neurodegenerative disease caused by mutant huntingtin protein containing an expanded polyglutamine tract, which may cause abnormal protein-protein interactions such as increased association with calmodulin (cam). |
2010-07-30 |
2023-08-12 |
Not clear |
| John S Bett, Caroline L Benn, Kwon-Yul Ryu, Ron R Kopito, Gillian P Bate. The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease. Journal of cellular and molecular medicine. vol 13. issue 8B. 2010-07-19. PMID:19602042. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by the expansion of a polyglutamine tract in the protein huntingtin (htt). |
2010-07-19 |
2023-08-12 |
mouse |
| Robert Schwarcz, Paolo Guidetti, Korrapati V Sathyasaikumar, Paul J Muchowsk. Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease. Progress in neurobiology. vol 90. issue 2. 2010-05-26. PMID:19394403. |
the neurodegenerative disease huntington's disease (hd) is caused by an expanded polyglutamine (polyq) tract in the protein huntingtin (htt). |
2010-05-26 |
2023-08-12 |
mouse |
| Leslie Michels Thompson, Charity T Aiken, Linda S Kaltenbach, Namita Agrawal, Katalin Illes, Ali Khoshnan, Marta Martinez-Vincente, Montserrat Arrasate, Jacqueline Gire O'Rourke, Hasan Khashwji, Tamas Lukacsovich, Ya-Zhen Zhu, Alice L Lau, Ashish Massey, Michael R Hayden, Scott O Zeitlin, Steven Finkbeiner, Kim N Green, Frank M LaFerla, Gillian Bates, Lan Huang, Paul H Patterson, Donald C Lo, Ana Maria Cuervo, J Lawrence Marsh, Joan S Steffa. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. The Journal of cell biology. vol 187. issue 7. 2010-02-10. PMID:20026656. |
expansion of the polyglutamine repeat within the protein huntingtin (htt) causes huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant htt in diseased neurons. |
2010-02-10 |
2023-08-12 |
Not clear |
| Amber L Southwell, Jan Ko, Paul H Patterso. Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 43. 2009-12-02. PMID:19864571. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease resulting from the expansion of a glutamine repeat in the huntingtin (htt) protein. |
2009-12-02 |
2023-08-12 |
mouse |
| Ming-Chang Chiang, Hui-Mei Chen, Hsing-Lin Lai, Hsiao-Wen Chen, Szu-Yi Chou, Chiung-Mei Chen, Fuu-Jen Tsai, Yijuang Cher. The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system. Human molecular genetics. vol 18. issue 16. 2009-10-27. PMID:19443488. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a cag trinucleotide expansion in the huntingtin (htt) gene. |
2009-10-27 |
2023-08-12 |
mouse |
| Ryan L Boudreau, Jodi L McBride, Inês Martins, Shihao Shen, Yi Xing, Barrie J Carter, Beverly L Davidso. Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 6. 2009-08-07. PMID:19240687. |
huntington's disease (hd) is a fatal neurodegenerative disease caused by mutant huntingtin (htt) protein, and there are currently no effective treatments. |
2009-08-07 |
2023-08-12 |
mouse |
| Wolfgang Fecke, Marco Gianfriddo, Giovanni Gaviraghi, Georg C Terstappen, Freddy Heit. Small molecule drug discovery for Huntington's Disease. Drug discovery today. vol 14. issue 9-10. 2009-07-28. PMID:19429504. |
huntington's disease (hd) is a rare neurodegenerative disease caused by mutation of the huntingtin gene that results in a protein with an expanded stretch of glutamine repeats (polyq). |
2009-07-28 |
2023-08-12 |
Not clear |
| Peter O Bauer, Hon Kit Wong, Fumitaka Oyama, Anand Goswami, Misako Okuno, Yoshihiro Kino, Haruko Miyazaki, Nobuyuki Nukin. Inhibition of Rho kinases enhances the degradation of mutant huntingtin. The Journal of biological chemistry. vol 284. issue 19. 2009-07-21. PMID:19278999. |
huntington disease (hd) is a fatal hereditary neurodegenerative disease caused by an expansion of the polyglutamine (polyq) stretch in huntingtin (htt). |
2009-07-21 |
2023-08-12 |
Not clear |