| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bruce X Wong, James A Duc. The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders. Frontiers in pharmacology. vol 5. 2014-06-24. PMID:24795635. |
recently proteins directly implicated in the most prevalent neurodegenerative diseases, such as amyloid-β precursor protein, tau, α-synuclein, prion protein and huntingtin, have been connected to neuronal iron homeostatic control. |
2014-06-24 |
2023-08-13 |
human |
| Maddalena Costanzo, Saïda Abounit, Ludovica Marzo, Anne Danckaert, Zeina Chamoun, Pascal Roux, Chiara Zurzol. Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes. Journal of cell science. vol 126. issue Pt 16. 2014-06-15. PMID:23781027. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by cag expansion in the huntingtin gene, which adds a homopolymeric tract of polyglutamine (polyq) to the encoded protein leading to the formation of toxic aggregates. |
2014-06-15 |
2023-08-12 |
Not clear |
| Juan I Sbodio, Bindu D Paul, Carolyn E Machamer, Solomon H Snyde. Golgi protein ACBD3 mediates neurotoxicity associated with Huntington's disease. Cell reports. vol 4. issue 5. 2014-06-12. PMID:24012756. |
huntington's disease (hd) is an autosomal-dominant neurodegenerative disease caused by the expansion of polyglutamine repeats in the gene for huntingtin (htt). |
2014-06-12 |
2023-08-12 |
mouse |
| Anan Yu, Yoko Shibata, Bijal Shah, Barbara Calamini, Donald C Lo, Richard I Morimot. Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 15. 2014-06-04. PMID:24706768. |
aggregation caused dysregulated ampa receptor internalization and also inhibited cme in primary neurons expressing mutant huntingtin, showing direct relevance of our findings to the pathology in neurodegenerative diseases. |
2014-06-04 |
2023-08-13 |
Not clear |
| Maxmore Chaibva, Kathleen A Burke, Justin Legleite. Curvature enhances binding and aggregation of huntingtin at lipid membranes. Biochemistry. vol 53. issue 14. 2014-06-03. PMID:24670006. |
huntington disease (hd) is a genetic neurodegenerative disease caused by an expanded polyglutamine (polyq) domain in the first exon of the huntingtin (htt) protein, facilitating its aggregation. |
2014-06-03 |
2023-08-12 |
Not clear |
| Giang D Nguyen, Aldrin E Molero, Solen Gokhan, Mark F Mehle. Functions of huntingtin in germ layer specification and organogenesis. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967334. |
huntington's disease (hd) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (htt). |
2014-05-14 |
2023-08-12 |
mouse |
| Giulia Lazzeroni, Tiziana Benicchi, Freddy Heitz, Letizia Magnoni, Daniela Diamanti, Lara Rossini, Luisa Massai, Cesare Federico, Wolfgang Fecke, Andrea Caricasole, Salvatore La Rosa, Valentina Porcar. A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation. Journal of biomolecular screening. vol 18. issue 9. 2014-04-08. PMID:23562876. |
huntington's disease is a rare neurodegenerative disease caused by an abnormal expansion of cag repeats encoding polyglutamine in the first exon of the huntingtin gene. |
2014-04-08 |
2023-08-12 |
Not clear |
| Nicola J Rutherford, Jada Lewis, Amy K Clippinger, Michael A Thomas, Jennifer Adamson, Pedro E Cruz, Ashley Cannon, Guilian Xu, Todd E Golde, Gerry Shaw, David R Borchelt, Benoit I Giasso. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain research. vol 1524. 2014-03-14. PMID:23774650. |
using specific ubiquilin-2 antibodies and a series of transgenic mouse models of proteinopathies associated with neurodegenerative disease, we show that ubiquilin-2 preferentially associates with huntingtin polyq expansion aggregates compared to α-synuclein, tau and several other types of protein inclusions. |
2014-03-14 |
2023-08-12 |
mouse |
| Magdalena Czeredys, Joanna Gruszczynska-Biegala, Teresa Schacht, Axel Methner, Jacek Kuznick. Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. Frontiers in molecular neuroscience. vol 6. 2013-12-10. PMID:24324398. |
huntington's disease (hd) is a hereditary neurodegenerative disease caused by the expansion of a polyglutamine stretch in the huntingtin (htt) protein and characterized by dysregulated calcium homeostasis. |
2013-12-10 |
2023-08-12 |
mouse |
| David J Harrison, Monica Busse, Rebecca Openshaw, Anne E Rosser, Stephen B Dunnett, Simon P Brook. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental neurology. vol 248. 2013-11-27. PMID:23911978. |
huntington's disease (hd) is a neurodegenerative disease caused by a mutation within the huntingtin gene that induces degeneration within the striatal nuclei, progressing to widespread brain atrophy and death. |
2013-11-27 |
2023-08-12 |
mouse |
| Elvira Valera, Eliezer Maslia. Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies. Pharmacology & therapeutics. vol 138. issue 3. 2013-11-01. PMID:23384597. |
in contrast, α-synuclein (α-syn), tau, huntingtin and other proteins involved in neurodegenerative diseases have been considered to be exclusively of intracellular nature. |
2013-11-01 |
2023-08-12 |
Not clear |
| Junghee Lee, Yu Jin Hwang, Jong-Yeon Shin, Won-Chul Lee, Jinhong Wie, Ki Yoon Kim, Min Young Lee, Daehee Hwang, Rajiv R Ratan, Ae Nim Pae, Neil W Kowall, Insuk So, Jong-Il Kim, Hoon Ry. Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease. Acta neuropathologica. vol 125. issue 5. 2013-10-31. PMID:23455440. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by an expanded trinucleotide cag repeat in the gene coding for huntingtin. |
2013-10-31 |
2023-08-12 |
Not clear |
| Laura M Harrison, Gerald J Lahost. The role of Rhes, Ras homolog enriched in striatum, in neurodegenerative processes. Experimental cell research. vol 319. issue 15. 2013-10-25. PMID:23583659. |
hd is an autosomal dominant neurodegenerative disease caused by a poly-glutamine expansion in the protein huntingtin. |
2013-10-25 |
2023-08-12 |
Not clear |
| Youngnam N Jin, Yanxun V Yu, Soner Gundemir, Chulman Jo, Mei Cui, Kim Tieu, Gail V W Johnso. Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin. PloS one. vol 8. issue 3. 2013-08-27. PMID:23469253. |
huntington disease (hd) is an inherited neurodegenerative disease resulting from an abnormal expansion of polyglutamine in huntingtin (htt). |
2013-08-27 |
2023-08-12 |
Not clear |
| Bruno M D C Godinho, Julien R Ogier, Raphael Darcy, Caitriona M O'Driscoll, John F Crya. Self-assembling modified β-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease. Molecular pharmaceutics. vol 10. issue 2. 2013-08-20. PMID:23116281. |
huntington's disease (hd) is a rare autosomal dominant neurodegenerative disease caused by the expression of a toxic huntingtin (htt) protein. |
2013-08-20 |
2023-08-12 |
mouse |
| Kazutomi Kanemar. [Immunotherapy targeting misfolded proteins in neurodegenerative disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 4. 2013-08-07. PMID:23568995. |
the major components of pathological aggregates have been characterized in various neurodegenerative diseases; for example, amyloid β-protein and phosphorylated tau in alzheimer's disease, α-synuclein in parkinson's disease, sod1 or tdp-43 in amyotrophic lateral sclerosis, and huntingtin in huntington's disease. |
2013-08-07 |
2023-08-12 |
Not clear |
| Liza M Sutton, Shaun S Sanders, Stefanie L Butland, Roshni R Singaraja, Sonia Franciosi, Amber L Southwell, Crystal N Doty, Mandi E Schmidt, Katherine K N Mui, Vlad Kovalik, Fiona B Young, Weining Zhang, Michael R Hayde. Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease. Human molecular genetics. vol 22. issue 3. 2013-07-01. PMID:23077216. |
huntingtin-interacting protein 14 (hip14), a well-characterized neuronal pat, has been implicated in the pathogenesis of huntington disease (hd), a fatal neurodegenerative disease associated with motor, psychiatric and cognitive symptoms, caused by a cag expansion in the huntingtin gene (htt). |
2013-07-01 |
2023-08-12 |
mouse |
| Shuqiu Zheng, Nima Ghitani, Jessica S Blackburn, Jeh-Ping Liu, Scott O Zeitli. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis. Molecular brain. vol 5. 2013-06-21. PMID:22892315. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease that is caused by the expansion of a polyglutamine (polyq) stretch within huntingtin (htt), the protein product of the hd gene. |
2013-06-21 |
2023-08-12 |
mouse |
| Jing Jin, Jennifer Albertz, Zhihong Guo, Qi Peng, Gay Rudow, Juan C Troncoso, Christopher A Ross, Wenzhen Dua. Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease. Journal of neurochemistry. vol 125. issue 3. 2013-06-20. PMID:23373812. |
huntington's disease (hd) is a devastating genetic neurodegenerative disease caused by cag trinucleotide expansion in the exon-1 region of the huntingtin gene. |
2013-06-20 |
2023-08-12 |
mouse |
| Peter O Bauer, Roman Hudec, Anand Goswami, Masaru Kurosawa, Gen Matsumoto, Katsuhiko Mikoshiba, Nobuyuki Nukin. ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT. Molecular neurodegeneration. vol 7. 2013-06-19. PMID:22929228. |
huntington's disease (hd) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (htt) containing an expanded polyglutamine (polyq) tract. |
2013-06-19 |
2023-08-12 |
Not clear |