| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anan Yu, Yoko Shibata, Bijal Shah, Barbara Calamini, Donald C Lo, Richard I Morimot. Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 15. 2014-06-04. PMID:24706768. |
aggregation caused dysregulated ampa receptor internalization and also inhibited cme in primary neurons expressing mutant huntingtin, showing direct relevance of our findings to the pathology in neurodegenerative diseases. |
2014-06-04 |
2023-08-13 |
Not clear |
| Maxmore Chaibva, Kathleen A Burke, Justin Legleite. Curvature enhances binding and aggregation of huntingtin at lipid membranes. Biochemistry. vol 53. issue 14. 2014-06-03. PMID:24670006. |
huntington disease (hd) is a genetic neurodegenerative disease caused by an expanded polyglutamine (polyq) domain in the first exon of the huntingtin (htt) protein, facilitating its aggregation. |
2014-06-03 |
2023-08-12 |
Not clear |
| Giang D Nguyen, Aldrin E Molero, Solen Gokhan, Mark F Mehle. Functions of huntingtin in germ layer specification and organogenesis. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967334. |
huntington's disease (hd) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (htt). |
2014-05-14 |
2023-08-12 |
mouse |
| Giulia Lazzeroni, Tiziana Benicchi, Freddy Heitz, Letizia Magnoni, Daniela Diamanti, Lara Rossini, Luisa Massai, Cesare Federico, Wolfgang Fecke, Andrea Caricasole, Salvatore La Rosa, Valentina Porcar. A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation. Journal of biomolecular screening. vol 18. issue 9. 2014-04-08. PMID:23562876. |
huntington's disease is a rare neurodegenerative disease caused by an abnormal expansion of cag repeats encoding polyglutamine in the first exon of the huntingtin gene. |
2014-04-08 |
2023-08-12 |
Not clear |
| Nicola J Rutherford, Jada Lewis, Amy K Clippinger, Michael A Thomas, Jennifer Adamson, Pedro E Cruz, Ashley Cannon, Guilian Xu, Todd E Golde, Gerry Shaw, David R Borchelt, Benoit I Giasso. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain research. vol 1524. 2014-03-14. PMID:23774650. |
using specific ubiquilin-2 antibodies and a series of transgenic mouse models of proteinopathies associated with neurodegenerative disease, we show that ubiquilin-2 preferentially associates with huntingtin polyq expansion aggregates compared to α-synuclein, tau and several other types of protein inclusions. |
2014-03-14 |
2023-08-12 |
mouse |
| Magdalena Czeredys, Joanna Gruszczynska-Biegala, Teresa Schacht, Axel Methner, Jacek Kuznick. Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. Frontiers in molecular neuroscience. vol 6. 2013-12-10. PMID:24324398. |
huntington's disease (hd) is a hereditary neurodegenerative disease caused by the expansion of a polyglutamine stretch in the huntingtin (htt) protein and characterized by dysregulated calcium homeostasis. |
2013-12-10 |
2023-08-12 |
mouse |
| David J Harrison, Monica Busse, Rebecca Openshaw, Anne E Rosser, Stephen B Dunnett, Simon P Brook. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental neurology. vol 248. 2013-11-27. PMID:23911978. |
huntington's disease (hd) is a neurodegenerative disease caused by a mutation within the huntingtin gene that induces degeneration within the striatal nuclei, progressing to widespread brain atrophy and death. |
2013-11-27 |
2023-08-12 |
mouse |
| Elvira Valera, Eliezer Maslia. Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies. Pharmacology & therapeutics. vol 138. issue 3. 2013-11-01. PMID:23384597. |
in contrast, α-synuclein (α-syn), tau, huntingtin and other proteins involved in neurodegenerative diseases have been considered to be exclusively of intracellular nature. |
2013-11-01 |
2023-08-12 |
Not clear |
| Junghee Lee, Yu Jin Hwang, Jong-Yeon Shin, Won-Chul Lee, Jinhong Wie, Ki Yoon Kim, Min Young Lee, Daehee Hwang, Rajiv R Ratan, Ae Nim Pae, Neil W Kowall, Insuk So, Jong-Il Kim, Hoon Ry. Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease. Acta neuropathologica. vol 125. issue 5. 2013-10-31. PMID:23455440. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by an expanded trinucleotide cag repeat in the gene coding for huntingtin. |
2013-10-31 |
2023-08-12 |
Not clear |
| Laura M Harrison, Gerald J Lahost. The role of Rhes, Ras homolog enriched in striatum, in neurodegenerative processes. Experimental cell research. vol 319. issue 15. 2013-10-25. PMID:23583659. |
hd is an autosomal dominant neurodegenerative disease caused by a poly-glutamine expansion in the protein huntingtin. |
2013-10-25 |
2023-08-12 |
Not clear |
| Youngnam N Jin, Yanxun V Yu, Soner Gundemir, Chulman Jo, Mei Cui, Kim Tieu, Gail V W Johnso. Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin. PloS one. vol 8. issue 3. 2013-08-27. PMID:23469253. |
huntington disease (hd) is an inherited neurodegenerative disease resulting from an abnormal expansion of polyglutamine in huntingtin (htt). |
2013-08-27 |
2023-08-12 |
Not clear |
| Bruno M D C Godinho, Julien R Ogier, Raphael Darcy, Caitriona M O'Driscoll, John F Crya. Self-assembling modified β-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease. Molecular pharmaceutics. vol 10. issue 2. 2013-08-20. PMID:23116281. |
huntington's disease (hd) is a rare autosomal dominant neurodegenerative disease caused by the expression of a toxic huntingtin (htt) protein. |
2013-08-20 |
2023-08-12 |
mouse |
| Kazutomi Kanemar. [Immunotherapy targeting misfolded proteins in neurodegenerative disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 4. 2013-08-07. PMID:23568995. |
the major components of pathological aggregates have been characterized in various neurodegenerative diseases; for example, amyloid β-protein and phosphorylated tau in alzheimer's disease, α-synuclein in parkinson's disease, sod1 or tdp-43 in amyotrophic lateral sclerosis, and huntingtin in huntington's disease. |
2013-08-07 |
2023-08-12 |
Not clear |
| Liza M Sutton, Shaun S Sanders, Stefanie L Butland, Roshni R Singaraja, Sonia Franciosi, Amber L Southwell, Crystal N Doty, Mandi E Schmidt, Katherine K N Mui, Vlad Kovalik, Fiona B Young, Weining Zhang, Michael R Hayde. Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease. Human molecular genetics. vol 22. issue 3. 2013-07-01. PMID:23077216. |
huntingtin-interacting protein 14 (hip14), a well-characterized neuronal pat, has been implicated in the pathogenesis of huntington disease (hd), a fatal neurodegenerative disease associated with motor, psychiatric and cognitive symptoms, caused by a cag expansion in the huntingtin gene (htt). |
2013-07-01 |
2023-08-12 |
mouse |
| Shuqiu Zheng, Nima Ghitani, Jessica S Blackburn, Jeh-Ping Liu, Scott O Zeitli. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis. Molecular brain. vol 5. 2013-06-21. PMID:22892315. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease that is caused by the expansion of a polyglutamine (polyq) stretch within huntingtin (htt), the protein product of the hd gene. |
2013-06-21 |
2023-08-12 |
mouse |
| Jing Jin, Jennifer Albertz, Zhihong Guo, Qi Peng, Gay Rudow, Juan C Troncoso, Christopher A Ross, Wenzhen Dua. Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease. Journal of neurochemistry. vol 125. issue 3. 2013-06-20. PMID:23373812. |
huntington's disease (hd) is a devastating genetic neurodegenerative disease caused by cag trinucleotide expansion in the exon-1 region of the huntingtin gene. |
2013-06-20 |
2023-08-12 |
mouse |
| Peter O Bauer, Roman Hudec, Anand Goswami, Masaru Kurosawa, Gen Matsumoto, Katsuhiko Mikoshiba, Nobuyuki Nukin. ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT. Molecular neurodegeneration. vol 7. 2013-06-19. PMID:22929228. |
huntington's disease (hd) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (htt) containing an expanded polyglutamine (polyq) tract. |
2013-06-19 |
2023-08-12 |
Not clear |
| Noel Fau. Single amino acid and trinucleotide repeats: function and evolution. Advances in experimental medicine and biology. vol 769. 2013-06-18. PMID:23560303. |
for example, the expansion of the glutamine repeat in huntingtin leads to the debilitating neurodegenerative disease, huntington's disease. |
2013-06-18 |
2023-08-12 |
Not clear |
| Rebecca K Lehman, Martha Nanc. Family history in juvenile Huntington disease: do the signs point to "yes" or "very doubtful"? Neurology. vol 80. issue 11. 2013-04-30. PMID:23390171. |
like the adult form of the disorder, jhd is a hereditary neurodegenerative disease characterized by dementia and behavioral changes, caused by an expanded cag repeat within the first exon of the huntingtin (htt) gene on chromosome 4. |
2013-04-30 |
2023-08-12 |
Not clear |
| Bernhard Suter, Jean-Fred Fontaine, Reha Yildirimman, Tamás Raskó, Martin H Schaefer, Axel Rasche, Pablo Porras, Blanca M Vázquez-Álvarez, Jenny Russ, Kirstin Rau, Raphaele Foulle, Martina Zenkner, Kathrin Saar, Ralf Herwig, Miguel A Andrade-Navarro, Erich E Wanke. Development and application of a DNA microarray-based yeast two-hybrid system. Nucleic acids research. vol 41. issue 3. 2013-04-17. PMID:23275563. |
applying a global pooling and selection scheme to a large collection of human open reading frames, proof-of-principle y2h interaction screens were performed for the human neurodegenerative disease proteins huntingtin and ataxin-1. |
2013-04-17 |
2023-08-12 |
human |