| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petr Vodicka, Shunyan Mo, Adelaide Tousley, Karin M Green, Ellen Sapp, Maria Iuliano, Ghazaleh Sadri-Vakili, Scott A Shaffer, Neil Aronin, Marian DiFiglia, Kimberly B Kegel-Gleaso. Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid. Journal of Huntington's disease. vol 4. issue 2. 2016-06-15. PMID:26397899. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag expansion in the hd gene, which encodes the protein huntingtin. |
2016-06-15 |
2023-08-13 |
mouse |
| Sheue-Er Wang, Ching-Lung Lin, Chih-Hsiang Hsu, Shuenn-Jyi Sheu, Chiang-Ting Chien, Chung-Hsin W. Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington's disease. Drug design, development and therapy. vol 9. 2016-05-17. PMID:25733809. |
we suggest that the herbal formula b401 can be developed as a medical supplement for ameliorating neurodegenerative diseases of hd via reducing mutant huntingtin aggregation and excitotoxicity, enhancing neuroprotection and angiogenesis, and alleviating inflammation in the brain. |
2016-05-17 |
2023-08-13 |
mouse |
| Xiang Gao, Warren A Campbell, Maxmore Chaibva, Pranav Jain, Ashley E Leslie, Shelli L Frey, Justin Legleite. Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes. Biochemistry. vol 55. issue 1. 2016-05-13. PMID:26652744. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by abnormally long cag-repeats in the huntingtin gene that encode an expanded polyglutamine (polyq) domain near the n-terminus of the huntingtin (htt) protein. |
2016-05-13 |
2023-08-13 |
Not clear |
| Ting Zhao, Yan Hong, Xiao-Jiang Li, Shi-Hua L. Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review. Frontiers in molecular neuroscience. vol 9. 2016-05-05. PMID:27147961. |
huntington's disease (hd) is an autosomal dominant, progressive neurodegenerative disease caused by an expanded polyglutamine (polyq) tract in the n-terminal region of mutant huntingtin (mhtt). |
2016-05-05 |
2023-08-13 |
Not clear |
| Sudha Bucha, Debashis Mukhopadhyay, Nitai Pada Bhattacharyy. Regulation of mitochondrial morphology and cell cycle by microRNA-214 targeting Mitofusin2. Biochemical and biophysical research communications. vol 465. issue 4. 2016-04-12. PMID:26307536. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by the increase in cag repeats beyond 36 at the exon1 of the gene huntingtin (htt). |
2016-04-12 |
2023-08-13 |
Not clear |
| Kazem Mousavizadeh, Peyman Rajabi, Mahsa Alaee, Sepideh Dadgar, Massoud Houshman. Usage of mitochondrial D-loop variation to predict risk for Huntington disease. Mitochondrial DNA. vol 26. issue 4. 2016-03-24. PMID:24471944. |
huntington's disease (hd) is an inherited autosomal neurodegenerative disease caused by the abnormal expansion of the cag repeats in the huntingtin (htt) gene. |
2016-03-24 |
2023-08-12 |
Not clear |
| Adriana S Trujillo, Raul Ramos, Rolf Bodmer, Sanford I Bernstein, Karen Ocorr, Girish C Melkan. Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis. Rare diseases (Austin, Tex.). vol 2. issue 1. 2016-03-04. PMID:26942103. |
cardiac disease is the second leading cause of death in hd, which has been mainly studied as a neurodegenerative disease that is caused by expanded polyglutamine repeats in the huntingtin protein. |
2016-03-04 |
2023-08-13 |
human |
| Virginia B Mattis, Colton Tom, Sergey Akimov, Jasmine Saeedian, Michael E Østergaard, Amber L Southwell, Crystal N Doty, Loren Ornelas, Anais Sahabian, Lindsay Lenaeus, Berhan Mandefro, Dhruv Sareen, Jamshid Arjomand, Michael R Hayden, Christopher A Ross, Clive N Svendse. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Human molecular genetics. vol 24. issue 11. 2016-02-16. PMID:25740845. |
huntington's disease (hd) is a fatal neurodegenerative disease, caused by expansion of polyglutamine repeats in the huntingtin gene, with longer expansions leading to earlier ages of onset. |
2016-02-16 |
2023-08-13 |
mouse |
| Vincent Kam Wai Wong, An Guo Wu, Jing Rong Wang, Liang Liu, Betty Yuen-Kwan La. Neferine attenuates the protein level and toxicity of mutant huntingtin in PC-12 cells via induction of autophagy. Molecules (Basel, Switzerland). vol 20. issue 3. 2016-01-26. PMID:25699594. |
recent literature has revealed the protective role of autophagy in neurodegenerative diseases through degradation of mutant toxic proteins, including huntingtin or a-synuclein. |
2016-01-26 |
2023-08-13 |
Not clear |
| Marianne J U Novak, Kiran K Seunarine, Clare R Gibbard, Peter McColgan, Bogdan Draganski, Karl Friston, Chris A Clark, Sarah J Tabriz. Basal ganglia-cortical structural connectivity in Huntington's disease. Human brain mapping. vol 36. issue 5. 2015-12-31. PMID:25640796. |
huntington's disease is an incurable neurodegenerative disease caused by inheritance of an expanded cytosine-adenine-guanine (cag) trinucleotide repeat within the huntingtin gene. |
2015-12-31 |
2023-08-13 |
human |
| Bibiana K Y Wong, Dagmar E Ehrnhoefer, Rona K Graham, Dale D O Martin, Safia Ladha, Valeria Uribe, Lisa M Stanek, Sonia Franciosi, Xiaofan Qiu, Yu Deng, Vlad Kovalik, Weining Zhang, Mahmoud A Pouladi, Lamya S Shihabuddin, Michael R Hayde. Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. Neurobiology of disease. vol 76. 2015-12-14. PMID:25583186. |
huntington disease (hd) is a progressive neurodegenerative disease caused by an elongated cag repeat in the huntingtin (htt) gene that encodes a polyglutamine tract in the htt protein. |
2015-12-14 |
2023-08-13 |
mouse |
| Ishrat Ahmed, Juan I Sbodio, Maged M Harraz, Richa Tyagi, Jonathan C Grima, Lauren K Albacarys, Maimon E Hubbi, Risheng Xu, Seyun Kim, Bindu D Paul, Solomon H Snyde. Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 31. 2015-11-17. PMID:26195796. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by a glutamine repeat expansion in mutant huntingtin (mhtt). |
2015-11-17 |
2023-08-13 |
Not clear |
| Peng Yin, Zhuchi Tu, An Yin, Ting Zhao, Sen Yan, Xiangyu Guo, Renbao Chang, Lianhe Zhang, Yan Hong, Xiahe Huang, Junxia Zhou, Yingchun Wang, Shihua Li, Xiao-Jiang L. Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Human molecular genetics. vol 24. issue 5. 2015-11-16. PMID:25343992. |
although misfolded proteins are ubiquitinated and cleared by the proteasome, they can accumulate in synapses in aged neurons to promote synaptic dysfunction in a variety of neurodegenerative diseases, including huntington's disease (hd), which is caused by polyglutamine expansion in huntingtin. |
2015-11-16 |
2023-08-13 |
mouse |
| Ilenia Ventura, Maria Teresa Russo, Chiara De Nuccio, Gabriele De Luca, Paolo Degan, Antonietta Bernardo, Sergio Visentin, Luisa Minghetti, Margherita Bignam. hMTH1 expression protects mitochondria from Huntington's disease-like impairment. Neurobiology of disease. vol 49. 2015-11-10. PMID:22974734. |
huntington disease (hd) is a neurodegenerative disease caused by expansion of cag repeats in the huntingtin (htt) gene. |
2015-11-10 |
2023-08-12 |
mouse |
| Joanne Kim, Henry J Waldvogel, Richard L M Faull, Maurice A Curtis, Louise F B Nicholso. The RAGE receptor and its ligands are highly expressed in astrocytes in a grade-dependant manner in the striatum and subependymal layer in Huntington's disease. Journal of neurochemistry. vol 134. issue 5. 2015-11-03. PMID:26011179. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by an expansion of the cag repeat in the huntingtin gene. |
2015-11-03 |
2023-08-13 |
human |
| Luana Naia, I Luísa Ferreira, Teresa Cunha-Oliveira, Ana I Duarte, Márcio Ribeiro, Tatiana R Rosenstock, Mário N Laço, Maria J Ribeiro, Catarina R Oliveira, Frédéric Saudou, Sandrine Humbert, A Cristina Reg. Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24841383. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the huntingtin protein. |
2015-10-20 |
2023-08-13 |
human |
| Yumiko Motoi, Kohei Shimada, Koichi Ishiguro, Nobutaka Hattor. Lithium and autophagy. ACS chemical neuroscience. vol 5. issue 6. 2015-10-08. PMID:24738557. |
in neurodegenerative diseases, lithium enhances degradation of aggregate-prone proteins, including mutated huntingtin, phosphorylated tau, and α-synuclein, and causes damaged mitochondria to degrade, while in a mouse model of cerebral ischemia and alzheimer's disease autophagy downregulation by lithium is observed. |
2015-10-08 |
2023-08-13 |
mouse |
| Han-Yun Hsiao, Yu-Chen Chen, Chien-Hsiang Huang, Chiao-Chi Chen, Yi-Hua Hsu, Hui-Mei Chen, Feng-Lan Chiu, Hung-Chih Kuo, Chen Chang, Yijuang Cher. Aberrant astrocytes impair vascular reactivity in Huntington disease. Annals of neurology. vol 78. issue 2. 2015-10-06. PMID:25914140. |
huntington disease (hd) is an inherited neurodegenerative disease caused by the mutant huntingtin gene (mhtt), which harbors expanded cag repeats. |
2015-10-06 |
2023-08-13 |
mouse |
| Andreas Neueder, Gillian P Bate. A common gene expression signature in Huntington's disease patient brain regions. BMC medical genomics. vol 7. 2015-09-30. PMID:25358814. |
in huntington's disease (hd), a neurodegenerative disease caused by a tri-nucleotide repeat expansion in the huntingtin gene, extensive transcriptional dysregulation has been reported. |
2015-09-30 |
2023-08-13 |
Not clear |
| Ladislav Mrzljak, Ignacio Munoz-Sanjua. Therapeutic Strategies for Huntington's Disease. Current topics in behavioral neurosciences. vol 22. 2015-09-10. PMID:24277342. |
huntington's disease (hd) is a devastating autosomal dominant neurodegenerative disease, caused by expansion of the cag repeat in the huntingtin (htt) gene and characterized pathologically by the loss of pyramidal neurons in several cortical areas, of striatal medium spiny neurons, and of hypothalamic neurons. |
2015-09-10 |
2023-08-12 |
Not clear |