| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ian H Kratter, Hengameh Zahed, Alice Lau, Andrey S Tsvetkov, Aaron C Daub, Kurt F Weiberth, Xiaofeng Gu, Frédéric Saudou, Sandrine Humbert, X William Yang, Alex Osmand, Joan S Steffan, Eliezer Masliah, Steven Finkbeine. Serine 421 regulates mutant huntingtin toxicity and clearance in mice. The Journal of clinical investigation. vol 126. issue 9. 2017-09-26. PMID:27525439. |
huntington's disease (hd) is a progressive, adult-onset neurodegenerative disease caused by a polyglutamine (polyq) expansion in the n-terminal region of the protein huntingtin (htt). |
2017-09-26 |
2023-08-13 |
mouse |
| Avraham Ashkenazi, Carla F Bento, Thomas Ricketts, Mariella Vicinanza, Farah Siddiqi, Mariana Pavel, Ferdinando Squitieri, Maarten C Hardenberg, Sara Imarisio, Fiona M Menzies, David C Rubinsztei. Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature. vol 545. issue 7652. 2017-09-19. PMID:28445460. |
nine neurodegenerative diseases are caused by expanded polyglutamine (polyq) tracts in different proteins, such as huntingtin in huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (sca3). |
2017-09-19 |
2023-08-13 |
mouse |
| Michał Wojciechowski, Àngel Gómez-Sicilia, Mariano Carrión-Vázquez, Marek Ciepla. Unfolding knots by proteasome-like systems: simulations of the behaviour of folded and neurotoxic proteins. Molecular bioSystems. vol 12. issue 9. 2017-07-24. PMID:27425826. |
huntingtin is associated with huntington's disease, a well-known genetically determined neurodegenerative disease. |
2017-07-24 |
2023-08-13 |
Not clear |
| Yu-Han Kao, Yijuang Chern, Hui-Ting Yang, Hui-Mei Chen, Chun-Jung Li. Regulation of P-glycoprotein expression in brain capillaries in Huntington's disease and its impact on brain availability of antipsychotic agents risperidone and paliperidone. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 36. issue 8. 2017-07-19. PMID:26661162. |
huntington's disease (hd) is a neurodegenerative disease marked by an expanded polyglutamine (polyq) tract on the huntingtin (htt) protein that may cause transcriptional dysfunction. |
2017-07-19 |
2023-08-13 |
mouse |
| Yan Hong, Ting Zhao, Xiao-Jiang Li, Shihua L. Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 34. 2017-07-17. PMID:27559163. |
we know that bdnf levels decline in the brains of patients with huntington's disease (hd), a neurodegenerative disease caused by the expression of mutant huntingtin protein (mhtt), and furthermore that administration of bdnf in hd mice is protective against hd neuropathology. |
2017-07-17 |
2023-08-13 |
mouse |
| Tanja Hering, Peter Braubach, G Bernhard Landwehrmeyer, Katrin S Lindenberg, Werner Melze. Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington's Disease. PloS one. vol 11. issue 11. 2017-06-27. PMID:27820862. |
huntington´s disease (hd) is a hereditary neurodegenerative disease resulting from an expanded polyglutamine sequence (poly-q) in the protein huntingtin (htt). |
2017-06-27 |
2023-08-13 |
mouse |
| C Connolly, A Magnusson-Lind, G Lu, P K Wagner, A L Southwell, M R Hayden, M Björkqvist, B R Leavit. Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin. Neuroscience. vol 325. 2017-06-07. PMID:27033979. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. |
2017-06-07 |
2023-08-13 |
mouse |
| Magdalena Czeredys, Filip Maciag, Axel Methner, Jacek Kuznick. Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease. Biochemical and biophysical research communications. vol 483. issue 4. 2017-06-06. PMID:27553284. |
huntington's disease (hd) is a hereditary neurodegenerative disease caused by a polyglutamine expansion within the huntingtin (htt) gene. |
2017-06-06 |
2023-08-13 |
mouse |
| Amber L Southwell, Niels H Skotte, Erika B Villanueva, Michael E Østergaard, Xiaofeng Gu, Holly B Kordasiewicz, Chris Kay, Daphne Cheung, Yuanyun Xie, Sabine Waltl, Louisa Dal Cengio, Hailey Findlay-Black, Crystal N Doty, Eugenia Petoukhov, Diepiriye Iworima, Ramy Slama, Jolene Ooi, Mahmoud A Pouladi, X William Yang, Eric E Swayze, Punit P Seth, Michael R Hayde. A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles. Human molecular genetics. vol 26. issue 6. 2017-05-15. PMID:28104789. |
huntington disease (hd) is a neurodegenerative disease caused by a mutation in the huntingtin (htt) gene. |
2017-05-15 |
2023-08-13 |
mouse |
| Fang Fang, Ting Peng, Shiming Yang, Weixi Wang, Yinong Zhang, He L. Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 52. 2017-03-27. PMID:27196502. |
huntington's disease (hd) is an inherited neurodegenerative disease that is caused by the abnormal expansion of cag repeats in the gene encoding huntingtin (htt). |
2017-03-27 |
2023-08-13 |
mouse |
| Lorraine F Clark, Thomas Kodade. The Immune System and Neuroinflammation as Potential Sources of Blood-Based Biomarkers for Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease. ACS chemical neuroscience. vol 7. issue 5. 2017-01-27. PMID:27046268. |
on the contrary, huntington's disease (hd) is a neurodegenerative disease solely caused by mutations in the gene for huntingtin protein. |
2017-01-27 |
2023-08-13 |
Not clear |
| K Lakshmi Narayanan, Vanita Chopra, H Diana Rosas, Keith Malarick, Steven Hersc. Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington's Disease. Molecular neurobiology. vol 53. issue 4. 2016-12-19. PMID:25941073. |
huntington's disease (hd) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the huntingtin gene. |
2016-12-19 |
2023-08-13 |
mouse |
| Bor-Tsang Wu, Ming-Chang Chiang, Ching-Yi Tasi, Chia-Hua Kuo, Woei-Cherng Shyu, Chung-Lan Kao, Chih-Yang Huang, Shin-Da Le. Cardiac Fas-Dependent and Mitochondria-Dependent Apoptotic Pathways in a Transgenic Mouse Model of Huntington's Disease. Cardiovascular toxicology. vol 16. issue 2. 2016-12-13. PMID:25800750. |
huntington's disease is an autosomal dominant neurodegenerative disease caused by a cag repeat expansion in the huntingtin gene. |
2016-12-13 |
2023-08-13 |
mouse |
| Nguyen T Tien, Ilker Karaca, Irfan Y Tamboli, Jochen Walte. Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein. The Journal of biological chemistry. vol 291. issue 20. 2016-12-13. PMID:26957541. |
cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, α-synuclein, and phosphorylated tau that are associated with neurodegenerative diseases. |
2016-12-13 |
2023-08-13 |
Not clear |
| Caodu Buren, Matthew P Parsons, Amy Smith-Dijak, Lynn A Raymon. Impaired development of cortico-striatal synaptic connectivity in a cell culture model of Huntington's disease. Neurobiology of disease. vol 87. 2016-10-20. PMID:26711622. |
huntington's disease (hd) is a genetically inherited neurodegenerative disease caused by a mutation in the gene encoding the huntingtin protein. |
2016-10-20 |
2023-08-13 |
mouse |
| Ulrike Träger, Ralph Andre, Anna Magnusson-Lind, James R C Miller, Colúm Connolly, Andreas Weiss, Stephan Grueninger, Edina Silajdžić, Donna L Smith, Blair R Leavitt, Gillian P Bates, Maria Björkqvist, Sarah J Tabriz. Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models. Neurobiology of disease. vol 73. 2016-08-29. PMID:25447230. |
in huntington's disease (hd), a fatal inherited neurodegenerative disease caused by a cag-repeat expansion in the gene encoding huntingtin, patients have increased plasma levels of inflammatory cytokines and circulating monocytes that are hyper-responsive to immune stimuli. |
2016-08-29 |
2023-08-13 |
mouse |
| Z Tan, W Dai, T G M van Erp, J Overman, A Demuro, M A Digman, A Hatami, R Albay, E M Sontag, K T Potkin, S Ling, F Macciardi, W E Bunney, J D Long, J S Paulsen, J M Ringman, I Parker, C Glabe, L M Thompson, W Chiu, S G Potki. Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:26100538. |
huntington's disease (hd), a progressive neurodegenerative disease, is caused by an expanded cag triplet repeat producing a mutant huntingtin protein (mhtt) with a polyglutamine-repeat expansion. |
2016-08-02 |
2023-08-13 |
human |
| Lydie Boussicault, Sandro Alves, Antonin Lamazière, Anabelle Planques, Nicolas Heck, Lara Moumné, Gaëtan Despres, Susanne Bolte, Amélie Hu, Christiane Pagès, Laurie Galvan, Francoise Piguet, Patrick Aubourg, Nathalie Cartier, Jocelyne Caboche, Sandrine Betuin. CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26912634. |
huntington's disease is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (exp-htt) leading to degeneration of striatal neurons. |
2016-07-18 |
2023-08-13 |
mouse |
| Georgeta Camelial Cozaru, Mariana Aşchie, Anca Florentina Mitroi, I Poinăreanu, E V Gorduz. ETHICAL AND GENETIC ASPECTS REGARDING PRESYMPTOMATIC TESTING FOR NEURODEGENERATIVE DISEASES. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. vol 120. issue 1. 2016-06-29. PMID:27125067. |
in huntington's chorea, the progressive neurodegenerative disease could be diagnose prenatal and presymptomatic by analyse of the number of cag repeats in exon 1 of the huntingtin gene. |
2016-06-29 |
2023-08-13 |
Not clear |
| Mayke Oosterloo, Martine J Van Belzen, Emilia K Bijlsma, Raymund A C Roo. Is There Convincing Evidence that Intermediate Repeats in the HTT Gene Cause Huntington's Disease? Journal of Huntington's disease. vol 4. issue 2. 2016-06-15. PMID:26397895. |
huntington's disease (hd) is a neurodegenerative disease associated with a cag repeat expansion in the huntingtin (htt) gene. |
2016-06-15 |
2023-08-13 |
Not clear |