| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maxmore Chaibva, Xiang Gao, Pranav Jain, Warren A Campbell, Shelli L Frey, Justin Legleite. Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes. ACS omega. vol 3. issue 1. 2020-09-29. PMID:29399649. |
huntington disease (hd) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyq) tract near the n-terminus of the huntingtin (htt) protein. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yueshan Sun, Xueqin Jiang, Rong Pan, Xiaogang Zhou, Dalian Qin, Rui Xiong, Yiling Wang, Wenqiao Qiu, Anguo Wu, Jianming W. Escins Isolated from Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32158393. |
escins isolated from the pathogenesis of huntington's disease (hd), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mhtt) protein. |
2020-09-28 |
2023-08-13 |
Not clear |
| Polina A Egorova, Aleksandra V Gavrilova, Ilya B Bezprozvann. Ataxic Symptoms in Huntington's Disease Transgenic Mouse Model Are Alleviated by Chlorzoxazone. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32317916. |
huntington's disease (hd) is a hereditary neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein, striatum atrophy in hd leads to a progressive disturbance of psychiatric, motor, and cognitive function. |
2020-09-28 |
2023-08-13 |
mouse |
| Eric N Anderson, Joseph A White, Shermali Gunawarden. Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation. Degenerative neurological and neuromuscular disease. vol 4. 2020-09-28. PMID:32669899. |
in this review, we focus on the assembly of the amyloid precursor protein, huntingtin, mitochondria, and the rna-motor complexes and discuss how these may be regulated during long-distance transport in the context of neurodegenerative disease. as knowledge of these motor-cargo complexes and their involvement in axonal transport expands, insight into how defects in this pathway contribute to the development of neurodegenerative diseases becomes evident. |
2020-09-28 |
2023-08-13 |
Not clear |
| Christine M Stahl, Andrew Feigi. Medical, Surgical, and Genetic Treatment of Huntington Disease. Neurologic clinics. vol 38. issue 2. 2020-09-21. PMID:32279715. |
huntington disease, a neurodegenerative disease characterized by progressive motor, behavioral, and cognitive decline, is caused by a cag trinucleotide repeat expansion in the huntingtin gene on chromosome 4. |
2020-09-21 |
2023-08-13 |
Not clear |
| Inês Caldeira Brás, Annekatrin König, Tiago Fleming Outeir. Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention. Journal of Huntington's disease. vol 8. issue 3. 2020-07-08. PMID:31322580. |
huntington's disease (hd) is a hereditary neurodegenerative disease caused by an expansion of a cag repeat in the huntingtin gene. |
2020-07-08 |
2023-08-13 |
Not clear |
| Tessa Sinnige, Anan Yu, Richard I Morimot. Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease. Advances in experimental medicine and biology. vol 1243. 2020-06-08. PMID:32297211. |
for alzheimer's, parkinson's, huntington's diseases and als, multiple classes of molecular chaperones interact with the highly aggregation-prone proteins amyloid-β, tau, α-synuclein, huntingtin and sod1 to influence the course of proteotoxicity associated with these neurodegenerative diseases. |
2020-06-08 |
2023-08-13 |
human |
| Weiqi Yang, Jingmo Xie, Qiang Qiang, Li Li, Xiang Lin, Yiqing Ren, Wenlei Ren, Qiong Liu, Guomin Zhou, Wenshi Wei, Hexige Saiyin, Lixiang M. Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington's Disease. Neuroscience bulletin. vol 35. issue 6. 2020-05-29. PMID:31432317. |
huntington's disease (hd) is a deadly neurodegenerative disease with abnormal expansion of cag repeats in the huntingtin gene. |
2020-05-29 |
2023-08-13 |
Not clear |
| Radhia Kacher, Antonin Lamazière, Nicolas Heck, Vincent Kappes, Coline Mounier, Gaëtan Despres, Yulia Dembitskaya, Elodie Perrin, Wilhelm Christaller, Satish Sasidharan Nair, Valérie Messent, Nathalie Cartier, Peter Vanhoutte, Laurent Venance, Frédéric Saudou, Christian Néri, Jocelyne Caboche, Sandrine Betuin. CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease. Brain : a journal of neurology. vol 142. issue 8. 2020-05-19. PMID:31286142. |
huntington's disease is a fatal autosomal dominant neurodegenerative disease caused by an abnormal cag expansion in huntingtin's gene. |
2020-05-19 |
2023-08-13 |
mouse |
| Zhihao Qi, Zhen Huang, Feng Xie, Linxi Che. Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30515821. |
here, we will give a detailed review about the recent developments in regards to dynamin-related protein 1 (drp1) induced unbalanced mitochondrial dynamics, excessive mitochondrial division, and neuronal injury in neural system dysfunctions and neurodegenerative diseases, including the drp1 knockout induced mice embryonic death, the dysfunction of the drp1-dependent mitochondrial division induced neuronal cell apoptosis and impaired neuronal axonal transportation, the abnormal interaction between drp1 and amyloid β (aβ) in alzheimer's disease (ad), the mutant huntingtin (htt) in huntington's disease (hd), and the drp1-associated pathogenesis of other neurodegenerative diseases such as parkinson's disease (pd) and amyotrophic lateral sclerosis (als). drp1 is required for mitochondrial division determining the size, shape, distribution, and remodeling as well as maintaining of mitochondrial integrity in mammalian cells. |
2020-05-04 |
2023-08-13 |
mouse |
| Sara Sameni, Run Zhang, Michelle A Digma. The Phasor FLIM Method Reveals a Link Between a Change in Energy Metabolism and mHtt protein spread in Healthy Mammalian Cells when Co-cultured with Huntington Diseased Cells. Methods and applications in fluorescence. 2020-04-04. PMID:32235053. |
huntington disease (hd) is a late-onset autosomal neurodegenerative disease characterized by the aggregations of mutant huntingtin proteins (mhtt). |
2020-04-04 |
2023-08-13 |
Not clear |
| Lisa M Stanek, Jie Bu, Lamya S Shihabuddi. Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics. Neurobiology of disease. vol 129. 2020-03-24. PMID:31042572. |
huntington's disease (hd) is a fatal autosomal dominant neurodegenerative disease caused by a cag expansion, which translates into an elongated polyglutamine (polyq) repeat near the amino-terminus of the huntingtin protein (htt). |
2020-03-24 |
2023-08-13 |
mouse |
| Chelsy R Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R Hayden, Christopher A Ros. Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor. Neurobiology of disease. vol 129. 2020-03-24. PMID:31108174. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag repeat expansion in the huntingtin gene (htt), translated into a huntingtin protein with a polyglutamine expansion. |
2020-03-24 |
2023-08-13 |
mouse |
| Nicholas S Caron, Amber L Southwell, Cynthia C Brouwers, Louisa Dal Cengio, Yuanyun Xie, Hailey Findlay Black, Lisa M Anderson, Seunghyun Ko, Xiang Zhu, Sander J van Deventer, Melvin M Evers, Pavlina Konstantinova, Michael R Hayde. Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease. Nucleic acids research. vol 48. issue 1. 2020-03-18. PMID:31745548. |
huntington disease (hd) is a fatal neurodegenerative disease caused by a pathogenic expansion of a cag repeat in the huntingtin (htt) gene. |
2020-03-18 |
2023-08-13 |
mouse |
| Annalise Di Marco, Odalys Gonzalez Paz, Ivan Fini, Domenico Vignone, Antonella Cellucci, Maria Rosaria Battista, Giulio Auciello, Laura Orsatti, Matteo Zini, Edith Monteagudo, Vinod Khetarpal, Mark Rose, Celia Dominguez, Todd Herbst, Leticia Toledo-Sherman, Vincenzo Summa, Ignacio Muñoz-Sanjuá. Application of an in Vitro Blood-Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington's Disease. Molecular pharmaceutics. vol 16. issue 5. 2020-03-10. PMID:30916978. |
huntington's disease (hd) is a neurodegenerative disease caused by polyglutamine expansion in the huntingtin protein. |
2020-03-10 |
2023-08-13 |
rat |
| Shinichiro Mori, Hiroyuki Honda, Takashi Ishii, Motoi Yoshimura, Naokazu Sasagasako, Satoshi O Suzuki, Takayuki Taniwaki, Toru Iwak. Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)-binding protein 1 in Huntington's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 39. issue 5. 2020-03-06. PMID:31599037. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the huntingtin protein. |
2020-03-06 |
2023-08-13 |
mouse |
| Zixing Fu, Fang Liu, Chunyue Liu, Beifang Jin, Yueqing Jiang, Mingliang Tang, Xin Qi, Xing Gu. Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 6. 2020-02-03. PMID:30802639. |
numerous studies have shown that mitochondrial dysfunction contributes to consequential phenotypes of huntington's disease (hd), a fatal and inherited neurodegenerative disease caused by the expanded cag repeats in the n-terminus of the huntingtin (htt) gene. |
2020-02-03 |
2023-08-13 |
Not clear |
| Ashley A Zurawel, Ruth Kabeche, Sonja E DiGregorio, Lin Deng, Kartikeya M Menon, Hannah Opalko, Martin L Duennwald, James B Moseley, Surachai Supattapon. CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins. mBio. vol 7. issue 5. 2019-12-30. PMID:27677791. |
in humans, proteins such as huntingtin (htt) with abnormally expanded polyq regions cause neurodegenerative diseases such as huntington's disease (hd). |
2019-12-30 |
2023-08-13 |
Not clear |
| Chenglong Yu, Chun Hei Li, Sidong Chen, Hanna Yoo, Xianan Qin, Hyokeun Par. Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington's Disease. Scientific reports. vol 8. issue 1. 2019-12-13. PMID:30451892. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by an increase in cag repeats in the huntingtin gene (htt). |
2019-12-13 |
2023-08-13 |
mouse |
| Manuel Menéndez-González, Jordi Clarimón, Irene Rosas-Allende, Marta Blázquez, Esther Suárez San Martín, Ciara García-Fernández, Alberto Lleó, Oriol Dols-Icardo, Ignacio Illán-Gala, Germán Morís, Renée Ribacoba, Victoria Álvarez, Carmen Martíne. HTT gene intermediate alleles in neurodegeneration: evidence for association with Alzheimer's disease. Neurobiology of aging. vol 76. 2019-12-06. PMID:30583877. |
the aim of this work was to analyze the association between intermediate huntingtin cag-repeat alleles (ias) and neurodegenerative diseases, other than hd. |
2019-12-06 |
2023-08-13 |
Not clear |