| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elodie Martin, Raheleh Heidari, Véronique Monnier, Hervé Tricoir. Genetic Screen in Adult Drosophila Reveals That dCBP Depletion in Glial Cells Mitigates Huntington Disease Pathology through a Foxo-Dependent Pathway. International journal of molecular sciences. vol 22. issue 8. 2021-05-25. PMID:33918672. |
huntington's disease (hd) is a progressive and fatal autosomal dominant neurodegenerative disease caused by a cag repeat expansion in the first exon of the huntingtin gene ( |
2021-05-25 |
2023-08-13 |
drosophila_melanogaster |
| Alexander S Falk, José M Bravo-Arredondo, Jobin Varkey, Sayuri Pacheco, Ralf Langen, Ansgar B Sieme. Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils. Biophysical journal. vol 119. issue 10. 2021-05-14. PMID:33096080. |
huntington's disease is a heritable neurodegenerative disease that is caused by a cag expansion in the first exon of the huntingtin gene. |
2021-05-14 |
2023-08-13 |
Not clear |
| Congcong Zhang, Rina M Ötjengerdes, Julian Roewe, Rebeca Mejias, Andrea L J Marschal. Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 34. issue 4. 2021-04-07. PMID:32301049. |
disease-related targets included proteins associated with neurodegenerative diseases such as parkinson's disease (α-synuclein), alzheimer's disease (amyloid-β) or huntington's disease (mutant huntingtin [mhtt]). |
2021-04-07 |
2023-08-13 |
human |
| Nicholas S Caron, Raul Banos, Christopher Yanick, Amirah E Aly, Lauren M Byrne, Ethan D Smith, Yuanyun Xie, Stephen E P Smith, Nalini Potluri, Hailey Findlay Black, Lorenzo Casal, Seunghyun Ko, Daphne Cheung, Hyeongju Kim, Ihn Sik Seong, Edward J Wild, Ji-Joon Song, Michael R Hayden, Amber L Southwel. Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 4. 2021-03-26. PMID:33310753. |
huntington disease (hd) is a neurodegenerative disease caused by a cag trinucleotide repeat expansion in the huntingtin ( |
2021-03-26 |
2023-08-13 |
Not clear |
| Iván Fernández-Cruz, Enrique Reynau. Proteasome Subunits Involved in Neurodegenerative Diseases. Archives of medical research. vol 52. issue 1. 2021-03-24. PMID:32962866. |
proteasome subunits interact with proteins that are known to accumulate in neurodegenerative diseases such as α-synuclein in parkinson's, tau in alzheimer's, and huntingtin in huntington's diseases. |
2021-03-24 |
2023-08-13 |
Not clear |
| Luisa Vernizzi, Chiara Paiardi, Giusimaria Licata, Teresa Vitali, Stefania Santarelli, Martino Raneli, Vera Manelli, Manuela Rizzetto, Mariarosa Gioria, Maria E Pasini, Daniela Grifoni, Maria A Vanoni, Cinzia Gellera, Franco Taroni, Paola Bellost. Glutamine Synthetase 1 Increases Autophagy Lysosomal Degradation of Mutant Huntingtin Aggregates in Neurons, Ameliorating Motility in a Cells. vol 9. issue 1. 2021-03-10. PMID:31941072. |
glutamine synthetase 1 increases autophagy lysosomal degradation of mutant huntingtin aggregates in neurons, ameliorating motility in a glutamine synthetase 1 (gs1) is a key enzyme that catalyzes the atp-dependent synthesis of l-glutamine from l-glutamate and is also member of the glutamate glutamine cycle, a complex physiological process between glia and neurons that controls glutamate homeostasis and is often found compromised in neurodegenerative diseases including huntington's disease (hd). |
2021-03-10 |
2023-08-13 |
Not clear |
| Christiana C Christodoulou, Margarita Zachariou, Marios Tomazou, Evangelos Karatzas, Christiana A Demetriou, Eleni Zamba-Papanicolaou, George M Spyro. Investigating the Transition of Pre-Symptomatic to Symptomatic Huntington's Disease Status Based on Omics Data. International journal of molecular sciences. vol 21. issue 19. 2021-03-08. PMID:33049985. |
huntington's disease is a rare neurodegenerative disease caused by a cytosine-adenine-guanine (cag) trinucleotide expansion in the huntingtin ( |
2021-03-08 |
2023-08-13 |
Not clear |
| Harleen Kohli, Pravir Kumar, Rashmi K Ambast. Heliyon. vol 7. issue 2. 2021-03-05. PMID:33659724. |
huntington's disease is a neurodegenerative disease caused by cag repeat in the first exon of htt (huntingtin) gene, leading to abnormal form of htt protein containing enlarged polyglutamine strands of variable length that stick together to form aggregates and is toxic to brain causing brain damage. |
2021-03-05 |
2023-08-13 |
Not clear |
| Faezeh Sedighi, Adewale Adegbuyiro, Justin Legleite. SUMOylation Prevents Huntingtin Fibrillization and Localization onto Lipid Membranes. ACS chemical neuroscience. vol 11. issue 3. 2021-03-03. PMID:31880908. |
huntington's disease (hd), a genetic neurodegenerative disease, is caused by an expanded polyglutamine (polyq) domain in the first exon of the huntingtin protein (htt). |
2021-03-03 |
2023-08-13 |
Not clear |
| Roger A Barker, Motoki Fujimaki, Priya Rogers, David C Rubinsztei. Huntingtin-lowering strategies for Huntington's disease. Expert opinion on investigational drugs. vol 29. issue 10. 2021-03-03. PMID:32745442. |
huntington's disease (hd) is an incurable, autosomal dominant neurodegenerative disease caused by an abnormally long polyglutamine tract in the huntingtin protein. |
2021-03-03 |
2023-08-13 |
Not clear |
| Annesha C King, Tara E Wood, Efrain Rodriguez, Vladimir Parpura, Michelle Gra. Differential effects of SNARE-dependent gliotransmission on behavioral phenotypes in a mouse model of Huntington's disease. Experimental neurology. vol 330. 2021-02-01. PMID:32387649. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by a polyglutamine expansion in the widely expressed huntingtin protein. |
2021-02-01 |
2023-08-13 |
mouse |
| Jennifer C Boatz, Talia Piretra, Alessia Lasorsa, Irina Matlahov, James F Conway, Patrick C A van der We. Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1. Journal of molecular biology. vol 432. issue 16. 2021-01-25. PMID:32598938. |
huntington's disease is a progressive neurodegenerative disease caused by expansion of the polyglutamine domain in the first exon of huntingtin (httex1). |
2021-01-25 |
2023-08-13 |
Not clear |
| Havva Yalinca, Charlotte Julie Caroline Gehin, Vladimiras Oleinikovas, Hilal A Lashuel, Francesco Luigi Gervasio, Annalisa Pastor. The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus. Frontiers in molecular biosciences. vol 6. 2021-01-10. PMID:31632982. |
huntington disease is a neurodegenerative disease characterized by a polymorphic tract of polyglutamine repeats in exon 1 of the huntingtin protein, which is thought to be responsible for protein aggregation and neuronal death. |
2021-01-10 |
2023-08-13 |
human |
| Endan Li, Hee Ra Park, Chang Pyo Hong, Younghoon Kim, Jiwoo Choi, Suji Lee, Hyun Jung Park, Bomi Lee, Tae Aug Kim, Seong Jin Kim, Hyun Sook Kim, Jihwan Son. Neural stem cells derived from the developing forebrain of YAC128 mice exhibit pathological features of Huntington's disease. Cell proliferation. vol 53. issue 10. 2020-10-29. PMID:32865873. |
huntington's disease (hd) is a devastating neurodegenerative disease caused by polyglutamine (polyq) expansion in the huntingtin (htt) gene. |
2020-10-29 |
2023-08-13 |
mouse |
| Martin L Duennwal. Cellular stress responses in protein misfolding diseases. Future science OA. vol 1. issue 2. 2020-10-01. PMID:28031871. |
huntington's disease is an inherited neurodegenerative disease caused by the misfolding of an abnormally expanded polyglutamine (polyq) region in the protein huntingtin (htt), polyqhtt. |
2020-10-01 |
2023-08-13 |
human |
| Bindu D Paul, Solomon H Snyde. Impaired Redox Signaling in Huntington's Disease: Therapeutic Implications. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:30941013. |
huntington's disease (hd) is a neurodegenerative disease triggered by expansion of polyglutamine repeats in the protein huntingtin. |
2020-10-01 |
2023-08-13 |
Not clear |
| Taylor A Intihar, Elisa A Martinez, Rocio Gomez-Pasto. Mitochondrial Dysfunction in Huntington's Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30941017. |
huntington's disease (hd) is a neurodegenerative disease caused by an expanded cag repeat in the huntingtin ( |
2020-10-01 |
2023-08-13 |
Not clear |
| Diogo Ferreira, Berta Carvalho, Ana P Neto, Joaquina Silva, Ana M Póvoa, Alberto Barros, Filipa Carvalh. Preimplantation genetic testing for Huntington disease: the perspective of one Portuguese center. Porto biomedical journal. vol 4. issue 5. 2020-10-01. PMID:31893246. |
huntington disease (hd) is an autosomal dominant late-onset neurodegenerative disease caused by an unstable cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin ( |
2020-10-01 |
2023-08-13 |
Not clear |
| Magdalena Czeredys, Vladimir A Vigont, Vasilisa A Boeva, Katsuhiko Mikoshiba, Elena V Kaznacheyeva, Jacek Kuznick. Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington's Disease. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30455632. |
huntington's disease (hd) is a hereditary neurodegenerative disease that is caused by polyglutamine expansion within the huntingtin (htt) gene. |
2020-09-30 |
2023-08-13 |
mouse |
| Ryoma Morigaki, Satoshi Got. Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity. Brain sciences. vol 7. issue 6. 2020-09-29. PMID:28590448. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by the expansion of a cag trinucleotide repeat encoding an abnormally long polyglutamine tract (polyq) in the huntingtin (htt) protein. |
2020-09-29 |
2023-08-13 |
Not clear |