| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tristano Pancani, Michelle Day, Tatiana Tkatch, David L Wokosin, Patricia González-Rodríguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D James Surmeie. Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington's disease model mice. Nature communications. vol 14. issue 1. 2023-03-14. PMID:36914640. |
huntington's disease (hd) is a progressive, neurodegenerative disease caused by a cag triplet expansion in huntingtin. |
2023-03-14 |
2023-08-14 |
mouse |
| Dorota Wronka, Anna Karlik, Julia O Misiorek, Lukasz Przyby. What the Gut Tells the Brain-Is There a Link between Microbiota and Huntington's Disease? International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901907. |
this dominantly heritable, incurable neurodegenerative disease is caused by the expansion of cag trinucleotide repeats in the huntingtin gene ( |
2023-03-11 |
2023-08-14 |
human |
| Christiana C Christodoulou, Eleni Zamba Papanicolao. Integrated Bioinformatics Analysis of Shared Genes, miRNA, Biological Pathways and Their Potential Role as Therapeutic Targets in Huntington's Disease Stages. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902304. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt). |
2023-03-11 |
2023-08-14 |
Not clear |
| Baljit S Khakh, Steven A Goldma. Astrocytic contributions to Huntington's disease pathophysiology. Annals of the New York Academy of Sciences. 2023-03-02. PMID:36864567. |
huntington's disease (hd) is a fatal, monogenic, autosomal dominant neurodegenerative disease caused by a polyglutamine-encoding cag expansion in the huntingtin (htt) gene that results in mutant huntingtin proteins (mhtt) in cells throughout the body. |
2023-03-02 |
2023-08-14 |
mouse |
| Monique C P Mendonça, Yao Sun, Michael F Cronin, Andrew J Lindsay, John F Cryan, Caitriona M O'Driscol. Cyclodextrin-Based Nanoparticles for Delivery of Antisense Oligonucleotides Targeting Huntingtin. Pharmaceutics. vol 15. issue 2. 2023-02-25. PMID:36839842. |
huntington's disease (hd) is a progressive inherited neurodegenerative disease caused by a cag repeat expansion in the huntingtin gene, which is translated into the pathologic mutant huntingtin (mhtt) protein. |
2023-02-25 |
2023-08-14 |
Not clear |
| Kun Li, Ziqiang Wan. lncRNA NEAT1: key player in neurodegenerative diseases. Ageing research reviews. 2023-02-04. PMID:36738893. |
this review summarizes our current knowledge of the role of neat1 in neurodegenerative diseases and its association with the characteristic aggregation of misfolded proteins: amyloid-β and tau in ad, α-synuclein in pd, mutant huntingtin in hd, and tar dna-binding protein-43 fused in sarcoma/translocated in liposarcoma in als. |
2023-02-04 |
2023-08-14 |
Not clear |
| Noria Okada, Shinsuke Nakamura, Masamitsu Shimazaw. 3-Nitropropionic Acid Enhances Ferroptotic Cell Death via NOX2-Mediated ROS Generation in STHdhQ111 Striatal Cells Carrying Mutant Huntingtin. Biological & pharmaceutical bulletin. vol 46. issue 2. 2023-02-01. PMID:36724946. |
huntington's disease (hd) is a hereditary neurodegenerative disease that involves an expansion of the cag repeats of the huntingtin (htt) gene, but the disease onset and progression do not necessarily correspond to the extent of cag repeats. |
2023-02-01 |
2023-08-14 |
mouse |
| Sirui Zhang, Yangfan Cheng, Huifang Shan. The updated development of blood-based biomarkers for Huntington's disease. Journal of neurology. 2023-01-24. PMID:36692635. |
huntington's disease is a progressive neurodegenerative disease caused by mutation of the huntingtin (htt) gene. |
2023-01-24 |
2023-08-14 |
Not clear |
| Julien Chambon, Pragya Komal, Gil M Lewitus, Gina M Kemp, Simone Valade, Houaria Adaidi, Noura Al Bistami, David Stellwage. Early TNF-Dependent Regulation of Excitatory and Inhibitory Synapses on Striatal Direct Pathway Medium Spiny Neurons in the YAC128 Mouse Model of Huntington's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-12-14. PMID:36517241. |
huntington's disease (hd) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin gene. |
2022-12-14 |
2023-08-14 |
mouse |
| Suleyman Serdar Alkanli, Nevra Alkanli, Arzu Ay, Isil Albeni. CRISPR/Cas9 Mediated Therapeutic Approach in Huntington's Disease. Molecular neurobiology. 2022-12-09. PMID:36482283. |
huntington's disease (hd), a dominant and neurodegenerative disease, is characterized by the cag re-expansion that occurs in the gene encoding the polyglutamine-expanded mutant huntingtin (mhtt) protein. |
2022-12-09 |
2023-08-14 |
mouse |
| Hyuck Kim, Rocio Gomez-Pasto. HSF1 and Its Role in Huntington's Disease Pathology. Advances in experimental medicine and biology. 2022-11-17. PMID:36396925. |
this review focuses on huntington's disease (hd), a neurodegenerative disease characterized by severe protein aggregation of the huntingtin (htt) protein. |
2022-11-17 |
2023-08-14 |
Not clear |
| Hannah S Hart, Madeline A Valentin, Stephanie Toering Peters, Susan W Holler, Hongmin Wang, Aaron F Harmon, Larry D Holle. The cytoprotective role of GM1 ganglioside in Huntington disease cells. Molecular biology reports. 2022-09-30. PMID:36180805. |
huntington disease (hd) is a neurodegenerative disease where a genetic mutation leads to excessive polyglutamine (q) repeats in the huntingtin protein. |
2022-09-30 |
2023-08-14 |
Not clear |
| Sai Sanwid Pradhan, Sai Manohar Thota, R Saiswaroop, Sai Krishna Srimadh Bhagavatham, Sujith Kumar Pulukool, Sriram Rathnakumar, Kanikaram Sai Phalguna, Rajesh Babu Dandamudi, Ashish Pargaonkar, Prasanth Joseph, Joshy E V, Venketesh Sivaramakrishna. Integrated multi-omic analysis of Huntington disease and yeast model delineates pathways modulating protein aggregation. Disease models & mechanisms. 2022-09-02. PMID:36052548. |
huntington's disease (hd) is a neurodegenerative disease associated with polyglutamine expansion in the protein huntingtin. |
2022-09-02 |
2023-08-14 |
mouse |
| Aziza Rahman, Bondeepa Saikia, Chimi Rekha Gogoi, Anupaul Barua. Advances in the understanding of protein misfolding and aggregation through molecular dynamics simulation. Progress in biophysics and molecular biology. 2022-08-31. PMID:36044970. |
it is noticeable that all four proteins considered in this review i.e prion, superoxide dismutase1, huntingtin and amyloid beta are linked to chronic neurodegenerative diseases with debilitating effects. |
2022-08-31 |
2023-08-14 |
Not clear |
| S M Ayala Mariscal, M L Pigazzini, Y Richter, M Özel, I L Grothaus, J Protze, K Ziege, M Kulke, M ElBediwi, J V Vermaas, L Colombi Ciacchi, S Köppen, F Liu, J Kirstei. Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT. Nature communications. vol 13. issue 1. 2022-08-10. PMID:35948542. |
huntington's disease is a neurodegenerative disease caused by an expanded polyq stretch within huntingtin (htt) that renders the protein aggregation-prone, ultimately resulting in the formation of amyloid fibrils. |
2022-08-10 |
2023-08-14 |
Not clear |
| Elena V Grigor'eva, Anastasia A Malakhova, Diana A Sorogina, Sofia V Pavlova, Tuyana B Malankhanova, Natalia Yu Abramycheva, Sergey A Klyushnikov, Sergey N Illarioshkin, Suren M Zakia. Generation of induced pluripotent stem cell line, ICGi033-A, by reprogramming peripheral blood mononuclear cells from a patient with Huntington's disease. Stem cell research. vol 63. 2022-07-25. PMID:35872525. |
huntington's disease (hd) is a hereditary autosomal dominant neurodegenerative disease caused by the polyglutamine stretch expansion in the huntingtin (htt) protein. |
2022-07-25 |
2023-08-14 |
Not clear |
| Sonia Podvin, Sara Brin Rosenthal, William Poon, Enlin Wei, Kathleen M Fisch, Vivian Hoo. Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease. Journal of Huntington's disease. 2022-07-24. PMID:35871359. |
huntington's disease (hd) is a genetic neurodegenerative disease caused by trinucleotide repeat (cag) expansions in the human htt gene encoding the huntingtin protein (htt) with an expanded polyglutamine tract. |
2022-07-24 |
2023-08-14 |
human |
| Khushboo Kapadia, Ashley E Trojniak, Kenneth B Guzmán Rodríguez, Nicholas J Klus, Coral Huntley, Peter McDonald, Anuradha Roy, Kevin J Frankowski, Jeffrey Aubé, Nancy A Mum. Small-Molecule Disruptors of Mutant Huntingtin-Calmodulin Protein-Protein Interaction Attenuate Deleterious Effects of Mutant Huntingtin. ACS chemical neuroscience. 2022-07-14. PMID:35833925. |
huntington's disease is a progressive and lethal neurodegenerative disease caused by an increased cag repeat mutation in exon 1 of the huntingtin gene (mutant huntingtin). |
2022-07-14 |
2023-08-14 |
mouse |
| Erpan Ahat, Sarah Bui, Jianchao Zhang, Felipe da Veiga Leprevost, Lisa Sharkey, Whitney Reid, Alexey I Nesvizhskii, Henry L Paulson, Yanzhuang Wan. GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin. The Journal of biological chemistry. 2022-07-05. PMID:35780830. |
here, we surveyed several neurodegenerative disease related proteins, including mutant huntingtin (htt-q74), sod1, tau, and tdp43, for unconventional secretion; our results show that htt-q74 is most robustly secreted in a grasp55-dependent manner. |
2022-07-05 |
2023-08-14 |
Not clear |
| Raleigh M Linville, Renée F Nerenberg, Gabrielle Grifno, Diego Arevalo, Zhaobin Guo, Peter C Searso. Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington's disease. Fluids and barriers of the CNS. vol 19. issue 1. 2022-06-30. PMID:35773691. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by expansion of cytosine-adenine-guanine (cag) repeats in the huntingtin gene, which leads to neuronal loss and decline in cognitive and motor function. |
2022-06-30 |
2023-08-14 |
Not clear |