| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerard Ross. Novel Pyrrolo-pyrazol-one Ligands of Alpha-Synuclein for Diagnosis of Parkinson's Disease. ACS medicinal chemistry letters. vol 15. issue 2. 2024-02-14. PMID:38352848. |
many neurodegenerative diseases are characterized by cellular deposits such as abeta, tau, alpha-synuclein, and huntingtin. |
2024-02-14 |
2024-02-16 |
human |
| b' Maria Grazia Maggio, Luana Billeri, Davide Cardile, Angelo Quartarone, Rocco Salvatore Calabr\\xc3\\xb. The Role of Innovation Technology in the Rehabilitation of Patients Affected by Huntington\'s Disease: A Scoping Review. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255146.' |
huntington's disease is an autosomal dominant neurodegenerative disease caused by the repetition of cytosine, adenine, and guanine trinucleotides on the short arm of chromosome 4p16.3 within the huntingtin gene. |
2024-01-23 |
2024-01-25 |
Not clear |
| Francesco D'Egidio, Vanessa Castelli, Giorgia Lombardozzi, Fabrizio Ammannito, Annamaria Cimini, Michele d'Angel. Therapeutic advances in neural regeneration for Huntington's disease. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227527. |
huntington's disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the htt gene which is responsible for the production of the huntingtin (htt) protein. |
2024-01-16 |
2024-01-18 |
Not clear |
| Max Gentenaar, Fleur L Meulmeester, Ximaine R van der Burg, Anna T Hoekstra, Hazel Hunt, Jan Kroon, Willeke M C van Roon-Mom, Onno C Meije. Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice. Experimental neurology. 2024-01-12. PMID:38216109. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by a mutation in the huntingtin gene. |
2024-01-12 |
2024-01-15 |
mouse |
| Chao Wu, Haoran Yin, Songdi Fu, Hanna Yoo, Min Zhang, Hyokeun Par. Altered anterograde axonal transport of mitochondria in cultured striatal neurons of a knock-in mouse model of Huntington's disease. Biochemical and biophysical research communications. vol 691. 2024-01-01. PMID:38029540. |
huntington's disease (hd) is a progressive genetic neurodegenerative disease caused by an abnormal expansion of a cytosine-adenine-guanine trinucleotide repeat in the huntingtin gene. |
2024-01-01 |
2024-01-05 |
mouse |
| Monika Chitre, Patrick Emer. ATXN2 is a target of N-terminal proteolysis. PloS one. vol 18. issue 12. 2023-12-21. PMID:38128014. |
other polyq-containing proteins such as atxn7 and huntingtin are associated with the development of neurodegenerative diseases when their n-terminal polyq domains are expanded. |
2023-12-21 |
2023-12-24 |
Not clear |
| Khalid A Ibrahim, Kristin S Grußmayer, Nathan Riguet, Lely Feletti, Hilal A Lashuel, Aleksandra Radenovi. Label-free identification of protein aggregates using deep learning. Nature communications. vol 14. issue 1. 2023-11-30. PMID:38016971. |
protein misfolding and aggregation play central roles in the pathogenesis of various neurodegenerative diseases (ndds), including huntington's disease, which is caused by a genetic mutation in exon 1 of the huntingtin protein (httex1). |
2023-11-30 |
2023-12-07 |
Not clear |
| Khalid A Ibrahim, Kristin S Grußmayer, Nathan Riguet, Lely Feletti, Hilal A Lashuel, Aleksandra Radenovi. Label-free identification of protein aggregates using deep learning. Nature communications. vol 14. issue 1. 2023-11-30. PMID:38016971. |
protein misfolding and aggregation play central roles in the pathogenesis of various neurodegenerative diseases (ndds), including huntington's disease, which is caused by a genetic mutation in exon 1 of the huntingtin protein (httex1). |
2023-11-28 |
2023-12-07 |
Not clear |
| Liang Li, Tong Lei, Cencan Xing, Hongwu D. Advances in microfluidic chips targeting toxic aggregation proteins for neurodegenerative diseases. International journal of biological macromolecules. 2023-11-22. PMID:37992921. |
our lab-on-a-chip system releases toxic proteins to simulate the pathological characteristics of neurodegenerative diseases, encompassing β-amyloid, α-synuclein, huntingtin, tar dna-binding protein 43, and myelin basic protein. |
2023-11-22 |
2023-11-29 |
human |
| Jonathan R Roth, Ruan Carlos Macedo de Moraes, Brittney P Xu, Savannah R Crawley, Malghalara A Khan, Girish C Melkan. Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Frontiers in aging neuroscience. vol 15. 2023-10-12. PMID:37823007. |
rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in huntington's disease (hd) is a neurodegenerative disease characterized by movement and cognitive dysfunction. |
2023-10-12 |
2023-10-15 |
Not clear |
| Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Jacyln B Fahey, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Yejin A Kim, Richard L M Faull, Suman Jayadev, Ted Yednock, X William Yang, Beth Steven. Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease. Nature medicine. 2023-10-09. PMID:37814059. |
huntington's disease (hd) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in the basal ganglia despite the ubiquitous expression of mutant huntingtin. |
2023-10-09 |
2023-10-15 |
Not clear |
| Huichun Tong, Tianqi Yang, Li Liu, Caijuan Li, Yize Sun, Qingqing Jia, Yiyang Qin, Laiqiang Chen, Xianxian Zhao, Gongke Zhou, Sen Yan, Xiao-Jiang Li, Shihua L. Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs. Neurobiology of disease. 2023-09-16. PMID:37716514. |
huntington's disease (hd) is an autosomal-dominant inherited neurodegenerative disease caused by a cag repeat expansion in exon1 of the huntingtin gene (htt). |
2023-09-16 |
2023-10-07 |
mouse |
| Costanza Ferrari Bardile, Carola I Radulescu, Mahmoud A Poulad. Oligodendrocyte pathology in Huntington's disease: from mechanisms to therapeutics. Trends in molecular medicine. 2023-08-17. PMID:37591764. |
there is new recognition of the role of olgs in the pathogenesis of neurodegenerative diseases (ndds), including huntington's disease (hd), a prototypic ndd caused by a polyglutamine tract expansion in huntingtin (htt), which results in gain- and loss-of-function effects. |
2023-08-17 |
2023-09-07 |
Not clear |
| Mohammed Khaled, Birgit Strodel, Abdallah Sayyed-Ahma. Comparative molecular dynamics simulations of pathogenic and non-pathogenic huntingtin protein monomers and dimers. Frontiers in molecular biosciences. vol 10. 2023-04-27. PMID:37101557. |
polyglutamine expansion at the n-terminus of the huntingtin protein exon 1 (htt-ex1) is closely associated with a number of neurodegenerative diseases, which result from the aggregation of the increased polyq repeat. |
2023-04-27 |
2023-08-14 |
Not clear |
| Christopher Daniel Morrone, Radha Raghuraman, S Abid Hussaini, Wai Haung Y. Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-04-21. PMID:37085942. |
this phenomenon extends beyond β-amyloid and tau, with interactions of sleep impairment with the homeostasis of tdp-43, α-synuclein, fus, and huntingtin proteins, implicating sleep loss as an important consideration in an array of neurodegenerative diseases and in cases of mixed neuropathology. |
2023-04-21 |
2023-08-14 |
Not clear |
| Alyssa R Stonebraker, Maryssa Beasley, Sophia Massinople, Michelle Wunder, Peng Li, Stephen J Valentine, Justin Legleite. Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation. Protein science : a publication of the Protein Society. 2023-04-13. PMID:37052951. |
huntington's disease (hd) is a neurodegenerative disease resulting from an expansion of the polyglutamine (polyq) domain within the huntingtin protein (htt). |
2023-04-13 |
2023-08-14 |
Not clear |
| Jenny Lange, Olivia Gillham, Michael Flower, Heather Ging, Simon Eaton, Sneha Kapadia, Andreas Neueder, Michael R Duchen, Patrizia Ferretti, Sarah J Tabriz. PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington's disease. Progress in neurobiology. 2023-04-06. PMID:37023937. |
huntington's disease (hd) is a neurodegenerative disease caused by a polyglutamine (polyq) expansion in the huntingtin gene. |
2023-04-06 |
2023-08-14 |
human |
| Cássia Arruda de Souza Pereira, Natalia de Castro Medaglia, Rodrigo Portes Ureshino, Claudia Bincoletto, Manuela Antonioli, Gian Maria Fimia, Mauro Piacentini, Gustavo José da Silva Pereira, Adolfo Garcia Erustes, Soraya Soubhi Smail. NAADP-Evoked Ca International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982672. |
naadp-evoked ca huntington's disease (hd) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mhtt), causing an unstable repeat of the cag trinucleotide, leading to abnormal long repeats of polyglutamine (poly-q) in the n-terminal region of the huntingtin, which form abnormal conformations and aggregates. |
2023-03-29 |
2023-08-14 |
Not clear |
| Tamara Vasilkovska, Mohit Adhikari, Johan Van Audekerke, Somaie Salajeghe, Dorian Pustina, Roger Cachope, Haiying Tang, Longbin Liu, Ignacio Munoz-Sanjuan, Annemie Van der Linden, Marleen Verhoy. Resting-state fMRI reveals longitudinal alterations in brain network connectivity in the zQ175DN mouse model of Huntington's disease. Neurobiology of disease. 2023-03-24. PMID:36963694. |
huntington's disease is an autosomal, dominantly inherited neurodegenerative disease caused by an expansion of the cag repeats in exon 1 of the huntingtin gene. |
2023-03-24 |
2023-08-14 |
mouse |
| Kizito-Tshitoko Tshilenge, Carlos Galicia Aguirre, Joanna Bons, Akos A Gerencser, Nathan Basisty, Sicheng Song, Jacob Rose, Alejandro Lopez-Ramirez, Swati Naphade, Ashley Loureiro, Elena Battistoni, Mateus Milani, Cameron Wehrfritz, Anja Holtz, Claudio Hetz, Sean D Mooney, Birgit Schilling, Lisa M Ellerb. Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets. Molecular & cellular proteomics : MCP. 2023-03-23. PMID:36958627. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag repeat expansion in the huntingtin (htt) gene. |
2023-03-23 |
2023-08-14 |
human |