| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna C Pfalzer, Yan Yan, Hakmook Kang, Melissa Totten, James Silverman, Aaron B Bowman, Keith Erikson, Daniel O Claasse. Alterations in metal homeostasis occur prior to canonical markers in Huntington disease. Scientific reports. vol 12. issue 1. 2022-06-20. PMID:35725749. |
the importance of metal biology in neurodegenerative diseases such as huntingtin disease is well documented with evidence of direct interactions between metals such as copper, zinc, iron and manganese and mutant huntingtin pathobiology. |
2022-06-20 |
2023-08-14 |
human |
| Mackenzie W Ferguson, Connor J Kennedy, Thulani H Palpagama, Henry J Waldvogel, Richard L M Faull, Andrea Kwakowsk. Current and Possible Future Therapeutic Options for Huntington's Disease. Journal of central nervous system disease. vol 14. 2022-05-26. PMID:35615642. |
huntington's disease (hd) is an autosomal neurodegenerative disease that is characterized by an excessive number of cag trinucleotide repeats within the huntingtin gene ( |
2022-05-26 |
2023-08-13 |
Not clear |
| Yiyang Qin, Shihua Li, Xiao-Jiang Li, Su Yan. CRISPR-Based Genome-Editing Tools for Huntington's Disease Research and Therapy. Neuroscience bulletin. 2022-05-24. PMID:35608753. |
huntington's disease (hd) is an autosomal dominantly-inherited neurodegenerative disease, which is caused by cag trinucleotide expansion in exon 1 of the huntingtin (htt) gene. |
2022-05-24 |
2023-08-13 |
Not clear |
| Jun Wan Shin, Aram Shin, Seri S Park, Jong-Min Le. Haplotype-specific insertion-deletion variations for allele-specific targeting in Huntington's disease. Molecular therapy. Methods & clinical development. vol 25. 2022-03-31. PMID:35356757. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by an expanded cag repeat in huntingtin ( |
2022-03-31 |
2023-08-13 |
Not clear |
| E Srinivasan, Vavish Ram, R Rajasekara. A review on Huntington protein Insight into protein aggregation and therapeutic interventions. Current drug metabolism. 2022-03-23. PMID:35319359. |
huntington disease (hd) is a distressing, innate neurodegenerative disease that descends from cag repeat expansion in the huntingtin gene causing behavioral changes, motor dysfunction, and dementia in children and adults. |
2022-03-23 |
2023-08-13 |
Not clear |
| Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escarti. Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway. Brain : a journal of neurology. 2022-03-17. PMID:35298632. |
huntington's disease is a fatal neurodegenerative disease characterized by striatal neurodegeneration, aggregation of mutant huntingtin and the presence of reactive astrocytes. |
2022-03-17 |
2023-08-13 |
mouse |
| Nicholas S Caron, Raul Banos, Amirah E Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M Anderson, Benjamin Gordon, Amber L Southwell, Michael R Hayde. Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice. Neurobiology of disease. 2022-02-10. PMID:35143966. |
huntington disease (hd) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the htt gene encoding an elongated polyglutamine tract in the huntingtin (htt) protein. |
2022-02-10 |
2023-08-13 |
mouse |
| Bin Tang, Wu Zeng, Lin Lin Song, Hui Miao Wang, Li Qun Qu, Hang Hong Lo, Lu Yu, An Guo Wu, Vincent Kam Wai Wong, Betty Yuen Kwan La. Extracellular Vesicle Delivery of Neferine for the Attenuation of Neurodegenerative Disease Proteins and Motor Deficit in an Alzheimer's Disease Mouse Model. Pharmaceuticals (Basel, Switzerland). vol 15. issue 1. 2022-01-21. PMID:35056140. |
in vitro cellular models confirmed that three of the selected exosome-encapsulated natural compounds-baicalin, hederagenin and neferine-could reduce the level of neurodegenerative disease mutant proteins-including huntingtin 74 (htt74), p301l tau and a53t α-synuclein (a53t α-syn)-more effectively than the compounds alone. |
2022-01-21 |
2023-08-13 |
mouse |
| Li Zhang, Tengteng Wu, Yangyang Shan, Ge Li, Xue Ni, Xiaorui Chen, Xiuting Hu, Lishan Lin, Yongchao Li, Yalun Guan, Jinfeng Gao, Dingbang Chen, Yu Zhang, Zhong Pei, Xi Che. Therapeutic reversal of Huntington's disease by in vivo self-assembled siRNAs. Brain : a journal of neurology. vol 144. issue 11. 2021-12-17. PMID:34918046. |
huntington's disease is an autosomal-dominant neurodegenerative disease caused by cag expansion in exon 1 of the huntingtin (htt) gene. |
2021-12-17 |
2023-08-13 |
mouse |
| Adewale Adegbuyiro, Faezeh Sedighi, Pranav Jain, Mark V Pinti, Chathuranga Siriwardhana, John M Hollander, Justin Legleite. Mitochondrial membranes modify mutant huntingtin aggregation. Biochimica et biophysica acta. Biomembranes. vol 1863. issue 10. 2021-11-23. PMID:34089719. |
huntington's disease (hd) is a neurodegenerative disease caused by the expansion of a polyglutamine (polyq) tract near the n-terminus of the huntingtin (htt) protein. |
2021-11-23 |
2023-08-13 |
Not clear |
| Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng, Shang-Hsun Yan. The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease. Journal of biomedical science. vol 28. issue 1. 2021-11-22. PMID:34412645. |
huntington's disease (hd) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of huntingtin gene. |
2021-11-22 |
2023-08-13 |
Not clear |
| Wiebke Frank, Katrin S Lindenberg, Alzbeta Mühlbäck, Jan Lewerenz, G Bernhard Landwehrmeye. [Disease-modifying treatment approaches in Huntington disease : Past and future]. Der Nervenarzt. 2021-11-11. PMID:34762178. |
huntington disease (hd) is the most frequent monogenetic neurodegenerative disease and can be unequivocally diagnosed even in the preclinical stage, at least in all individuals in whom the cag expansion mutation in the huntingtin gene (htt) is in the range of full penetrance. |
2021-11-11 |
2023-08-13 |
Not clear |
| Mandi Gandelman, Warunee Dansithong, Karla P Figueroa, Sharan Paul, Daniel R Scoles, Stefan M Puls. Staufen 1 amplifies proapoptotic activation of the unfolded protein response. Cell death and differentiation. vol 27. issue 10. 2021-11-08. PMID:32415281. |
staufen-1 (stau1) is an rna-binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (psen1), microtubule-associated protein tau (mapt), huntingtin (htt), tar dna-binding protein-43 gene (tardbp), or c9orf72. |
2021-11-08 |
2023-08-13 |
Not clear |
| Hannah S Bakels, Raymund A C Roos, Willeke M C van Roon-Mom, Susanne T de Bo. Juvenile-Onset Huntington Disease Pathophysiology and Neurodevelopment: A Review. Movement disorders : official journal of the Movement Disorder Society. 2021-10-26. PMID:34636452. |
a specific focus is placed on molecular mechanisms of mutant huntingtin in early neurodevelopment and the interaction of a neurodegenerative disease and postnatal brain maturation. |
2021-10-26 |
2023-08-13 |
Not clear |
| Xiang Li, Jianbin Wan. Maintenance of chaperone-mediated autophagy activity in cultured cells expressing mutant huntingtin. Biomedical reports. vol 2. issue 4. 2021-10-21. PMID:24944802. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by mutant huntingtin (htt) with an expanded polyglutamine tract. |
2021-10-21 |
2023-08-13 |
Not clear |
| X Zhao, A Chen, Z Wang, Xiao-Han Xu, Y Ta. Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2021-09-26. PMID:34564830. |
huntington disease (hd) is a single-gene autosomal dominant inherited neurodegenerative disease caused by a polyglutamine expansion of the protein huntingtin (htt). |
2021-09-26 |
2023-08-13 |
Not clear |
| Sharon E Groover, Adewale Adegbuyiro, Caleb K Fan, Breanna L Hodges, Maryssa Beasley, Katelyn Taylor, Alyssa R Stonebraker, Chathuranga Siriwardhana, Justin Legleite. Macromolecular crowding in solution alters huntingtin interaction and aggregation at interfaces. Colloids and surfaces. B, Biointerfaces. vol 206. 2021-09-07. PMID:34246856. |
huntington's disease (hd) is a fatal neurodegenerative disease caused by an extended polyglutamine (polyq) domain within the first exon of the huntingtin protein (htt). |
2021-09-07 |
2023-08-13 |
Not clear |
| Saurabh Gupta, Arzoo Khan, Sukriti Vishwas, Monica Gulati, Thakur Gurjeet Singh, Kamal Dua, Sachin Kumar Singh, Agnieszka Najda, Amany A Sayed, Rafa Almeer, Mohamed M Abdel-Dai. Demethyleneberberine: A possible treatment for Huntington's disease. Medical hypotheses. vol 153. 2021-08-09. PMID:34229236. |
huntington disease (hd) is a type of neurodegenerative disease that is characterized by presence of multiple repeats (more than 36) of cytosine-adenine-guanine (cag) trinucleotides and mutated huntingtin (mhtt). |
2021-08-09 |
2023-08-13 |
Not clear |
| Peter Klinkmueller, Martin Kronenbuerger, Xinyuan Miao, Jee Bang, Kia E Ultz, Adrian Paez, Xiaoyu Zhang, Wenzhen Duan, Russell L Margolis, Peter Cm van Zijl, Christopher A Ross, Jun Hu. Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 5. 2021-07-29. PMID:32807001. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag triplet repeat expansion in the huntingtin gene. |
2021-07-29 |
2023-08-13 |
Not clear |
| Heather Dahlenburg, David Cameron, Sheng Yang, Angelica Bachman, Kari Pollock, Whitney Cary, Missy Pham, Kyle Hendrix, Jeannine White, Haley Nelson, Peter Deng, Joseph S Anderson, Kyle Fink, Jan Nolt. A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies. Stem cells translational medicine. vol 10. issue 7. 2021-07-01. PMID:33710799. |
huntington's disease (hd) is a fatal autosomal-dominant neurodegenerative disease caused by a trinucleotide cag repeat expansion of the huntingtin gene (htt) that affects 1 in every 10 000 individuals in the united states. |
2021-07-01 |
2023-08-13 |
mouse |