| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinlin Su, Pei Huang, Meiling Qin, Qingqing Lu, Xiao Sang, Yijun Cai, Ying Wang, Fubing Liu, Rong Wu, Xiaoping Wang, Xiaoxing Jiang, Jian Wang, Qiang Sun, Shengdi Chen, Jin X. Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models. Cell death & disease. vol 9. issue 10. 2019-11-14. PMID:30282965. |
huntingtin interaction protein 2 (hip2) is an e2 ubiquitin-conjugating enzyme associated with neurodegenerative diseases, and hip2 mrna has been implicated as a potential blood biomarker for parkinson's disease (pd). |
2019-11-14 |
2023-08-13 |
mouse |
| Shagun R Mehta, Colton M Tom, Yizhou Wang, Catherine Bresee, David Rushton, Pranav P Mathkar, Jie Tang, Virginia B Matti. Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation. Cell reports. vol 25. issue 4. 2019-11-14. PMID:30355486. |
huntington's disease (hd) is a neurodegenerative disease caused by an expanded cag repeat in the huntingtin (htt) gene. |
2019-11-14 |
2023-08-13 |
mouse |
| Priscila Aparecida Costa Valadão, Bruna da Silva Oliveira, Julliane V Joviano-Santos, Érica Leandro Marciano Vieira, Natalia Pessoa Rocha, Antônio Lúcio Teixeira, Cristina Guatimosim, Aline Silva de Mirand. Inflammatory changes in peripheral organs in the BACHD murine model of Huntington's disease. Life sciences. vol 232. 2019-10-07. PMID:31302194. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag repeat expansion in the gene encoding the huntingtin protein (htt). |
2019-10-07 |
2023-08-13 |
mouse |
| Sonia Marco, Alvaro Murillo, Isabel Pérez-Otañ. RNAi-Based GluN3A Silencing Prevents and Reverses Disease Phenotypes Induced by Mutant huntingtin. Molecular therapy : the journal of the American Society of Gene Therapy. vol 26. issue 8. 2019-07-29. PMID:29914757. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by expansion of a polyglutamine tract in the huntingtin protein. |
2019-07-29 |
2023-08-13 |
mouse |
| Joanna Gerszon, Aleksandra Rodack. Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase in neurodegenerative processes and the role of low molecular weight compounds in counteracting its aggregation and nuclear translocation. Ageing research reviews. vol 48. 2019-07-29. PMID:30254002. |
also the role of gapdh in neurodegenerative diseases is linked to it directly binding to specific amyloidogenic proteins and petides such as β-amyloid precursor protein, β-amyloid peptide and tau protein in alzheimer's disease, huntingtin in huntington's disease and α-synuclein in parkinson disease. |
2019-07-29 |
2023-08-13 |
Not clear |
| Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones, Sarah J Tabriz. FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat. Human molecular genetics. vol 28. issue 4. 2019-06-21. PMID:30358836. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by an expanded cag repeat in the huntingtin (htt) gene. |
2019-06-21 |
2023-08-13 |
human |
| Edith L Pfister, Natalie DiNardo, Erica Mondo, Florie Borel, Faith Conroy, Cara Fraser, Gwladys Gernoux, Xin Han, Danjing Hu, Emily Johnson, Lori Kennington, PengPeng Liu, Suzanne J Reid, Ellen Sapp, Petr Vodicka, Tim Kuchel, A Jennifer Morton, David Howland, Richard Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, Marian DiFiglia, Neil Aroni. Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease. Human gene therapy. vol 29. issue 6. 2019-06-07. PMID:29207890. |
huntington's disease (hd) is a fatal neurodegenerative disease caused by a genetic expansion of the cag repeat region in the huntingtin (htt) gene. |
2019-06-07 |
2023-08-13 |
mouse |
| Caterina Fusilli, Simone Migliore, Tommaso Mazza, Federica Consoli, Alessandro De Luca, Gaetano Barbagallo, Andrea Ciammola, Emilia Mabel Gatto, Martin Cesarini, Jose Luis Etcheverry, Virginia Parisi, Musallam Al-Oraimi, Salma Al-Harrasi, Qasem Al-Salmi, Massimo Marano, Jean-Paul Gerard Vonsattel, Umberto Sabatini, Georg Bernhard Landwehrmeyer, Ferdinando Squitier. Biological and clinical manifestations of juvenile Huntington's disease: a retrospective analysis. The Lancet. Neurology. vol 17. issue 11. 2019-06-06. PMID:30243861. |
huntington's disease is a rare, neurodegenerative disease caused by an expanded cag repeat mutation in the huntingtin gene. |
2019-06-06 |
2023-08-13 |
Not clear |
| Greggory Wroblewski, Md Nabiul Islam, Akie Yanai, Mir Rubayet Jahan, Koh-Hei Masumoto, Koh Shinod. Distribution of HAP1-immunoreactive Cells in the Retrosplenial-retrohippocampal Area of Adult Rat Brain and Its Application to a Refined Neuroanatomical Understanding of the Region. Neuroscience. vol 394. 2019-03-01. PMID:30367943. |
huntingtin-associated protein 1 (hap1) is a neural interactor of huntingtin in huntington's disease and interacts with gene products in a number of other neurodegenerative diseases. |
2019-03-01 |
2023-08-13 |
rat |
| Tanut Kunkanjanawan, Richard Carter, Kwan-Sung Ahn, Jinjing Yang, Rangsun Parnpai, Anthony W S Cha. Induced Pluripotent HD Monkey Stem Cells Derived Neural Cells for Drug Discovery. SLAS discovery : advancing life sciences R & D. vol 22. issue 6. 2019-02-21. PMID:28027448. |
huntington's disease (hd) is a neurodegenerative disease caused by an expansion of cag trinucleotide repeat (polyglutamine [polyq]) in the huntingtin ( htt) gene, which leads to the formation of mutant htt (mhtt) protein aggregates. |
2019-02-21 |
2023-08-13 |
monkey |
| b' Daniela Vidinsk\\xc3\\xa1, Petra Vochozkov\\xc3\\xa1, Petra \\xc5\\xa0matl\\xc3\\xadkov\\xc3\\xa1, Taras Ardan, Ji\\xc5\\x99\\xc3\\xad Kl\\xc3\\xadma, \\xc5\\xa0tefan Juh\\xc3\\xa1s, Jana Juh\\xc3\\xa1sov\\xc3\\xa1, Bo\\xc5\\xbeena Bohuslavov\\xc3\\xa1, Monika Baxa, Ivona Valekov\\xc3\\xa1, Jan Motl\\xc3\\xadk, Zdenka Ellederov\\xc3\\xa. Gradual Phenotype Development in Huntington Disease Transgenic Minipig Model at 24 Months of Age. Neuro-degenerative diseases. vol 18. issue 2-3. 2019-01-30. PMID:29870995.' |
huntington disease (hd) is an incurable neurodegenerative disease caused by the expansion of a polyglutamine sequence in a gene encoding the huntingtin (htt) protein, which is expressed in almost all cells of the body. |
2019-01-30 |
2023-08-13 |
Not clear |
| Tamara Maiuri, Laura E Bowie, Ray Truan. DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage. DNA and cell biology. vol 38. issue 1. 2019-01-28. PMID:30481056. |
dna repair signaling of huntingtin: the next link between late-onset neurodegenerative disease and oxidative dna damage. |
2019-01-28 |
2023-08-13 |
Not clear |
| Hao Chi, Hui-Yun Chang, Tzu-Kang San. Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases. International journal of molecular sciences. vol 19. issue 10. 2019-01-14. PMID:30304824. |
in this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common neurodegenerative diseases, discussing our current understanding of cell death by connecting with renowned pathogenic proteins, including tau, amyloid-beta, alpha-synuclein, huntingtin and tdp-43. |
2019-01-14 |
2023-08-13 |
Not clear |
| Wan Song, Nóra Zsindely, Anikó Faragó, J Lawrence Marsh, László Boda. Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease. Human molecular genetics. vol 27. issue 4. 2019-01-07. PMID:29281014. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). |
2019-01-07 |
2023-08-13 |
drosophila_melanogaster |
| Lydie Boussicault, Radhia Kacher, Antonin Lamazière, Peter Vanhoutte, Jocelyne Caboche, Sandrine Betuing, Marie-Claude Potie. CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content. Biochimie. vol 153. 2018-12-11. PMID:30107216. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (mhtt) protein leading to degeneration of striatal neurons. |
2018-12-11 |
2023-08-13 |
mouse |
| Ching-Chi Chang, Tzu-Chin Lin, Hsiao-Li Ho, Chien-Yin Kuo, Hsin-Hua Li, Tatiana A Korolenko, Wei-Jen Chen, Te-Jen Lai, Ying-Jui Ho, Chih-Li Li. GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. International journal of molecular sciences. vol 19. issue 9. 2018-12-11. PMID:30149534. |
huntington's disease (hd) is a progressive and fatal neurodegenerative disease caused by cag repeat expansion in the coding region of huntingtin (htt) protein. |
2018-12-11 |
2023-08-13 |
Not clear |
| P McColgan, S J Tabriz. Huntington's disease: a clinical review. European journal of neurology. vol 25. issue 1. 2018-11-27. PMID:28817209. |
huntington's disease (hd) is a fully penetrant neurodegenerative disease caused by a dominantly inherited cag trinucleotide repeat expansion in the huntingtin gene on chromosome 4. |
2018-11-27 |
2023-08-13 |
Not clear |
| Chaohua Peng, Gaochun Zhu, Xiangqian Liu, He L. Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. Neuroscience bulletin. vol 34. issue 5. 2018-11-06. PMID:29713895. |
huntington's disease (hd) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin (htt) protein. |
2018-11-06 |
2023-08-13 |
mouse |
| Xiaoyu Dong, Shuyan Con. Bioinformatic analysis of microRNA expression in Huntington's disease. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015953. |
huntington's disease (hd) is an inherited, progressive neurodegenerative disease caused by a cag expansion in the huntingtin (htt) gene and various dysfunctions of biological processes in hd have been proposed. |
2018-10-26 |
2023-08-13 |
Not clear |
| Andreas Reif, Anass Chiki, Jonathan Ricci, Hilal A Lashue. Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy. Journal of visualized experiments : JoVE. issue 136. 2018-09-10. PMID:30010666. |
huntington's disease (hd) is an inherited fatal neurodegenerative disease caused by a cag expansion (≥36) in the first exon of the hd gene, resulting in the expression of the huntingtin protein (htt) or n-terminal fragments thereof with an expanded polyglutamine (polyq) stretch. |
2018-09-10 |
2023-08-13 |
Not clear |