| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Herminia D Rosas, Gheorghe Doros, Swati Bhasin, Beena Thomas, Sona Gevorkian, Keith Malarick, Wayne Matson, Steven M Hersc. A systems-level "misunderstanding": the plasma metabolome in Huntington's disease. Annals of clinical and translational neurology. vol 2. issue 7. 2015-08-14. PMID:26273688. |
huntington's disease (hd) is a rare neurodegenerative disease caused by the expansion of an n-terminal repeat in the huntingtin protein. |
2015-08-14 |
2023-08-13 |
Not clear |
| Chien-fei Lee, Yijuang Cher. Adenosine receptors and Huntington's disease. International review of neurobiology. vol 119. 2015-05-12. PMID:25175968. |
huntington's disease (hd) is a dominant neurodegenerative disease caused by an abnormal cag expansion in the huntingtin gene. |
2015-05-12 |
2023-08-13 |
human |
| Nicolas Merienne, Nicole Déglo. [Gene silencing approaches for the treatment of Huntington's disease]. Medecine sciences : M/S. vol 31. issue 2. 2015-04-30. PMID:25744262. |
huntington's disease is a rare neurodegenerative disease caused by a pathologic cag expansion in the exon 1 of the huntingtin (htt) gene. |
2015-04-30 |
2023-08-13 |
Not clear |
| Alex Mas Monteys, Matthew J Wilson, Ryan L Boudreau, Ryan M Spengler, Beverly L Davidso. Artificial miRNAs Targeting Mutant Huntingtin Show Preferential Silencing In Vitro and In Vivo. Molecular therapy. Nucleic acids. vol 4. 2015-04-08. PMID:25849618. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by cag repeat expansion in exon 1 of huntingtin (htt). |
2015-04-08 |
2023-08-13 |
mouse |
| X Du, T Y Pang, C Mo, T Renoir, D J Wright, A J Hanna. The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease. Experimental neurology. vol 263. 2015-02-09. PMID:25246229. |
huntington's disease (hd) is an autosomal dominant, neurodegenerative disease caused by a cag tandem repeat mutation encoding a polyglutamine tract expansion in the huntingtin protein. |
2015-02-09 |
2023-08-13 |
mouse |
| Alex Mas Monteys, Ryan M Spengler, Brett D Dufour, Matt S Wilson, Clayton K Oakley, Matt J Sowada, Jodi L McBride, Beverly L Davidso. Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain. Nucleic acids research. vol 42. issue 21. 2015-01-27. PMID:25332397. |
huntington's disease is a fatal neurodegenerative disease caused by polyglutamine-expansion in huntingtin (htt). |
2015-01-27 |
2023-08-13 |
mouse |
| Lisa M Stanek, Sergio P Sardi, Bryan Mastis, Amy R Richards, Christopher M Treleaven, Tatyana Taksir, Kuma Misra, Seng H Cheng, Lamya S Shihabuddi. Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease. Human gene therapy. vol 25. issue 5. 2014-12-30. PMID:24484067. |
huntington's disease (hd) is a fatal autosomal dominant neurodegenerative disease caused by an increase in the number of polyglutamine residues in the huntingtin (htt) protein. |
2014-12-30 |
2023-08-12 |
mouse |
| Daniel Todd, Ian Gowers, Simon J Dowler, Michael D Wall, George McAllister, David F Fischer, Sipke Dijkstra, Silvina A Fratantoni, Rhea van de Bospoort, Jessica Veenman-Koepke, Geraldine Flynn, Jamshid Arjomand, Celia Dominguez, Ignacio Munoz-Sanjuan, John Wityak, Jonathan A Bar. A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease. PloS one. vol 9. issue 2. 2014-12-28. PMID:24503862. |
huntington's disease (hd) is a devastating, genetic neurodegenerative disease caused by a tri-nucleotide expansion in exon 1 of the huntingtin gene. |
2014-12-28 |
2023-08-12 |
Not clear |
| Zaira Ortega, Jose J Luca. Ubiquitin-proteasome system involvement in Huntington's disease. Frontiers in molecular neuroscience. vol 7. 2014-10-17. PMID:25324717. |
huntington's disease (hd) is a genetic autosomal dominant neurodegenerative disease caused by the expansion of a cag repeat in the huntingtin (htt) gene. |
2014-10-17 |
2023-08-13 |
Not clear |
| Spencer U McKinstry, Yonca B Karadeniz, Atesh K Worthington, Volodya Y Hayrapetyan, M Ilcim Ozlu, Karol Serafin-Molina, W Christopher Risher, Tuna Ustunkaya, Ioannis Dragatsis, Scott Zeitlin, Henry H Yin, Cagla Erogl. Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 28. 2014-09-09. PMID:25009276. |
huntington's disease (hd) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-q) stretch in the huntingtin (htt) protein. |
2014-09-09 |
2023-08-13 |
mouse |
| Tian Liu, Wooseok Im, Soon-Tae Lee, Jae-Jun Ban, Ye Jin Chai, Mijung Lee, Inhee Mook-Jung, Kon Chu, Manho Ki. Modulation of mitochondrial function by stem cell-derived cellular components. Biochemical and biophysical research communications. vol 448. issue 4. 2014-08-13. PMID:24802395. |
huntington's disease (hd) is the most common hereditary neurodegenerative diseases, in which the loss of striatal neuron caused by the aggregation of mutant huntingtin protein (mhtt) is the main pathological feature. |
2014-08-13 |
2023-08-13 |
human |
| Hiroko Yano, Sergei V Baranov, Oxana V Baranova, Jinho Kim, Yanchun Pan, Svitlana Yablonska, Diane L Carlisle, Robert J Ferrante, Albert H Kim, Robert M Friedlande. Inhibition of mitochondrial protein import by mutant huntingtin. Nature neuroscience. vol 17. issue 6. 2014-08-04. PMID:24836077. |
mitochondrial dysfunction is associated with neuronal loss in huntington's disease (hd), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (htt). |
2014-08-04 |
2023-08-13 |
mouse |
| Paul G Unschuld, Xinyang Liu, Megan Shanahan, Russell L Margolis, Susan S Bassett, Jason Brandt, David J Schretlen, Graham W Redgrave, Jun Hua, Christoph Hock, Sarah A Reading, Peter C M van Zijl, James J Pekar, Christopher A Ros. Prefrontal executive function associated coupling relates to Huntington's disease stage. Cortex; a journal devoted to the study of the nervous system and behavior. vol 49. issue 10. 2014-07-30. PMID:23906595. |
huntington's disease (hd) is a neurodegenerative disease caused by cytosine-adenine-guanine (cag)-repeat expansion in the huntingtin (htt) gene. |
2014-07-30 |
2023-08-12 |
human |
| Daria Mochly-Rosen, Marie-Helene Disatnik, Xin Q. The challenge in translating basic research discoveries to treatment of Huntington disease. Rare diseases (Austin, Tex.). vol 2. 2014-07-23. PMID:25054095. |
huntington disease is a rare neurodegenerative disease resulting from insertion and/or expansion of a polyglutamine repeats close to the n-terminal of the huntingtin protein. |
2014-07-23 |
2023-08-13 |
Not clear |
| Peng-Fei Wei, Li Zhang, Susheel Kumar Nethi, Ayan Kumar Barui, Jun Lin, Wei Zhou, Yi Shen, Na Man, Yun-Jiao Zhang, Jing Xu, Chitta Ranjan Patra, Long-Ping We. Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods. Biomaterials. vol 35. issue 3. 2014-06-25. PMID:24169003. |
in the present article, we have demonstrated that europium hydroxide [eu(iii)(oh)3] nanorods can reduce huntingtin protein aggregation (egfp-tagged huntingtin protein with 74 polyq repeats), responsible for neurodegenerative diseases. |
2014-06-25 |
2023-08-12 |
Not clear |
| Peng-Fei Wei, Li Zhang, Susheel Kumar Nethi, Ayan Kumar Barui, Jun Lin, Wei Zhou, Yi Shen, Na Man, Yun-Jiao Zhang, Jing Xu, Chitta Ranjan Patra, Long-Ping We. Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods. Biomaterials. vol 35. issue 3. 2014-06-25. PMID:24169003. |
since [eu(iii)(oh)3] nanorods can enhance the degradation of huntingtin protein aggregation via autophagy induction, we strongly believe that these nanorods would be useful for the development of therapeutic treatment strategies for various neurodegenerative diseases in near future using nanomedicine approach. |
2014-06-25 |
2023-08-12 |
Not clear |
| Lara Moumné, Sandrine Betuing, Jocelyne Caboch. Multiple Aspects of Gene Dysregulation in Huntington's Disease. Frontiers in neurology. vol 4. 2014-06-24. PMID:24167500. |
huntington's disease (hd) is a genetic neurodegenerative disease caused by a cag expansion in the gene encoding huntingtin (htt). |
2014-06-24 |
2023-08-12 |
mouse |
| Bruce X Wong, James A Duc. The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders. Frontiers in pharmacology. vol 5. 2014-06-24. PMID:24795635. |
recently proteins directly implicated in the most prevalent neurodegenerative diseases, such as amyloid-β precursor protein, tau, α-synuclein, prion protein and huntingtin, have been connected to neuronal iron homeostatic control. |
2014-06-24 |
2023-08-13 |
human |
| Maddalena Costanzo, Saïda Abounit, Ludovica Marzo, Anne Danckaert, Zeina Chamoun, Pascal Roux, Chiara Zurzol. Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes. Journal of cell science. vol 126. issue Pt 16. 2014-06-15. PMID:23781027. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by cag expansion in the huntingtin gene, which adds a homopolymeric tract of polyglutamine (polyq) to the encoded protein leading to the formation of toxic aggregates. |
2014-06-15 |
2023-08-12 |
Not clear |
| Juan I Sbodio, Bindu D Paul, Carolyn E Machamer, Solomon H Snyde. Golgi protein ACBD3 mediates neurotoxicity associated with Huntington's disease. Cell reports. vol 4. issue 5. 2014-06-12. PMID:24012756. |
huntington's disease (hd) is an autosomal-dominant neurodegenerative disease caused by the expansion of polyglutamine repeats in the gene for huntingtin (htt). |
2014-06-12 |
2023-08-12 |
mouse |