| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryoma Morigaki, Satoshi Got. Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity. Brain sciences. vol 7. issue 6. 2020-09-29. PMID:28590448. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by the expansion of a cag trinucleotide repeat encoding an abnormally long polyglutamine tract (polyq) in the huntingtin (htt) protein. |
2020-09-29 |
2023-08-13 |
Not clear |
| Maxmore Chaibva, Xiang Gao, Pranav Jain, Warren A Campbell, Shelli L Frey, Justin Legleite. Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes. ACS omega. vol 3. issue 1. 2020-09-29. PMID:29399649. |
huntington disease (hd) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyq) tract near the n-terminus of the huntingtin (htt) protein. |
2020-09-29 |
2023-08-13 |
Not clear |
| Irene Rosas, Carmen Martínez, Jordi Clarimón, Alberto Lleó, Ignacio Illán-Gala, Oriol Dols-Icardo, Barbara Borroni, Maria Rosário Almeida, Julie van der Zee, Christine Van Broeckhoven, Amalia C Bruni, Maria Anfossi, Livia Bernardi, Raffaele Maletta, María Serpente, Daniela Galimberti, Elio Scarpini, Giacomina Rossi, Paola Caroppo, Luisa Benussi, Roberta Ghidoni, Giuliano Binetti, Benedetta Nacmias, Sandro Sorbi, Irene Piaceri, Silvia Bagnoli, Anna Antonell, Raquel Sánchez-Valle, Beatriz De la Casa-Fages, Francisco Grandas, Mónica Diez-Fairen, Pau Pastor, Raffaele Ferrari, Victoria Álvarez, Manuel Menéndez-Gonzále. Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease. Neurobiology of aging. vol 87. 2020-09-14. PMID:31810584. |
we analyzed the frequency of intermediate alleles (ias) in the atxn1, atxn2, and htt genes in several neurodegenerative diseases. |
2020-09-14 |
2023-08-13 |
Not clear |
| Yi-Ying Wu, Hung-Chih Ku. Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases. Journal of biomedical science. vol 27. issue 1. 2020-09-11. PMID:32264890. |
here, we review the ncrnas that have so far been identified in major neurodegenerative disease etiology and the mechanisms that link ncrnas with disease-specific phenotypes, such as htt aggregation in hd, α-synuclein in pd, and aβ plaques and hyperphosphorylated tau in ad. |
2020-09-11 |
2023-08-13 |
Not clear |
| Zhihao Qi, Zhen Huang, Feng Xie, Linxi Che. Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30515821. |
here, we will give a detailed review about the recent developments in regards to dynamin-related protein 1 (drp1) induced unbalanced mitochondrial dynamics, excessive mitochondrial division, and neuronal injury in neural system dysfunctions and neurodegenerative diseases, including the drp1 knockout induced mice embryonic death, the dysfunction of the drp1-dependent mitochondrial division induced neuronal cell apoptosis and impaired neuronal axonal transportation, the abnormal interaction between drp1 and amyloid β (aβ) in alzheimer's disease (ad), the mutant huntingtin (htt) in huntington's disease (hd), and the drp1-associated pathogenesis of other neurodegenerative diseases such as parkinson's disease (pd) and amyotrophic lateral sclerosis (als). drp1 is required for mitochondrial division determining the size, shape, distribution, and remodeling as well as maintaining of mitochondrial integrity in mammalian cells. |
2020-05-04 |
2023-08-13 |
mouse |
| Linda M van der Graaf, Sarah L Gardiner, Merve Tok, Tom Brands, Merel W Boogaard, Barry A Pepers, Bert Eussen, Annelies de Klein, N Ahmad Aziz, Christian Freund, Ronald A M Buijsen, Willeke M C van Roon-Mo. Generation of 5 induced pluripotent stem cell lines, LUMCi007-A and B and LUMCi008-A, B and C, from 2 patients with Huntington disease. Stem cell research. vol 39. 2020-04-27. PMID:31326748. |
huntington disease (hd) is an autosomal dominant, neurodegenerative disease caused by a cag repeat expansion within the coding sequence of the htt gene, resulting in a highly toxic protein with an expanded polyglutamine stretch that forms typical protein aggregates throughout the brain. |
2020-04-27 |
2023-08-13 |
human |
| Lisa M Stanek, Jie Bu, Lamya S Shihabuddi. Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics. Neurobiology of disease. vol 129. 2020-03-24. PMID:31042572. |
huntington's disease (hd) is a fatal autosomal dominant neurodegenerative disease caused by a cag expansion, which translates into an elongated polyglutamine (polyq) repeat near the amino-terminus of the huntingtin protein (htt). |
2020-03-24 |
2023-08-13 |
mouse |
| Chelsy R Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R Hayden, Christopher A Ros. Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor. Neurobiology of disease. vol 129. 2020-03-24. PMID:31108174. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag repeat expansion in the huntingtin gene (htt), translated into a huntingtin protein with a polyglutamine expansion. |
2020-03-24 |
2023-08-13 |
mouse |
| Nicholas S Caron, Amber L Southwell, Cynthia C Brouwers, Louisa Dal Cengio, Yuanyun Xie, Hailey Findlay Black, Lisa M Anderson, Seunghyun Ko, Xiang Zhu, Sander J van Deventer, Melvin M Evers, Pavlina Konstantinova, Michael R Hayde. Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease. Nucleic acids research. vol 48. issue 1. 2020-03-18. PMID:31745548. |
huntington disease (hd) is a fatal neurodegenerative disease caused by a pathogenic expansion of a cag repeat in the huntingtin (htt) gene. |
2020-03-18 |
2023-08-13 |
mouse |
| Zixing Fu, Fang Liu, Chunyue Liu, Beifang Jin, Yueqing Jiang, Mingliang Tang, Xin Qi, Xing Gu. Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 6. 2020-02-03. PMID:30802639. |
numerous studies have shown that mitochondrial dysfunction contributes to consequential phenotypes of huntington's disease (hd), a fatal and inherited neurodegenerative disease caused by the expanded cag repeats in the n-terminus of the huntingtin (htt) gene. |
2020-02-03 |
2023-08-13 |
Not clear |
| Ashley A Zurawel, Ruth Kabeche, Sonja E DiGregorio, Lin Deng, Kartikeya M Menon, Hannah Opalko, Martin L Duennwald, James B Moseley, Surachai Supattapon. CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins. mBio. vol 7. issue 5. 2019-12-30. PMID:27677791. |
in humans, proteins such as huntingtin (htt) with abnormally expanded polyq regions cause neurodegenerative diseases such as huntington's disease (hd). |
2019-12-30 |
2023-08-13 |
Not clear |
| Chenglong Yu, Chun Hei Li, Sidong Chen, Hanna Yoo, Xianan Qin, Hyokeun Par. Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington's Disease. Scientific reports. vol 8. issue 1. 2019-12-13. PMID:30451892. |
huntington's disease (hd) is a dominantly inherited neurodegenerative disease caused by an increase in cag repeats in the huntingtin gene (htt). |
2019-12-13 |
2023-08-13 |
mouse |
| Shagun R Mehta, Colton M Tom, Yizhou Wang, Catherine Bresee, David Rushton, Pranav P Mathkar, Jie Tang, Virginia B Matti. Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation. Cell reports. vol 25. issue 4. 2019-11-14. PMID:30355486. |
huntington's disease (hd) is a neurodegenerative disease caused by an expanded cag repeat in the huntingtin (htt) gene. |
2019-11-14 |
2023-08-13 |
mouse |
| Priscila Aparecida Costa Valadão, Bruna da Silva Oliveira, Julliane V Joviano-Santos, Érica Leandro Marciano Vieira, Natalia Pessoa Rocha, Antônio Lúcio Teixeira, Cristina Guatimosim, Aline Silva de Mirand. Inflammatory changes in peripheral organs in the BACHD murine model of Huntington's disease. Life sciences. vol 232. 2019-10-07. PMID:31302194. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag repeat expansion in the gene encoding the huntingtin protein (htt). |
2019-10-07 |
2023-08-13 |
mouse |
| E V Grigor'eva, T B Malankhanova, A Surumbayeva, J M Minina, V V Morozov, N Yu Abramycheva, S N Illarioshkin, A A Malakhova, S M Zakia. Generation of induced pluripotent stem cell line, ICGi007-A, by reprogramming peripheral blood mononuclear cells from a patient with Huntington's disease. Stem cell research. vol 34. 2019-08-06. PMID:30658253. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by mutation in the htt gene encoding htt protein. |
2019-08-06 |
2023-08-13 |
human |
| Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones, Sarah J Tabriz. FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat. Human molecular genetics. vol 28. issue 4. 2019-06-21. PMID:30358836. |
huntington's disease (hd) is an inherited neurodegenerative disease caused by an expanded cag repeat in the huntingtin (htt) gene. |
2019-06-21 |
2023-08-13 |
human |
| Edith L Pfister, Natalie DiNardo, Erica Mondo, Florie Borel, Faith Conroy, Cara Fraser, Gwladys Gernoux, Xin Han, Danjing Hu, Emily Johnson, Lori Kennington, PengPeng Liu, Suzanne J Reid, Ellen Sapp, Petr Vodicka, Tim Kuchel, A Jennifer Morton, David Howland, Richard Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, Marian DiFiglia, Neil Aroni. Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease. Human gene therapy. vol 29. issue 6. 2019-06-07. PMID:29207890. |
huntington's disease (hd) is a fatal neurodegenerative disease caused by a genetic expansion of the cag repeat region in the huntingtin (htt) gene. |
2019-06-07 |
2023-08-13 |
mouse |
| Sonia Podvin, Holly T Reardon, Katrina Yin, Charles Mosier, Vivian Hoo. Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. Journal of neurology. vol 266. issue 3. 2019-06-06. PMID:29956026. |
huntington's disease (hd) is a fatal neurodegenerative disease caused by mutant htt gene expansions of cag triplet repeat numbers that are inherited in an autosomal dominant manner. |
2019-06-06 |
2023-08-13 |
human |
| Tanut Kunkanjanawan, Richard Carter, Kwan-Sung Ahn, Jinjing Yang, Rangsun Parnpai, Anthony W S Cha. Induced Pluripotent HD Monkey Stem Cells Derived Neural Cells for Drug Discovery. SLAS discovery : advancing life sciences R & D. vol 22. issue 6. 2019-02-21. PMID:28027448. |
huntington's disease (hd) is a neurodegenerative disease caused by an expansion of cag trinucleotide repeat (polyglutamine [polyq]) in the huntingtin ( htt) gene, which leads to the formation of mutant htt (mhtt) protein aggregates. |
2019-02-21 |
2023-08-13 |
monkey |
| Matthew B Veldman, X William Yan. Molecular insights into cortico-striatal miscommunications in Huntington's disease. Current opinion in neurobiology. vol 48. 2019-02-11. PMID:29125980. |
huntington's disease (hd), a dominantly inherited neurodegenerative disease, is defined by its genetic cause, a cag-repeat expansion in the htt gene, its motor and psychiatric symptomology and primary loss of striatal medium spiny neurons (msns). |
2019-02-11 |
2023-08-13 |
mouse |